Aliases for POLD2 Gene
- DNA Polymerase Delta 2, Accessory Subunit 2 3
- Polymerase (DNA) Delta 2, Accessory Subunit 2 5
- DNA Polymerase Delta Subunit P50 2 4
- EC 22.214.171.124 4 61
- Polymerase (DNA Directed), Delta 2, Regulatory Subunit (50kD) 2
- Polymerase (DNA Directed), Delta 2, Regulatory Subunit 50kDa 2
- Pol Delta B Subunit (P50) 2
External Ids for POLD2 Gene
Previous GeneCards Identifiers for POLD2 Gene
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
GeneCards Summary for POLD2 Gene
POLD2 (DNA Polymerase Delta 2, Accessory Subunit) is a Protein Coding gene. Among its related pathways are DNA strand elongation and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. GO annotations related to this gene include DNA-directed DNA polymerase activity.
UniProtKB/Swiss-Prot for POLD2 Gene
The function of the small subunit is not yet clear.