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POLB Gene

protein-coding GIFtS: 69

GC08P042315

polymerase (DNA directed), beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.7.7,EC 4.2.99.- ^³
MGC125976 ^²

Descriptions
DNA pol beta ^²
DNA polymerase beta subunit ^²
DNA-directed DNA polymerase beta ^²
polymerase (DNA directed), beta ^²

External Ids
HGNC: 9174¹
Entrez Gene: 5423²
UniProtKB: P06746³
Ensembl: ENSG00000070501⁷

Search outside databases for aliases for POLB gene

Previous GC identifers: GC08M041722 GC08P042220 GC08P041936 GC08P042213

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for POLB:

In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for

DNA maintenance, replication, recombination, and drug resistance. Also see POLA (MIM

312040).[supplied by OMIM]

UniProtKB/Swiss-Prot: DPOLB_HUMAN, P06746

Function: Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive

fashion rather than in a processive fashion as for other DNA polymerases. Has a

5'-deoxyribose-5-phosphate lyase (dRP lyase) activity

Gene Wiki entry for POLB (DNA_polymerase_beta)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the POLB gene

Entrez Gene cytogenetic band: 8p11.2 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p12-p11

POLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P042315: (about GC identifiers)

Start:	42,315,166 bp from pter
End:	42,348,482 bp from pter
Size:	33,317 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_007995.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DPOLB_HUMAN, P06746 (See protein sequence)

Recommended Name: DNA polymerase beta

Size: 335 amino acids; 38178 Da

Cofactor: Binds 2 magnesium ions per subunit (By similarity)

Subunit: Monomer

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1BPX (3D)

1BPY (3D)

1BPZ (3D)

1MQ2 (3D)

1MQ3 (3D)

1TV9 (3D)

1TVA (3D)

1ZJM (3D)

1ZJN (3D)

1ZQA (3D)

1ZQB (3D)

1ZQC (3D)

1ZQD (3D)

1ZQE (3D)

1ZQF (3D)

1ZQG (3D)

1ZQH (3D)

1ZQI (3D)

1ZQJ (3D)

1ZQK (3D)

1ZQL (3D)

1ZQM (3D)

1ZQN (3D)

1ZQO (3D)

1ZQP (3D)

1ZQQ (3D)

1ZQR (3D)

1ZQS (3D)

1ZQT (3D)

2FMP (3D)

2FMQ (3D)

2FMS (3D)

2I9G (3D)

2ISO (3D)

2ISP (3D)

2P66 (3D)

2PXI (3D)

3C2K (3D)

3C2L (3D)

3C2M (3D)

3GDX (3D)

7ICE (3D)

7ICF (3D)

7ICG (3D)

7ICH (3D)

7ICI (3D)

7ICJ (3D)

7ICK (3D)

7ICL (3D)

7ICM (3D)

7ICN (3D)

7ICO (3D)

7ICP (3D)

7ICQ (3D)

7ICR (3D)

7ICS (3D)

7ICT (3D)

7ICU (3D)

7ICV (3D)

8ICA (3D)

8ICB (3D)

8ICC (3D)

8ICE (3D)

8ICF (3D)

8ICG (3D)

8ICH (3D)

8ICI (3D)

8ICJ (3D)

8ICK (3D)

8ICL (3D)

8ICM (3D)

8ICN (3D)

8ICO (3D)

8ICP (3D)

8ICQ (3D)

8ICR (3D)

8ICS (3D)

8ICT (3D)

8ICU (3D)

8ICV (3D)

8ICW (3D)

8ICX (3D)

8ICY (3D)

8ICZ (3D)

9ICA (3D)

9ICB (3D)

9ICC (3D)

9ICE (3D)

9ICF (3D)

9ICG (3D)

9ICH (3D)

9ICI (3D)

9ICJ (3D)

9ICK (3D)

9ICL (3D)

9ICM (3D)

9ICN (3D)

9ICO (3D)

9ICP (3D)

9ICQ (3D)

9ICR (3D)

9ICS (3D)

9ICT (3D)

9ICU (3D)

9ICV (3D)

9ICW (3D)

9ICX (3D)

9ICY (3D)

Secondary accessions: B2RC78 Q3KP48 Q6FI34

Post-translational modifications:

Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002681.1

ENSEMBL proteins:

ENSP00000265421

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DNA Polymerase beta)
	Human Recombinant Proteins from Abnova (POLB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	8978692 9207062 10559261 11250913
GO:0005737	cytoplasm	IDA	15725623
GO:0005876	spindle microtubule	IDA	15725623

About this table

Antibodies for POLB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for POLB
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DNA Polymerase beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (POLB)
	Novus Biologicals Antibodies for POLB

Assays for POLB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06746

ProtoNet protein and cluster: P06746

2 Blocks protein families:

IPB002008 DNA-polymerase family X pol beta-like signature

IPB003583 Helix-hairpin-helix DNA-binding

UniProtKB/Swiss-Prot: DPOLB_HUMAN, P06746

Domain: Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity (By

similarity)

Similarity: Belongs to the DNA polymerase type-X family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (POLB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (POLB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002690

Applied Biosystems Silencer® siRNAs for POLB

Sigma-Aldrich siRNA and siRNA Panels for POLB

Sigma-Aldrich shRNA Panels and shRNA for POLB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for POLB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002690
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002690
untagged cDNA clones in CMV expression vector (see all 2): NM_002690

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002690

UniProtKB/Swiss-Prot: DPOLB_HUMAN, P06746

Function: Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive

fashion rather than in a processive fashion as for other DNA polymerases. Has a

5'-deoxyribose-5-phosphate lyase (dRP lyase) activity

Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

Enzyme Number (IUBMB): EC 2.7.7.7,EC

Genatlas biochemistry entry for POLB:

polymerase (DNA directed),beta,39kDa,highly expressed (rat) in testis may be involved in DNA repair

and in meiosis,not involved in DNA replication

10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Polb):

behavior/neurological	embryogenesis	growth/size	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	nervous system	no phenotypic analysis	respiratory system	skin/coat/nails

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0003684	damaged DNA binding	IEA	--
GO:0003887	DNA-directed DNA polymerase activity	TAS	8168825
GO:0005515	protein binding	IPI	15520167
GO:0008017	microtubule binding	IDA	15725623

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for POLB (Your Favorite Gene powered by Ingenuity)

Pyrimidine Metabolism
Purine Metabolism

GeneDecks POLB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for POLB

5/38 Interacting proteins for POLB (P06746^{1, 2} ENSP00000265421³) via UniProtKB, MINT, and/or STRING (see all 38 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TAF1D	Q9H5J8¹, ENSP00000314971³	EBI-713836, EBI-716128 STRING (score=.966)
MYST2	O95251²	MINT-63414
TLE1	Q04724²	MINT-63415
XRCC1	ENSP00000262887³	STRING (score=.999)
APEX1	ENSP00000216714³	STRING (score=.995)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006261	DNA-dependent DNA replication	TAS	8168825
GO:0006290	pyrimidine dimer repair	IEA	--
GO:0006916	anti-apoptosis	IEA	--
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0008219	cell death	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for POLB:

Inhibitor

Browse Tocris compounds for POLB
10/45 Novoseek chemical compound relationships for POLB gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dideoxythymidine	82.54	6	9057979 (2), 1905189 (1), 8376804 (1), 2117783 (1) (see all 5)
ddttp	77.14	6	7918688 (1), 1657184 (1), 16283517 (1), 1315927 (1)
dctp	74.90	11	17293403 (2), 1384425 (1), 8702991 (1), 17321545 (1) (see all 8)
8-oxoguanine	73.04	7	12517331 (2), 16054643 (2), 16051529 (1), 17293403 (1)
aphidicolin glycinate	72.47	2	8674158 (1)
deoxynucleoside triphosphate	72.39	3	10200168 (1), 11756435 (1)
2-deoxyribonolactone	70.98	6	16793362 (2), 11805079 (2), 16199212 (1)
dttp	70.89	5	9237675 (1), 12139481 (1), 8809118 (1), 7680045 (1) (see all 5)
dcmp	70.36	1	1400458 (1)
quercetagetin	68.49	1	1695572 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (POLB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (POLB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002690

Sigma-Aldrich siRNA and siRNA Panels for POLB

Sigma-Aldrich shRNA Panels and shRNA for POLB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002690

REFSEQ mRNAs for POLB gene:

NM_002690.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002690

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002690
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002690
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002690

Additional cDNA sequence:

AK223537.1 AK294025.1 AK314976.1 BC100288.1 BC106909.1 CR536503.1 CR541802.1 CR623008.1

CR624336.1 CR627365.1 D29013.1 L11607.1 M13140.1

18 DOTS entries:

DT.95091040 DT.101960721 DT.121466683 DT.100794886 DT.95091024 DT.92054355 DT.87015228 DT.121466677

DT.97800015 DT.40314170 DT.40276214 DT.87015231 DT.100794885 DT.121466675 DT.91853249 DT.121016792

DT.85100102 DT.91975491

24/198 AceView cDNA sequences (see all 198 ):

CB130159 AU121247 BM979958 BP347878 BQ574627 AI654839 AA172228 BI008037

BM931013 BX646755 AI652201 BP369116 BP337965 CB139224 BQ184899 BP370570

BQ430835 BF507649 D29013 AI818230 CA314334 CB141008 CR623008 CB144384

highest scoring ESTs for POLB:

D29013 AA195692 AA195722 AW362902 AA361437 BG200837 BI000769 BU659187 AA130175 AA130183

Unigene Cluster for POLB:

Polymerase (DNA directed), beta

Hs.654484 [show with all ESTs]

Unigene Representative Sequence: CR627365

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POLB (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15
SP1:											-						-						-												-
SP2:											-						-
SP3:									-		-						-						-
SP4:									-		-						-
SP5:											-

About this scheme

ECgene alternative splicing isoforms for POLB

1 Ensembl transcript including schematic representation:

ENST00000265421

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

POLB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for POLB

¹ / ² / ³

5 probe-sets matching POLB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1696_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D29013	0.80	0.80	0.80	1
203616_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002690	0.40	0.67	0.55	1
234907_x_at*²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
203616_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234907_x_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks POLB for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACTATTAAA

SOURCE GeneReport for Unigene cluster: Hs.654484
Expression variation in blood from EXPOLDB for POLB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for POLB gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	POLB¹	--	polymerase (DNA directed), beta	94.73(n) 98.81(a)	494001 XM_532790.2 XP_532790.2
chimpanzee (Pan troglodytes)	POLB¹	--	polymerase (DNA directed), beta	99.6(n) 100(a)	737210 XM_001143904.1 XP_001143904.1
cow (Bos taurus)	POLB¹	--	polymerase (DNA directed), beta	93.43(n) 98.21(a)	614688 NM_001034764.1 NP_001029936.1
rat (Rattus norvegicus)	Polb¹	--	polymerase (DNA directed), beta	89.25(n) 95.52(a)	29240 NM_017141.1 NP_058837.1
mouse (Mus musculus)	Polb^{1, 5}	8 (8.00 cM)⁵	polymerase (DNA directed), beta^{1, 5}	89.15(n)¹ 96.42(a)¹	18970¹ NM_011130.1¹ NP_035260.1¹ AF513911⁵ AI643046⁵ (see all 18)

About this table Species with no ortholog for POLB

ENSEMBL Gene Tree for POLB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for POLB gene

DNTT² POLM² POLL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/242 NCBI SNPs in POLB are shown (see all 242 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 89)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3136711^1,2	C,F,H	42314623(+)	`GACACT/CGGTTG`	1	--	ng5¹		9		NS EU EA WA	994
	rs2307155^1,2	C,F,H	42315132(+)	`CACAAC/AAAGCG`	1	--	ng5¹		6		NA NS EU EA WA	670
	rs3136797^1,2	C,F,H	42345962(+)	`GCTTCC/GCAGTA`	1	P/R	mis¹ ese³		15		NS MN CSAM EA EU WA	1590
	rs3136713^1,2	F,H	42315032(+)	`TCCACG/ATCCAC`	1	--	ng5¹		5		NS EU EA WA	588
	rs3136712^1,2	F,H	42315003(+)	`TCTGAG/AGTGCC`	1	--	ng5¹		5		NS EU EA WA	592
	rs2307158^1,2	C,F	42315104(+)	`GCCCCG/TCCCCG`	1	--	ng5¹		2		NA NS	252
--	rs7462320^1,2	A,C	42313551(+)	`gaatcA/Gcttga`	1	--	ng5¹ tfbs³		0	--	--	--	--
--	rs7463029^1,2	A,C	42313605(+)	`cactcC/Tggcct`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs2307160^1,2	C,F	42315238(+)	`CTTCAA/GGCTGG`	1	--	ut5¹ ese³		10		NA NS MN CSAM EA	786
	rs10091081^1,2	C,H	42333852(+)	`TTTTGG/CGGACT`	1	A/G	mis¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for POLB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 174760

10/25 Novoseek disease relationships for POLB gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloblastosis	53.88	2	1371865 (1), 7687565 (1)
werner syndrome	49.94	2	8168825 (1), 16449207 (1)
immunodeficiency	32.58	17	15701045 (2), 8702991 (1), 9367179 (1), 7516580 (1) (see all 16)
cancer	16.44	11	15280658 (2), 11593426 (2), 15963946 (1), 16722994 (1) (see all 9)
familial adenomatous polyposis	11.49	2	17999539 (1), 17176113 (1)
tumors	7.39	25	15280658 (2), 11593426 (2), 9078303 (1), 10357787 (1) (see all 23)
aids	2.74	2	7516580 (1), 1932601 (1)
brain tumors	0.04	1	8692923 (1)
colon cancer	0.00	1	15075389 (1)
melanoma	0.00	1	12388548 (1)

About this table

Human Gene Mutation Database: POLB
Genetic Association Database: POLB
Human Genome Epidemiology Navigator: POLB (17 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/357 PubMed articles for POLB gene (see all 357 ):

Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. (PubMed id 11805079)^{1, 3, 4} DeMott M.S.... Demple B. (2002)
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)^{1, 3, 6} Zienolddiny S....Haugen A. (2006)
A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. (PubMed id 8841119)^{1, 3, 4} Pelletier H.... Kraut J. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure of DNA polymerase beta with the mutagenic DNA lesion 8- oxodeoxyguanine reveals structural insights into its coding potential. (PubMed id 12517346)^{3, 4} Krahn J.M.... Wilson S.H. (2003)
Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups. (PubMed id 9572863)^{3, 4} Matsumoto Y.... Feng J.-A. (1998)
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. (PubMed id 9287163)^{3, 4} Sawaya M.R.... Pelletier H. (1997)
Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. (PubMed id 8841120)^{3, 4} Pelletier H. and Sawaya M.R. (1996)
Polymorphisms in the human DNA polymerase beta gene. (PubMed id 7705833)^{3, 4} Dobashi Y.... Hosaka M. (1995)
The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression. (PubMed id 7914364)^{3, 4} Chyan Y.-J.... Wood T.G. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5423	HGNC: 9174	AceView: POLB	Ensembl:ENSG00000070501	euGenes: HUgn5423
ECgene: POLB	H-InvDB: POLB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for POLB	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/polb/

Licensable Technologies for POLB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for POLB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for POLB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for POLB		Antibodies for POLB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for POLB		Small molecules for POLB
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (POLB)
	Antibodies (POLB)
	Chimera RNAi (POLB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (DNA Polymerase beta)
	Antibodies (DNA Polymerase beta)

Search OriGene for POLB

Search Tocris compounds for POLB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for POLB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
POLB Gene at Home site.
Version 2.41.1
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POLB Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for POLB

Summaries
for POLB

Genomic Location
for POLB

Proteins
for POLB

Protein Domains/
Families
for POLB

Gene Function
for POLB

Pathways & Interactions
for POLB

Drugs & Compounds
for POLB

Transcripts
for POLB

Expression
for POLB

Orthologs
for POLB

Paralogs
for POLB

SNPs/Variants
for POLB

Disorders & Mutations
for POLB

Medical News
for POLB

Publications
for POLB

Search for POLB

Genome Databases showing POLB

Other Databases showing POLB

Specialized Databases showing POLB

Licensable Technologies
for POLB

Services
for POLB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

POLB Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor POLB

Summariesfor POLB

Genomic Locationfor POLB

Proteinsfor POLB

Protein Domains/Familiesfor POLB

Gene Functionfor POLB

Pathways & Interactionsfor POLB

Drugs & Compoundsfor POLB

Transcriptsfor POLB

Expression for POLB

Orthologsfor POLB

Paralogsfor POLB

SNPs/Variantsfor POLB

Disorders & Mutationsfor POLB

Medical Newsfor POLB

Publicationsfor POLB

Search for POLB

Genome Databases showing POLB

Other Databases showing POLB

Specialized Databases showing POLB

Licensable Technologiesfor POLB

Servicesfor POLB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for POLB

Summaries
for POLB

Genomic Location
for POLB

Proteins
for POLB

Protein Domains/
Families
for POLB

Gene Function
for POLB

Pathways & Interactions
for POLB

Drugs & Compounds
for POLB

Transcripts
for POLB

Expression
for POLB

Orthologs
for POLB

Paralogs
for POLB

SNPs/Variants
for POLB

Disorders & Mutations
for POLB

Medical News
for POLB

Publications
for POLB

Licensable Technologies
for POLB

Services
for POLB