Aliases for POGZ Gene
External Ids for POGZ Gene
Previous GeneCards Identifiers for POGZ Gene
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
GeneCards Summary for POGZ Gene
POGZ (Pogo Transposable Element With ZNF Domain) is a Protein Coding gene. Diseases associated with POGZ include Mental Retardation, Autosomal Dominant 37 and Mowat-Wilson Syndrome. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF280D.
UniProtKB/Swiss-Prot for POGZ Gene
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.