Aliases for POLD4 Gene
External Ids for POLD4 Gene
Previous GeneCards Identifiers for POLD4 Gene
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for POLD4 Gene
POLD4 (DNA Polymerase Delta 4, Accessory Subunit) is a Protein Coding gene. Diseases associated with POLD4 include Bloom Syndrome. Among its related pathways are DNA strand elongation and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. GO annotations related to this gene include DNA-directed DNA polymerase activity. An important paralog of this gene is ENSG00000256514.
UniProtKB/Swiss-Prot for POLD4 Gene
Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.