POGK Gene
protein-coding GIFtS: 49
GCID: GC01P166809
|
|
pogo transposable element with KRAB domain
| |
Aliases
for POGK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pogo Transposable Element With KRAB Domain1 2 | | LST0031 | | BASS21 2 | | KRAB Box Domain Containing 22 | | KRBOX21 2 | | KIAA15133 | | KIAA151311 | | |
Export aliases for POGK gene to outside databasesPrevious GC identifers: GC01P164443 GC01P162459 GC01P163504 GC01P163996 GC01P163540 GC01P165075 GC01P138055 |
Summaries
for POGK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for POGK:
The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain(which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus,suggesting that it may belong to the family of DNA-mediated transposons in human. (provided by RefSeq, Jul 2008)
|
Genomic Views
for POGK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POGK gene promoter:
NF-1 SREBP-1c SREBP-1b Evi-1 c-Rel SREBP-1a FOXO4 Msx-1 Ik-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for POGK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POGK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24.1 Ensembl cytogenetic band: 1q24.1 HGNC cytogenetic band: 1q23.2POGK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P166809: view genomic region
(about GC identifiers)
Start:
|
166,808,681 bp from pter |
End:
|
166,825,581 bp from pter |
Size:
|
16,901 bases |
Orientation:
|
plus strand |
|
Proteins
for POGK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: POGK_HUMAN, Q9P215 (See
protein sequence)Recommended Name: Pogo transposable element with KRAB domain Size: 609 amino acids; 69444 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAM12422.1; Type=Erroneous initiation; Sequence=BAA96037.1; Type=Erroneous initiation;
Secondary accessions: Q5TIJ1 Q8TE07Explore the universe of human proteins at neXtProt for POGK: NX_Q9P215
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P215
POGK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060012.3
ENSEMBL proteins: ENSP00000404402 ENSP00000356850 ENSP00000356849 ENSP00000442763 ENSP00000441187
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
POGK for ontologies About GeneDecksing
POGK Antibody Products:
Assay Products for POGK: |
Protein
Domains /
Families
for POGK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POGK for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P215ProtoNet protein and cluster: Q9P215 2 Blocks protein families: IPB001909 KRAB box IPB004875 CENP-B protein
UniProtKB/Swiss-Prot: POGK_HUMAN, Q9P215Similarity: Contains 1 DDE domainSimilarity: Contains 1 HTH CENPB-type DNA-binding domainSimilarity: Contains 1 KRAB domain |
Function
for POGK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POGK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POGK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POGK (NM_017542) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POGK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POGK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POGK |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
POGK for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for POGK:
|
Pathways & Interactions
for POGK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POGK
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for POGK (Q9P2151, 2, 3 ENSP000003568494) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- |
POGK for ontologies About GeneDecksing
|
Drugs & Compounds
for POGK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for POGK
Search CenterWatch for drugs/clinical trials and news about POGK
|
Transcripts
for POGK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POGK gene: NM_017542.3 Unigene Cluster for POGK: Pogo transposable element with KRAB domain Hs.432752 [show with all ESTs]Unigene Representative Sequence: NM_0175425 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449930 ENST00000367876(uc001gdt.1 uc010plf.1) ENST00000367875
ENST00000537173 ENST00000536514(uc010ple.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POGK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POGK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POGK (NM_017542) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POGK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POGK |
Additional cDNA sequence: AF111706.1 AF131746.1 AF139898.1 AK027079.1 AK056711.1 AK093951.1 AK293946.1 AK299537.1 BC016390.1 BC131624.1 9 DOTS entries: DT.414808 DT.100816067 DT.97794696 DT.100816069 DT.100837067 DT.121371485 DT.75196718 DT.91755304 DT.40248165 24/148 AceView cDNA sequences (see all 148): AA150509 BM693563 AB040946 BE677803 Z40638 AA307326 CB126014 AI561066 F02061 BM510620 AA321781 BM668885 BQ220246 BQ224391 BQ216993 AW672798 AA406249 AA954780 AA394188 AI091865 BM470839 BU509712 AI254739 BU194253
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for POGK (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for POGK
|
Expression
for POGK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POGK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTATTTCT
About this image
See POGK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POGK
SOURCE GeneReport for Unigene cluster: Hs.432752
SABiosciences Expression via Pathway-Focused PCR Array including POGK:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POGK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POGK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POGK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POGK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POGK |
Orthologs
for POGK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for POGK gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for POGK (if available)
TreeFam Gene Tree for POGK (if available) |
Paralogs
for POGK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POGK gene
13 SIMAP similar genes for POGK using alignment to 4 protein entries: POGK_HUMAN (see all proteins):ZNF28 ZNF761 ZNF300P1 ZNF169 ZNF789 ZNF718
ZNF544 ZNF684 ZNF250 ZNF254 ZNF248 ZNF493
ZNF93
POGK for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for POGK
PGOHUM00000235244
|
Genomic Variants
for POGK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POGK (166808681 - 166825581 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for POGK: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POGK |
|
Disorders
/ Diseases
for POGK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POGK for disorders About GeneDecksing
4  diseases for POGK: About MalaCardsessential hypertension hypertension t-cell leukemia leukemia
Human Genome Epidemiology (HuGE) Navigator: POGK (2 documents)
Export disorders for POGK gene to outside databases
|
Publications
for POGK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POGK gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with POGK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
- Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1 Cheung C.L....Kung A.W. (2009)
|
External Searches for POGK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POGK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POGK gene
(According to HUGE)
About This Section
| |
Specialized Databases showing POGK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for POGK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for POGK gene:
Search GeneIP for patents involving POGK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POGK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for POGK | | OriGene shRNA RFP for POGK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POGK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POGK | | | OriGene Protein Over-expression Lysate for POGK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POGK | | OriGene 3'-UTR Clone for POGK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POGK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POGK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for POGK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POGK | | OriGene Custom Protein Services for POGK | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POGK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POGK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POGK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POGK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POGK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POGK |
| |
 |  |  |  | |
| | | | Search Tocris compounds for POGK |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | POGK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POGK |
|  |  |  | | | | Search ThermoFisher Antibodies for POGK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POGK |
|
|
|
|
