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Aliases for POLA2 Gene

Aliases for POLA2 Gene

  • DNA Polymerase Alpha 2, Accessory Subunit 2 3 5
  • DNA Polymerase Alpha 70 KDa Subunit 2 4
  • Polymerase (DNA Directed), Alpha 2 (70kD Subunit) 2
  • Polymerase (DNA) Alpha 2, Accessory Subunit 2
  • DNA Polymerase Alpha Subunit B 2

External Ids for POLA2 Gene

Previous GeneCards Identifiers for POLA2 Gene

  • GC11P067545
  • GC11P066711
  • GC11P064804
  • GC11P064786
  • GC11P065029
  • GC11P061356

Summaries for POLA2 Gene

GeneCards Summary for POLA2 Gene

POLA2 (DNA Polymerase Alpha 2, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and E2F mediated regulation of DNA replication. GO annotations related to this gene include protein heterodimerization activity and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLA2 Gene

  • May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.

Gene Wiki entry for POLA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLA2 Gene

Genomics for POLA2 Gene

Regulatory Elements for POLA2 Gene

Enhancers for POLA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 26.1 +228.3 228322 40.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 LOC105369352 ZFPL1 KAT5 ENSG00000254461 EIF1AD NEAT1 FRMD8 EHBP1L1 POLA2 LOC101927789
GH11G065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 24.7 +162.4 162420 18.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZFPL1 NEAT1 LOC105369352 KAT5 EIF1AD FRMD8 MUS81 PCNX3 POLA2 ENSG00000255320
GH11G065307 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.8 +46.8 46839 1.6 STAT1 NFIA EBF1 NR2F2 NFIC GLIS2 MAFF JUND ZNF316 POLR2A POLA2 EHD1 BATF2 DPF2 RELA CDC42EP2 LOC728975 EHBP1L1 AP5B1 FAU
GH11G065288 2 FANTOM5 Ensembl ENCODE dbSUPER 21 +34.0 34036 14.5 HDGF PKNOX1 FOXA2 SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF766 FOS POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC CAPN1 PGAM1P8
GH11G065260 1.1 ENCODE 28.2 +0.3 314 2.3 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 POLA2 ZFPL1 EIF1AD PCNX3 TRMT112 FRMD8 KAT5 ENSG00000255320 FAU CAPN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLA2 on UCSC Golden Path with GeneCards custom track

Promoters for POLA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040799 338 1401 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for POLA2 Gene

Chromosome:
11
Start:
65,261,762 bp from pter
End:
65,305,598 bp from pter
Size:
43,837 bases
Orientation:
Plus strand

Genomic View for POLA2 Gene

Genes around POLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLA2 Gene

Proteins for POLA2 Gene

  • Protein details for POLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14181-DPOA2_HUMAN
    Recommended name:
    DNA polymerase alpha subunit B
    Protein Accession:
    Q14181
    Secondary Accessions:
    • B4DNB4
    • Q9BPV3

    Protein attributes for POLA2 Gene

    Size:
    598 amino acids
    Molecular mass:
    65948 Da
    Quaternary structure:
    • DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds to subunit A.

    Three dimensional structures from OCA and Proteopedia for POLA2 Gene

    Alternative splice isoforms for POLA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLA2 Gene

Post-translational modifications for POLA2 Gene

  • Phosphorylated in a cell cycle-dependent manner, in G2/M phase.
  • Ubiquitination at posLast=7272, posLast=160160, posLast=194194, Lys207, posLast=212212, posLast=292292, posLast=500500, and Lys564
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for POLA2 Gene

Domains & Families for POLA2 Gene

Gene Families for POLA2 Gene

Suggested Antigen Peptide Sequences for POLA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14181

UniProtKB/Swiss-Prot:

DPOA2_HUMAN :
  • The N-terminal 240 amino acids are sufficient to mediate complex formation.
  • Belongs to the DNA polymerase alpha subunit B family.
Domain:
  • The N-terminal 240 amino acids are sufficient to mediate complex formation.
Family:
  • Belongs to the DNA polymerase alpha subunit B family.
genes like me logo Genes that share domains with POLA2: view

Function for POLA2 Gene

Molecular function for POLA2 Gene

UniProtKB/Swiss-Prot Function:
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.

Gene Ontology (GO) - Molecular Function for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0046982 protein heterodimerization activity IEA,IBA --
genes like me logo Genes that share ontologies with POLA2: view
genes like me logo Genes that share phenotypes with POLA2: view

Animal Models for POLA2 Gene

MGI Knock Outs for POLA2:

Animal Model Products

CRISPR Products

miRNA for POLA2 Gene

miRTarBase miRNAs that target POLA2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLA2 Gene

Localization for POLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLA2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005658 alpha DNA polymerase:primase complex IBA,IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with POLA2: view

Pathways & Interactions for POLA2 Gene

genes like me logo Genes that share pathways with POLA2: view

Gene Ontology (GO) - Biological Process for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0006260 DNA replication NAS,IEA 8223465
GO:0006270 DNA replication initiation TAS --
genes like me logo Genes that share ontologies with POLA2: view

No data available for SIGNOR curated interactions for POLA2 Gene

Drugs & Compounds for POLA2 Gene

(2) Drugs for POLA2 Gene - From: DrugBank, ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dacarbazine Approved, Investigational Pharma Target, other/unknown 688
Fludarabine Phosphate (Fludara) Pharma Inhibits STAT1 activation and DNA synthesis 0

(1) ApexBio Compounds for POLA2 Gene

Compound Action Cas Number
Fludarabine Phosphate (Fludara) Inhibits STAT1 activation and DNA synthesis 75607-67-9
genes like me logo Genes that share compounds with POLA2: view

Transcripts for POLA2 Gene

Unigene Clusters for POLA2 Gene

Polymerase (DNA directed), alpha 2, accessory subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a ·
SP1: - - - -
SP2:
SP3: - - -
SP4:
SP5:
SP6: - -
SP7: -

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for POLA2 Gene

GeneLoc Exon Structure for
POLA2
ECgene alternative splicing isoforms for
POLA2

Expression for POLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLA2 Gene

This gene is overexpressed in Pancreas (30.5), Heart (18.9), and Fetal ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLA2 Gene



Protein tissue co-expression partners for POLA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of POLA2 Gene:

POLA2

SOURCE GeneReport for Unigene cluster for POLA2 Gene:

Hs.201897

Evidence on tissue expression from TISSUES for POLA2 Gene

  • Lung(4.5)
  • Heart(4.1)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with POLA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLA2 Gene

Orthologs for POLA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLA2 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia POLA2 34 35
  • 86.64 (n)
cow
(Bos Taurus)
Mammalia POLA2 34 35
  • 85.84 (n)
rat
(Rattus norvegicus)
Mammalia Pola2 34
  • 82.83 (n)
mouse
(Mus musculus)
Mammalia Pola2 34 16 35
  • 81.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia POLA2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859759 34
  • 59.87 (n)
POLA2 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLA2 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pola2 34
  • 64.59 (n)
Str.6808 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4593 34
zebrafish
(Danio rerio)
Actinopterygii pola2 34 35
  • 62.21 (n)
wufb48f05 34
fruit fly
(Drosophila melanogaster)
Insecta DNApol-alpha73 34 35
  • 47.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004392 34
  • 45.82 (n)
worm
(Caenorhabditis elegans)
Secernentea div-1 35
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL12 35 37
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons POLA2 34
  • 50.25 (n)
rice
(Oryza sativa)
Liliopsida Os12g0242900 34
  • 48.98 (n)
Species where no ortholog for POLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLA2 Gene

ENSEMBL:
Gene Tree for POLA2 (if available)
TreeFam:
Gene Tree for POLA2 (if available)

Paralogs for POLA2 Gene

No data available for Paralogs for POLA2 Gene

Variants for POLA2 Gene

Sequence variations from dbSNP and Humsavar for POLA2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000084332 -- 65,278,648(+) TCCCC(A/G)TTTCC intron-variant
rs1000275740 -- 65,269,282(+) TCGAG(A/G)CCATC intron-variant
rs1000329695 -- 65,292,916(+) TAAAC(A/G)GCCCC intron-variant
rs1000333923 -- 65,303,191(+) CAAAA(A/T)ATTGG intron-variant
rs1000409375 -- 65,262,596(+) GGAAT(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLA2 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
esv2744631 CNV deletion 23290073
nsv526181 CNV gain 19592680
nsv832190 CNV loss 17160897

Variation tolerance for POLA2 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLA2 Gene

Disorders for POLA2 Gene

Relevant External Links for POLA2

Genetic Association Database (GAD)
POLA2
Human Genome Epidemiology (HuGE) Navigator
POLA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLA2

No disorders were found for POLA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLA2 Gene

Publications for POLA2 Gene

  1. The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication. (PMID: 8223465) Collins K.L. … Kelly T.J. (EMBO J. 1993) 2 3 4 64
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  3. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for POLA2 Gene

Sources for POLA2 Gene

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