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Aliases for POLA2 Gene

Aliases for POLA2 Gene

  • Polymerase (DNA Directed), Alpha 2, Accessory Subunit 2 3
  • DNA Polymerase Alpha 70 KDa Subunit 2 4
  • Polymerase (DNA Directed), Alpha 2 (70kD Subunit) 2
  • DNA Polymerase Alpha Subunit B 2

External Ids for POLA2 Gene

Summaries for POLA2 Gene

GeneCards Summary for POLA2 Gene

POLA2 (Polymerase (DNA Directed), Alpha 2, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLA2 Gene

  • May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.

Gene Wiki entry for POLA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLA2 Gene

Genomics for POLA2 Gene

Genomic Location for POLA2 Gene

Start:
65,261,762 bp from pter
End:
65,305,589 bp from pter
Size:
43,828 bases
Orientation:
Plus strand

Genomic View for POLA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLA2 Gene

Regulatory Elements for POLA2 Gene

Proteins for POLA2 Gene

  • Protein details for POLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14181-DPOA2_HUMAN
    Recommended name:
    DNA polymerase alpha subunit B
    Protein Accession:
    Q14181
    Secondary Accessions:
    • B4DNB4
    • Q9BPV3

    Protein attributes for POLA2 Gene

    Size:
    598 amino acids
    Molecular mass:
    65948 Da
    Quaternary structure:
    • DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds to subunit A

    Three dimensional structures from OCA and Proteopedia for POLA2 Gene

    Alternative splice isoforms for POLA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLA2 Gene

Proteomics data for POLA2 Gene at MOPED

Post-translational modifications for POLA2 Gene

  • Phosphorylated in a cell cycle-dependent manner, in G2/M phase.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys72, Lys160, Lys194, Lys207, Lys212, Lys292, Lys500, and Lys564

Other Protein References for POLA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for POLA2 Gene

Domains for POLA2 Gene

Gene Families for POLA2 Gene

HGNC:
  • POL :DNA polymerases

Suggested Antigen Peptide Sequences for POLA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14181

UniProtKB/Swiss-Prot:

DPOA2_HUMAN
Domain:
  • The N-terminal 240 amino acids are sufficient to mediate complex formation:
    • Q14181
Family:
  • Belongs to the DNA polymerase alpha subunit B family.:
    • Q14181
genes like me logo Genes that share domains with POLA2: view

Function for POLA2 Gene

Molecular function for POLA2 Gene

UniProtKB/Swiss-Prot Function: May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.

Gene Ontology (GO) - Molecular Function for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0005515 protein binding --
GO:0046982 protein heterodimerization activity IBA --
genes like me logo Genes that share ontologies with POLA2: view

Phenotypes for POLA2 Gene

GenomeRNAi human phenotypes for POLA2:
genes like me logo Genes that share phenotypes with POLA2: view

miRNA for POLA2 Gene

miRTarBase miRNAs that target POLA2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLA2 Gene

Localization for POLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLA2 Gene COMPARTMENTS Subcellular localization image for POLA2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005658 alpha DNA polymerase:primase complex IBA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with POLA2: view

Pathways for POLA2 Gene

genes like me logo Genes that share pathways with POLA2: view

Gene Ontology (GO) - Biological Process for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0000723 telomere maintenance TAS --
genes like me logo Genes that share ontologies with POLA2: view

Compounds for POLA2 Gene

(1) Drugbank Compounds for POLA2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dacarbazine
  • Biocarbazine R
4342-03-4 target other/unknown
genes like me logo Genes that share compounds with POLA2: view

Transcripts for POLA2 Gene

Unigene Clusters for POLA2 Gene

Polymerase (DNA directed), alpha 2, accessory subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a ·
SP1: - - - -
SP2:
SP3: - - -
SP4:
SP5:
SP6: - -
SP7: -

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for POLA2 Gene

GeneLoc Exon Structure for
POLA2
ECgene alternative splicing isoforms for
POLA2

Expression for POLA2 Gene

mRNA expression in normal human tissues for POLA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLA2 Gene

SOURCE GeneReport for Unigene cluster for POLA2 Gene Hs.201897

genes like me logo Genes that share expressions with POLA2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLA2 Gene

Orthologs for POLA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLA2 35
  • 99.72 (n)
  • 99.83 (a)
POLA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLA2 35
  • 85.84 (n)
  • 86.96 (a)
POLA2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLA2 35
  • 86.64 (n)
  • 88.72 (a)
POLA2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pola2 35
  • 81.77 (n)
  • 83.28 (a)
Pola2 16
Pola2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLA2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pola2 35
  • 82.83 (n)
  • 84.28 (a)
chicken
(Gallus gallus)
Aves LOC100859759 35
  • 59.87 (n)
  • 58.74 (a)
POLA2 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLA2 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4593 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pola2 35
  • 64.59 (n)
  • 65.38 (a)
Str.6808 35
zebrafish
(Danio rerio)
Actinopterygii pola2 35
  • 62.21 (n)
  • 58.38 (a)
pola2 36
  • 57 (a)
OneToOne
wufb48f05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004392 35
  • 45.82 (n)
  • 35.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta DNApol-alpha73 35
  • 47.62 (n)
  • 37.69 (a)
DNApol-alpha73 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea div-1 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL12 36
  • 21 (a)
OneToOne
POL12 38
thale cress
(Arabidopsis thaliana)
eudicotyledons POLA2 35
  • 50.25 (n)
  • 41.74 (a)
rice
(Oryza sativa)
Liliopsida Os12g0242900 35
  • 48.98 (n)
  • 41.1 (a)
Species with no ortholog for POLA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLA2 Gene

ENSEMBL:
Gene Tree for POLA2 (if available)
TreeFam:
Gene Tree for POLA2 (if available)

Paralogs for POLA2 Gene

No data available for Paralogs for POLA2 Gene

Variants for POLA2 Gene

Sequence variations from dbSNP and Humsavar for POLA2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8638 -- 65,297,447(+) TGCCT(C/G)TGAGT utr-variant-3-prime
rs473696 -- 65,261,882(-) TTCCC(C/T)TGCTT upstream-variant-2KB
rs476327 -- 65,277,099(+) AGCTC(C/T)ATCAC intron-variant
rs476926 -- 65,274,427(-) gctgg(A/G)attac intron-variant
rs477089 -- 65,274,384(-) ttccc(C/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLA2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
nsv832190 CNV Loss 17160897
esv2422285 CNV Deletion 17116639
esv2744631 CNV Deletion 23290073

Relevant External Links for POLA2 Gene

HapMap Linkage Disequilibrium report
POLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLA2 Gene

Disorders for POLA2 Gene

Relevant External Links for POLA2

Genetic Association Database (GAD)
POLA2
Human Genome Epidemiology (HuGE) Navigator
POLA2
genes like me logo Genes that share disorders with POLA2: view

No data available for UniProtKB/Swiss-Prot for POLA2 Gene

Publications for POLA2 Gene

  1. The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication. (PMID: 8223465) Collins K.L. … Kelly T.J. (EMBO J. 1993) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Cell cycle-dependent phosphorylation of human DNA polymerase alpha. (PMID: 1902230) Nasheuer H.-P. … Wang T.S.-F. (J. Biol. Chem. 1991) 3 4
  5. E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase varepsilon B-subunit gene POLE2. (PMID: 11433027) Huang D. … Syvaoja J.E. (Nucleic Acids Res. 2001) 2 3

Products for POLA2 Gene

Sources for POLA2 Gene

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