Aliases for POLD1 Gene
External Ids for POLD1 Gene
Previous HGNC Symbols for POLD1 Gene
Previous GeneCards Identifiers for POLD1 Gene
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
GeneCards Summary for POLD1 Gene
POLD1 (Polymerase (DNA) Delta 1, Catalytic Subunit) is a Protein Coding gene. Diseases associated with POLD1 include mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome and colorectal cancer 10. Among its related pathways are Metabolism and Cell Cycle, Mitotic. GO annotations related to this gene include nucleic acid binding and chromatin binding.
UniProtKB/Swiss-Prot for POLD1 Gene
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3- to 5-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.