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Aliases for POGK Gene

Aliases for POGK Gene

  • Pogo Transposable Element With KRAB Domain 2 3
  • KRAB Box Domain Containing 2 2 3
  • KIAA1513 4
  • KRBOX2 3
  • LST003 3
  • BASS2 3

External Ids for POGK Gene

Previous GeneCards Identifiers for POGK Gene

  • GC01P164443
  • GC01P162459
  • GC01P163504
  • GC01P163996
  • GC01P163540
  • GC01P165075
  • GC01P138055

Summaries for POGK Gene

Entrez Gene Summary for POGK Gene

  • The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. [provided by RefSeq, Jul 2008]

GeneCards Summary for POGK Gene

POGK (Pogo Transposable Element With KRAB Domain) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POGK Gene

Genomics for POGK Gene

Regulatory Elements for POGK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POGK Gene

Chromosome:
1
Start:
166,839,447 bp from pter
End:
166,856,344 bp from pter
Size:
16,898 bases
Orientation:
Plus strand

Genomic View for POGK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for POGK Gene

Proteins for POGK Gene

  • Protein details for POGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P215-POGK_HUMAN
    Recommended name:
    Pogo transposable element with KRAB domain
    Protein Accession:
    Q9P215
    Secondary Accessions:
    • Q5TIJ1
    • Q8TE07

    Protein attributes for POGK Gene

    Size:
    609 amino acids
    Molecular mass:
    69444 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM12422.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96037.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for POGK Gene

Proteomics data for POGK Gene at MOPED

Post-translational modifications for POGK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POGK Gene

No data available for DME Specific Peptides for POGK Gene

Domains & Families for POGK Gene

Gene Families for POGK Gene

Graphical View of Domain Structure for InterPro Entry

Q9P215

UniProtKB/Swiss-Prot:

POGK_HUMAN :
  • Contains 1 DDE domain.
Domain:
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 KRAB domain.
genes like me logo Genes that share domains with POGK: view

Function for POGK Gene

Gene Ontology (GO) - Molecular Function for POGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with POGK: view
genes like me logo Genes that share phenotypes with POGK: view

Animal Model Products

miRNA for POGK Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POGK

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for POGK Gene

Localization for POGK Gene

Subcellular locations from UniProtKB/Swiss-Prot for POGK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POGK Gene COMPARTMENTS Subcellular localization image for POGK gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for POGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with POGK: view

Pathways & Interactions for POGK Gene

SuperPathways for POGK Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for POGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with POGK: view

No data available for Pathways by source and SIGNOR curated interactions for POGK Gene

Drugs & Compounds for POGK Gene

No Compound Related Data Available

Transcripts for POGK Gene

Unigene Clusters for POGK Gene

Pogo transposable element with KRAB domain:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POGK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POGK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - -
SP2: -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - -

Relevant External Links for POGK Gene

GeneLoc Exon Structure for
POGK
ECgene alternative splicing isoforms for
POGK

Expression for POGK Gene

mRNA expression in normal human tissues for POGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POGK Gene

This gene is overexpressed in Blymphocyte (15.3), Monocytes (14.3), Peripheral blood mononuclear cells (12.5), Retina (9.6), CD8 Tcells (7.4), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POGK Gene



SOURCE GeneReport for Unigene cluster for POGK Gene Hs.432752

genes like me logo Genes that share expression patterns with POGK: view

Protein tissue co-expression partners for POGK Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POGK Gene

Orthologs for POGK Gene

This gene was present in the common ancestor of animals.

Orthologs for POGK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POGK 35
  • 88.23 (n)
  • 95.57 (a)
POGK 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POGK 35
  • 88.07 (n)
  • 95.4 (a)
POGK 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pogk 35
  • 87.48 (n)
  • 91.27 (a)
Pogk 16
Pogk 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POGK 35
  • 99.62 (n)
  • 99.84 (a)
POGK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pogk 35
  • 87.82 (n)
  • 92.89 (a)
oppossum
(Monodelphis domestica)
Mammalia POGK 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495328 35
  • 47.38 (n)
  • 37.06 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101887057 35
  • 46.74 (n)
  • 33.78 (a)
POGK (1 of 3) 36
  • 31 (a)
OneToMany
POGK (2 of 3) 36
  • 31 (a)
OneToMany
POGK (3 of 3) 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W02H5.4 35
  • 43.21 (n)
  • 28.04 (a)
W02H5.4 36
  • 18 (a)
OneToOne
Species with no ortholog for POGK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POGK Gene

ENSEMBL:
Gene Tree for POGK (if available)
TreeFam:
Gene Tree for POGK (if available)

Paralogs for POGK Gene

(10) SIMAP similar genes for POGK Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for POGK Gene

genes like me logo Genes that share paralogs with POGK: view

No data available for Paralogs for POGK Gene

Variants for POGK Gene

Sequence variations from dbSNP and Humsavar for POGK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs742006 -- 166,854,939(-) GGTCA(C/G)ACTTG downstream-variant-500B
rs760536 -- 166,845,119(+) CAGGC(A/G)GTGGT intron-variant
rs765739 -- 166,837,568(-) CTGTA(A/C)TTGCT upstream-variant-2KB
rs879654 -- 166,839,745(-) GGCGC(A/C)GCCCG intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs1476347 -- 166,846,350(+) AGTTA(G/T)TTTTC intron-variant

Variation tolerance for POGK Gene

Residual Variation Intolerance Score: 56.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POGK Gene

HapMap Linkage Disequilibrium report
POGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for POGK Gene

Disorders for POGK Gene

Relevant External Links for POGK

Genetic Association Database (GAD)
POGK
Human Genome Epidemiology (HuGE) Navigator
POGK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POGK
genes like me logo Genes that share disorders with POGK: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POGK Gene

Publications for POGK Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. (PMID: 25456346) Nievergelt C.M. … Baker D.G. (Psychoneuroendocrinology 2015) 67
  3. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for POGK Gene

Sources for POGK Gene

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