Aliases for POGZ Gene
External Ids for POGZ Gene
Previous GeneCards Identifiers for POGZ Gene
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
GeneCards Summary for POGZ Gene
POGZ (Pogo Transposable Element With ZNF Domain) is a Protein Coding gene. Diseases associated with POGZ include Mental Retardation, Autosomal Dominant 37. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF280D.
UniProtKB/Swiss-Prot for POGZ Gene
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.