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Aliases for PODXL2 Gene

Aliases for PODXL2 Gene

  • Podocalyxin Like 2 2 3
  • Podocalyxin-Like 2 2 3 5
  • Endoglycan 2 3 4
  • PODLX2 3
  • EG 3

External Ids for PODXL2 Gene

Previous GeneCards Identifiers for PODXL2 Gene

  • GC03P128830
  • GC03P127348
  • GC03P124737

Summaries for PODXL2 Gene

Entrez Gene Summary for PODXL2 Gene

  • This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]

GeneCards Summary for PODXL2 Gene

PODXL2 (Podocalyxin Like 2) is a Protein Coding gene. GO annotations related to this gene include glycosaminoglycan binding.

UniProtKB/Swiss-Prot for PODXL2 Gene

  • Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PODXL2 Gene

Genomics for PODXL2 Gene

Regulatory Elements for PODXL2 Gene

Enhancers for PODXL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PODXL2 on UCSC Golden Path with GeneCards custom track

Promoters for PODXL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PODXL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PODXL2 Gene

127,629,159 bp from pter
127,672,810 bp from pter
43,652 bases
Plus strand

Genomic View for PODXL2 Gene

Genes around PODXL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PODXL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PODXL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PODXL2 Gene

Proteins for PODXL2 Gene

  • Protein details for PODXL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Podocalyxin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6UVY4
    • Q8WUV6

    Protein attributes for PODXL2 Gene

    605 amino acids
    Molecular mass:
    65076 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with SELL, SELE and SELP.

    Alternative splice isoforms for PODXL2 Gene


neXtProt entry for PODXL2 Gene

Proteomics data for PODXL2 Gene at MOPED

Post-translational modifications for PODXL2 Gene

  • Glycosylated; contains chondroitin sulfate. Displays sialylated O-linked oligosaccharides.
  • Sulfation is necessary for interaction with SELL. Sialylated O-linked oligosaccharides are necessary for interaction with SELL, SELE and SELP.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PODXL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PODXL2 Gene

Domains & Families for PODXL2 Gene

Protein Domains for PODXL2 Gene


Suggested Antigen Peptide Sequences for PODXL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the podocalyxin family.
  • Belongs to the podocalyxin family.
genes like me logo Genes that share domains with PODXL2: view

No data available for Gene Families for PODXL2 Gene

Function for PODXL2 Gene

Molecular function for PODXL2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.

Gene Ontology (GO) - Molecular Function for PODXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18606703
genes like me logo Genes that share ontologies with PODXL2: view
genes like me logo Genes that share phenotypes with PODXL2: view

Animal Model Products

miRNA for PODXL2 Gene

miRTarBase miRNAs that target PODXL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PODXL2 Gene

Localization for PODXL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PODXL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PODXL2 Gene COMPARTMENTS Subcellular localization image for PODXL2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for PODXL2 Gene

Pathways & Interactions for PODXL2 Gene

SuperPathways for PODXL2 Gene

No Data Available

Interacting Proteins for PODXL2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000345359 Q9NZ53-PDXL2_HUMAN for PODXL2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PODXL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for PODXL2 Gene

Drugs & Compounds for PODXL2 Gene

No Compound Related Data Available

Transcripts for PODXL2 Gene

mRNA/cDNA for PODXL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(266) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PODXL2 Gene

Podocalyxin-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PODXL2 Gene

No ASD Table

Relevant External Links for PODXL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PODXL2 Gene

mRNA expression in normal human tissues for PODXL2 Gene

mRNA differential expression in normal tissues according to GTEx for PODXL2 Gene

This gene is overexpressed in Brain - Hypothalamus (x4.7).

Protein differential expression in normal tissues from HIPED for PODXL2 Gene

This gene is overexpressed in Fetal Brain (50.2), Adrenal (9.7), and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PODXL2 Gene

SOURCE GeneReport for Unigene cluster for PODXL2 Gene Hs.591290

mRNA Expression by UniProt/SwissProt for PODXL2 Gene

Tissue specificity: Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.
genes like me logo Genes that share expression patterns with PODXL2: view

Protein tissue co-expression partners for PODXL2 Gene

Primer Products

Orthologs for PODXL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PODXL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PODXL2 35
  • 78.71 (n)
  • 73.31 (a)
  • 71 (a)
(Canis familiaris)
Mammalia PODXL2 35
  • 85.91 (n)
  • 85.02 (a)
  • 83 (a)
(Mus musculus)
Mammalia Podxl2 35
  • 79.99 (n)
  • 76.48 (a)
Podxl2 16
Podxl2 36
  • 76 (a)
(Pan troglodytes)
Mammalia PODXL2 35
  • 99.55 (n)
  • 99.61 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Podxl2 35
  • 80.39 (n)
  • 76.64 (a)
(Monodelphis domestica)
Mammalia PODXL2 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia PODXL2 36
  • 58 (a)
(Gallus gallus)
Aves PODXL2 35
  • 60.44 (n)
  • 55.54 (a)
  • 47 (a)
(Anolis carolinensis)
Reptilia PODXL2 36
  • 46 (a)
(Danio rerio)
Actinopterygii wufi40b04 35
Species with no ortholog for PODXL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PODXL2 Gene

Gene Tree for PODXL2 (if available)
Gene Tree for PODXL2 (if available)

Paralogs for PODXL2 Gene

No data available for Paralogs for PODXL2 Gene

Variants for PODXL2 Gene

Sequence variations from dbSNP and Humsavar for PODXL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs34117815 - 127,669,144(-) GCACC(A/G)CCCCT reference, missense
rs782426 -- 127,658,866(+) atttt(A/G)ttggt intron-variant
rs782429 -- 127,638,673(-) CAGTG(C/G)TGCAA intron-variant
rs782430 -- 127,667,659(+) CTCTT(A/G)TTTTT intron-variant
rs2304551 -- 127,669,307(+) GGAGT(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PODXL2 Gene

Variant ID Type Subtype PubMed ID
dgv5249n71 CNV Loss 21882294
esv29518 CNV Loss 19812545
nsv460848 CNV Loss 19166990

Variation tolerance for PODXL2 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PODXL2 Gene

Disorders for PODXL2 Gene

Relevant External Links for PODXL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PODXL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PODXL2 Gene

Publications for PODXL2 Gene

  1. Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins. (PMID: 10722749) Sassetti C. … Rosen S.D. (J. Biol. Chem. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. (PMID: 18606703) Kerr S.C. … Rosen S.D. (J. Immunol. 2008) 3
  5. Novel functions of the CD34 family. (PMID: 18987355) Nielsen J.S. … McNagny K.M. (J. Cell. Sci. 2008) 3

Products for PODXL2 Gene

Sources for PODXL2 Gene