POLD2 Gene
protein-coding GIFtS: 57
GCID: GC07M044120
|
|
polymerase (DNA directed), delta 2, accessory subunit(Previous names: polymerase (DNA directed), delta 2, regulatory subunit...)
| |
Aliases
for POLD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Polymerase (DNA Directed), Delta 2, Accessory Subunit1 2 | | Polymerase (DNA Directed), Delta 2, Regulatory Subunit (50kD)1 | | Polymerase (DNA Directed), Delta 2, Regulatory Subunit 50kDa1 2 | | DNA Polymerase Delta Subunit 22 | | DNA Polymerase Delta Subunit P502 3 | | Pol Delta B Subunit (P50)2 | | EC 2.7.7.73 8 | | |
Export aliases for POLD2 gene to outside databasesPrevious GC identifers: GC07M043800 GC07M043861 GC07M043895 GC07M043927 GC07M044039 |
Summaries
for POLD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for POLD2:
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymeraseand 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein isrequired for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclearantigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcriptvariants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on thelong arm of chromosome 5. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: DPOD2_HUMAN, P49005Function: The function of the small subunit is not yet clear
Gene Wiki entry for POLD2
|
Genomic Views
for POLD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POLD2 gene promoter:
ER-alpha Pax-2 AP-4 Pax-2a Egr-4 Max Pax-2b c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for POLD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13POLD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M044120: view genomic region
(about GC identifiers)
Start:
|
44,154,286 bp from pter |
End:
|
44,163,957 bp from pter |
Size:
|
9,672 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 44,193,781-44,202,644 |
|
Proteins
for POLD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPOD2_HUMAN, P49005 (See
protein sequence)Recommended Name: DNA polymerase delta subunit 2 Size: 469 amino acids; 51289 Da
Subunit: Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with KCTD10 (Bysimilarity). Interacts with KCTD13/POLDIP1, POLDIP2 and POLDIP3. Interacts with WRNIP1. Interacts with POLD4
Subcellular location: Nucleus
1 PDB 3D structure from  and Proteopedia  for POLD2:3E0J (3D)
Explore the universe of human proteins at neXtProt for POLD2: NX_P49005
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49005
4/6 DME Specific Peptides for POLD2 (P49005) (see all 6)
POLD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001120690.1 NP_001243808.1 NP_006221.2
ENSEMBL proteins: ENSP00000386105 ENSP00000223361 ENSP00000395231 ENSP00000399447 ENSP00000416203 ENSP00000389816 ENSP00000397461 ENSP00000406702 Reactome Protein details: P49005
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
POLD2 for ontologies About GeneDecksing
POLD2 Antibody Products:
Assay Products for POLD2: |
Protein
Domains /
Families
for POLD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POLD2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49005ProtoNet protein and cluster: P49005 UniProtKB/Swiss-Prot: DPOD2_HUMAN, P49005Similarity: Belongs to the DNA polymerase delta/II small subunit family |
Function
for POLD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DPOD2_HUMAN, P49005Function: The function of the small subunit is not yet clearCatalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) Genatlas biochemistry entry for POLD2:polymerase (DNA directed) delta 2,small catalytic subunit 48kDa,involved in DNA replication of nuclear genome
Enzyme Number (IUBMB): EC 2.7.7.71 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLD2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLD2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): POLD2 (NM_006230) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
POLD2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for POLD2:
|
Pathways & Interactions
for POLD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lagging Strand Synthesis | | | 2 | Resolution of Abasic Sites (AP sites) | | | 3 | Nucleotide Excision Repair | | | 4 | Ubiquitinated Orc1 is degraded by the proteasome | | | 5 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for POLD2
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLD2
1  GeneGo (Thomson Reuters) Pathway for POLD2
2  BioSystems Pathways for POLD2
5/31 
Reactome Pathways for POLD2 (see all 31)
5/8 
Kegg Pathways (Kegg details for POLD2) (see all 8):
POLD2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLD2
5/28 Interacting proteins for POLD2 (P490051, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
POLD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for POLD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POLD2
Search CenterWatch for drugs/clinical trials and news about POLD2 / DPOD2
|
Transcripts
for POLD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POLD2 gene (3 alternative transcripts): NM_001127218.2 NM_001256879.1 NM_006230.3 Unigene Cluster for POLD2: Polymerase (DNA directed), delta 2, accessory subunit Hs.306791 [show with all ESTs]Unigene Representative Sequence: NM_00125687917 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000406581(uc010kxz.3 uc003tkf.4) ENST00000489883 ENST00000223361
ENST00000452185(uc010kya.3) ENST00000436400 ENST00000436844 ENST00000481104
ENST00000433715 ENST00000463464 ENST00000470867 ENST00000464871 ENST00000461116
ENST00000467469 ENST00000456038 ENST00000418438 ENST00000496539 ENST00000481763
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLD2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLD2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): POLD2 (NM_006230) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD2 |
Additional cDNA sequence: AK292347.1 AK298168.1 AK312294.1 BC000459.2 BC030001.2 U21090.1 24/32 DOTS entries (see all 32): DT.97855172 DT.75153120 DT.100884161 DT.100038843 DT.100884147 DT.100836470 DT.100722986 DT.100726622 DT.121045056 DT.100884156 DT.92467260 DT.100884142 DT.95232125 DT.95247546 DT.97780886 DT.100038845 DT.100884162 DT.100038844 DT.100683602 DT.100712649 DT.100838342 DT.100884140 DT.121044981 DT.121045082 24/767 AceView cDNA sequences (see all 767): BQ068142 CR595850 CR597999 CR590132 BI823047 BM564731 AU279537 BM742463 BG942633 BQ669213 BQ226893 AW248456 BX387190 AI986382 BM764744 BE731991 BU617266 AU117477 BQ276459 BQ962946 AW967181 BU557314 AI668956 CR608121
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for POLD2 (see all 17) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | - | | - | | - | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for POLD2
|
Expression
for POLD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POLD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTACTTTTG
About this image
See POLD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLD2
SOURCE GeneReport for Unigene cluster: Hs.306791
SABiosciences Custom PCR Arrays for POLD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD2 |
Orthologs
for POLD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for POLD2 gene from 10/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pold21 , 5 |
polymerase (DNA directed), delta 2, regulatory subunit1, 5 |
87.99(n)1
94.24(a)1 |
|
11 (3.88 cM)5
189721 NM_008894.21 NP_032920.21
58721805 |
chicken
(Gallus gallus) |
Aves |
LOC1008593981 |
DNA polymerase delta subunit 2-like |
73.64(n)
74.07(a) |
|
100859398 XM_003643917.1 XP_003643965.1 |
lizard
(Anolis carolinensis) |
Reptilia |
POLD26 |
-- |
75(a) |
1 ↔ 1 |
GL343238.1(318848-334572) |
African clawed frog
(Xenopus laevis) |
Amphibia |
pold2-prov2 |
polymerase (DNA directed), delta 2, regulatory subunit more |
73.9(n) |
|
BC047262.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.180662 |
Danio rerio mRNA similar to polymerase (DNA directed), more |
73.72(n) |
|
BC045410.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
BcDNA:HL038743
CG120181 |
DNA replication delta DNA polymerase3
CG120181 |
43(a)3
51.6(n)1
44.47(a)1 |
|
62B43
382281 NM_139402.21 NP_647659.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F12F6.73 |
Yeast HUS2 protein like |
28(a) |
|
IV(11559070-11562004) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
POL31(YJR006W)4
POL311 |
DNA polymerase III (delta) subunit, essential for cell more4
Pol31p1 |
45.25(n)1
34.11(a)1 |
|
10(449202-450665)4
8534621, 4 NP_012539.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
POLD21 |
DNA polymerase delta subunit 2 |
48.8(n)
44.71(a) |
|
818812 NM_201935.2 NP_973664.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g01285001 |
hypothetical protein |
49.84(n)
44.02(a) |
|
4331489 NM_001055376.1 NP_001048841.1 |
ENSEMBL Gene Tree for POLD2 (if available)
TreeFam Gene Tree for POLD2 (if available) |
Paralogs
for POLD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POLD2 gene
POLD2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for POLD2
PGOHUM00000235694
|
Genomic Variants
for POLD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POLD2 (44154286 - 44163957 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for POLD2
2 CNVs: 4532 31342 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for POLD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POLD2 for disorders About GeneDecksing
OMIM gene information: 600815
OMIM disorders: --
6  diseases for POLD2: About MalaCardsovarian carcinoma graft versus host disease carcinoma werner syndrome
hepatocellular carcinoma malaria
Human Genome Epidemiology (HuGE) Navigator: POLD2 (3 documents)
Export disorders for POLD2 gene to outside databases
|
Publications
for POLD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POLD2 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with POLD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2). (PubMed id 8530069)1, 2, 3 Zhang J.... So A.G. (1995)
- Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PubMed id 16510448)1, 2 Li H.... Lee M.Y. (2006)
- Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. (PubMed id 15670210)1, 2 Tsurimoto T.... Enomoto T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PubMed id 12522211)1, 2 Liu L.... Lee M.Y.W.T. (2003)
- A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PubMed id 11593007)1, 2 He H.... So A.G. (2001)
- Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta. (PubMed id 10978529)1, 2 Perez A.... Lee M.Y.W.T. (2000)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
|
External Searches for POLD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POLD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POLD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POLD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POLD2 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/pold2/ |
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About This Section
| Patent Information for POLD2 gene:
Search GeneIP for patents involving POLD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for POLD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POLD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLD2 | | | OriGene Protein Over-expression Lysate for POLD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POLD2 | | OriGene 3'-UTR Clone for POLD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for POLD2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POLD2 | | OriGene Custom Protein Services for POLD2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLD2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLD2 |
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| | | | Search Tocris compounds for POLD2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD2 |
|  |  |  | | | | Search ThermoFisher Antibodies for POLD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD2 |
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