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Aliases & Descriptions for PODXL
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases Gp200 1 , 2 MGC138240 2 PC 1 , 2 PCLP 1 , 2 , 3 , 5 PCLP1 3 podocalyxin-like 2
Search outside databases for aliases for PODXL genePrevious GC identifers: GC07M129527 GC07M130587 GC07M130601 GC07M130642
Summaries for PODXL (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for PODXL : This gene encodes a member of the sialomucin protein family. The encoded protein was originallyidentified as an important component of glomerular podocytes. Podocytes are highly differentiatedepithelial cells with interdigitating foot processes covering the outer aspect of the glomerularbasement membrane. Other biological activities of the encoded protein include: binding in amembrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletalelements, playing a role in hematopoetic cell differentiation, and being expressed in vascularendothelium cells and binding to L-selectin. [provided by RefSeq] UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592 Function : Functions as an antiadhesin that maintains an open filtration pathway between neighboringfoot processes in the podocyte by charge repulsion
Gene Wiki entry for PODXL
Genomic Location for PODXL
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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UCSC and
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the PODXL gene Entrez Gene cytogenetic band: 7q32-q33 Ensembl cytogenetic band: 7q32.3 HGNC cytogenetic band: 7q32-q33 PODXL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M130835:
(about GC identifiers )
Start:
130,835,561 bp from pter
End:
130,891,916 bp from pter
Size:
56,356 bases
Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 130,524,660-130,580,998
RefSeq DNA sequence: NC_000007.12 NT_007933.14 NT_079596.2 Proteins for PODXL
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
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Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592 (See
protein sequence )Recommended Name: Podocalyxin-like protein 1 precursor Size : 558 amino acids; 58635 Da
Subcellular location : Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions : A6NHX8 Q52LZ7 Q53ER6Alternative splicing : 2 isoforms : O00592-1 O00592-2
Post-translational modifications:
Glycosylated; contains sialic acid1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001018121.1 NP_005388.2 ENSEMBL proteins: ENSP00000319782 ENSP00000367817 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for PODXL: Assays for PODXL:
Protein
Domains/ Families for PODXL(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O00592 ProtoNet protein and cluster: O00592
1 Blocks protein family : IPB013836 CD34/Podocalyxin UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592 Similarity : Belongs to the podocalyxin family
Gene Function for PODXL
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005397 Applied Biosystems Silencer ® siRNAs for PODXL Sigma-Aldrich siRNA for PODXL Sigma-Aldrich shRNA Panels and shRNA for PODXL Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018111                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018111                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001018111  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001018111 UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592 Function : Functions as an antiadhesin that maintains an open filtration pathway between neighboringfoot processes in the podocyte by charge repulsion
Genatlas biochemistry entry for PODXL :podocalyxin-like protein,integral component of the glomerular epithelial cell glycocalyx
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Podxl) : Pathways & Interactions for PODXL
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for PODXL 3 Interacting proteins for PODXL (ENSP00000367817 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for PODXL (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for PODXL
Transcripts for PODXL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005397 Sigma-Aldrich siRNA for PODXL Sigma-Aldrich shRNA Panels and shRNA for PODXL Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001018111 NM_005397
REFSEQ mRNAs for PODXL gene (2 alternative transcripts): NM_001018111.2 NM_005397.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001018111 NM_005397
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018111                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018111                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001018111  
Additional cDNA sequence: AK055816.1 AK223573.1 BC042466.1 BC093730.1 BC112035.1 BC143318.1 BX641124.1 U97519.1
11 DOTS entries : DT.99948575 DT.97845993 DT.418229 DT.92439324 DT.100796895 DT.97845992 DT.100796902 DT.100796898 DT.121064152 DT.92439326 DT.95098144
24/366 AceView cDNA sequences (see all 366
):BP363647 AA486344 BU845769 AA989333 AW376607 BF941480 AW296846 CD656813 AW026403 AA450293 AA983640 AA024856 CK430109 BU844975 AI052596 H65205 CA866864 AW517478 AI868205 BU930904 BE223020 AI280171 AW131922 CA443883
highest scoring ESTs for PODXL :U97519 BC042466 BU849471 AA024856 AA024939 AA037673 AA070415 AA070416 AA075507 AA075508
Unigene Cluster for PODXL: Podocalyxin-like Hs.690098 [show with all ESTs ] Unigene Representative Sequence: BX641124 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for PODXL ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d SP1 :       -         -                 SP2 :       -         -                 SP3 :               -                 SP4 :               -                 SP5 :                              
About this scheme ECgene alternative splicing isoforms for PODXL 2 Ensembl transcripts including schematic representations : ENST00000322985
ENST00000378555
Expression for PODXL
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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PODXL expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for PODXL 1 / 2 / 3
3 probe-sets matching PODXL gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAGGACACAGSOURCE GeneReport for Unigene cluster: Hs.690098 Expression variation in blood from EXPOLDB for PODXL
UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592 Tissue specificity : Glomerular epithelium cell (podocyte)
Orthologs for PODXL
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for PODXL gene from 5/9 species (see all 9
)
About this table Species with no ortholog for PODXL ENSEMBL Gene Tree for PODXL Paralogs for PODXL (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for PODXL (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for PODXL (up to first 250kb)
Disorders & Mutations for PODXL
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 602632 4 Novoseek disease relationships for PODXL gene
About this table Human Genome Epidemiology Navigator: PODXL (1 document)
Medical News for PODXL (Possibly Related Articles in
Doctor's Guide )
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Publications for PODXL (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/44 PubMed articles for PODXL gene (see all 44
): Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin. (PubMed id 9188463) 1, 3, 4 Kershaw D.B.... Wiggins R.C. (1997) Human chromosome 7: DNA sequence and biology. (PubMed id 12690205) 3, 4 Scherer S.W....Tsui L.C. (2003) Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells. (PubMed id 19118161) 1, 3 Thomas S.N....Konstantopoulos K. (2009) Expression of podocalyxin enhances the adherence, migration, and intercellular communication of cells. (PubMed id 18456258) 1, 3 Larrucea S....Parrilla R. (2008) Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. (PubMed id 9625756) 1, 3 Sassetti C....Rosen S.D. (1998) Podocalyxin variants and risk of prostate cancer and tumor aggressiveness. (PubMed id 16434482) 1, 3 Casey G....Witte J.S. (2006) Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin. (PubMed id 12504081) 1, 3 Schopperle W.M....DeWolf W.C. (2003) Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1. (PubMed id 18356574) 1, 3 Choo A.B....Yap M. (2008) Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts. (PubMed id 17137615) 1, 3 Ney J.T....Gutgemann I. (2007) Extracellular and transmembrane region of a podocalyxin-like protein 1 fragment identified from colon cancer cell lines. (PubMed id 17719804) 1, 3 Ito T....Nekooki M. (2007)
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Genome Databases showing PODXL
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing PODXL
(According to HUGE )
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Specialized Databases showing PODXL (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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