POLD1 Gene
protein-coding GIFtS: 67
GCID: GC19P050889
|
|
polymerase (DNA directed), delta 1, catalytic subunit(Previous names: polymerase (DNA directed), delta 1, catalytic subunit (125kD)...)
(Previous symbol: POLD)
| |
Aliases
for POLD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Polymerase (DNA Directed), Delta 1, Catalytic Subunit1 2 | | Polymerase (DNA Directed), Delta 1, Catalytic Subunit (125kD)1 | | POLD1 2 3 | | CRCS102 | | CDC21 2 | | CDC2 Homolog2 | | DNA Polymerase Subunit Delta P1252 3 | | DNA Polymerase Delta Catalytic Subunit2 | | EC 2.7.7.73 8 | | Polymerase (DNA Directed), Delta 1, Catalytic Subunit 125kDa2 |
Export aliases for POLD1 gene to outside databasesPrevious GC identifers: GC19P051516 GC19P051248 GC19P055563 GC19P055580 GC19P055581 GC19P055582 GC19P047225 |
Summaries
for POLD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for POLD1:
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymeraseand 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively splicedtranscript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm ofchromosome 6. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: DPOD1_HUMAN, P28340Function: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degradessingle stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclearantigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved incompleting Okazaki fragments initiated by the DNA polymerase alpha/primase complex
Gene Wiki entry for POLD1
|
Genomic Views
for POLD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POLD1 gene promoter:
Elk-1 Pax-5 HOXA3 Nkx2-5 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for POLD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3POLD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P050889: view genomic region
(about GC identifiers)
Start:
|
50,887,593 bp from pter |
End:
|
50,921,271 bp from pter |
Size:
|
33,679 bases |
Orientation:
|
plus strand |
|
Proteins
for POLD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPOD1_HUMAN, P28340 (See
protein sequence)Recommended Name: DNA polymerase delta catalytic subunit Size: 1107 amino acids; 123631 Da
Cofactor: Binds 1 4Fe-4S cluster (By similarity)
Subunit: Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. The 125 kDa subunit contains thepolymerase active site and most likely the active site for the 3'-5' exonuclease activity. Interacts with WRNIP1.Interacts with POLD4 and PCNA
Subcellular location: Nucleus
Miscellaneous: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which areresponsible for different reactions of DNA synthesis
Secondary accessions: Q8NER3 Q96H98Explore the universe of human proteins at neXtProt for POLD1: NX_P28340
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P28340
4/38 DME Specific Peptides for POLD1 (P28340) (see all 38)
POLD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243778.1 NP_002682.2
ENSEMBL proteins: ENSP00000406046 Reactome Protein details: P28340
Human Recombinant Protein Products for POLD1:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
POLD1 for ontologies About GeneDecksing
POLD1 Antibody Products:
Assay Products for POLD1: |
Protein
Domains /
Families
for POLD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POLD1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P28340ProtoNet protein and cluster: P28340 1 Blocks protein family: IPB006134 DNA polymerase B domain
UniProtKB/Swiss-Prot: DPOD1_HUMAN, P28340Domain: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes (By similarity)Similarity: Belongs to the DNA polymerase type-B familySimilarity: Contains 1 CysA-type zinc finger |
Function
for POLD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DPOD1_HUMAN, P28340Function: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degradessingle stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclearantigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved incompleting Okazaki fragments initiated by the DNA polymerase alpha/primase complexCatalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) Genatlas biochemistry entry for POLD1:polymerase (DNA directed),delta 1,catalytic subunit 125kDa,involved in DNA replication of nuclear genome,alsopossessing an intrinsic proofreading function that reduces the levels of errors during replication,deleted in sporadiccolorectal cancers
Enzyme Number (IUBMB): EC 2.7.7.71 2
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
POLD1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for POLD1:
9 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Pold1):
POLD1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Pold1tm1.1Uchi for POLD1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POLD1 (NM_002691) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD1 |
|
Pathways & Interactions
for POLD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lagging Strand Synthesis | | | 2 | Resolution of Abasic Sites (AP sites) | | | 3 | Global Genomic NER (GG-NER) | | | 4 | Nucleotide Excision Repair | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for POLD1
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLD1
1  GeneGo (Thomson Reuters) Pathway for POLD1
4  BioSystems Pathways for POLD1
5/34 
Reactome Pathways for POLD1 (see all 34)
5/8 
Kegg Pathways (Kegg details for POLD1) (see all 8):
POLD1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLD1
5/824 Interacting proteins for POLD1 (P283401, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 824)About this table
Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table
POLD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for POLD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POLD1
6 HMDB Compounds for POLD1 About this table
Search CenterWatch for drugs/clinical trials and news about POLD1 / DPOD1
|
Transcripts
for POLD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POLD1 gene (2 alternative transcripts): NM_001256849.1 NM_002691.3 Unigene Cluster for POLD1: Polymerase (DNA directed), delta 1, catalytic subunit Hs.279413 [show with all ESTs]Unigene Representative Sequence: NM_0012568491 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000440232(uc002psb.4 uc002psc.4 uc010enx.3 uc010eny.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POLD1 (NM_002691) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD1 |
Additional cDNA sequence: BC008800.1 DQ234348.1 M80397.1 M81735.1 NR_046402.1 8 DOTS entries: DT.213261 DT.92435774 DT.97775691 DT.92435776 DT.102831522 DT.92435775 DT.75103553 DT.92435777 24/214 AceView cDNA sequences (see all 214): R05675 CA396923 BF874672 BE298157 AI049554 AI580005 AW247826 BC008800 T29087 BM457847 BU859048 BQ054258 BU931011 BQ918345 BM905305 CB321982 CR597968 BE535321 BU501677 BQ955289 BQ070749 BE791519 CA455120 NM_002691
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for POLD1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | · | 24c | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for POLD1
|
Expression
for POLD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POLD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See POLD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLD1
SOURCE GeneReport for Unigene cluster: Hs.279413
SABiosciences Custom PCR Arrays for POLD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD1 |
Orthologs
for POLD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for POLD1 gene from 10/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pold11 , 5 |
polymerase (DNA directed), delta 1, catalytic subunit1, 5 |
84.71(n)1
89.68(a)1 |
|
7 (28.83 cM)5
189711 NM_011131.31 NP_035261.31
445327465 |
lizard
(Anolis carolinensis) |
Reptilia |
POLD16 |
-- |
70(a) |
1 ↔ 1 |
6(79699864-79723846) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.15642 |
Transcribed sequence with moderate similarity to protein more |
78.9(n) |
|
137694477 |
zebrafish
(Danio rerio) |
Actinopterygii |
iktdsubc_1d112 |
iktdsubc_1d11 |
78.56(n) |
|
368928 BM342416.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
DNApol-&dgr;3
DNApol-delta1 |
lagging strand elongation 3'-5'
exodeoxyribonuclease3
DNA-polymerase-delta1 |
58(a)3
60.89(n)1
61.27(a)1 |
|
72C13
397461 NM_079375.21 NP_524099.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
F10C2.41 , 3 |
DNA polymerase family B3
Protein F10C2.41 |
49(a)3
51.25(n)1
51.25(a)1 |
|
V(12044206-12047802)3
1796521 NM_073616.21 NP_506017.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
POL31 |
Pol3p |
50.88(n)
51.37(a) |
|
851456 NP_010181.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
EMB27801 |
DNA polymerase delta subunit 1 |
53.99(n)
55.13(a) |
|
836517 NM_125792.2 NP_201201.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.37382 |
Oryza sativa (japonica cultivar-group) OspolD1 mRNA more |
73.91(n) |
|
AB037899.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
polB6 |
DNA polymerase II |
20(a) |
possible ortholog |
Chromosome(63429-65780) |
ENSEMBL Gene Tree for POLD1 (if available)
TreeFam Gene Tree for POLD1 (if available) |
Paralogs
for POLD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POLD1 gene
POLD1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for POLD1
PGOHUM00000243670
|
Genomic Variants
for POLD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POLD1 (50887593 - 50921271 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for POLD1
1 CNV: 78239
Human Gene Mutation Database (HGMD): POLD1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLD1 |
|
Disorders
/ Diseases
for POLD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POLD1 for disorders About GeneDecksing
OMIM gene information: 174761
OMIM disorders: --
20/26  diseases for POLD1 (see all 26): About MalaCardschronic progressive external ophthalmoplegia human immunodeficiency virus infectious disease graft versus host disease skin tag
xeroderma pigmentosum herpes zoster alpers syndrome mutism
cockayne syndrome ophthalmoplegia familial breast cancer multiple sclerosis
hepatitis b vaccinia breast cancer encephalitis
pulmonary disease hepatocellular carcinoma colon cancer meningioma
2 diseases from the University of Copenhagen DISEASES database for POLD1:Mutism Leukodystrophy Genetic Association Database (GAD): POLD1
Human Genome Epidemiology (HuGE) Navigator: POLD1 (18 documents)
Export disorders for POLD1 gene to outside databases
|
Publications
for POLD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POLD1 gene, integrated from 9 sources (see all 91):
(articles sorted by number of sources associating them with POLD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene. (PubMed id 1722322)1, 2, 3 Chung D.W.... Downey K.M. (1991)
- Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PubMed id 16510448)1, 2 Li H.... Lee M.Y. (2006)
- Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. (PubMed id 15670210)1, 2 Tsurimoto T.... Enomoto T. (2005)
- Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PubMed id 15113441)1, 4 Sigurdson A.J....Struewing J.P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta. (PubMed id 1542570)1, 2 Yang C.-L....Lee M.Y.W.T. (1992)
- Structure of the gene for the catalytic subunit of human DNA polymerase delta (POLD1). (PubMed id 7490075)1, 9 Chang L.S....Lee M.Y. (1995)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase delta catalytic subunit gene, POLD1. (PubMed id 22761421)1 Karkhanis V.... Sif S. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
|
External Searches for POLD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POLD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing POLD1 gene
(According to HUGE)
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Specialized Databases showing POLD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for POLD1 gene:
Search GeneIP for patents involving POLD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for POLD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for POLD1 | | OriGene shRNA RFP for POLD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLD1 | | | OriGene Protein Over-expression Lysate for POLD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POLD1 | | OriGene 3'-UTR Clone for POLD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POLD1 | | OriGene Custom Protein Services for POLD1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLD1 |
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| | | | Search Tocris compounds for POLD1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLD1 |
|  |  |  |  | | | | ThermoFisher Antibodies for POLD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLD1 |
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