Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



POLD4 Gene

protein-coding   GIFtS: 55
GCID: GC11M067119

Polymerase (DNA-Directed), Delta 4, Accessory Subunit

(Previous names: polymerase (DNA-directed), delta 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Polymerase (DNA-Directed), Delta 4, Accessory Subunit1 2     DNA Polymerase Delta Subunit 42
POLDS2 3 5     p122
DNA Polymerase Delta Smallest Subunit P121 2     DNA Polymerase Delta Subunit P123
Polymerase (DNA-Directed), Delta 41     P125

External Ids:    HGNC: 141061   Entrez Gene: 578042   Ensembl: ENSG000001754827   OMIM: 6115255   UniProtKB: Q9HCU83   

Export aliases for POLD4 gene to outside databases

Previous GC identifers: GC11M069752 GC11M068815 GC11M067369 GC11M066894 GC11M066875 GC11M063448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for POLD4 Gene:
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and
3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein
enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through
interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for POLD4 Gene:
POLD4 (polymerase (DNA-directed), delta 4, accessory subunit) is a protein-coding gene. Diseases associated with POLD4 include bloom syndrome, and endotheliitis. GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot: DPOD4_HUMAN, Q9HCU8
Function: Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA
polymerase delta

Gene Wiki entry for POLD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLD4 gene promoter:
         c-Rel   NF-1   Sp1   Lmo2   MIF-1   C/EBPalpha   FOXL1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLD4 promoter sequence
   Search Chromatin IP Primers for POLD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

POLD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLD4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067119:  view genomic region     (about GC identifiers)

Start:
67,118,248 bp from pter      End:
67,124,443 bp from pter
Size:
6,196 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DPOD4_HUMAN, Q9HCU8 (See protein sequence)
Recommended Name: DNA polymerase delta subunit 4  
Size: 107 amino acids; 12433 Da
Subunit: Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1.
Interacts with POLD4, POLD2, POLD1 and PCNA
Secondary accessions: F5H506
Alternative splicing: 2 isoforms:  Q9HCU8-1   Q9HCU8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for POLD4: NX_Q9HCU8

Explore proteomics data for POLD4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POLD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243799.1  NP_066996.3  

    ENSEMBL proteins: 
     ENSP00000436361   ENSP00000311368   ENSP00000444780   ENSP00000433408  
    Reactome Protein details: Q9HCU8

    POLD4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for POLD4
    OriGene Protein Over-expression Lysate for POLD4
    OriGene MassSpec for POLD4
    OriGene Custom Protein Services for POLD4
    GenScript Custom Purified and Recombinant Proteins Services for POLD4
    Novus Biologicals POLD4 Proteins
    Novus Biologicals POLD4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for POLD4
    Browse Proteins at Cloud-Clone Corp.

    POLD4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POLD4
    Novus Biologicals POLD4 Antibodies
    Abcam antibodies for POLD4
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for POLD4
    Search LSBio for Antibodies for POLD4

    POLD4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POLD4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POLD4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    POL: DNA polymerases

    1 InterPro protein domain:
     IPR007218 DNA_pol_delta_4

    Graphical View of Domain Structure for InterPro Entry Q9HCU8

    ProtoNet protein and cluster: Q9HCU8

    1 Blocks protein domain: IPB007218 DNA polymerase delta

    UniProtKB/Swiss-Prot: DPOD4_HUMAN, Q9HCU8
    Similarity: Belongs to the DNA polymerase delta subunit 4 family


    POLD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPOD4_HUMAN, Q9HCU8
    Function: Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA
    polymerase delta

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0005515protein binding IPI12403614
         
    POLD4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for POLD4:
     Increased gamma-H2AX phosphory  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLD4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POLD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target POLD4:
    hsa-mir-335-5p (MIRT017868), hsa-mir-26b-5p (MIRT029515)

    Block miRNA regulation of human, mouse, rat POLD4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate POLD4:
    hsa-miR-3161 hsa-miR-544b hsa-miR-575 hsa-miR-3157-5p hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidPOLD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POLD4
    Predesigned siRNA for gene silencing in human, mouse, rat POLD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POLD4

    Clone
    Products:
         
    OriGene clones in human, mouse for POLD4 (see all 7)
    OriGene ORF clones in mouse, rat for POLD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLD4 (NM_021173)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POLD4
    Browse ESI BIO Cell Lines and PureStem Progenitors for POLD4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DPOD4_HUMAN, Q9HCU8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10751307
    GO:0005654nucleoplasm TAS--

    POLD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for POLD4 About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Telomere C-strand (Lagging Strand) Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Removal of the Flap Intermediate from the C-strand0.00
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    Polymerase switching on the C-strand of the telomere0.00
    Telomere C-strand (Lagging Strand) Synthesis0.79
    Lagging Strand Synthesis0.00
    Extension of Telomeres0.79
    Removal of the Flap Intermediate0.00
    2Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Base Excision Repair0.00
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    Removal of DNA patch containing abasic residue0.00
    Base excision repair0.53
    3Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Nucleotide excision repair0.69
    4DNA strand elongation
    DNA strand elongation0.63
    DNA replication0.63
    5Homologous recombination
    Homologous recombination0.40
    Homologous recombination0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POLD4
        DNA Repair Mechanisms
    Cell Cycle Control of Chromosomal Replication

    1 GeneGo (Thomson Reuters) Pathway for POLD4
        Cell cycle Transition and termination of DNA replication

    2 BioSystems Pathways for POLD4
        Homologous recombination
    DNA Replication

    Selected Reactome Pathways for POLD4 (see all 12)
        Processive synthesis on the lagging strand
    Removal of DNA patch containing abasic residue
    Processive synthesis on the C-strand of the telomere
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway
    Repair synthesis for gap-filling by DNA polymerase in TC-NER


    Selected Kegg Pathways  (Kegg details for POLD4) (see all 9):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    DNA replication
    Base excision repair


    POLD4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLD4
    Interactions:

        GeneGlobe Interaction Network for POLD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLD4 (Q9HCU81, 3 ENSP000003113684) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120041, 3, ENSP000003684384EBI-864968,EBI-358311 I2D: score=3 STRING: ENSP00000368438
    WRNIP1Q96S551, 3, ENSP000003701504EBI-864968,EBI-2513471 I2D: score=1 STRING: ENSP00000370150
    POLD1P283401, 3EBI-864968,EBI-716569 I2D: score=4 
    POLD2P490051, 3EBI-864968,EBI-372354 I2D: score=1 
    SEC23IPQ9Y6Y83, ENSP000003580714I2D: score=2 STRING: ENSP00000358071
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0006260DNA replication TAS10751307

    POLD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLD4 (DPOD4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for POLD4 gene (2 alternative transcripts): 
    NM_001256870.1  NM_021173.4  

    Unigene Cluster for POLD4:

    Polymerase (DNA-directed), delta 4, accessory subunit
    Hs.523829  [show with all ESTs]
    Unigene Representative Sequence: NR_046411
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529704 ENST00000533429 ENST00000530584(uc001okn.3) ENST00000312419
    ENST00000532830 ENST00000534515(uc001okm.3) ENST00000528087 ENST00000539074
    ENST00000531239 ENST00000524743 ENST00000525255 ENST00000542982 ENST00000529000

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat POLD4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate POLD4:
    hsa-miR-3161 hsa-miR-544b hsa-miR-575 hsa-miR-3157-5p hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidPOLD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for POLD4
    Predesigned siRNA for gene silencing in human, mouse, rat POLD4
    Clone
    Products:
         
    OriGene clones in human, mouse for POLD4 (see all 7)
    OriGene ORF clones in mouse, rat for POLD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLD4 (NM_021173)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for POLD4
    OriGene qSTAR qPCR primer pairs in human, mouse for POLD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLD4
      QuantiTect SYBR Green Assays in human, mouse, rat POLD4
      QuantiFast Probe-based Assays in human, mouse, rat POLD4

    Additional mRNA sequence: 

    AF179890.1 BC001334.1 BC070250.1 NR_046411.1 NR_046412.1 NR_046413.1 U09196.1 

    23 DOTS entries:

    DT.316638  DT.100784183  DT.100784187  DT.100727955  DT.99942022  DT.120703546  DT.95367986  DT.120703527 
    DT.120703510  DT.120703633  DT.100811636  DT.92435239  DT.95098142  DT.100784193  DT.120703610  DT.100784189 
    DT.120703586  DT.95094863  DT.100784194  DT.120703449  DT.65286442  DT.92435241  DT.120703620 

    Selected AceView cDNA sequences (see all 411):

    CD369579 AW206160 BI760542 CB107206 BG756629 AW149130 AW002872 F36077 
    AA830376 BE464342 AI373207 CD674858 AA922759 BU543841 BF432597 BE348257 
    CA868063 AI492146 BX281459 BM456916 BU631710 BQ014760 BG386916 AA917435 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POLD4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -     -     -     -     -     -     -     -                 -     -     -                                 
    SP2:                                                  -     -     -                 -     -     -                                 
    SP3:                                            -     -     -     -                 -     -     -                                 
    SP4:                                                        -     -                 -     -     -                                 
    SP5:                                                                                -     -     -                                 


    ECgene alternative splicing isoforms for POLD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    POLD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAAAGAT
    POLD4 Expression
    About this image


    POLD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Liver (Hepatobiliary System)
     
     Tonsil (Hematopoietic System)
    POLD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523829
        Custom PCR Arrays for POLD4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POLD4
    OriGene qSTAR qPCR primer pairs in human, mouse for POLD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLD4
    QuantiTect SYBR Green Assays in human, mouse, rat POLD4
    QuantiFast Probe-based Assays in human, mouse, rat POLD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for POLD4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pold41 , 5 polymerase (DNA-directed), delta 41, 5 85.67(n)1
    83.18(a)1
      19 (3.93 cM)5
    697451  NM_027196.31  NP_081472.11 
     42318995 
    zebrafish
    (Danio rerio)
    Actinopterygii POLD46
    polymerase (DNA-directed), delta 4, accessory subu...
    38(a)
    1 ↔ 1
    1(45162532-45166415) ENSDARG00000079632


    ENSEMBL Gene Tree for POLD4 (if available)
    TreeFam Gene Tree for POLD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    2 SNPs for POLD4    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283642401,2,4
    ----see VAR_0222692 mis40--------
    rs341362631,2,4
    ----see VAR_0575262 mis40--------

    HapMap Linkage Disequilibrium report for POLD4 (67118248 - 67124443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for POLD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv367CNV Insertion18451855
    nsv897796CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv468603CNV Loss19166990
    nsv897804CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POLD4
    DNA2.0 Custom Variant and Variant Library Synthesis for POLD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611525    OMIM disorders: --

    3 diseases for POLD4:    
    About MalaCards
    bloom syndrome    endotheliitis    lung cancer


    POLD4 for disorders           About GeneDecksing


    Export disorders for POLD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for POLD4 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with POLD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a fourth subunit of mammalian DNA polymerase delta. (PubMed id 10751307)1, 2, 3 Liu L.... Lee M.Y.W.T. (J. Biol. Chem. 2000)
    2. Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PubMed id 16510448)1, 2 Li H.... Lee M.Y. (J. Biol. Chem. 2006)
    3. Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. (PubMed id 15670210)1, 2 Tsurimoto T.... Enomoto T. (Genes Cells 2005)
    4. A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase I' in response to DNA damage and during the S phase. (PubMed id 23913683)1 Zhang S....Lee M.Y. (J. Biol. Chem. 2013)
    5. Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase I' for degradation in response to DNA damage. (PubMed id 23233665)1 Zhang S....Lee M.Y. (J. Biol. Chem. 2013)
    6. Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage. (PubMed id 24022480)1 Terai K....Dutta A. (J. Biol. Chem. 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication. (PubMed id 21705323)1 Bermudez V.P....Hurwitz J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57804 HGNC: 14106 AceView: CLCandPOLD4 Ensembl:ENSG00000175482 euGenes: HUgn57804
    ECgene: POLD4 Kegg: 57804 H-InvDB: POLD4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for POLD4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pold4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for POLD4 gene:
    Search GeneIP for patents involving POLD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for POLD4  
     OriGene qPCR primer pairs and template standards for POLD4   OriGene Protein Over-expression Lysate for POLD4  
     OriGene MassSpec something-or-other for POLD4   OriGene clones in human, mouse for POLD4  
     OriGene qSTAR qPCR primer pairs in human, mouse for POLD4   OriGene Purified Protein for POLD4  
     OriGene ORF clones in mouse, rat for POLD4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POLD4   OriGene Custom Protein Services for POLD4  

     
     
     Block miRNA regulation of human, mouse, rat POLD4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing POLD4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLD4 Predesigned siRNA for gene silencing in human, mouse, rat POLD4
     QuantiFast Probe-based Assays in human, mouse, rat POLD4 QuantiTect SYBR Green Assays in human, mouse, rat POLD4
     Custom PCR Arrays for POLD4 Search Chromatin IP Primers for POLD4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLD4  GeneGlobe Interaction Network for POLD4
     Regulatory tfbs in POLD4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for POLD4 GenScript cDNA clones with any tag delivered in your preferred vector for POLD4
     GenScript Custom Assay Services for POLD4 GenScript Custom overexpressing Cell Line Services for POLD4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for POLD4 (DPOD4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     POLD4 antibodies
     POLD4 proteins
     POLD4 lysates
     Antibodies for POLD4
     See all of Abcam's Antibodies, Kits and Proteins for POLD4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for POLD4
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for POLD4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD4
     SwitchGear 3'UTR luciferase reporter plasmids for POLD4
     SwitchGear Promoter luciferase reporter plasmids for POLD4
     Search ThermoFisher Antibodies for POLD4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLD4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POLD4
     Search LSBio for Antibodies for POLD4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      POLD4 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4