Aliases for POLB Gene
External Ids for POLB Gene
Previous GeneCards Identifiers for POLB Gene
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
GeneCards Summary for POLB Gene
POLB (DNA Polymerase Beta) is a Protein Coding gene. Diseases associated with POLB include Werner Syndrome and Retinitis Pigmentosa, Y-Linked. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include enzyme binding and damaged DNA binding. An important paralog of this gene is POLL.
UniProtKB/Swiss-Prot for POLB Gene
Repair polymerase that plays a key role in base-excision repair. Has 5-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5 sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3 end of the arising single-nucleotide gap. Conducts gap-filling DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.