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POLD3 Gene

protein-coding   GIFtS: 64
GCID: GC11P074207

Polymerase (DNA-Directed), Delta 3, Accessory Subunit

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (DNA-Directed), Delta 3, Accessory Subunit1 2     P682
DNA Polymerase Delta Subunit P661 2 3     DNA Polymerase Delta Subunit 32
Pol Delta C Subunit (P66)1 2     KIAA00393
P662     

External Ids:    HGNC: 209321   Entrez Gene: 107142   Ensembl: ENSG000000775147   OMIM: 6114155   UniProtKB: Q150543   

Export aliases for POLD3 gene to outside databases

Previous GC identifers: GC11P076630 GC11P075843 GC11P074526 GC11P074008 GC11P074029 GC11P073981 GC11P074303 GC11P070599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POLD3 Gene:
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and
3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays
a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the
processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have
been observed for this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for POLD3 Gene:
POLD3 (polymerase (DNA-directed), delta 3, accessory subunit) is a protein-coding gene. GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot: DPOD3_HUMAN, Q15054
Function: Required for optimal DNA polymerase delta activity

Gene Wiki entry for POLD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POLD3 gene promoter:
         Sox5   FOXO3b   Evi-1   NF-AT   NF-AT4   GATA-6   NF-AT2   FOXO3a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLD3 promoter sequence
   Search Chromatin IP Primers for POLD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q14

POLD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLD3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P074207:  view genomic region     (about GC identifiers)

Start:
74,204,896 bp from pter      End:
74,380,162 bp from pter
Size:
175,267 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPOD3_HUMAN, Q15054 (See protein sequence)
Recommended Name: DNA polymerase delta subunit 3  
Size: 466 amino acids; 51400 Da
Subunit: Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with POLD2.
Interacts with PCNA
Sequence caution: Sequence=BAA05039.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for POLD3:
1U76 (3D)        3E0J (3D)    
Secondary accessions: B7ZAI6

Explore the universe of human proteins at neXtProt for POLD3: NX_Q15054

Explore proteomics data for POLD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POLD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006582.1  
    ENSEMBL proteins: 
     ENSP00000431239   ENSP00000263681   ENSP00000432951   ENSP00000436018   ENSP00000432233  
     ENSP00000437231   ENSP00000432969   ENSP00000436781  
    Reactome Protein details: Q15054

    POLD3 Human Recombinant Protein Products:

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    Novus Biologicals POLD3 Protein
    Novus Biologicals POLD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for POLD3

     
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    POLD3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for POLD3

    POLD3 Assay Products:

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    Cloud-Clone Corp. ELISAs for POLD3
    Cloud-Clone Corp. CLIAs for POLD3
    Search eBioscience for ELISAs for POLD3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POL: DNA polymerases

    1 InterPro protein domain:
     IPR019038 DNA_polymerase_subunit_Cdc27

    Graphical View of Domain Structure for InterPro Entry Q15054

    ProtoNet protein and cluster: Q15054


    Find genes that share domains with POLD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPOD3_HUMAN, Q15054
    Function: Required for optimal DNA polymerase delta activity

         Genatlas biochemistry entry for POLD3:
    polymerase (DNA directed) delta 3,accessory subunit 66kDa,involved in DNA replication of nuclear genome,also
    complexing with DNA ligase 1,homolog to S pombe Cdc27

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003887DNA-directed DNA polymerase activity NAS10219083
    GO:0005515protein binding IPI16000169
         
    Find genes that share ontologies with POLD3           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for POLD3:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POLD3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POLD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POLD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target POLD3:
    hsa-mir-186-5p (MIRT045077), hsa-mir-130b-5p (MIRT038291), hsa-mir-744-5p (MIRT037579), hsa-mir-103a-3p (MIRT027117), hsa-mir-29a-3p (MIRT049970), hsa-mir-149-5p (MIRT045481)

    Block miRNA regulation of human, mouse, rat POLD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POLD3 (see all 16):
    hsa-miR-623 hsa-miR-4328 hsa-miR-218 hsa-miR-2115 hsa-miR-493 hsa-miR-3690 hsa-miR-3140-3p hsa-miR-3166
    SwitchGear 3'UTR luciferase reporter plasmidPOLD3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat POLD3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: POLD3 (NM_006591)
    Sino Biological Human cDNA Clone for POLD3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD3

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPOD3_HUMAN, Q15054: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0043625delta DNA polymerase complex NAS10219083

    Find genes that share ontologies with POLD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLD3 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Telomere C-strand (Lagging Strand) Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Removal of the Flap Intermediate from the C-strand0.00
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    Polymerase switching on the C-strand of the telomere0.00
    Telomere C-strand (Lagging Strand) Synthesis0.79
    Lagging Strand Synthesis0.00
    Extension of Telomeres0.79
    Removal of the Flap Intermediate0.00
    2Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Base Excision Repair0.00
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    Removal of DNA patch containing abasic residue0.00
    Base excision repair0.53
    3Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Nucleotide excision repair0.69
    4DNA strand elongation
    DNA strand elongation0.63
    DNA replication0.63
    5Homologous recombination
    Homologous recombination0.40
    Homologous recombination0.40


    Find genes that share SuperPaths with POLD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for POLD3
        Cell cycle Transition and termination of DNA replication

    3 BioSystems Pathways for POLD3
        Homologous recombination
    DNA Replication
    RB in Cancer


    Selected Reactome Pathways for POLD3 (see all 12)
        Processive synthesis on the lagging strand
    Removal of DNA patch containing abasic residue
    Processive synthesis on the C-strand of the telomere
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway
    Repair synthesis for gap-filling by DNA polymerase in TC-NER


    Selected Kegg Pathways  (Kegg details for POLD3) (see all 9):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    DNA replication
    Base excision repair

        Pathway & Disease-focused RT2 Profiler PCR Arrays including POLD3: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POLD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLD3 (Q150541, 2, 3 ENSP000002636814) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120041, 3, ENSP000003684384EBI-864956,EBI-358311 I2D: score=5 STRING: ENSP00000368438
    POLD2P490051, 3EBI-864956,EBI-372354 I2D: score=4 
    MBD3L2Q8NHZ73, ENSP000003708004I2D: score=1 STRING: ENSP00000370800
    SUMO3P558543, ENSP000003303434I2D: score=1 STRING: ENSP00000330343
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0000731DNA synthesis involved in DNA repair NAS7910606
    GO:0006260DNA replication ----

    Find genes that share ontologies with POLD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLD3 (DPOD3)

    4 HMDB Compounds for POLD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    dATP2'-Deoxy-5'-ATP (see all 8)1927-31-7--
    dCTP2'-deoxycytidine-5'-triphosphate (see all 4)2056-98-6--
    dGTP2'-Deoxyguanosine 5'-triphosphate (see all 4)2564-35-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLD3 gene: 
    NM_006591.2  

    Unigene Cluster for POLD3:

    Polymerase (DNA-directed), delta 3, accessory subunit
    Hs.82502  [show with all ESTs]
    Unigene Representative Sequence: NR_046410
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528481 ENST00000263681(uc001ovf.1 uc009yua.1) ENST00000532784
    ENST00000527458 ENST00000532497 ENST00000530511 ENST00000531615 ENST00000524752
    ENST00000530163 ENST00000532954
    miRNA
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    Block miRNA regulation of human, mouse, rat POLD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POLD3 (see all 16):
    hsa-miR-623 hsa-miR-4328 hsa-miR-218 hsa-miR-2115 hsa-miR-493 hsa-miR-3690 hsa-miR-3140-3p hsa-miR-3166
    SwitchGear 3'UTR luciferase reporter plasmidPOLD3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POLD3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POLD3 (NM_006591)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD3
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat POLD3
      QuantiFast Probe-based Assays in human, mouse, rat POLD3

    Additional mRNA sequence: 

    AK297375.1 AK302677.1 AK316301.1 AK316370.1 BC020587.1 BC032636.1 BC041703.1 BC058840.1 
    BC092454.1 BC108908.1 BC108909.1 D26018.1 NR_046409.1 NR_046410.1 

    9 DOTS entries:

    DT.91927664  DT.40283016  DT.445161  DT.100817732  DT.100817735  DT.95369269  DT.101965338  DT.120759911 
    DT.95369271 

    Selected AceView cDNA sequences (see all 156):

    NM_006591 BQ226790 BU176223 BC020587 BC041703 AA401552 BM974294 BU170826 
    CB143383 AA630598 BQ434946 AA865170 T24710 AA102066 D26018 AA454074 
    CR604252 AI338706 AA356330 CB243414 BX116309 AA929034 BF515711 BG180116 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POLD3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                          -     -           -                                                           -                     
    SP2:                                            -                                                           -                     
    SP3:                          -     -           -     -                                                     -                     
    SP4:                                -           -                                                                                 
    SP5:                          -     -                                                                                             


    ECgene alternative splicing isoforms for POLD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    POLD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTAAATAA
    POLD3 Expression
    About this image


    POLD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Kidney (Urinary System)
             Metanephros
    POLD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82502
        Pathway & Disease-focused RT2 Profiler PCR Arrays including POLD3: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for POLD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POLD3
    QuantiTect SYBR Green Assays in human, mouse, rat POLD3
    QuantiFast Probe-based Assays in human, mouse, rat POLD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for POLD3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pold31 , 5 polymerase (DNA-directed), delta 3, accessory subunit1, 5 86.55(n)1
    85.25(a)1
      7 (54.32 cM)5
    679671  NM_133692.21  NP_598453.11 
     1000821115 
    chicken
    (Gallus gallus)
    Aves POLD31 polymerase (DNA-directed), delta 3, accessory subunit 66.81(n)
    61.49(a)
      419053  NM_001006284.1  NP_001006284.1 
    lizard
    (Anolis carolinensis)
    Reptilia POLD36
    polymerase (DNA-directed), delta 3, accessory subu...
    55(a)
    1 ↔ 1
    GL343489.1(584520-619273)
    African clawed frog
    (Xenopus laevis)
    Amphibia POLD32 DNA polymerase delta p66 subunit 74.92(n)    AB080267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.291272 Transcribed sequence with weak similarity to protein more 71.07(n)    CK142880.1 


    ENSEMBL Gene Tree for POLD3 (if available)
    TreeFam Gene Tree for POLD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLD3 (see all 1123)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114244501,2
    C--74214120(+) TGCAC-/TTTTTT 3 -- int1 trp30--------
    rs339747891,2
    C--74214121(+) GCACTT/-TTTTT 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1175232661,2
    F--74301651(+) ACAGGG/TTCTCA 3 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1168936101,2
    F--74301669(+) ACCCAG/CGCTGT 3 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1873056941,2
    --74301672(+) CAGGCA/TGTATG 3 -- us2k10--------
    rs1469741221,2
    --74301732(+) CCATCC/TTCCCA 3 -- us2k10--------
    rs1380330971,2
    --74301938(+) TACCCC/TATTTT 3 -- us2k10--------
    rs1912950151,2
    --74302067(+) CCTCCC/TGAGTA 3 -- us2k10--------
    rs1420383901,2
    C--74302070(+) CCCGAG/TTAGCT 3 -- us2k10--------
    rs1844365361,2
    --74302187(+) ATCTGC/TCTGCC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for POLD3 (74204896 - 74380162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for POLD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509431CNV Insertion20534489
    dgv1222n71CNV Loss21882294
    esv34979CNV Gain17911159
    nsv832209CNV Gain17160897
    nsv825994CNV Gain20364138
    dgv397e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POLD3
    DNA2.0 Custom Variant and Variant Library Synthesis for POLD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611415    OMIM disorders: --


    Find genes that share disorders with POLD3           About GenesLikeMe

    1 Novoseek inferred disease relationship for POLD3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 18.8 2 1849244 (1)

    Genetic Association Database (GAD): POLD3
    Human Genome Epidemiology (HuGE) Navigator: POLD3 (1 document)

    Export disorders for POLD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLD3 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with POLD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. (PubMed id 10219083)1, 2, 3 Hughes P.... Baldacci G. (Nucleic Acids Res. 1999)
    2. Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PubMed id 16510448)1, 2, 9 Li H.... Lee M.Y. (J. Biol. Chem. 2006)
    3. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA. (PubMed id 10852724)1, 2 Mo J.-Y.... Lee M.Y.W.T. (Biochemistry 2000)
    6. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    7. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. (PubMed id 11595739)1, 9 Ducoux M....Hughes P. (J. Biol. Chem. 2001)
    8. An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit. (PubMed id 16000169)1, 9 Pohler J.R....Warbrick E. (BMC Mol. Biol. 2005)
    9. Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease- 1. (PubMed id 15576034)1, 9 Bruning J.B. and Shamoo Y. (Structure 2004)
    10. Break-induced replication repair of damaged forks induces genomic duplications in human cells. (PubMed id 24310611)1 Costantino L....Halazonetis T.D. (Science 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10714 HGNC: 20932 AceView: POLD3 Ensembl:ENSG00000077514 euGenes: HUgn10714
    ECgene: POLD3 Kegg: 10714 H-InvDB: POLD3

    (According to HUGE)
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    HUGE: KIAA0039

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POLD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLD3 gene:
    Search GeneIP for patents involving POLD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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