Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POLD4 Gene

Aliases for POLD4 Gene

  • Polymerase (DNA) Delta 4, Accessory Subunit 2 3
  • Polymerase (DNA-Directed), Delta 4, Accessory Subunit 2 3 5
  • DNA Polymerase Delta Smallest Subunit P12 2 3
  • POLDS 3 4
  • DNA Polymerase Delta Subunit P12 4
  • P12 3

External Ids for POLD4 Gene

Previous GeneCards Identifiers for POLD4 Gene

  • GC11M069752
  • GC11M068815
  • GC11M067369
  • GC11M066894
  • GC11M066875
  • GC11M067119
  • GC11M063448

Summaries for POLD4 Gene

Entrez Gene Summary for POLD4 Gene

  • This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for POLD4 Gene

POLD4 (Polymerase (DNA) Delta 4, Accessory Subunit) is a Protein Coding gene. Diseases associated with POLD4 include bloom syndrome. Among its related pathways are Metabolism and Cell Cycle, Mitotic. GO annotations related to this gene include DNA-directed DNA polymerase activity. An important paralog of this gene is ENSG00000256514.

UniProtKB/Swiss-Prot for POLD4 Gene

  • Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.

Gene Wiki entry for POLD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLD4 Gene

Genomics for POLD4 Gene

Regulatory Elements for POLD4 Gene

Genomic Location for POLD4 Gene

Chromosome:
11
Start:
67,350,765 bp from pter
End:
67,356,972 bp from pter
Size:
6,208 bases
Orientation:
Minus strand

Genomic View for POLD4 Gene

Genes around POLD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLD4 Gene

Proteins for POLD4 Gene

  • Protein details for POLD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCU8-DPOD4_HUMAN
    Recommended name:
    DNA polymerase delta subunit 4
    Protein Accession:
    Q9HCU8
    Secondary Accessions:
    • F5H506

    Protein attributes for POLD4 Gene

    Size:
    107 amino acids
    Molecular mass:
    12433 Da
    Quaternary structure:
    • Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD4, POLD2, POLD1 and PCNA.

    Alternative splice isoforms for POLD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLD4 Gene

Proteomics data for POLD4 Gene at MOPED

Post-translational modifications for POLD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLD4 Gene

No data available for DME Specific Peptides for POLD4 Gene

Domains & Families for POLD4 Gene

Gene Families for POLD4 Gene

Protein Domains for POLD4 Gene

Suggested Antigen Peptide Sequences for POLD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCU8

UniProtKB/Swiss-Prot:

DPOD4_HUMAN :
  • Belongs to the DNA polymerase delta subunit 4 family.
Family:
  • Belongs to the DNA polymerase delta subunit 4 family.
genes like me logo Genes that share domains with POLD4: view

Function for POLD4 Gene

Molecular function for POLD4 Gene

UniProtKB/Swiss-Prot Function:
Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.
genes like me logo Genes that share phenotypes with POLD4: view

Animal Model Products

miRNA for POLD4 Gene

miRTarBase miRNAs that target POLD4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLD4 Gene

Localization for POLD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLD4 Gene COMPARTMENTS Subcellular localization image for POLD4 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for POLD4 Gene

Pathways & Interactions for POLD4 Gene

SuperPathways for POLD4 Gene

Superpath Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
4 DNA Double-Strand Break Repair
5 Mismatch repair
genes like me logo Genes that share pathways with POLD4: view

Gene Ontology (GO) - Biological Process for POLD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination TAS --
GO:0000731 DNA synthesis involved in DNA repair IBA --
GO:0006260 DNA replication IEA,TAS 10751307
GO:0006261 DNA-dependent DNA replication IBA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with POLD4: view

No data available for SIGNOR curated interactions for POLD4 Gene

Drugs & Compounds for POLD4 Gene

(2) Drugs for POLD4 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clofarabine Approved, Investigational Pharma Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 153
Cytarabine Approved, Investigational Pharma 1035
genes like me logo Genes that share compounds with POLD4: view

Transcripts for POLD4 Gene

Unigene Clusters for POLD4 Gene

Polymerase (DNA-directed), delta 4, accessory subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - -
SP11:
SP12: - - -

Relevant External Links for POLD4 Gene

GeneLoc Exon Structure for
POLD4
ECgene alternative splicing isoforms for
POLD4

Expression for POLD4 Gene

mRNA expression in normal human tissues for POLD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLD4 Gene

This gene is overexpressed in Breast (31.8) and Plasma (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLD4 Gene



SOURCE GeneReport for Unigene cluster for POLD4 Gene Hs.523829

genes like me logo Genes that share expression patterns with POLD4: view

Protein tissue co-expression partners for POLD4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLD4 Gene

Orthologs for POLD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLD4 35
  • 99.69 (n)
  • 100 (a)
POLD4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLD4 36
  • 86 (a)
OneToOne
POLD4 35
  • 88.16 (n)
  • 85.98 (a)
dog
(Canis familiaris)
Mammalia POLD4 35
  • 90.03 (n)
  • 91.59 (a)
POLD4 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pold4 16
Pold4 36
  • 83 (a)
OneToOne
Pold4 35
  • 85.67 (n)
  • 83.18 (a)
oppossum
(Monodelphis domestica)
Mammalia POLD4 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pold4 35
  • 85.36 (n)
  • 83.18 (a)
zebrafish
(Danio rerio)
Actinopterygii POLD4 36
  • 38 (a)
OneToOne
Species with no ortholog for POLD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLD4 Gene

ENSEMBL:
Gene Tree for POLD4 (if available)
TreeFam:
Gene Tree for POLD4 (if available)

Paralogs for POLD4 Gene

Paralogs for POLD4 Gene

genes like me logo Genes that share paralogs with POLD4: view

Variants for POLD4 Gene

Sequence variations from dbSNP and Humsavar for POLD4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_022269 -
VAR_057526 -

Structural Variations from Database of Genomic Variants (DGV) for POLD4 Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
nsv468603 CNV Loss 19166990
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
nsv367 CNV Insertion 18451855

Variation tolerance for POLD4 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLD4 Gene

HapMap Linkage Disequilibrium report
POLD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLD4 Gene

Disorders for POLD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLD4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bloom syndrome
  • bloom-torre-machacek syndrome
- elite association - COSMIC cancer census association via MalaCards
Search POLD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for POLD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLD4
genes like me logo Genes that share disorders with POLD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLD4 Gene

Publications for POLD4 Gene

  1. Identification of a fourth subunit of mammalian DNA polymerase delta. (PMID: 10751307) Liu L. … Lee M.Y.W.T. (J. Biol. Chem. 2000) 2 3 4 67
  2. Proteolysis of the human DNA polymerase delta smallest subunit p12 by I1-calpain in calcium-triggered apoptotic HeLa cells. (PMID: 24691096) Fan X. … Zhou Y. (PLoS ONE 2014) 3
  3. The tail that wags the dog: p12, the smallest subunit of DNA polymerase I', is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression. (PMID: 24300032) Lee M.Y. … Lee E.Y. (Cell Cycle 2014) 3
  4. Regulation of error-prone translesion synthesis by Spartan/C1orf124. (PMID: 23254330) Kim M.S. … Machida Y.J. (Nucleic Acids Res. 2013) 3
  5. Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase I'. (PMID: 24035200) Lin S.H. … Lee M.Y. (DNA Repair (Amst.) 2013) 3

Products for POLD4 Gene

Sources for POLD4 Gene

Back to Top

Content