Aliases for POLD3 Gene
External Ids for POLD3 Gene
Previous GeneCards Identifiers for POLD3 Gene
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for POLD3 Gene
POLD3 (DNA Polymerase Delta 3, Accessory Subunit) is a Protein Coding gene. Diseases associated with POLD3 include Mental Retardation, Autosomal Dominant 18. Among its related pathways are DNA strand elongation and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. GO annotations related to this gene include DNA-directed DNA polymerase activity.
UniProtKB/Swiss-Prot for POLD3 Gene
Required for optimal DNA polymerase delta activity.