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Aliases for POLD2 Gene

Aliases for POLD2 Gene

  • DNA Polymerase Delta 2, Accessory Subunit 2 3 5
  • DNA Polymerase Delta Subunit P50 2 4
  • Polymerase (DNA Directed), Delta 2, Regulatory Subunit (50kD) 2
  • Polymerase (DNA Directed), Delta 2, Regulatory Subunit 50kDa 2
  • Polymerase (DNA) Delta 2, Accessory Subunit 2
  • Pol Delta B Subunit (P50) 2
  • EC 2.7.7.7 61

External Ids for POLD2 Gene

Previous GeneCards Identifiers for POLD2 Gene

  • GC07M043800
  • GC07M043861
  • GC07M043895
  • GC07M043927
  • GC07M044120
  • GC07M044039

Summaries for POLD2 Gene

Entrez Gene Summary for POLD2 Gene

  • This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

GeneCards Summary for POLD2 Gene

POLD2 (DNA Polymerase Delta 2, Accessory Subunit) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLD2 Gene

  • As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the POLZ complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).

Gene Wiki entry for POLD2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLD2 Gene

Genomics for POLD2 Gene

Regulatory Elements for POLD2 Gene

Enhancers for POLD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G044086 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +36.0 36044 3.4 BCOR CTCF ZNF146 SAP130 ZSCAN4 SIN3A YY1 ZNF664 ZNF791 POLR2A POLM RASA4CP UBE2D4 ENSG00000241057 PGAM2 ENSG00000239775 POLD2 AEBP1 YKT6
GH07G044145 1.2 ENCODE dbSUPER 10.6 -22.7 -22730 2.5 HDGF PKNOX1 ATF1 ARNT TCF12 GATA2 KLF13 ZNF263 NCOA1 REST POLD2 GCK LOC105375258 MYL7
GH07G044093 1 dbSUPER 11.7 +32.2 32154 1.1 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 NFYC MXD4 REST MIER2 POLM ENSG00000241057 ENSG00000239775 PGAM2 POLD2 AEBP1
GH07G044460 1.1 Ensembl ENCODE 10.3 -336.7 -336686 2.1 TBL1XR1 ZBTB40 GATA2 FOS RELB ETV6 IKZF2 CREM CBFB USF2 NUDCD3 POLD2 AEBP1 RPL32P18 PIR50224
GH07G043925 1.1 ENCODE 9.8 +197.6 197611 2.2 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 DDX56 POLM SPDYE1 TUBG1P ENSG00000272768 POLD2 RASA4CP DBNL UBE2D4 PIR62464
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLD2 on UCSC Golden Path with GeneCards custom track

Promoters for POLD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211789 658 1800 HDGF PKNOX1 MLX AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for POLD2 Gene

Chromosome:
7
Start:
44,114,680 bp from pter
End:
44,124,358 bp from pter
Size:
9,679 bases
Orientation:
Minus strand

Genomic View for POLD2 Gene

Genes around POLD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLD2 Gene

Proteins for POLD2 Gene

  • Protein details for POLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49005-DPOD2_HUMAN
    Recommended name:
    DNA polymerase delta subunit 2
    Protein Accession:
    P49005
    Secondary Accessions:
    • A4D2J4
    • B2R5S4

    Protein attributes for POLD2 Gene

    Size:
    469 amino acids
    Molecular mass:
    51289 Da
    Quaternary structure:
    • Component of the tetrameric DNA polymerase delta complex (Pol-delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing DNA polymerase and 3 to 5 proofreading exonuclease activities (PubMed:22801543, PubMed:17317665). Within Pol-delta4, directly interacts with POLD1, POLD3 and POLD4 (PubMed:11328591, PubMed:16510448). Following stress caused by DNA damaging agents or by replication stress, POLD4 is degraded and Pol-delta4 is converted into a trimeric form of the complex (Pol-delta3), which consists of POLD1, POLD2 and POLD3. Pol-delta3 is the major form occurring at S phase replication sites, as well as DNA damage sites (PubMed:22801543, PubMed:17317665). Also observed as a dimeric complex with POLD2 (Pol-delta2 complex). Pol-delta2 is relatively insensitive to the PCNA stimulation (2-5-fold) compared to Pol-delta4 that is stimulated by over 50-fold (PubMed:12403614). Contrary to the other components of Pol-delta4, does not directly interact with PCNA (PubMed:12403614, PubMed:16510448). As POLD1 and POLD4, directly interacts with WRNIP1; this interaction stimulates DNA polymerase delta-mediated DNA synthesis, independently of the presence of PCNA. This stimulation may be due predominantly to an increase of initiation frequency and also to increased processivity (PubMed:15670210). Directly interacts with POLDIP2 and POLDIP3 (PubMed:12522211). Directly interacts with KCTD13/PDIP1; in the presence of PCNA, this interaction may stimulate DNA polymerase activity (PubMed:11593007). Component of the DNA polymerase zeta complex (POLZ), which consists of REV3L, MAD2L2, POLD2 and POLD3, with REV3L bearing DNA polymerase catalytic activity (PubMed:24449906). Interacts with KCTD10 (By similarity).

    Three dimensional structures from OCA and Proteopedia for POLD2 Gene

neXtProt entry for POLD2 Gene

Selected DME Specific Peptides for POLD2 Gene

P49005:
  • PTAPDTLGCYPFYK
  • RQYAHIYATRL
  • ECPHVYFCGNTPSFGSK
  • KKTQAASVEAVKMLDEILLQ
  • VKKLCELQP
  • SRVILAGNLLS

Post-translational modifications for POLD2 Gene

  • Ubiquitination at posLast=8181, posLast=9090, posLast=9999, posLast=125125, posLast=267267, Lys389, and Lys413
  • Modification sites at PhosphoSitePlus

Domains & Families for POLD2 Gene

Gene Families for POLD2 Gene

Protein Domains for POLD2 Gene

Graphical View of Domain Structure for InterPro Entry

P49005

UniProtKB/Swiss-Prot:

DPOD2_HUMAN :
  • Belongs to the DNA polymerase delta/II small subunit family.
Family:
  • Belongs to the DNA polymerase delta/II small subunit family.
genes like me logo Genes that share domains with POLD2: view

Function for POLD2 Gene

Molecular function for POLD2 Gene

GENATLAS Biochemistry:
polymerase (DNA directed) delta 2,small catalytic subunit 48kDa,involved in DNA replication of nuclear genome
UniProtKB/Swiss-Prot Function:
As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the POLZ complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).

Enzyme Numbers (IUBMB) for POLD2 Gene

Gene Ontology (GO) - Molecular Function for POLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA,TAS --
GO:0005515 protein binding IPI 12403614
genes like me logo Genes that share ontologies with POLD2: view
genes like me logo Genes that share phenotypes with POLD2: view

Animal Models for POLD2 Gene

MGI Knock Outs for POLD2:

Animal Model Products

miRNA for POLD2 Gene

miRTarBase miRNAs that target POLD2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLD2 Gene

Localization for POLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLD2 Gene

Nucleus. Note=Recruited to DNA damage sites within 2 hours following UV irradiation. {ECO:0000269 PubMed:22801543}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLD2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for POLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8530069
GO:0005654 nucleoplasm IDA,TAS --
GO:0043625 delta DNA polymerase complex IBA,IEA --
genes like me logo Genes that share ontologies with POLD2: view

Pathways & Interactions for POLD2 Gene

SuperPathways for POLD2 Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
3 Mismatch repair
4 DNA Double-Strand Break Repair
5 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
genes like me logo Genes that share pathways with POLD2: view

Pathways by source for POLD2 Gene

Gene Ontology (GO) - Biological Process for POLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination TAS --
GO:0000723 telomere maintenance TAS --
GO:0006260 DNA replication TAS,IEA 8530069
GO:0006261 DNA-dependent DNA replication IEA --
GO:0006266 DNA ligation TAS --
genes like me logo Genes that share ontologies with POLD2: view

No data available for SIGNOR curated interactions for POLD2 Gene

Drugs & Compounds for POLD2 Gene

(3) Drugs for POLD2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
dgtp Experimental Pharma 0

(2) Additional Compounds for POLD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with POLD2: view

Transcripts for POLD2 Gene

Unigene Clusters for POLD2 Gene

Polymerase (DNA directed), delta 2, accessory subunit:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLD2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - -
SP9:
SP10:
SP11: - - -
SP12: - - - -
SP13: - - - -
SP14: - - - - - - - - - -
SP15:
SP16:
SP17: -

ExUns: 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c
SP1: -
SP2:
SP3:
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:

Relevant External Links for POLD2 Gene

GeneLoc Exon Structure for
POLD2
ECgene alternative splicing isoforms for
POLD2

Expression for POLD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLD2 Gene

This gene is overexpressed in Breast (30.6) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLD2 Gene



Protein tissue co-expression partners for POLD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLD2 Gene:

POLD2

SOURCE GeneReport for Unigene cluster for POLD2 Gene:

Hs.306791

Evidence on tissue expression from TISSUES for POLD2 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Skin(3)
  • Intestine(2.7)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with POLD2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLD2 Gene

Orthologs for POLD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLD2 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia POLD2 34 35
  • 89.55 (n)
mouse
(Mus musculus)
Mammalia Pold2 34 16 35
  • 88.14 (n)
oppossum
(Monodelphis domestica)
Mammalia POLD2 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pold2 34
  • 87.41 (n)
dog
(Canis familiaris)
Mammalia POLD2 34 35
  • 85.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POLD2 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLD2 34 35
  • 73.64 (n)
lizard
(Anolis carolinensis)
Reptilia POLD2 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pold2 34
  • 68.7 (n)
Str.12411 34
African clawed frog
(Xenopus laevis)
Amphibia pold2-prov 34
zebrafish
(Danio rerio)
Actinopterygii pold2 34 35
  • 66.59 (n)
Dr.18066 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008910 34
  • 51.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12018 34 35
  • 51.28 (n)
BcDNA:HL03874 36
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea F12F6.7 36 35
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL31 35 37
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons POLD2 34
  • 48.64 (n)
rice
(Oryza sativa)
Liliopsida Os03g0128500 34
  • 49.92 (n)
Species where no ortholog for POLD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLD2 Gene

ENSEMBL:
Gene Tree for POLD2 (if available)
TreeFam:
Gene Tree for POLD2 (if available)

Paralogs for POLD2 Gene

Pseudogenes.org Pseudogenes for POLD2 Gene

genes like me logo Genes that share paralogs with POLD2: view

No data available for Paralogs for POLD2 Gene

Variants for POLD2 Gene

Sequence variations from dbSNP and Humsavar for POLD2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000097122 -- 44,115,028(+) GGAGT(C/T)CCCAT intron-variant, downstream-variant-500B
rs1000215120 -- 44,122,322(+) TAGGA(A/G)TGTTT intron-variant, utr-variant-5-prime
rs1000277471 -- 44,121,614(+) GTCCT(C/T)ATCTC intron-variant
rs1001100722 -- 44,116,741(+) CTACT(C/T)GCCCT intron-variant
rs1001164351 -- 44,122,415(+) GTTTG(C/T)CCCAA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for POLD2 Gene

Variant ID Type Subtype PubMed ID
dgv11297n54 CNV loss 21841781
esv998294 CNV deletion 20482838
nsv428165 CNV gain 18775914
nsv470210 CNV loss 18288195
nsv8082 CNV gain 18304495
nsv830983 CNV loss 17160897

Variation tolerance for POLD2 Gene

Residual Variation Intolerance Score: 7.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLD2 Gene

Disorders for POLD2 Gene

Relevant External Links for POLD2

Genetic Association Database (GAD)
POLD2
Human Genome Epidemiology (HuGE) Navigator
POLD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLD2

No disorders were found for POLD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLD2 Gene

Publications for POLD2 Gene

  1. Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2). (PMID: 8530069) Zhang J. … So A.G. (Genomics 1995) 2 3 4 64
  2. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PMID: 20226869) Thyagarajan B. … Arora M. (Biol. Blood Marrow Transplant. 2010) 3 46 64
  3. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PMID: 20574454) Arora M. … Thyagarajan B. (Leukemia 2010) 3 46 64
  4. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 46 64
  5. X-ray structure of the complex of regulatory subunits of human DNA polymerase delta. (PMID: 18818516) Baranovskiy A.G. … Tahirov T.H. (Cell Cycle 2008) 3 4 64

Products for POLD2 Gene

Sources for POLD2 Gene

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