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Aliases for POGZ Gene

Aliases for POGZ Gene

  • Pogo Transposable Element With ZNF Domain 2 3 5
  • Zinc Finger Protein 280E 2 3 4
  • Putative Protein Product Of Nbla00003 2 3
  • Zinc Finger Protein 635 3 4
  • ZNF280E 3 4
  • ZNF635 3 4
  • Suppressor Of Hairy Wing Homolog 5 4
  • KIAA0461 4
  • ZNF635m 3
  • MRD37 3
  • WHSUS 3
  • SUHW5 4

External Ids for POGZ Gene

Previous GeneCards Identifiers for POGZ Gene

  • GC01M149217
  • GC01M147122
  • GC01M148150
  • GC01M148591
  • GC01M148188
  • GC01M149641
  • GC01M122753

Summaries for POGZ Gene

Entrez Gene Summary for POGZ Gene

  • The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]

GeneCards Summary for POGZ Gene

POGZ (Pogo Transposable Element With ZNF Domain) is a Protein Coding gene. Diseases associated with POGZ include Mental Retardation, Autosomal Dominant 37. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF280D.

UniProtKB/Swiss-Prot for POGZ Gene

  • Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.

Gene Wiki entry for POGZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POGZ Gene

Genomics for POGZ Gene

Regulatory Elements for POGZ Gene

Enhancers for POGZ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POGZ on UCSC Golden Path with GeneCards custom track

Promoters for POGZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POGZ on UCSC Golden Path with GeneCards custom track

Genomic Location for POGZ Gene

Chromosome:
1
Start:
151,402,724 bp from pter
End:
151,459,465 bp from pter
Size:
56,742 bases
Orientation:
Minus strand

Genomic View for POGZ Gene

Genes around POGZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POGZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POGZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POGZ Gene

Proteins for POGZ Gene

  • Protein details for POGZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3K3-POGZ_HUMAN
    Recommended name:
    Pogo transposable element with ZNF domain
    Protein Accession:
    Q7Z3K3
    Secondary Accessions:
    • B4DTP8
    • B4DYL9
    • B7ZBY5
    • E9PM80
    • O75049
    • Q3LIC4
    • Q5SZS1
    • Q5SZS2
    • Q5SZS3
    • Q5SZS4
    • Q8TDZ7
    • Q9Y4X7

    Protein attributes for POGZ Gene

    Size:
    1410 amino acids
    Molecular mass:
    155344 Da
    Quaternary structure:
    • Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1.
    SequenceCaution:
    • Sequence=BAE45744.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI16808.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16810.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POGZ Gene

    Alternative splice isoforms for POGZ Gene

neXtProt entry for POGZ Gene

Proteomics data for POGZ Gene at MOPED

Post-translational modifications for POGZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POGZ Gene

Domains & Families for POGZ Gene

Gene Families for POGZ Gene

Suggested Antigen Peptide Sequences for POGZ Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3K3

UniProtKB/Swiss-Prot:

POGZ_HUMAN :
  • Contains 1 DDE domain.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with POGZ: view

Function for POGZ Gene

Molecular function for POGZ Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.

Gene Ontology (GO) - Molecular Function for POGZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with POGZ: view
genes like me logo Genes that share phenotypes with POGZ: view

Human Phenotype Ontology for POGZ Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for POGZ Gene

miRTarBase miRNAs that target POGZ

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for POGZ Gene

Localization for POGZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for POGZ Gene

Nucleus. Chromosome. Cytoplasm. Note=According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated Lys-9 of histone H3 (H3K9me3). {ECO:0000269 PubMed:19244240}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POGZ Gene COMPARTMENTS Subcellular localization image for POGZ gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for POGZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20562864
genes like me logo Genes that share ontologies with POGZ: view

Pathways & Interactions for POGZ Gene

SuperPathways for POGZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for POGZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with POGZ: view

No data available for Pathways by source and SIGNOR curated interactions for POGZ Gene

Drugs & Compounds for POGZ Gene

No Compound Related Data Available

Transcripts for POGZ Gene

Unigene Clusters for POGZ Gene

Pogo transposable element with ZNF domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POGZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - - - -
SP7: -
SP8: - -
SP9: - -
SP10:
SP11: -
SP12:
SP13:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for POGZ Gene

GeneLoc Exon Structure for
POGZ
ECgene alternative splicing isoforms for
POGZ

Expression for POGZ Gene

mRNA expression in normal human tissues for POGZ Gene

Protein differential expression in normal tissues from HIPED for POGZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8), Blymphocyte (9.2), CD8 Tcells (7.6), and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POGZ Gene



SOURCE GeneReport for Unigene cluster for POGZ Gene Hs.489873

genes like me logo Genes that share expression patterns with POGZ: view

Protein tissue co-expression partners for POGZ Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POGZ Gene

Orthologs for POGZ Gene

This gene was present in the common ancestor of animals.

Orthologs for POGZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POGZ 35
  • 87.14 (n)
  • 89.1 (a)
POGZ 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POGZ 35
  • 93 (n)
  • 96.38 (a)
POGZ 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pogz 35
  • 89.57 (n)
  • 94.03 (a)
Pogz 16
Pogz 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POGZ 35
  • 99.93 (n)
  • 100 (a)
POGZ 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pogz 35
  • 88.57 (n)
  • 93.2 (a)
oppossum
(Monodelphis domestica)
Mammalia POGZ 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POGZ 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves POGZ 35
  • 74.92 (n)
  • 83.67 (a)
POGZ 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POGZ 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158529 35
  • 65.77 (n)
  • 68.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30774 35
zebrafish
(Danio rerio)
Actinopterygii LOC561483 35
  • 52.91 (n)
  • 43.89 (a)
pogza 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta row 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37D6.2 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for POGZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POGZ Gene

ENSEMBL:
Gene Tree for POGZ (if available)
TreeFam:
Gene Tree for POGZ (if available)

Paralogs for POGZ Gene

Paralogs for POGZ Gene

(3) SIMAP similar genes for POGZ Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with POGZ: view

Variants for POGZ Gene

Sequence variations from dbSNP and Humsavar for POGZ Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35198305 - 151,404,940(-) TCTGA(G/T)TCTTC reference, missense
VAR_073179 -
rs1137932 -- 151,456,446(-) agtat(C/T)tggca intron-variant, upstream-variant-2KB
rs1137935 -- 151,456,145(-) agatc(C/T)tttga intron-variant, upstream-variant-2KB
rs1137936 -- 151,456,024(-) ggctc(A/G)ctcct intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POGZ Gene

Variant ID Type Subtype PubMed ID
esv34461 CNV Gain 17911159
nsv831581 CNV Loss 17160897
dgv386n71 CNV Gain 21882294
dgv128e1 CNV Complex 17122850
nsv872428 CNV Gain 21882294
nsv8380 CNV Gain 18304495
nsv824575 CNV Gain 20364138
nsv470737 CNV Gain 18288195
nsv818467 CNV Gain 17921354
dgv36n27 CNV Gain 19166990
nsv441714 CNV CNV 18776908
nsv872436 CNV Gain 21882294
dgv387n71 CNV Gain 21882294
nsv872439 CNV Gain 21882294
nsv872440 CNV Gain 21882294
nsv2832 CNV Insertion 18451855
esv2717862 CNV Deletion 23290073
esv2674265 CNV Deletion 23128226
nsv824587 CNV Loss 20364138

Variation tolerance for POGZ Gene

Residual Variation Intolerance Score: 2.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POGZ Gene

Human Gene Mutation Database (HGMD)
POGZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POGZ Gene

Disorders for POGZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for POGZ Gene - From: OMIM, ClinVar, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 37
  • white-sutton syndrome
- elite association - COSMIC cancer census association via MalaCards
Search POGZ in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

POGZ_HUMAN
  • Mental retardation, autosomal dominant 37 (MRD37) [MIM:616364]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:25533962}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Defects in POGZ may be associated with neuropsychiatric disorders such as autism spectrum disorders (ASD), bipolar affective disorders and early dementia onset. ASD are characterized by impairments in reciprocal social interaction and communication as well as restricted and stereotyped patterns of interest and activities. ASD include forms with moderate to severe cognitive impairment and milder forms with higher cognitive ability (Asperger syndrome). {ECO:0000269 PubMed:25694107}.

Relevant External Links for POGZ

Genetic Association Database (GAD)
POGZ
Human Genome Epidemiology (HuGE) Navigator
POGZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POGZ
genes like me logo Genes that share disorders with POGZ: view

No data available for Genatlas for POGZ Gene

Publications for POGZ Gene

  1. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. (PMID: 10976766) Gunther M. … Brison O. (Mol. Cell. Biochem. 2000) 2 3 4 67
  2. Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ. (PMID: 19244240) Bartholomeeusen K. … De Rijck J. (J. Biol. Chem. 2009) 3 23
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for POGZ Gene

Sources for POGZ Gene

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