External Ids for POLB Gene
Previous GeneCards Identifiers for POLB Gene
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
GeneCards Summary for POLB Gene
POLB (Polymerase (DNA Directed), Beta) is a Protein Coding gene. Diseases associated with POLB include critical illness polyneuropathy and inflammatory and toxic neuropathy. Among its related pathways are Chks in Checkpoint Regulation and DNA damage_Role of Brca1 and Brca2 in DNA repair. GO annotations related to this gene include enzyme binding and damaged DNA binding. An important paralog of this gene is POLL.
UniProtKB/Swiss-Prot for POLB Gene
Repair polymerase that plays a key role in base-excision repair. Has 5-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5 sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3 end of the arising single-nucleotide gap. Conducts gap-filling DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.