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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POGK Gene

protein-coding   GIFtS: 50
GCID: GC01P166809

Pogo Transposable Element With KRAB Domain

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pogo Transposable Element With KRAB Domain1 2
KRAB Box Domain Containing 21 2
BASS22
KRBOX22
KIAA15133

External Ids:    HGNC: 188001   Entrez Gene: 576452   Ensembl: ENSG000001431577   UniProtKB: Q9P2153   

Export aliases for POGK gene to outside databases

Previous GC identifers: GC01P164443 GC01P162459 GC01P163504 GC01P163996 GC01P163540 GC01P165075 GC01P138055


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POGK Gene:
The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB
domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the
C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. (provided by
RefSeq, Jul 2008)

GeneCards Summary for POGK Gene: 
POGK (pogo transposable element with KRAB domain) is a protein-coding gene. Diseases associated with POGK include essential hypertension, and hypertension. GO annotations related to this gene include protein binding and DNA binding.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POGK gene promoter:
         NF-1   SREBP-1c   SREBP-1b   Evi-1   c-Rel   SREBP-1a   FOXO4   Msx-1   Ik-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): POGK promoter sequence
   Search SABiosciences Chromatin IP Primers for POGK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POGK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.1   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q23.2

POGK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POGK gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P166809:  view genomic region     (about GC identifiers)

Start:
166,808,681 bp from pter      End:
166,825,581 bp from pter
Size:
16,901 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: POGK_HUMAN, Q9P215 (See protein sequence)
Recommended Name: Pogo transposable element with KRAB domain  
Size: 609 amino acids; 69444 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAM12422.1; Type=Erroneous initiation; Sequence=BAA96037.1; Type=Erroneous initiation;
Secondary accessions: Q5TIJ1 Q8TE07

Explore the universe of human proteins at neXtProt for POGK: NX_Q9P215

Explore proteomics data for POGK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P215

  • POGK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POGK Protein Expression
    REFSEQ proteins: NP_060012.3  
    ENSEMBL proteins: 
     ENSP00000404402   ENSP00000356850   ENSP00000356849   ENSP00000442763   ENSP00000441187  

    Human Recombinant Protein Products for POGK: 
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    Novus Biologicals POGK Proteins
    Novus Biologicals POGK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for POGK 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    POGK for ontologies           About GeneDecksing



    POGK Antibody Products: 
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    Cloud-Clone Corp. ELISAs for POGK 
    Cloud-Clone Corp. CLIAs for POGK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR006600 HTH_CenpB_DNA-bd_dom
     IPR001909 Krueppel-associated_box
     IPR004875 DDE_SF_endonuclease_CENPB-like
     IPR018586 Brinker_DNA-bd
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9P215

    ProtoNet protein and cluster: Q9P215

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB004875 CENP-B protein


    UniProtKB/Swiss-Prot: POGK_HUMAN, Q9P215
    Similarity: Contains 1 DDE domain
    Similarity: Contains 1 HTH CENPB-type DNA-binding domain
    Similarity: Contains 1 KRAB domain


    POGK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
         
    POGK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POGK:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for POGK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POGK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POGK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POGK 

    miRNA
    Products:
        
    miRTarBase miRNAs that target POGK:
    hsa-mir-1 (MIRT002759)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POGK
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate POGK (see all 34):
    hsa-miR-194* hsa-miR-4307 hsa-miR-1224-3p hsa-miR-3908 hsa-miR-4293 hsa-miR-4324 hsa-miR-1283 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidPOGK 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for POGK
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of POGK 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POGK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POGK

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for POGK (Q9P2151, 2, 3 ENSP000003568494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL3P153742, 3, ENSP000003668194MINT-8276695 I2D: score=2 STRING: ENSP00000366819
    HSP90AB1P082381EBI-2555775,EBI-352572
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development IEA--

    POGK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POGK

    Search CenterWatch for drugs/clinical trials and news about POGK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POGK gene: 
    NM_017542.3  

    Unigene Cluster for POGK:

    Pogo transposable element with KRAB domain
    Hs.432752  [show with all ESTs]
    Unigene Representative Sequence: NM_017542
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449930 ENST00000367876(uc001gdt.1 uc010plf.1) ENST00000367875
    ENST00000537173 ENST00000536514(uc010ple.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POGK
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate POGK (see all 34):
    hsa-miR-194* hsa-miR-4307 hsa-miR-1224-3p hsa-miR-3908 hsa-miR-4293 hsa-miR-4324 hsa-miR-1283 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidPOGK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for POGK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POGK
    Clone
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    OriGene clones in human, mouse for POGK (see all 8)
    OriGene ORF clones in mouse, rat for POGK
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    GenScript: all cDNA clones in your preferred vector: POGK (NM_017542)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POGK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POGK
    Sirion Biotech Customized lentivirus for stable overexpression of POGK 
                         Customized lentivirus expression plasmids for stable overexpression of POGK 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for POGK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POGK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POGK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POGK

    Additional mRNA sequence: 

    AF111706.1 AF131746.1 AF139898.1 AK027079.1 AK056711.1 AK093951.1 AK293946.1 AK299537.1 
    BC016390.1 BC131624.1 

    9 DOTS entries:

    DT.414808  DT.100816067  DT.97794696  DT.100816069  DT.100837067  DT.121371485  DT.75196718  DT.91755304 
    DT.40248165 

    24/148 AceView cDNA sequences (see all 148):

    AA321781 BM693563 CA427156 AA770655 BF445676 AA642458 AI091865 BI492232 
    BU194253 BC016390 BU509712 AF131746 AA954780 AA150509 AA243079 AA406249 
    BQ267919 Z44870 BM668885 AI079204 BM510620 BQ425948 AI002239 BQ224391 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for POGK (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
    SP1:                          -                       -                                             
    SP2:                                                  -                                             
    SP3:                          -                 -     -     -     -     -     -     -               
    SP4:                          -                                                                     
    SP5:                          -           -     -     -     -                                       


    ECgene alternative splicing isoforms for POGK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POGK expression in normal human tissues (normalized intensities)      POGK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTATTTCT
    POGK Expression
    About this image


    POGK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             prefrontal cortex   
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood

    See POGK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POGK

    SOURCE GeneReport for Unigene cluster: Hs.432752
        SABiosciences Expression via Pathway-Focused PCR Array including POGK: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POGK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POGK gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pogk1 , 5 pogo transposable element with KRAB domain1, 5 87.48(n)1
    91.27(a)1
      1 (73.75 cM)5
    715921  NM_001142948.11  NP_001136420.11 
     1663846225 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    42(a)
    36(a)
    (see all 8)
    many → 1
    possible ortholog
    (see all 8)
    GL343575.1(139206-143374)
    GL343312.1(1323717-1324961)
    zebrafish
    (Danio rerio)
    Actinopterygii BX957234.16
    BX649341.36
    (see all 3)
    Uncharacterized protein
    (see all 3)
    31(a)
    30(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    4(51804597-51805675)
    4(41118054-41119174)
    worm
    (Caenorhabditis elegans)
    Secernentea W02H5.41 Protein W02H5.4 43.01(n)
    27.44(a)
      189136  NM_071319.1  NP_503720.1 


    ENSEMBL Gene Tree for POGK (if available)
    TreeFam Gene Tree for POGK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POGK gene
    10 SIMAP similar genes for POGK using alignment to 4 protein entries:     POGK_HUMAN (see all proteins):
    ZNF28    ZNF761    ZNF300P1    ZNF169    ZNF718    ZNF544
    ZNF684    ZNF250    ZNF254    ZNF248

    POGK for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for POGK
    PGOHUM00000235244


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/304 SNPs in POGK are shown (see all 304)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917665841,2
    --166806767(+) GCCTAA/GGCCAG 1 -- us2k10--------
    rs1425845951,2
    C--166807002(+) GTGTC-/TGTG  
     
    /TGTGTG
    TGTGT
    2 -- us2k1 cds10--------
    rs556918381,2
    C--166807005(+) TGTGT-/GTGT  
            
    CTATC
    1 -- us2k10--------
    rs2001607781,2
    --166807044(+) GTATT-/AATTTC 1 -- us2k10--------
    rs105882031,2
    C--166807045(+) TATTAATTTC/
            
    TTTTC
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs787972321,2
    --166807045(+) TATTAT/ATTTCT 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1417583451,2
    C--166807045(+) TATTA-/ATTTC 
            
    TTTTC
    1 -- us2k10--------
    rs2011024271,2
    C--166807049(-) GAAAAG/TANNNN 1 -- us2k10--------
    rs1839809841,2
    --166807067(+) CTGGGA/GTGCCA 1 -- us2k10--------
    rs75449401,2
    C,F,A,H--166807182(+) ACTAAG/CATGTC 1 -- us2k123Minor allele frequency- C:0.19NS EA NA WA CSA 2350

    HapMap Linkage Disequilibrium report for POGK (166808681 - 166825581 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for POGK: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing POGK
    DNA2.0 Custom Variant and Variant Library Synthesis for POGK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for POGK:    About MalaCards
    essential hypertension    hypertension    t-cell leukemia    leukemia


    POGK for disorders           About GeneDecksing

    Genetic Association Database (GAD): POGK
    Human Genome Epidemiology (HuGE) Navigator: POGK (2 documents)

    Export disorders for POGK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POGK gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with POGK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    2. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    5. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57645 HGNC: 18800 AceView: POGK Ensembl:ENSG00000143157 euGenes: HUgn57645
    ECgene: POGK H-InvDB: POGK

    (According to HUGE)
    About This Section
    HUGE: KIAA1513

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POGK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POGK gene:
    Search GeneIP for patents involving POGK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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