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Aliases for PODXL2 Gene

Aliases for PODXL2 Gene

  • Podocalyxin Like 2 2 3 5
  • Endoglycan 2 3 4
  • Podocalyxin-Like Protein 2 3
  • Podocalyxin-Like 2 2
  • PODLX2 3
  • EG 3

External Ids for PODXL2 Gene

Previous GeneCards Identifiers for PODXL2 Gene

  • GC03P128830
  • GC03P127348
  • GC03P124737

Summaries for PODXL2 Gene

Entrez Gene Summary for PODXL2 Gene

  • This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]

GeneCards Summary for PODXL2 Gene

PODXL2 (Podocalyxin Like 2) is a Protein Coding gene. GO annotations related to this gene include glycosaminoglycan binding.

UniProtKB/Swiss-Prot for PODXL2 Gene

  • Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PODXL2 Gene

Genomics for PODXL2 Gene

Regulatory Elements for PODXL2 Gene

Enhancers for PODXL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G127688 1.3 Ensembl ENCODE dbSUPER 21 +60.9 60935 4.0 CTCF PKNOX1 BMI1 ZIC2 RAD21 ZBTB48 POLR2A SCRT2 ZNF143 SMC3 PODXL2 TPRA1 ABTB1 MGLL
GH03G127588 1.3 ENCODE dbSUPER 18.8 -38.1 -38132 4.7 HDGF PKNOX1 ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 TPRA1 PODXL2 ABTB1 PIR40762 MIR7976
GH03G127766 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +143.9 143886 12.1 TBP RAD21 YY1 GATA2 SCRT2 ZNF143 RCOR1 FOS RELB IKZF2 MCM2 TPRA1 MGLL ABTB1 PODXL2
GH03G127888 1.6 FANTOM5 Ensembl ENCODE 10 +260.7 260727 3.2 PKNOX1 E2F7 FEZF1 CBX5 ZNF143 FOS SP3 YY2 JUNB TSHZ1 KBTBD12 PODXL2 GC03P127885 GC03P127895
GH03G127737 1.2 Ensembl ENCODE dbSUPER 11.2 +109.7 109665 2.0 SUZ12 ZSCAN9 GATA3 POLR2A FOS EZH2 KLF6 MIER1 CBX2 REST PODXL2 ABTB1 MGLL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PODXL2 on UCSC Golden Path with GeneCards custom track

Promoters for PODXL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157968 141 601 CREB3L1 ARID4B SIN3A ZNF48 SLC30A9 ZNF766 GLIS2 ELK1 NFYC REST

Genomic Location for PODXL2 Gene

Chromosome:
3
Start:
127,629,159 bp from pter
End:
127,672,810 bp from pter
Size:
43,652 bases
Orientation:
Plus strand

Genomic View for PODXL2 Gene

Genes around PODXL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PODXL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PODXL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PODXL2 Gene

Proteins for PODXL2 Gene

  • Protein details for PODXL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ53-PDXL2_HUMAN
    Recommended name:
    Podocalyxin-like protein 2
    Protein Accession:
    Q9NZ53
    Secondary Accessions:
    • Q6UVY4
    • Q8WUV6

    Protein attributes for PODXL2 Gene

    Size:
    605 amino acids
    Molecular mass:
    65076 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with SELL, SELE and SELP.

    Alternative splice isoforms for PODXL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PODXL2 Gene

Post-translational modifications for PODXL2 Gene

  • Glycosylated; contains chondroitin sulfate. Displays sialylated O-linked oligosaccharides.
  • Sulfation is necessary for interaction with SELL. Sialylated O-linked oligosaccharides are necessary for interaction with SELL, SELE and SELP.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PODXL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PODXL2 (Endoglycan/PODXL2)

No data available for DME Specific Peptides for PODXL2 Gene

Domains & Families for PODXL2 Gene

Protein Domains for PODXL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PODXL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZ53

UniProtKB/Swiss-Prot:

PDXL2_HUMAN :
  • Belongs to the podocalyxin family.
Family:
  • Belongs to the podocalyxin family.
genes like me logo Genes that share domains with PODXL2: view

No data available for Gene Families for PODXL2 Gene

Function for PODXL2 Gene

Molecular function for PODXL2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.

Gene Ontology (GO) - Molecular Function for PODXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18606703
GO:0005539 glycosaminoglycan binding TAS 10722749
genes like me logo Genes that share ontologies with PODXL2: view
genes like me logo Genes that share phenotypes with PODXL2: view

Animal Model Products

CRISPR Products

miRNA for PODXL2 Gene

miRTarBase miRNAs that target PODXL2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PODXL2 Gene

Localization for PODXL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PODXL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PODXL2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PODXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0005887 integral component of plasma membrane TAS 10722749
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PODXL2: view

Pathways & Interactions for PODXL2 Gene

SuperPathways for PODXL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PODXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
GO:0050901 leukocyte tethering or rolling IDA 18606703
genes like me logo Genes that share ontologies with PODXL2: view

No data available for Pathways by source and SIGNOR curated interactions for PODXL2 Gene

Drugs & Compounds for PODXL2 Gene

No Compound Related Data Available

Transcripts for PODXL2 Gene

mRNA/cDNA for PODXL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(266) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PODXL2 Gene

Podocalyxin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PODXL2 Gene

No ASD Table

Relevant External Links for PODXL2 Gene

GeneLoc Exon Structure for
PODXL2
ECgene alternative splicing isoforms for
PODXL2

Expression for PODXL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PODXL2 Gene

mRNA differential expression in normal tissues according to GTEx for PODXL2 Gene

This gene is overexpressed in Brain - Hypothalamus (x4.7).

Protein differential expression in normal tissues from HIPED for PODXL2 Gene

This gene is overexpressed in Fetal Brain (50.2), Adrenal (9.7), and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PODXL2 Gene



Protein tissue co-expression partners for PODXL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PODXL2 Gene:

PODXL2

SOURCE GeneReport for Unigene cluster for PODXL2 Gene:

Hs.591290

mRNA Expression by UniProt/SwissProt for PODXL2 Gene:

Q9NZ53-PDXL2_HUMAN
Tissue specificity: Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.

Evidence on tissue expression from TISSUES for PODXL2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with PODXL2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PODXL2 Gene

Orthologs for PODXL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PODXL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PODXL2 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia PODXL2 34 35
  • 85.91 (n)
rat
(Rattus norvegicus)
Mammalia Podxl2 34
  • 80.39 (n)
mouse
(Mus musculus)
Mammalia Podxl2 34 16 35
  • 79.99 (n)
cow
(Bos Taurus)
Mammalia PODXL2 34 35
  • 78.71 (n)
oppossum
(Monodelphis domestica)
Mammalia PODXL2 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PODXL2 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PODXL2 34 35
  • 60.44 (n)
lizard
(Anolis carolinensis)
Reptilia PODXL2 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wufi40b04 34
Species where no ortholog for PODXL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PODXL2 Gene

ENSEMBL:
Gene Tree for PODXL2 (if available)
TreeFam:
Gene Tree for PODXL2 (if available)

Paralogs for PODXL2 Gene

No data available for Paralogs for PODXL2 Gene

Variants for PODXL2 Gene

Sequence variations from dbSNP and Humsavar for PODXL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000002380 -- 127,657,800(+) GCATT(A/C)TATCT intron-variant
rs1000013907 -- 127,661,024(+) TCAGC(C/T)TCTTC reference, synonymous-codon
rs1000148757 -- 127,652,050(+) CTCCT(A/G)TCCAG intron-variant
rs1000187507 -- 127,667,471(+) CATGT(A/T)CAGGA intron-variant
rs1000286891 -- 127,635,259(+) CTAAC(C/T)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PODXL2 Gene

Variant ID Type Subtype PubMed ID
dgv8563n54 CNV loss 21841781
esv29518 CNV loss 19812545
nsv1074621 CNV deletion 25765185
nsv460848 CNV loss 19166990
nsv591582 CNV gain+loss 21841781
nsv591583 CNV loss 21841781
nsv591584 CNV loss 21841781
nsv591585 CNV loss 21841781
nsv955342 CNV deletion 24416366

Variation tolerance for PODXL2 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PODXL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PODXL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PODXL2 Gene

Disorders for PODXL2 Gene

Relevant External Links for PODXL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PODXL2

No disorders were found for PODXL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PODXL2 Gene

Publications for PODXL2 Gene

  1. Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins. (PMID: 10722749) Sassetti C. … Rosen S.D. (J. Biol. Chem. 2000) 2 3 4 64
  2. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. (PMID: 18606703) Kerr S.C. … Rosen S.D. (J. Immunol. 2008) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. (PMID: 12889478) Fieger C.B. … Rosen S.D. (J. Biol. Chem. 2003) 3 4 64

Products for PODXL2 Gene

Sources for PODXL2 Gene

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