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Aliases for POLD3 Gene

Aliases for POLD3 Gene

  • DNA Polymerase Delta 3, Accessory Subunit 2 3 5
  • DNA Polymerase Delta Subunit P66 2 3 4
  • Polymerase (DNA-Directed), Delta 3, Accessory Subunit 2 3
  • Protein Phosphatase 1, Regulatory Subunit 128 2 3
  • Polymerase (DNA) Delta 3, Accessory Subunit 2 3
  • DNA Polymerase Delta Subunit P68 3 4
  • DNA Polymerase Delta Subunit C 3 4
  • Pol Delta C Subunit (P66) 2 3
  • DNA Polymerase Delta Subunit 3 3
  • PPP1R128 3
  • KIAA0039 4
  • P68 3
  • P66 3

External Ids for POLD3 Gene

Previous GeneCards Identifiers for POLD3 Gene

  • GC11P076630
  • GC11P075843
  • GC11P074008
  • GC11P074029
  • GC11P073981
  • GC11P074303
  • GC11P070599
  • GC11P074207

Summaries for POLD3 Gene

Entrez Gene Summary for POLD3 Gene

  • This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for POLD3 Gene

POLD3 (DNA Polymerase Delta 3, Accessory Subunit) is a Protein Coding gene. Diseases associated with POLD3 include Retinitis Pigmentosa 35. Among its related pathways are DNA Double-Strand Break Repair and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLD3 Gene

  • As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the POLZ complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).

Gene Wiki entry for POLD3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLD3 Gene

Genomics for POLD3 Gene

Regulatory Elements for POLD3 Gene

Enhancers for POLD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G073786 1.2 ENCODE 42.5 -705.5 -705491 3.2 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D POLD3 ENSG00000206913 RNF169 RAB6A RPS12P22 MRPL48 ENSG00000256034 ENSG00000254837 PLEKHB1 RN7SKP243
GH11G074009 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -482.5 -482535 3.0 HDGF PKNOX1 CREB3L1 ARNT ZNF766 CBX5 ZNF143 KLF13 JUNB REST ENSG00000206913 UCP2 POLD3 RNF169 RN7SL239P FAM168A LIPT2 C2CD3 UCP3 ENSG00000256098
GH11G075398 1.2 ENCODE 22 +907.4 907441 4.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 KLHL35 POLD3 RNF169 RPS3 SERPINH1 UVRAG GDPD5 RPS12P22 GC11P075403 GC11P075405
GH11G073778 1.8 FANTOM5 Ensembl ENCODE 14.1 -713.9 -713876 2.7 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000206913 MRPL48 POLD3 RNF169 RAB6A UCP2 FAM168A
GH11G073872 1.1 ENCODE 22.1 -618.9 -618897 5.9 HDGF PKNOX1 MLX ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B MRPL48 POLD3 RNF169 ENSG00000206913 PLEKHB1 RN7SL239P FAM168A PAAF1 CCDC58P5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLD3 on UCSC Golden Path with GeneCards custom track

Promoters for POLD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042008 270 1601 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 DEK SP3 SP5 REST

Genomic Location for POLD3 Gene

Chromosome:
11
Start:
74,493,851 bp from pter
End:
74,669,341 bp from pter
Size:
175,491 bases
Orientation:
Plus strand

Genomic View for POLD3 Gene

Genes around POLD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLD3 Gene

Proteins for POLD3 Gene

  • Protein details for POLD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15054-DPOD3_HUMAN
    Recommended name:
    DNA polymerase delta subunit 3
    Protein Accession:
    Q15054
    Secondary Accessions:
    • B7ZAI6
    • Q32MZ9
    • Q32N00

    Protein attributes for POLD3 Gene

    Size:
    466 amino acids
    Molecular mass:
    51400 Da
    Quaternary structure:
    • Component of the tetrameric DNA polymerase delta complex (Pol-delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing DNA polymerase and 3 to 5 proofreading exonuclease activities (PubMed:11328591, PubMed:11595739, PubMed:17317665, PubMed:22801543). Within this complex, directly interacts with POLD2 (PubMed:11328591, PubMed:16510448, PubMed:18818516). Following stress caused by DNA damaging agents or by replication stress, POLD4 is degraded and Pol-delta4 is converted into a trimeric form of the complex (Pol-delta3), which consists of POLD1, POLD2 and POLD3. Pol-delta3 is the major form occurring at S phase replication sites, as well as DNA damage sites (PubMed:11595739, PubMed:17317665, PubMed:22801543, PubMed:23913683). Directly interacts with PCNA, as do POLD1 and POLD4; this interaction stimulates Pol-delta polymerase activity (PubMed:11328591, PubMed:11595739, PubMed:12403614, PubMed:16510448, PubMed:22148433). POLD3 phosphorylation at Ser-458 impairs PCNA binding (PubMed:22148433). Component of the DNA polymerase zeta complex (POLZ), which consists of REV3L, MAD2L2, POLD2 and POLD3, with REV3L bearing DNA polymerase catalytic activity (PubMed:24449906). The DNA polymerase delta complex interacts with POLDIP2; this interaction is probably mediated through direct binding to POLD2 (PubMed:12522211).
    SequenceCaution:
    • Sequence=BAA05039.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POLD3 Gene

    Alternative splice isoforms for POLD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLD3 Gene

Post-translational modifications for POLD3 Gene

  • Phosphorylation at Ser-458 is catalyzed in vitro by PKA. It is thought to decrease the affinity for PCNA and Pol-delta4 processivity (PubMed:22148433). Can also be phosphorylated in vitro by CDK1-cyclin-A complex, as well as CDK2-cyclin-A and CDK2-cyclin-E complexes. PCNA interferes with CDK-cyclin phosphorylation (PubMed:11595739).
  • Ubiquitinated, but not targeted to the proteasome (PubMed:16934752). Sumoylated (PubMed:16934752, PubMed:25218447). Sumoylation with SUMO3 may be predominant (PubMed:16934752).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POLD3 Gene

Domains & Families for POLD3 Gene

Protein Domains for POLD3 Gene

Suggested Antigen Peptide Sequences for POLD3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POLD3: view

No data available for UniProtKB/Swiss-Prot for POLD3 Gene

Function for POLD3 Gene

Molecular function for POLD3 Gene

GENATLAS Biochemistry:
polymerase (DNA directed) delta 3,accessory subunit 66kDa,involved in DNA replication of nuclear genome,also complexing with DNA ligase 1,homolog to S pombe Cdc27
UniProtKB/Swiss-Prot Function:
As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the POLZ complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).

Gene Ontology (GO) - Molecular Function for POLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003887 DNA-directed DNA polymerase activity TAS --
GO:0005515 protein binding IPI 16000169
genes like me logo Genes that share ontologies with POLD3: view
genes like me logo Genes that share phenotypes with POLD3: view

Animal Models for POLD3 Gene

MGI Knock Outs for POLD3:

Animal Model Products

miRNA for POLD3 Gene

miRTarBase miRNAs that target POLD3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLD3 Gene

Localization for POLD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLD3 Gene

Cytoplasm. Nucleus. Note=Partially colocalizes with PCNA and POLD1 at S phase replication sites (PubMed:11595739). Recruited to DNA damage sites within 2 hours following UV irradiation (PubMed:20227374, PubMed:22801543). {ECO:0000269 PubMed:11595739, ECO:0000269 PubMed:20227374, ECO:0000269 PubMed:22801543}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLD3 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for POLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0043625 delta DNA polymerase complex NAS 10219083
genes like me logo Genes that share ontologies with POLD3: view

Pathways & Interactions for POLD3 Gene

SuperPathways for POLD3 Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
3 Mismatch repair
4 DNA Double-Strand Break Repair
5 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
genes like me logo Genes that share pathways with POLD3: view

SIGNOR curated interactions for POLD3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for POLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination TAS --
GO:0000723 telomere maintenance TAS --
GO:0000731 DNA synthesis involved in DNA repair NAS 7910606
GO:0006260 DNA replication IEA --
GO:0006261 DNA-dependent DNA replication IEA --
genes like me logo Genes that share ontologies with POLD3: view

Drugs & Compounds for POLD3 Gene

(3) Drugs for POLD3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
dgtp Experimental Pharma 0

(1) Additional Compounds for POLD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with POLD3: view

Transcripts for POLD3 Gene

Unigene Clusters for POLD3 Gene

Polymerase (DNA-directed), delta 3, accessory subunit:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLD3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for POLD3 Gene

GeneLoc Exon Structure for
POLD3
ECgene alternative splicing isoforms for
POLD3

Expression for POLD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Monocytes (10.5), and Testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLD3 Gene



Protein tissue co-expression partners for POLD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLD3 Gene:

POLD3

SOURCE GeneReport for Unigene cluster for POLD3 Gene:

Hs.82502

Evidence on tissue expression from TISSUES for POLD3 Gene

  • Bone marrow(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with POLD3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLD3 Gene

Orthologs for POLD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLD3 34 35
  • 99 (n)
dog
(Canis familiaris)
Mammalia POLD3 34 35
  • 91.52 (n)
cow
(Bos Taurus)
Mammalia POLD3 34 35
  • 89.08 (n)
rat
(Rattus norvegicus)
Mammalia Pold3 34
  • 87.2 (n)
mouse
(Mus musculus)
Mammalia Pold3 34 16 35
  • 86.55 (n)
oppossum
(Monodelphis domestica)
Mammalia POLD3 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLD3 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLD3 34 35
  • 66.81 (n)
lizard
(Anolis carolinensis)
Reptilia POLD3 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pold3 34
  • 67.49 (n)
Str.4281 34
African clawed frog
(Xenopus laevis)
Amphibia POLD3 34
zebrafish
(Danio rerio)
Actinopterygii pold3 34 35
  • 56.54 (n)
Dr.29127 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2047 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2854 35
  • 30 (a)
OneToOne
Species where no ortholog for POLD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLD3 Gene

ENSEMBL:
Gene Tree for POLD3 (if available)
TreeFam:
Gene Tree for POLD3 (if available)

Paralogs for POLD3 Gene

No data available for Paralogs for POLD3 Gene

Variants for POLD3 Gene

Sequence variations from dbSNP and Humsavar for POLD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000079058 -- 74,618,393(+) AAACA(A/G)TATTA intron-variant
rs1000102554 -- 74,647,145(+) ATGCT(C/G)TTTGC intron-variant
rs1000133184 -- 74,618,596(+) TTCGT(C/T)TTCCA nc-transcript-variant, reference, missense
rs1000134231 -- 74,656,388(+) TTGAG(A/G)CCAGC intron-variant
rs1000168060 -- 74,648,399(+) GTACC(A/T)TGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLD3 Gene

Variant ID Type Subtype PubMed ID
dgv209e214 CNV gain 21293372
esv2759837 CNV gain 17122850
esv34979 CNV gain 17911159
nsv509431 CNV insertion 20534489
nsv825994 CNV gain 20364138
nsv832209 CNV gain 17160897
nsv983207 CNV deletion 23825009

Variation tolerance for POLD3 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLD3 Gene

Human Gene Mutation Database (HGMD)
POLD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLD3 Gene

Disorders for POLD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 35
  • rp35
- elite association - COSMIC cancer census association via MalaCards
Search POLD3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for POLD3

Genetic Association Database (GAD)
POLD3
Human Genome Epidemiology (HuGE) Navigator
POLD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLD3
genes like me logo Genes that share disorders with POLD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLD3 Gene

Publications for POLD3 Gene

  1. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. (PMID: 20227374) Ogi T. … Lehmann A.R. (Mol. Cell 2010) 3 4 22 64
  2. Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PMID: 16510448) Li H. … Lee M.Y. (J. Biol. Chem. 2006) 3 4 22 64
  3. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. (PMID: 11595739) Ducoux M. … Hughes P. (J. Biol. Chem. 2001) 3 4 22 64
  4. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. (PMID: 10219083) Hughes P. … Baldacci G. (Nucleic Acids Res. 1999) 2 3 4 64
  5. Break-induced replication repair of damaged forks induces genomic duplications in human cells. (PMID: 24310611) Costantino L. … Halazonetis T.D. (Science 2014) 3 4 64

Products for POLD3 Gene

Sources for POLD3 Gene

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