Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PODXL Gene

protein-coding   GIFtS: 60
GCID: GC07M131185

Podocalyxin-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
podocalyxin-like1 2     PCLP-12 3
PCLP2 3 5     GCTM-2 Antigen2 3
Podocalyxin-Like Protein 12 3     podocalyxin2
Gp2002 3     PCLP13
PC2 3     

External Ids:    HGNC: 91711   Entrez Gene: 54202   Ensembl: ENSG000001285677   OMIM: 6026325   UniProtKB: O005923   
ORGUL members:         

Export aliases for PODXL gene to outside databases

Previous GC identifers: GC07M129527 GC07M130587 GC07M130601 GC07M130642 GC07M130835 GC07M125500


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PODXL Gene:
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an
important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with
interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological
activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory
factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being
expressed in vascular endothelium cells and binding to L-selectin. (provided by RefSeq, Jul 2008)

GeneCards Summary for PODXL Gene:
PODXL (podocalyxin-like) is a protein-coding gene. Diseases associated with PODXL include sick sinus syndrome, and proteinuria.

UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592
Function: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an
anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the
podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized
ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the
formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane
subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis.
Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its
interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased
activities of the MAPK and PI3K pathways in cancer cells

Gene Wiki entry for PODXL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the PODXL gene promoter:
         USF1   Sp1   p53   NRSF form 1   NF-kappaB   NRSF form 2   USF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PODXL promoter sequence
   Search Chromatin IP Primers for PODXL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PODXL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32-q33   Ensembl cytogenetic band:  7q32.3   HGNC cytogenetic band: 7q32-q33

PODXL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PODXL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M131185:  view genomic region     (about GC identifiers)

Start:
131,185,021 bp from pter      End:
131,242,976 bp from pter
Size:
57,956 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 130,524,660-130,580,998     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592 (See protein sequence)
Recommended Name: Podocalyxin precursor  
Size: 558 amino acids; 58635 Da
Subunit: Monomer; when associated with the membrane raft. Oligomer; when integrated in the apical membrane.
Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R1 (via the PDZ domains); the interaction is not
detected in glomerular epithelium cells, take place early in the secretory pathway and is necessary for its
apical membrane sorting. Found in a complex with EZR, PODXL and SLC9A3R2. Associates with the actin cytoskeleton
through complex formation with EZR and SLC9A3R2. Interacts (via the C-terminal PDZ-binding motif DTHL) with
SLC9A3R2 (via the PDZ 1 domain); interaction is detected in glomerular epithelium cells (By similarity).
Interacts with EZR
Secondary accessions: A6NHX8 Q52LZ7 Q53ER6
Alternative splicing: 2 isoforms:  O00592-1   O00592-2   

Explore the universe of human proteins at neXtProt for PODXL: NX_O00592

Explore proteomics data for PODXL at MOPED

Post-translational modifications: 

  • N- and O-linked glycosylated. Sialoglycoprotein (By similarity)1
  • Ubiquitination2 at Lys526
  • Modification sites at PhosphoSitePlus

  • See PODXL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001018121.1  NP_005388.2  

    ENSEMBL proteins: 
     ENSP00000390152   ENSP00000367817   ENSP00000319782   ENSP00000440518   ENSP00000442655  

    PODXL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PODXL
    OriGene Protein Over-expression Lysate for PODXL
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PODXL
    GenScript Custom Purified and Recombinant Proteins Services for PODXL
    Novus Biologicals PODXL Protein
    Novus Biologicals PODXL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PODXL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PODXL
    R&D Systems Antibodies for PODXL (Podocalyxin)
    OriGene Antibodies for PODXL
    OriGene Custom Antibody Services for PODXL
    Novus Biologicals PODXL Antibodies
    Abcam antibodies for PODXL
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PODXL
    LSBio Antibodies in human, mouse, rat for PODXL

    PODXL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PODXL
    R&D Systems Proteome Profiler Antibody Arrays for PODXL (Podocalyxin)
    GenScript Custom Assay Services for PODXL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR013836 CD34/Podocalyxin
     IPR017403 Podocalyxin-like_p1

    Graphical View of Domain Structure for InterPro Entry O00592

    ProtoNet protein and cluster: O00592

    1 Blocks protein domain: IPB013836 CD34/Podocalyxin

    UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592
    Domain: Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in
    the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane
    targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for
    interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is
    necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to
    maintain open filtration pathways between neighboring podocyte foot processes
    Similarity: Belongs to the podocalyxin family


    PODXL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PODXL_HUMAN, O00592
    Function: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an
    anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the
    podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized
    ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the
    formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane
    subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis.
    Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its
    interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased
    activities of the MAPK and PI3K pathways in cancer cells

         Genatlas biochemistry entry for PODXL:
    podocalyxin-like protein,integral component of the glomerular epithelial cell glycocalyx

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    PODXL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PODXL:
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Podxl):
     cardiovascular system  digestive/alimentary  homeostasis/metabolism  mortality/aging  nervous system 
     normal  renal/urinary system 

    PODXL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Podxltm1Kmn for PODXL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PODXL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PODXL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PODXL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PODXL

    miRNA
    Products:
        
    miRTarBase miRNAs that target PODXL:
    hsa-mir-124-3p (MIRT002657), hsa-mir-26b-5p (MIRT028791), hsa-mir-215-5p (MIRT024915), hsa-mir-192-5p (MIRT026206), hsa-mir-145-5p (MIRT021537), hsa-mir-155-5p (MIRT001522)

    Block miRNA regulation of human, mouse, rat PODXL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PODXL (see all 63):
    hsa-miR-15a hsa-miR-219-5p hsa-miR-766 hsa-miR-449a hsa-miR-3916 hsa-miR-424 hsa-miR-629* hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PODXL
    Predesigned siRNA for gene silencing in human, mouse, rat PODXL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PODXL

    Clone
    Products:
         
    OriGene clones in human, mouse for PODXL (see all 12)
    OriGene ORF clones in mouse, rat for PODXL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PODXL (NM_001018111)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PODXL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PODXL

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PODXL
    ESI BIO PureStem Progenitors for PODXL: 
    PureStem 4D20.8, NCr-fac Progenitor, PureStem E15, Meso-prx/latp Progenitor,
    PureStem ES-210, Ecto-ntu Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PODXL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PODXL_HUMAN, O00592: Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell
    projection, ruffle. Cell projection, microvillus (By similarity). Membrane raft (By similarity). Membrane;
    Single-pass type I membrane protein (Potential). Note=In single attached epithelial cells is restricted to a
    preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized.
    Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1
    at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane
    raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell
    surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular
    epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a
    polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of
    filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of
    lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells.
    Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane
    initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA18456258
    GO:0005737cytoplasm IDA18456258
    GO:0005886plasma membrane IDA18456258
    GO:0005887integral component of plasma membrane TAS9188463
    GO:0016324apical plasma membrane ISS--

    PODXL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PODXL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of p53
    Selected targets of p53



        Pathway & Disease-focused RT2 Profiler PCR Arrays including PODXL: 
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PODXL

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for PODXL (O005921, 3 ENSP000003678174) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R2Q155993, ENSP000004080054I2D: score=3 STRING: ENSP00000408005
    SELLP141513, ENSP000002361474I2D: score=2 STRING: ENSP00000236147
    IQGAP1P469401EBI-6897823,EBI-297509
    SELEENSP000003317364STRING: ENSP00000331736
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007162negative regulation of cell adhesion ISS--
    GO:0016477cell migration ISS--
    GO:0022408negative regulation of cell-cell adhesion ISS--
    GO:0030335positive regulation of cell migration IDA18456258

    PODXL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PODXL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PODXL gene (2 alternative transcripts): 
    NM_001018111.2  NM_005397.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446198 ENST00000484346 ENST00000378555 ENST00000322985 ENST00000490761
    ENST00000487965 ENST00000482581 ENST00000465001 ENST00000541194(uc003vqw.4 uc003vqx.4)
    ENST00000537928
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PODXL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PODXL (see all 63):
    hsa-miR-15a hsa-miR-219-5p hsa-miR-766 hsa-miR-449a hsa-miR-3916 hsa-miR-424 hsa-miR-629* hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PODXL
    Predesigned siRNA for gene silencing in human, mouse, rat PODXL
    Clone
    Products:
         
    OriGene clones in human, mouse for PODXL (see all 12)
    OriGene ORF clones in mouse, rat for PODXL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PODXL (NM_001018111)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PODXL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PODXL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PODXL
    OriGene qSTAR qPCR primer pairs in human, mouse for PODXL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PODXL
      QuantiTect SYBR Green Assays in human, mouse, rat PODXL
      QuantiFast Probe-based Assays in human, mouse, rat PODXL

    Selected AceView cDNA sequences (see all 366):

    CD722816 BU956150 H65205 CA866864 BF941480 BU856234 BP355358 AA989333 
    AW296846 BM979686 AA902447 BU849526 AI418156 BU678140 BU850089 AA340766 
    AW131922 T87719 AA565479 AI190975 BU930904 AW026403 AW513098 AA902519 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PODXL    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                    -                       -                                             
    SP2:                    -                       -                                             
    SP3:                                            -                                             
    SP4:                                            -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for PODXL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PODXL expression in normal human tissues (normalized intensities)      PODXL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGACACAG
    PODXL Expression
    About this image


    PODXL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Kidney (Urinary System)    fully expand to see all 10 entries
             Presumptive Podocytes Podocyte Layer
             Metanephric Mesenchyme
             Podocalyxin+, CD24+, GCTM2-
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 9 entries
             ESI-017
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
    PODXL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PODXL Protein Expression

    UniProtKB/Swiss-Prot: PODXL_HUMAN, O00592
    Tissue specificity: Glomerular epithelium cell (podocyte)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PODXL: 
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PODXL
    OriGene qSTAR qPCR primer pairs in human, mouse for PODXL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PODXL
    QuantiTect SYBR Green Assays in human, mouse, rat PODXL
    QuantiFast Probe-based Assays in human, mouse, rat PODXL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PODXL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PODXL gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Podxl5 podocalyxin-like   --   6 (12.57 cM) 31519488 
    chicken
    (Gallus gallus)
    Aves PODXL6
    Gallus gallus podocalyxin-like (PODXL), mRNA.
    27(a)
    1 ↔ 1
    1(2987400-3028096)
    lizard
    (Anolis carolinensis)
    Reptilia PODXL6
    podocalyxin-like
    50(a)
    1 ↔ 1
    5(1321237-1328822)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.184702 Xenopus laevis transcribed sequences 85.56(n)    BI347883.1 
    zebrafish
    (Danio rerio)
    Actinopterygii podxl6
    podocalyxin-like
    22(a)
    1 ↔ 1
    4(10796680-10815561) ENSDARG00000031228


    ENSEMBL Gene Tree for PODXL (if available)
    TreeFam Gene Tree for PODXL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PODXL gene
    7 SIMAP similar genes for PODXL using alignment to 5 protein entries:     PODXL_HUMAN (see all proteins):
    FP6651    DNAPTP3    PACSIN2    CCT3    OK/SW-cl.41    KIAA1651
    AREL1

    PODXL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PODXL (see all 1251)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665983241,2
    C--125529551(+) AAAAT-/GTTGAGA 2 -- int10--------
    rs105934821,2
    C--130571126(+) aaaaa-/A/AA  
            
    GTCTG
    2 -- int11NA 2
    rs1437029931,2
    C--131184528(+) AGAGC-/TTTGTT
            
    TTTGT
    2 -- cds10--------
    rs556950771,2
    --131184551(+) ATATAC/TATATA 2 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1813228861,2
    --131184565(+) ATATAC/TATATA 2 -- ds50010--------
    rs1855350211,2
    --131184567(+) ATATAC/TATATA 2 -- ds50010--------
    rs2021385481,2
    C--131184573(+) ATATAC/TATACA 2 -- ds50010--------
    rs69764991,2
    C--131184577(+) ATATAC/TATACA 2 -- ds50010--------
    rs4370051,2
    C--131184579(-) TGTGTA/GTGTAT 2 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1996637221,2
    --131184734(+) AAGGA-/AGAC  
            
    AGACA
    2 -- ds50010--------

    HapMap Linkage Disequilibrium report for PODXL (131185021 - 131242976 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PODXL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735156CNV Deletion23290073
    esv2735155CNV Deletion23290073
    esv2735154CNV Deletion23290073
    nsv831134CNV Gain17160897
    esv7269CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PODXL
    DNA2.0 Custom Variant and Variant Library Synthesis for PODXL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602632    OMIM disorders: --

    Selected diseases for PODXL (see all 25):    About MalaCards
    sick sinus syndrome    proteinuria    sinusitis    pancreatic ductal adenocarcinoma
    wilms tumor    nephritis    diabetic nephropathy    labyrinthitis
    kidney disease    hepatocellular carcinoma    acute myeloid leukemia    pancreatitis
    endotheliitis    renal cell carcinoma    myeloid leukemia    pancreatic cancer
    adenocarcinoma    ovarian cancer    colorectal cancer    prostate cancer

    2 diseases from the University of Copenhagen DISEASES database for PODXL:
    Sick sinus syndrome     Embryonal carcinoma

    PODXL for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PODXL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 58.5 3 1416983 (2), 12504081 (1)
    hepatocellular carcinoma 21.5 1 15154008 (1)
    proteinuria 19.1 1 17229675 (1)
    tumors 14.3 13 17922228 (2), 12504081 (2), 19118161 (1), 16434482 (1) (see all 6)

    Genetic Association Database (GAD): PODXL
    Human Genome Epidemiology (HuGE) Navigator: PODXL (2 documents)

    Export disorders for PODXL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PODXL gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with PODXL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of podocalyxin enhances the adherence, migration, and intercellular communication of cells. (PubMed id 18456258)1, 2, 9 Larrucea S.... Parrilla R. (Exp. Cell Res. 2008)
    2. Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin. (PubMed id 9188463)1, 2, 9 Kershaw D.B.... Wiggins R.C. (J. Biol. Chem. 1997)
    3. Podocalyxin variants and risk of prostate cancer and tumor aggressiveness. (PubMed id 16434482)1, 4, 9 Casey G....Witte J.S. (Hum. Mol. Genet. 2006)
    4. Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin. (PubMed id 12504081)1, 2, 9 Schopperle W.M.... DeWolf W.C. (Biochem. Biophys. Res. Commun. 2003)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    6. Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin. (PubMed id 17616675)1, 2 Sizemore S.... Casey G. (Cancer Res. 2007)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    8. Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells. (PubMed id 19118161)1, 9 Thomas S.N....Konstantopoulos K. (Am. J. Physiol., Cell Physiol. 2009)
    9. Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. (PubMed id 9625756)1, 9 Sassetti C....Rosen S.D. (J. Exp. Med. 1998)
    10. Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1. (PubMed id 18356574)1, 9 Choo A.B....Yap M. (Stem Cells 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5420 HGNC: 9171 AceView: PODXL Ensembl:ENSG00000128567 euGenes: HUgn5420
    ECgene: PODXL H-InvDB: PODXL

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PODXL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PODXL gene:
    Search GeneIP for patents involving PODXL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PODXL
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for PODXL (Podocalyxin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for PODXL (Podocalyxin)  
     OriGene Antibodies for PODXL   OriGene RNAi products in human, mouse, rat for PODXL  
     OriGene qPCR primer pairs and template standards for PODXL   OriGene Protein Over-expression Lysate for PODXL  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PODXL  
     OriGene qSTAR qPCR primer pairs in human, mouse for PODXL   OriGene Purified Protein for PODXL  
     OriGene ORF clones in mouse, rat for PODXL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PODXL   OriGene Custom Protein Services for PODXL  

     
     
     Block miRNA regulation of human, mouse, rat PODXL using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PODXL
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PODXL Predesigned siRNA for gene silencing in human, mouse, rat PODXL
     QuantiFast Probe-based Assays in human, mouse, rat PODXL QuantiTect SYBR Green Assays in human, mouse, rat PODXL
     PCR Arrays including human, mouse, rat PODXL Search Chromatin IP Primers for PODXL
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PODXL  GeneGlobe Interaction Network for PODXL
     Regulatory tfbs in PODXL promoter
     GenScript Custom Purified and Recombinant Proteins Services for PODXL GenScript cDNA clones with any tag delivered in your preferred vector for PODXL
     GenScript Custom Assay Services for PODXL GenScript Custom overexpressing Cell Line Services for PODXL
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PODXL
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PODXL antibodies
     PODXL proteins
     PODXL lysates
     Antibodies for PODXL
     See all of Abcam's Antibodies, Kits and Proteins for PODXL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     PureStem Progenitors for PODXL: PureStem 4D20.8, NCr-fac Progenitor, PureStem E15, Meso-prx/latp Progenitor,
    PureStem ES-210, Ecto-ntu Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PODXL
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PODXL
     SwitchGear Promoter luciferase reporter plasmids for PODXL
     ThermoFisher Antibody for PODXL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PODXL
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PODXL
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PODXL
     LSBio Antibodies in human, mouse, rat for PODXL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PODXL gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4