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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POLA2 Gene

protein-coding GIFtS: 59
GCID: GC11P065029

polymerase (DNA directed), alpha 2, accessory subunit

(Previous names: polymerase (DNA directed), alpha 2 (70kD subunit) )

Explore 1 disease affiliated with
POLA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Polymerase (DNA Directed), Alpha 2, Accessory Subunit¹ ²
Polymerase (DNA Directed), Alpha 2 (70kD Subunit)¹ ²
DNA Polymerase Alpha 70 KDa Subunit² ³
FLJ21662¹
DNA Polymerase Alpha Subunit B²
Polymerase (DNA-Directed), Alpha (70kD)²

External Ids:	HGNC: 30073¹	Entrez Gene: 23649²	Ensembl: ENSG00000014138⁷	UniProtKB: Q14181³

Export aliases for POLA2 gene to outside databases

Previous GC identifers: GC11P067545 GC11P066711 GC11P065279 GC11P064804 GC11P064786 GC11P061356

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DPOA2_HUMAN, Q14181

Function: May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase

alpha/primase complex to the cellular replication machinery (By similarity)

Gene Wiki entry for POLA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POLA2 gene promoter:
Max1 NF-1 NF-1/L AML1a MyoD Meis-1b E47 SEF-1 (1) Meis-1a c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: POLA2 promoter sequence

Search SABiosciences Chromatin IP Primers for POLA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

POLA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLA2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065029: view genomic region (about GC identifiers)

Start:	65,029,233 bp from pter	End:	65,073,060 bp from pter
Size:	43,828 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DPOA2_HUMAN, Q14181 (See protein sequence)

Recommended Name: DNA polymerase alpha subunit B

Size: 598 amino acids; 65948 Da

Subunit: DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle,

and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds

to subunit A

Subcellular location: Nucleus

2 PDB 3D structures from and Proteopedia for POLA2:

2KEB (3D)

4E2I (3D)

Secondary accessions: Q9BPV3

Explore the universe of human proteins at neXtProt for POLA2: NX_Q14181

Post-translational modifications:

Phosphorylated in a cell cycle-dependent manner, in G2/M phase¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14181

POLA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002680.2

ENSEMBL proteins:

ENSP00000265465 ENSP00000432536 ENSP00000433952 ENSP00000434173 ENSP00000443222

Reactome Protein details: Q14181
Human Recombinant Protein Products for POLA2:

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	GenScript Custom Purified and Recombinant Proteins Services for POLA2
	Novus Biologicals POLA2 Protein Novus Biologicals POLA2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--
GO:0005654	nucleoplasm	TAS	--
GO:0005658	alpha DNA polymerase:primase complex	IEA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

POLA2 for ontologies About GeneDecksing

POLA2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals POLA2 Antibodies
	Abcam antibodies for POLA2
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for POLA2

Assay Products for POLA2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for POLA2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POLA2 for domains About GeneDecksing

3 InterPro domains/families:

IPR013627 Pol_alpha_B_N

IPR007185 DNA_pol_alpha/epsilon_bsu

IPR016722 DNA_pol_alpha_bsu

Graphical View of Domain Structure for InterPro Entry Q14181

ProtoNet protein and cluster: Q14181

1 Blocks protein family: IPB013627 DNA polymerase alpha

UniProtKB/Swiss-Prot: DPOA2_HUMAN, Q14181

Domain: The N-terminal 240 amino acids are sufficient to mediate complex formation

Similarity: Belongs to the DNA polymerase alpha subunit B family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DPOA2_HUMAN, Q14181

Function: May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase

alpha/primase complex to the cellular replication machinery (By similarity)

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	IEA	--
GO:0003887	DNA-directed DNA polymerase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0046982	protein heterodimerization activity	IEA	--

POLA2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for POLA2:

Cell cycle / mitosis defect

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for POLA2

miRNA Products:		miRTarBase miRNAs that target POLA2: hsa-mir-1 (MIRT001348)

		OriGene 3'-UTR Clone: POLA2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLA2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate POLA2:
		hsa-miR-515-5p hsa-miR-519e*
		SwitchGear 3'UTR luciferase reporter plasmid: POLA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLA2 (see all 7) OriGene shRNA RFP: POLA2 OriGene siRNA: POLA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLA2
		Sirion Biotech Custom design and validation of potent shRNA sequences against POLA2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for POLA2
			Sirion Biotech Customized adenovirus for overexpression of POLA2 Sirion Biotech Customized adenovirus for potent knockdown of POLA2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLA2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLA2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POLA2 (NM_002689)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLA2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for POLA2
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		Sirion Biotech Customized stable knockdown cell line services for POLA2 Sirion Biotech Customized inducible knockdown cell line services for POLA2 Sirion Biotech Customized stable overexpressing cell line services for POLA2 Sirion Biotech Customized inducible overexpressing cell line services for POLA2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLA2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lagging Strand Synthesis

8/13 pathways (see all 13)
Lagging Strand Synthesis	1.00	Polymerase switching	0.70
Telomere C-strand (Lagging Strand) Synthesis	0.91	DNA strand elongation	0.65
Extension of Telomeres	0.83	DNA replication	0.56
Processive synthesis on the lagging strand	0.75	Processive synthesis on the leading strand	0.45

Ubiquitinated Orc1 is degraded by the proteasome

DNA Replication Pre-Initiation	0.62	DNA Replication	0.49
M/G1 Transition	0.62	S Phase	0.40
Synthesis of DNA	0.51

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Activation of the pre-replicative complex

Activation of the pre-replicative complex

1.00

DNA Replication

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for POLA2

	Cell cycle Transition and termination of DNA replacation
	Cell cycle Start of DNA replication in early S phase
	Transcription Ligand-dependent activation of the ESR1/SP pathway

3 GeneGo (Thomson Reuters) Pathways for POLA2

	Transcription Ligand-dependent activation of the ESR1/SP pathway
	Cell cycle Transition and termination of DNA replication
	Cell cycle Start of DNA replication in early S phase

2 BioSystems Pathways for POLA2

	G1 to S cell cycle control
	DNA Replication

5/27 Reactome Pathways for POLA2 (see all 27)

	Extension of Telomeres
	Processive synthesis on the lagging strand
	Telomere Maintenance
	Leading Strand Synthesis
	Mitotic G1-G1/S phases

4 Kegg Pathways (Kegg details for POLA2):

	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways
	DNA replication

POLA2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for POLA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/141 Interacting proteins for POLA2 (Q14181^{2, 3} ENSP00000265465⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 141)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HDAC6	Q9UBN7²^,³, ENSP00000334061⁴	MINT-8258076 I2D: score=2 STRING: ENSP00000334061
KCNE3	Q9Y6H6²^,³, ENSP00000310557⁴	MINT-8259106 I2D: score=2 STRING: ENSP00000310557
AKTIP	Q9H8T0²^,³	MINT-64326 I2D: score=5
ASCC2	Q9H1I8²^,³	MINT-65476 I2D: score=5
ATP5C1	P36542²^,³	MINT-63712 I2D: score=5

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IEA	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

POLA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for POLA2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POLA2

1 DrugBank Compound for POLA2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dacarbazine	Biocarbazine R (see all 9)	4342-03-4	target	other/unknown	3098406 17139284 17016423

Search CenterWatch for drugs/clinical trials and news about POLA2 / DPOA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for POLA2 gene:

NM_002689.2

Unigene Cluster for POLA2:

Polymerase (DNA directed), alpha 2, accessory subunit

Hs.201897 [show with all ESTs]

Unigene Representative Sequence: NM_002689

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265465(uc001odj.3) ENST00000527850(uc010rod.1) ENST00000532469(uc009yqf.1)

ENST00000532391 ENST00000527618(uc001odk.3) ENST00000525924 ENST00000533192

ENST00000534785 ENST00000541089

miRNA Products:		OriGene 3'-UTR Clone: POLA2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POLA2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate POLA2:
		hsa-miR-515-5p hsa-miR-519e*
		SwitchGear 3'UTR luciferase reporter plasmid: POLA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLA2 (see all 7) OriGene shRNA RFP: POLA2 OriGene siRNA: POLA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLA2
		Sirion Biotech Custom design and validation of potent shRNA sequences against POLA2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLA2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLA2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: POLA2 (NM_002689)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for POLA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLA2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLA2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLA2

Additional cDNA sequence:

AK025315.1 AK094569.1 AK297842.1 AK307831.1 AK309284.1 BC001347.2 BC002990.1 BC018813.2

BC018814.2 CR456737.1 L24559.1

14 DOTS entries:

DT.454903 DT.91675144 DT.91804763 DT.100784508 DT.101967173 DT.92445948 DT.120694607 DT.65287278

DT.86847417 DT.91687380 DT.100784509 DT.40131855 DT.40262983 DT.92414328

24/352 AceView cDNA sequences (see all 352):

BQ670878 BP364564 BM672105 BX393023 AI971790 BI333064 AU130810 AA806156

AL702193 BU509748 AU124433 AI374993 AW250402 BC001347 CD674893 BQ929232

CR600071 BF508931 BQ959027 BI868986 BM672995 CF135681 BQ945958 BM918136

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POLA2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17a	·	17b	·	17c	^	18a	·
SP1:					-																-																				-								-
SP2:
SP3:																																									-				-				-
SP4:
SP5:

ExUns:	18b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for POLA2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POLA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCAAACAC

About this image

POLA2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See POLA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLA2

SOURCE GeneReport for Unigene cluster: Hs.201897

SABiosciences Custom PCR Arrays for POLA2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLA2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat POLA2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLA2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLA2 gene from 10/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pola2^{1 , 5}	polymerase (DNA directed), alpha 2^{1, 5}	81.77(n)¹ 83.28(a)¹		19 (4.34 cM)⁵ 18969¹ NM_008893.3¹ NP_032919.2¹ 5940543⁵
chicken (Gallus gallus)	Aves	LOC100858476¹	DNA polymerase alpha subunit B-like	65.78(n) 67.56(a)		100858476 XM_003643794.1 XP_003643842.1
lizard (Anolis carolinensis)	Reptilia	POLA2⁶ --	--	71(a) 68(a)	many → 1 many → 1	GL343994.1(138293-143216) AAWZ02039834(720-7592)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4593²	Xenopus laevis transcribed sequence with weak similarity more	76.91(n)		CA790264.1
zebrafish (Danio rerio)	Actinopterygii	wufb48f05²	wufb48f05	74.86(n)		322059 BC045928.1
fruit fly (Drosophila melanogaster)	Insecta	DNApol-alpha73¹	DNA polymerase alpha 73kD	42.54(n) 31.82(a)		43278 NM_170327.3 NP_733206.3
worm (Caenorhabditis elegans)	Secernentea	div-1⁶	DNA polymerase alpha subunit B	22(a)	1 ↔ 1	III(10244958-10248814)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	POL12(YBL035C)⁴ POL12¹	B subunit of DNA polymerase alpha-primase complex, more⁴ Pol12p¹	44.01(n)¹ 31.61(a)¹		2(153610-151493)⁴ 852245^{1, 4} NP_009518.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	POLA2¹	DNA polymerase alpha 2	50.15(n) 41.44(a)		843086 NM_105430.3 NP_176930.2
rice (Oryza sativa)	Liliopsida	Os12g0242900¹	hypothetical protein	48.73(n) 40.06(a)		4351872 NM_001073015.1 NP_001066483.1

ENSEMBL Gene Tree for POLA2 (if available)
TreeFam Gene Tree for POLA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113371921^1,2	C	--	65027528(+)	`AGTCTC/TGCTCT`	1	--	int¹		1		WA	2
rs185222218^1,2		--	65027576(+)	`TACTGC/TAAGCT`	1	--	int¹		0	--	--	--	--
rs112469456^1,2	C	--	65027619(+)	`CAGCCG/TCCCAA`	1	--	int¹		1		WA	2
rs71064875^1,2	C	--	65027666(-)	`AAAAGA/-AAAAA`	1	--	int¹		1		NA	2
rs12422090^1,2	H	--	65027675(+)	`tttttC/Tctttt`	1	--	int¹ trp³		0	--	--	--	--
rs12420602^1,2	C,A,H	--	65027676(+)	`tttttC/Tttttt`	1	--	int¹ trp³		0	--	--	--	--
rs113862246^1,2	C	--	65027731(+)	`GTCTCG/AATCTC`	1	--	int¹		1		WA	2
rs71462337^1,2	C	--	65027801(+)	`ACCGCG/ACCCGG`	1	--	int¹		3		NA	6
rs187714412^1,2		--	65027805(+)	`CACCCA/GGCCTT`	1	--	int¹		0	--	--	--	--
rs58946655^1,2	C	--	65027809(+)	`CTTTG-/TTTG CTTTT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for POLA2 (65029233 - 65073060 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for POLA2
1 CNV: 5423

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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POLA2 for disorders About GeneDecksing

1 disease for POLA2: About MalaCards

malaria

Human Genome Epidemiology (HuGE) Navigator: POLA2 (3 documents)

Export disorders for POLA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POLA2 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with POLA2)

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The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication. (PubMed id 8223465)^{1, 2, 3} Collins K.L.... Kelly T.J. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase varepsilon B-subunit gene POLE2. (PubMed id 11433027)^{1, 3} Huang D.... Syvaoja J.E. (2001)
Cell cycle-dependent phosphorylation of human DNA polymerase alpha. (PubMed id 1902230)^{1, 2} Nasheuer H.-P.... Wang T.S.-F. (1991)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
A conserved motif in the C-terminal tail of DNA polyme rase a tethers primase to the eukaryotic replisome. (PubMed id 22593576)¹ Kilkenny M.L....Pellegrini L. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23649	HGNC: 30073	AceView: POLA2andCDC42EP2	Ensembl:ENSG00000014138	euGenes: HUgn23649
ECgene: POLA2	Kegg: 23649	H-InvDB: POLA2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POLA2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POLA2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for POLA2 gene:
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GeneCards and IP:
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POLA2 Gene

polymerase (DNA directed), alpha 2, accessory subunit

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POLA2 Gene

polymerase (DNA directed), alpha 2, accessory subunit

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