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Aliases for POGK Gene

Aliases for POGK Gene

  • Pogo Transposable Element Derived With KRAB Domain 2 3
  • Pogo Transposable Element With KRAB Domain 2 3 5
  • KRAB Box Domain Containing 2 2 3
  • KIAA1513 4
  • KRBOX2 3
  • LST003 3
  • BASS2 3

External Ids for POGK Gene

Previous GeneCards Identifiers for POGK Gene

  • GC01P164443
  • GC01P162459
  • GC01P163504
  • GC01P163996
  • GC01P163540
  • GC01P165075
  • GC01P138055

Summaries for POGK Gene

Entrez Gene Summary for POGK Gene

  • The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. [provided by RefSeq, Jul 2008]

GeneCards Summary for POGK Gene

POGK (Pogo Transposable Element Derived With KRAB Domain) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POGK Gene

Genomics for POGK Gene

Regulatory Elements for POGK Gene

Enhancers for POGK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G166858 0.6 FANTOM5 1.6 +19.6 19593 0.4 ZFHX2 SCRT2 EGR2 DUTP6 POU2F1 POGK
GH01G166838 1.1 ENCODE 0.7 +0.5 480 3.3 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 DUTP6 POGK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POGK on UCSC Golden Path with GeneCards custom track

Promoters for POGK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015169 153 1601 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143

Genomic Location for POGK Gene

Chromosome:
1
Start:
166,839,447 bp from pter
End:
166,856,344 bp from pter
Size:
16,898 bases
Orientation:
Plus strand

Genomic View for POGK Gene

Genes around POGK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POGK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POGK Gene

Proteins for POGK Gene

  • Protein details for POGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P215-POGK_HUMAN
    Recommended name:
    Pogo transposable element with KRAB domain
    Protein Accession:
    Q9P215
    Secondary Accessions:
    • Q5TIJ1
    • Q8TE07

    Protein attributes for POGK Gene

    Size:
    609 amino acids
    Molecular mass:
    69444 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM12422.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96037.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for POGK Gene

Post-translational modifications for POGK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POGK Gene

Domains & Families for POGK Gene

No data available for UniProtKB/Swiss-Prot for POGK Gene

Function for POGK Gene

Gene Ontology (GO) - Molecular Function for POGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with POGK: view
genes like me logo Genes that share phenotypes with POGK: view

Animal Model Products

CRISPR Products

miRNA for POGK Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for POGK

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POGK Gene

Localization for POGK Gene

Subcellular locations from UniProtKB/Swiss-Prot for POGK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POGK gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for POGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with POGK: view

Pathways & Interactions for POGK Gene

No Data Available

Gene Ontology (GO) - Biological Process for POGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with POGK: view

No data available for Pathways by source and SIGNOR curated interactions for POGK Gene

Drugs & Compounds for POGK Gene

No Compound Related Data Available

Transcripts for POGK Gene

Unigene Clusters for POGK Gene

Pogo transposable element with KRAB domain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for POGK

Alternative Splicing Database (ASD) splice patterns (SP) for POGK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - -
SP2: -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - -

Relevant External Links for POGK Gene

GeneLoc Exon Structure for
POGK
ECgene alternative splicing isoforms for
POGK

Expression for POGK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POGK Gene

This gene is overexpressed in Blymphocyte (15.3), Monocytes (14.3), Peripheral blood mononuclear cells (12.5), Retina (9.6), CD8 Tcells (7.4), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POGK Gene



Protein tissue co-expression partners for POGK Gene

NURSA nuclear receptor signaling pathways regulating expression of POGK Gene:

POGK

SOURCE GeneReport for Unigene cluster for POGK Gene:

Hs.432752

Evidence on tissue expression from TISSUES for POGK Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with POGK: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POGK Gene

Orthologs for POGK Gene

This gene was present in the common ancestor of animals.

Orthologs for POGK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POGK 34 35
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia POGK 34 35
  • 88.23 (n)
dog
(Canis familiaris)
Mammalia POGK 34 35
  • 88.07 (n)
rat
(Rattus norvegicus)
Mammalia Pogk 34
  • 87.82 (n)
mouse
(Mus musculus)
Mammalia Pogk 34 16 35
  • 87.48 (n)
oppossum
(Monodelphis domestica)
Mammalia POGK 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 41 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 21 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495328 34
  • 47.38 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101887057 34
  • 46.74 (n)
POGK (1 of 3) 35
  • 31 (a)
OneToMany
POGK (2 of 3) 35
  • 31 (a)
OneToMany
POGK (3 of 3) 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W02H5.4 34 35
  • 43.21 (n)
Species where no ortholog for POGK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POGK Gene

ENSEMBL:
Gene Tree for POGK (if available)
TreeFam:
Gene Tree for POGK (if available)

Paralogs for POGK Gene

(10) SIMAP similar genes for POGK Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for POGK Gene

genes like me logo Genes that share paralogs with POGK: view

No data available for Paralogs for POGK Gene

Variants for POGK Gene

Sequence variations from dbSNP and Humsavar for POGK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000034282 -- 166,854,383(+) TACCC(C/T)AGAAT utr-variant-3-prime
rs1000298954 -- 166,852,598(+) ACTCT(G/T)ATTTA utr-variant-3-prime
rs1000345677 -- 166,850,236(+) TCATG(A/G)TCGCG reference, missense
rs1000845448 -- 166,844,644(+) TAGAT(C/T)GTATA intron-variant
rs1000875069 -- 166,839,169(+) AGCAC(A/T)TGGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POGK Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185

Variation tolerance for POGK Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POGK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POGK Gene

Disorders for POGK Gene

Relevant External Links for POGK

Genetic Association Database (GAD)
POGK
Human Genome Epidemiology (HuGE) Navigator
POGK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POGK

No disorders were found for POGK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POGK Gene

Publications for POGK Gene

  1. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 46 64
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for POGK Gene

  • Addgene plasmids for POGK

Sources for POGK Gene

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