PODNL1 Gene
protein-coding GIFtS: 41
GCID: GC19M014044
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|
podocan-like 1
| |
Aliases
for PODNL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Podocan-Like 11 2 | | SLRR5B1 2 3 | | FLJ234471 | | Podocan-Like Protein 12 |
Export aliases for PODNL1 gene to outside databasesPrevious GC identifers: GC19M013905 GC19M013906 GC19M013613 |
Summaries
for PODNL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PODNL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PODNL1 gene promoter:
Max1 SRF NF-1/L NF-1 SRF (504 AA) AP-2gamma CHOP-10 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for PODNL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PODNL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.12PODNL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M014044: view genomic region
(about GC identifiers)
Start:
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14,042,000 bp from pter |
End:
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14,064,204 bp from pter |
Size:
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22,205 bases |
Orientation:
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minus strand |
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Proteins
for PODNL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PONL1_HUMAN, Q6PEZ8 (See
protein sequence)Recommended Name: Podocan-like protein 1 precursor Size: 512 amino acids; 56539 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Sequence caution: Sequence=BAB15657.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: B7Z564 Q9H5G9Alternative splicing: 3 isoforms: Q6PEZ8-1 Q6PEZ8-2 Q6PEZ8-3 Explore the universe of human proteins at neXtProt for PODNL1: NX_Q6PEZ8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PEZ8
PODNL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001139726.1 NP_001139727.1 NP_079101.3
ENSEMBL proteins: ENSP00000468630 ENSP00000467395 ENSP00000440080 ENSP00000345175 ENSP00000254320 ENSP00000442553 ENSP00000464972 ENSP00000468225 ENSP00000468151 ENSP00000466659 ENSP00000467495
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005578 | proteinaceous extracellular matrix |
IEA | -- |
PODNL1 for ontologies About GeneDecksing
PODNL1 Antibody Products:
Assay Products for PODNL1: |
Protein
Domains /
Families
for PODNL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PODNL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PEZ8ProtoNet protein and cluster: Q6PEZ8 1 Blocks protein family: IPB000372 Cysteine-rich flanking region
UniProtKB/Swiss-Prot: PONL1_HUMAN, Q6PEZ8Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamilySimilarity: Contains 17 LRR (leucine-rich) repeatsSimilarity: Contains 1 LRRNT domain |
Function
for PODNL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PODNL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PODNL1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PODNL1 (NM_024825) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PODNL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PODNL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PODNL1 |
5 GenomeRNAi human phenotypes for PODNL1:
|
Pathways & Interactions
for PODNL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PODNL1
|
Drugs & Compounds
for PODNL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PODNL1
Search CenterWatch for drugs/clinical trials and news about PODNL1 / PONL1
|
Transcripts
for PODNL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PODNL1 gene (3 alternative transcripts): NM_001146254.1 NM_001146255.1 NM_024825.3 Unigene Cluster for PODNL1: Podocan-like 1 Hs.448497 [show with all ESTs]Unigene Representative Sequence: NM_02482513 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587954 ENST00000588872 ENST00000538517(uc002mxs.3) ENST00000339560(uc002mxr.3)
ENST00000254320 ENST00000538371(uc010xni.2 uc010xnj.2) ENST00000588764
ENST00000591353 ENST00000586075 ENST00000587288 ENST00000585607 ENST00000587458
ENST00000588317
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PODNL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PODNL1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PODNL1 (NM_024825) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PODNL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PODNL1 |
Additional cDNA sequence: AK027100.1 AK290731.1 AK296101.1 AK298489.1 BC052610.1 BC057786.1 5 DOTS entries: DT.101982012 DT.97772922 DT.92414051 DT.95174685 DT.95300816 24/41 AceView cDNA sequences (see all 41): BQ447218 AW134690 AI761790 AA582901 AI625211 BQ774383 AI582382 BC052610 AI935140 BQ897913 AK027100 CF272293 AI149879 AI347894 BU179504 NM_024825 AU253831 BQ448451 BE393393 AU253832 BU633774 BC057786 BQ675525 AI219486
GeneLoc Exon Structure
|
Expression
for PODNL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PODNL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGAGCATCG
About this image
See PODNL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PODNL1
SOURCE GeneReport for Unigene cluster: Hs.448497
SABiosciences Custom PCR Arrays for PODNL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PODNL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PODNL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PODNL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PODNL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PODNL1 |
Orthologs
for PODNL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PODNL1 gene from 2/10 species (see all 10) About this table
ENSEMBL Gene Tree for PODNL1 (if available)
TreeFam Gene Tree for PODNL1 (if available) |
Paralogs
for PODNL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PODNL1 gene
- OGN2 PODN2 OPTC2 FMOD2 PRELP2 KERA2 ASPN2 OMD2
- BGN2 DCN2 EPYC2 ECM22 LUM2
7 SIMAP similar genes for PODNL1 using alignment to 9 protein entries: PONL1_HUMAN (see all proteins):PODN SLIT2 ISLR2 LRTM2 BGN MST161
FLII
PODNL1 for paralogs About GeneDecksing
|
Genomic Variants
for PODNL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PODNL1 (14042000 - 14064204 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for PODNL1
6 CNVs: 89103 89105 78099 78100 89106 5088
5 Indels: 89108 89107 89104 78101 89109 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PODNL1 |
|
Disorders
/ Diseases
for PODNL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for PODNL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PODNL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PODNL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for PODNL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PODNL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PODNL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PODNL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PODNL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PODNL1 gene:
Search GeneIP for patents involving PODNL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PODNL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PODNL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PODNL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PODNL1 | | | OriGene Protein Over-expression Lysate for PODNL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PODNL1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PODNL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PODNL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | PODNL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PODNL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for PODNL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PODNL1 |
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