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Aliases for PODNL1 Gene

Aliases for PODNL1 Gene

  • Podocan Like 1 2 3 5
  • SLRR5B 3 4
  • Podocan-Like Protein 1 3

External Ids for PODNL1 Gene

Previous GeneCards Identifiers for PODNL1 Gene

  • GC19M013905
  • GC19M013906
  • GC19M014044
  • GC19M013613

Summaries for PODNL1 Gene

GeneCards Summary for PODNL1 Gene

PODNL1 (Podocan Like 1) is a Protein Coding gene. An important paralog of this gene is PODN.

Additional gene information for PODNL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PODNL1 Gene

Genomics for PODNL1 Gene

Regulatory Elements for PODNL1 Gene

Enhancers for PODNL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H013937 0.9 Ensembl ENCODE 6.8 +15.1 15124 1.7 ZBTB10 RFX1 CEBPB KLF17 ZBTB7A MCM7 ZFP69B POLR2A ZNF692 ZNF600 PODNL1 DCAF15 C19orf57
GH19H013951 1.1 ENCODE 0.7 +0.5 485 2.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 FOS LOC284454 DDX39A DCAF15 RFX1 PODNL1
GH19H013982 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -32.7 -32747 6.5 HDGF PKNOX1 TBL1XR1 SIN3A KLF17 BATF RFX5 ZNF121 GLIS2 SCRT2 IL27RA RFX1 CCDC130 PKN1 DDX39A DCAF15 ADGRE5 ENSG00000275091 PODNL1
GH19H013959 1 Ensembl ENCODE 0.4 -8.6 -8593 5.1 CTCF ZIC2 RAD21 BCL11B ZFHX2 POLR2A FOS NR2F6 ATF7 KLF8 PKN1 PODNL1 ENSG00000275091
GH19H013977 1.3 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -25.7 -25739 2.8 KLF1 GATA3 POLR2A PKN1 ADGRE5 CCDC130 RFX1 ENSG00000275091 PODNL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PODNL1 on UCSC Golden Path with GeneCards custom track

Promoters for PODNL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107464 792 1601 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 FOS

Genomic Locations for PODNL1 Gene

Genomic Locations for PODNL1 Gene
chr19:13,931,187-13,953,392
(GRCh38/hg38)
Size:
22,206 bases
Orientation:
Minus strand
chr19:14,042,000-14,064,204
(GRCh37/hg19)

Genomic View for PODNL1 Gene

Genes around PODNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PODNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PODNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PODNL1 Gene

Proteins for PODNL1 Gene

  • Protein details for PODNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEZ8-PONL1_HUMAN
    Recommended name:
    Podocan-like protein 1
    Protein Accession:
    Q6PEZ8
    Secondary Accessions:
    • B7Z564
    • Q9H5G9

    Protein attributes for PODNL1 Gene

    Size:
    512 amino acids
    Molecular mass:
    56539 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15657.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for PODNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PODNL1 Gene

Post-translational modifications for PODNL1 Gene

No data available for DME Specific Peptides for PODNL1 Gene

Domains & Families for PODNL1 Gene

Gene Families for PODNL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PODNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PEZ8

UniProtKB/Swiss-Prot:

PONL1_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.
genes like me logo Genes that share domains with PODNL1: view

Function for PODNL1 Gene

Gene Ontology (GO) - Molecular Function for PODNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with PODNL1: view
genes like me logo Genes that share phenotypes with PODNL1: view

miRNA for PODNL1 Gene

miRTarBase miRNAs that target PODNL1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PODNL1 Gene

Localization for PODNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PODNL1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PODNL1 gene
Compartment Confidence
extracellular 4
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PODNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005737 cytoplasm IBA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with PODNL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PODNL1 Gene

Pathways & Interactions for PODNL1 Gene

SuperPathways for PODNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PODNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0046426 negative regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with PODNL1: view

No data available for Pathways by source and SIGNOR curated interactions for PODNL1 Gene

Drugs & Compounds for PODNL1 Gene

No Compound Related Data Available

Transcripts for PODNL1 Gene

Unigene Clusters for PODNL1 Gene

Podocan-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PODNL1 Gene

No ASD Table

Relevant External Links for PODNL1 Gene

GeneLoc Exon Structure for
PODNL1
ECgene alternative splicing isoforms for
PODNL1

Expression for PODNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PODNL1 Gene

mRNA differential expression in normal tissues according to GTEx for PODNL1 Gene

This gene is overexpressed in Nerve - Tibial (x4.8) and Artery - Coronary (x4.1).

Protein differential expression in normal tissues from HIPED for PODNL1 Gene

This gene is overexpressed in Plasma (40.3) and Bone marrow mesenchymal stem cell (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PODNL1 Gene



Protein tissue co-expression partners for PODNL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PODNL1 Gene:

PODNL1

SOURCE GeneReport for Unigene cluster for PODNL1 Gene:

Hs.448497

Evidence on tissue expression from TISSUES for PODNL1 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with PODNL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PODNL1 Gene

Orthologs for PODNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PODNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PODNL1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PODNL1 33 34
  • 87.43 (n)
cow
(Bos Taurus)
Mammalia PODNL1 33 34
  • 86.16 (n)
mouse
(Mus musculus)
Mammalia Podnl1 33 16 34
  • 80 (n)
rat
(Rattus norvegicus)
Mammalia Podnl1 33
  • 79.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PODNL1 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PODNL1 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PODNL1 34
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:113307 34
  • 29 (a)
ManyToMany
Species where no ortholog for PODNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PODNL1 Gene

ENSEMBL:
Gene Tree for PODNL1 (if available)
TreeFam:
Gene Tree for PODNL1 (if available)

Paralogs for PODNL1 Gene

Paralogs for PODNL1 Gene

genes like me logo Genes that share paralogs with PODNL1: view

Variants for PODNL1 Gene

Sequence variations from dbSNP and Humsavar for PODNL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000035776 -- 13,931,315(+) GGTCG(C/T)ACAGG downstream-variant-500B, utr-variant-3-prime
rs1000040102 -- 13,941,248(+) GTAAT(C/T)CCAGC intron-variant
rs1000111425 -- 13,954,049(+) TTCTT(A/G)GGGGC intron-variant, upstream-variant-2KB
rs1000279383 -- 13,942,143(+) TCCAT(G/T)GCAAA intron-variant
rs1000880519 -- 13,949,252(+) ACCGT(A/G)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PODNL1 Gene

Variant ID Type Subtype PubMed ID
nsv953979 CNV deletion 24416366
nsv833757 CNV loss 17160897
nsv828451 CNV loss 20364138
esv3428891 CNV duplication 20981092
esv3336175 CNV duplication 20981092

Variation tolerance for PODNL1 Gene

Gene Damage Index Score: 4.47; 64.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PODNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PODNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PODNL1 Gene

Disorders for PODNL1 Gene

Relevant External Links for PODNL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PODNL1

No disorders were found for PODNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PODNL1 Gene

Publications for PODNL1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for PODNL1 Gene

Sources for PODNL1 Gene

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