Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POLD4 Gene

protein-coding   GIFtS: 54
GCID: GC11M067119

Polymerase (DNA-Directed), Delta 4, Accessory Subunit

(Previous names: polymerase (DNA-directed), delta 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polymerase (DNA-Directed), Delta 4, Accessory Subunit1 2     DNA Polymerase Delta Subunit 42
POLDS2 3 5     p122
DNA Polymerase Delta Smallest Subunit P121 2     DNA Polymerase Delta Subunit P123
Polymerase (DNA-Directed), Delta 41     P125

External Ids:    HGNC: 141061   Entrez Gene: 578042   Ensembl: ENSG000001754827   OMIM: 6115255   UniProtKB: Q9HCU83   

Export aliases for POLD4 gene to outside databases

Previous GC identifers: GC11M069752 GC11M068815 GC11M067369 GC11M066894 GC11M066875 GC11M063448


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLD4 Gene:
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and
3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein
enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through
interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for POLD4 Gene: 
POLD4 (polymerase (DNA-directed), delta 4, accessory subunit) is a protein-coding gene. Diseases associated with POLD4 include bloom syndrome, and lung cancer, and among its related super-pathways are Lagging Strand Synthesis and Removal of DNA patch containing abasic residue. GO annotations related to this gene include protein binding and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot: DPOD4_HUMAN, Q9HCU8
Function: Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA
polymerase delta

Gene Wiki entry for POLD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLD4 gene promoter:
         c-Rel   NF-1   Sp1   Lmo2   MIF-1   C/EBPalpha   FOXL1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for POLD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

POLD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLD4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067119:  view genomic region     (about GC identifiers)

Start:
67,118,248 bp from pter      End:
67,124,443 bp from pter
Size:
6,196 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPOD4_HUMAN, Q9HCU8 (See protein sequence)
Recommended Name: DNA polymerase delta subunit 4  
Size: 107 amino acids; 12433 Da
Subunit: Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1.
Interacts with POLD4, POLD2, POLD1 and PCNA
Subcellular location: Nucleus
Secondary accessions: F5H506
Alternative splicing: 2 isoforms:  Q9HCU8-1   Q9HCU8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for POLD4: NX_Q9HCU8

Explore proteomics data for POLD4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCU8

  • POLD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POLD4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243799.1  NP_066996.3  

    ENSEMBL proteins: 
     ENSP00000436361   ENSP00000311368   ENSP00000444780   ENSP00000433408  
    Reactome Protein details: Q9HCU8
    Human Recombinant Protein Products for POLD4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for POLD4
    OriGene Protein Over-expression Lysate for POLD4
    OriGene MassSpec for POLD4 
    OriGene Custom Protein Services for POLD4
    GenScript Custom Purified and Recombinant Proteins Services for POLD4
    Novus Biologicals POLD4 Proteins
    Novus Biologicals POLD4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10751307
    GO:0005654nucleoplasm TAS--

    POLD4 for ontologies           About GeneDecksing



    POLD4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POLD4
    GenScript Custom Superior Antibodies Services for POLD4
    Novus Biologicals POLD4 Antibodies
    Abcam antibodies for POLD4
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for POLD4
    Search LSBio for Antibodies for POLD4 

    Assay Products for POLD4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POLD4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POLD4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POL: DNA polymerases

    1 InterPro protein domain:
     IPR007218 DNA_pol_delta_4

    Graphical View of Domain Structure for InterPro Entry Q9HCU8

    ProtoNet protein and cluster: Q9HCU8

    1 Blocks protein domain: IPB007218 DNA polymerase delta

    UniProtKB/Swiss-Prot: DPOD4_HUMAN, Q9HCU8
    Similarity: Belongs to the DNA polymerase delta subunit 4 family


    POLD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPOD4_HUMAN, Q9HCU8
    Function: Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA
    polymerase delta

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0005515protein binding IPI12403614
         
    POLD4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for POLD4:
     Increased gamma-H2AX phosphory  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for POLD4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLD4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLD4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLD4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate POLD4:
    hsa-miR-3161 hsa-miR-544b hsa-miR-575 hsa-miR-3157-5p hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidPOLD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POLD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POLD4
    Sirion Biotech Customized adenovirus for overexpression of POLD4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for POLD4 (see all 7)
    OriGene ORF clones in mouse, rat for POLD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLD4 (NM_021173)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD4
    Sirion Biotech Customized lentivirus for stable overexpression of POLD4 
                         Customized lentivirus expression plasmids for stable overexpression of POLD4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POLD4
    Search LifeMap BioReagents cell lines for POLD4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POLD4 About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Lagging Strand Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Removal of the Flap Intermediate from the C-strand0.91
    Gap-filling DNA repair synthesis and ligation in GG-NER0.94
    Processive synthesis on the C-strand of the telomere0.91
    Repair synthesis for gap-filling by DNA polymerase in TC-NER0.94
    Polymerase switching on the C-strand of the telomere0.70
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    Leading Strand Synthesis0.70
    2Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Removal of DNA patch containing abasic residue0.89
    Base Excision Repair0.89
    Base excision repair0.53
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    3Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replacation0.95
    Cell cycle Transition and termination of DNA replication0.95
    4Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.70
    Nucleotide excision repair0.70
    5Homologous recombination
    Homologous recombination0.40
    Homologous recombination0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for POLD4
        Cell cycle Transition and termination of DNA replacation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLD4
        DNA Repair Mechanisms
    Cell Cycle Control of Chromosomal Replication

    1 GeneGo (Thomson Reuters) Pathway for POLD4
        Cell cycle Transition and termination of DNA replication

    2 BioSystems Pathways for POLD4
        Homologous recombination
    DNA Replication

    5/30        Reactome Pathways for POLD4 (see all 30)
        Extension of Telomeres
    Processive synthesis on the lagging strand
    Telomere Maintenance
    DNA Repair
    Leading Strand Synthesis


    5/9         Kegg Pathways  (Kegg details for POLD4) (see all 9):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    DNA replication
    Base excision repair


    POLD4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for POLD4 (Q9HCU81, 3 ENSP000003113684) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120041, 3, ENSP000003684384EBI-864968,EBI-358311 I2D: score=3 STRING: ENSP00000368438
    WRNIP1Q96S551, 3, ENSP000003701504EBI-864968,EBI-2513471 I2D: score=1 STRING: ENSP00000370150
    POLD1P283401, 3EBI-864968,EBI-716569 I2D: score=4 
    POLD2P490051, 3EBI-864968,EBI-372354 I2D: score=1 
    SEC23IPQ9Y6Y83, ENSP000003580714I2D: score=2 STRING: ENSP00000358071
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0006260DNA replication TAS10751307

    POLD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLD4 (DPOD4)

    Search CenterWatch for drugs/clinical trials and news about POLD4 / DPOD4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POLD4 gene (2 alternative transcripts): 
    NM_001256870.1  NM_021173.4  

    Unigene Cluster for POLD4:

    Polymerase (DNA-directed), delta 4, accessory subunit
    Hs.523829  [show with all ESTs]
    Unigene Representative Sequence: NR_046411
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529704 ENST00000533429 ENST00000530584(uc001okn.3) ENST00000312419
    ENST00000532830 ENST00000534515(uc001okm.3) ENST00000528087 ENST00000539074
    ENST00000531239 ENST00000524743 ENST00000525255 ENST00000542982 ENST00000529000

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLD4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate POLD4:
    hsa-miR-3161 hsa-miR-544b hsa-miR-575 hsa-miR-3157-5p hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidPOLD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POLD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLD4
    Clone
    Products:
         
    OriGene clones in human, mouse for POLD4 (see all 7)
    OriGene ORF clones in mouse, rat for POLD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLD4 (NM_021173)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD4
    Sirion Biotech Customized lentivirus for stable overexpression of POLD4 
                         Customized lentivirus expression plasmids for stable overexpression of POLD4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for POLD4
    OriGene qSTAR qPCR primer pairs in human, mouse for POLD4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLD4

    Additional mRNA sequence: 

    AF179890.1 BC001334.1 BC070250.1 NR_046411.1 NR_046412.1 NR_046413.1 U09196.1 

    23 DOTS entries:

    DT.316638  DT.100784183  DT.100784187  DT.100727955  DT.99942022  DT.120703546  DT.95367986  DT.120703527 
    DT.120703510  DT.120703633  DT.100811636  DT.92435239  DT.95098142  DT.100784193  DT.120703610  DT.100784189 
    DT.120703586  DT.95094863  DT.100784194  DT.120703449  DT.65286442  DT.92435241  DT.120703620 

    24/411 AceView cDNA sequences (see all 411):

    CA868311 BI832607 CA748807 AA928343 BM668171 AI492146 AI880302 BM142655 
    AI797845 BU731959 BC012939 BG386916 AA565206 AA399224 BM263082 AI393921 
    CR620867 AW137779 AW002872 BI766826 CB107211 BU192463 AW611984 BM980490 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for POLD4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -     -     -     -     -     -     -     -                 -     -     -                                 
    SP2:                                                  -     -     -                 -     -     -                                 
    SP3:                                            -     -     -     -                 -     -     -                                 
    SP4:                                                        -     -                 -     -     -                                 
    SP5:                                                                                -     -     -                                 


    ECgene alternative splicing isoforms for POLD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POLD4 expression in normal human tissues (normalized intensities)      POLD4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAAAGAT
    POLD4 Expression
    About this image


    POLD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   
     
     Cartilage (Muscoskeletal System)
             skeleton/cranium   

    See POLD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POLD4

    SOURCE GeneReport for Unigene cluster: Hs.523829
        SABiosciences Custom PCR Arrays for POLD4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POLD4
    OriGene qSTAR qPCR primer pairs in human, mouse for POLD4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLD4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLD4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for POLD4 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pold41 , 5 polymerase (DNA-directed), delta 41, 5 85.67(n)1
    83.18(a)1
      19 (3.93 cM)5
    697451  NM_027196.31  NP_081472.11 
     42318995 
    zebrafish
    (Danio rerio)
    Actinopterygii POLD46
    polymerase (DNA-directed), delta 4, accessory subu...
    26(a)
    1 ↔ 1
    1(45162532-45166458)


    ENSEMBL Gene Tree for POLD4 (if available)
    TreeFam Gene Tree for POLD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in POLD4 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0222694
    ----see VAR_0222692 R P mis40--------
    VAR_0575264
    ----see VAR_0575262 G R mis40--------

    HapMap Linkage Disequilibrium report for POLD4 (67118248 - 67124443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for POLD4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv367CNV Insertion18451855
    nsv897796CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv468603CNV Loss19166990
    nsv897804CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing POLD4
    DNA2.0 Custom Variant and Variant Library Synthesis for POLD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611525    OMIM disorders: --

    3 diseases for POLD4:    About MalaCards
    bloom syndrome    lung cancer    endotheliitis


    POLD4 for disorders           About GeneDecksing


    Export disorders for POLD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POLD4 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with POLD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a fourth subunit of mammalian DNA polymerase delta. (PubMed id 10751307)1, 2, 3 Liu L.... Lee M.Y.W.T. (2000)
    2. Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PubMed id 16510448)1, 2 Li H.... Lee M.Y. (2006)
    3. Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. (PubMed id 15670210)1, 2 Tsurimoto T.... Enomoto T. (2005)
    4. Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase d for degradation in response to DNA damage. (PubMed id 23233665)1 Zhang S....Lee M.Y. (2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. Studies on human DNA polymerase epsilon and GINS compl ex and their role in DNA replication. (PubMed id 21705323)1 Bermudez V.P....Hurwitz J. (2011)
    9. Roles of POLD4, smallest subunit of DNA polymerase de lta, in nuclear structures and genomic stability of human cells. (PubMed id 19931513)1 Huang Q.M....Suzuki M. (2010)
    10. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. (PubMed id 20861182)1 Huang Q.M....Suzuki M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57804 HGNC: 14106 AceView: CLCandPOLD4 Ensembl:ENSG00000175482 euGenes: HUgn57804
    ECgene: POLD4 Kegg: 57804 H-InvDB: POLD4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POLD4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pold4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POLD4 gene:
    Search GeneIP for patents involving POLD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for POLD4  
     OriGene qPCR primer pairs and template standards for POLD4   OriGene Protein Over-expression Lysate for POLD4  
     OriGene MassSpec something-or-other for POLD4   OriGene clones in human, mouse for POLD4  
     OriGene qSTAR qPCR primer pairs in human, mouse for POLD4   OriGene Purified Protein for POLD4  
     OriGene ORF clones in mouse, rat for POLD4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POLD4   OriGene Custom Protein Services for POLD4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLD4
     QIAGEN SeqTarget long-range PCR primers for resequencing POLD4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLD4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLD4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLD4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLD4
     GenScript Custom Purified and Recombinant Proteins Services for POLD4 GenScript cDNA clones with any tag delivered in your preferred vector for POLD4
     GenScript Custom Assay Services for POLD4 GenScript Custom Superior Antibodies Services for POLD4
     GenScript Custom overexpressing Cell Line Services for POLD4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in POLD4 promoter
     Search Chromatin IP Primers for POLD4
     RT2 qPCR Primer Assay in human, mouse, rat POLD4
     GNC Network for POLD4
     SABiosciences PCR Arrays including human, mouse, rat POLD4
     Search Tocris compounds for POLD4 (DPOD4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     POLD4 antibodies
     POLD4 proteins
     POLD4 lysates
     Antibodies for POLD4
     See all of Abcam's Antibodies, Kits and Proteins for POLD4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for POLD4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD4
     SwitchGear 3'UTR luciferase reporter plasmids for POLD4
     SwitchGear Promoter luciferase reporter plasmids for POLD4
     Search ThermoFisher Antibodies for POLD4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for POLD4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POLD4
    Customized:
     lentivirus for stable overexpression of POLD4
     lentivirus expression plasmids for stable overexpression of POLD4
     adenovirus for overexpression of POLD4
     Search LSBio for Antibodies for POLD4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      POLD4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4