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Aliases for PODN Gene

Aliases for PODN Gene

  • Podocan 2 3
  • Podocan Proteoglycan 2 3
  • SLRR5A 3 4
  • PCAN 3

External Ids for PODN Gene

Summaries for PODN Gene

GeneCards Summary for PODN Gene

PODN (Podocan) is a Protein Coding gene. GO annotations related to this gene include collagen binding. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for PODN Gene

  • Negatively regulates cell proliferation and cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PODN Gene

Genomics for PODN Gene

Genomic Location for PODN Gene

Start:
53,062,052 bp from pter
End:
53,085,502 bp from pter
Size:
23,451 bases
Orientation:
Plus strand

Genomic View for PODN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PODN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PODN Gene

Regulatory Elements for PODN Gene

Proteins for PODN Gene

  • Protein details for PODN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5L7-PODN_HUMAN
    Recommended name:
    Podocan
    Protein Accession:
    Q7Z5L7
    Secondary Accessions:
    • B4DKN5
    • B4E373
    • Q5VVZ2
    • Q5VVZ3
    • Q6PIR3
    • Q6UXL8
    • Q8N641

    Protein attributes for PODN Gene

    Size:
    613 amino acids
    Molecular mass:
    68976 Da
    Quaternary structure:
    • Binds to type I collagen
    SequenceCaution:
    • Sequence=AAH28292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72591.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PODN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PODN Gene

Proteomics data for PODN Gene at MOPED

Post-translational modifications for PODN Gene

Other Protein References for PODN Gene

No data available for DME Specific Peptides for PODN Gene

Domains for PODN Gene

Gene Families for PODN Gene

HGNC:
  • SLRR :Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

UniProtKB/Swiss-Prot:

PODN_HUMAN
Domain:
  • Contains 1 LRRNT domain.:
    • Q7Z5L7
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.:
    • Q7Z5L7
Similarity:
  • Contains 20 LRR (leucine-rich) repeats.:
    • Q7Z5L7
genes like me logo Genes that share domains with PODN: view

Function for PODN Gene

Molecular function for PODN Gene

UniProtKB/Swiss-Prot Function: Negatively regulates cell proliferation and cell migration.

Gene Ontology (GO) - Molecular Function for PODN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005518 collagen binding IDA 15063725
genes like me logo Genes that share ontologies with PODN: view

Phenotypes for PODN Gene

genes like me logo Genes that share phenotypes with PODN: view

miRNA for PODN Gene

miRTarBase miRNAs that target PODN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PODN Gene

Localization for PODN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PODN Gene

Isoform 1: Secreted, extracellular space, extracellular matrix.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PODN Gene COMPARTMENTS Subcellular localization image for PODN gene
Compartment Confidence
extracellular 5
peroxisome 2
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PODN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 15063725
GO:0005737 cytoplasm IDA 15063725
genes like me logo Genes that share ontologies with PODN: view

Pathways for PODN Gene

SuperPathways for PODN Gene

No Data Available

Interacting Proteins for PODN Gene

Gene Ontology (GO) - Biological Process for PODN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 15063725
GO:0030336 negative regulation of cell migration IDA 15063725
genes like me logo Genes that share ontologies with PODN: view

No data available for Pathways by source for PODN Gene

Transcripts for PODN Gene

Unigene Clusters for PODN Gene

Podocan:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PODN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6: - -
SP7:
SP8: - -

Relevant External Links for PODN Gene

GeneLoc Exon Structure for
PODN
ECgene alternative splicing isoforms for
PODN

Expression for PODN Gene

mRNA expression in normal human tissues for PODN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PODN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PODN Gene

SOURCE GeneReport for Unigene cluster for PODN Gene Hs.586141

mRNA Expression by UniProt/SwissProt for PODN Gene

Q7Z5L7-PODN_HUMAN
Tissue specificity: Kidney, heart, liver, pancreas and vascular smooth muscle cells. Also detected in aortic intima (at protein level).
genes like me logo Genes that share expressions with PODN: view

Orthologs for PODN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PODN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PODN 36
  • 99.29 (n)
  • 99.24 (a)
PODN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PODN 36
  • 89.65 (n)
  • 91.42 (a)
PODN 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PODN 36
  • 90.28 (n)
  • 95.33 (a)
PODN 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Podn 36
  • 87.8 (n)
  • 92.82 (a)
Podn 16
Podn 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PODN 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102552895 36
  • 87.35 (n)
  • 93.13 (a)
chicken
(Gallus gallus)
Aves PODN 36
  • 70.31 (n)
  • 75.89 (a)
PODN 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PODN 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia podn 36
  • 63.49 (n)
  • 65.42 (a)
zebrafish
(Danio rerio)
Actinopterygii podn 36
  • 64.05 (n)
  • 63.43 (a)
podn 37
  • 61 (a)
OneToOne
Species with no ortholog for PODN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PODN Gene

ENSEMBL:
Gene Tree for PODN (if available)
TreeFam:
Gene Tree for PODN (if available)

Paralogs for PODN Gene

Paralogs for PODN Gene

Selected SIMAP similar genes for PODN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PODN: view

Variants for PODN Gene

Sequence variations from dbSNP and Humsavar for PODN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs725509 -- 53,060,432(+) CACAC(A/G)TGGGC upstream-variant-2KB
rs725510 -- 53,060,575(+) CAGGG(C/T)TAGGA upstream-variant-2KB
rs756052 -- 53,076,267(+) CATTG(A/G)GAGGA intron-variant
rs899972 -- 53,077,121(+) TAGAG(G/T)CTCAC intron-variant
rs899973 -- 53,082,623(+) GACTG(C/G)CGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PODN Gene

Variant ID Type Subtype PubMed ID
nsv870582 CNV Gain 21882294
dgv51e1 CNV Complex 17122850
nsv522862 CNV Loss 19592680
essv13816 CNV CNV 17122850
nsv516780 CNV Gain+Loss 19592680
dgv226n71 CNV Loss 21882294
nsv818167 CNV Loss 17921354

Relevant External Links for PODN Gene

HapMap Linkage Disequilibrium report
PODN

Disorders for PODN Gene

(1) University of Copenhagen DISEASES for PODN Gene

Relevant External Links for PODN

Genetic Association Database (GAD)
PODN
Human Genome Epidemiology (HuGE) Navigator
PODN
genes like me logo Genes that share disorders with PODN: view

No data available for UniProtKB/Swiss-Prot for PODN Gene

Publications for PODN Gene

  1. Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. (PMID: 12796502) Ross M.D. … Klotman P.E. (J. Biol. Chem. 2003) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Functional characterization of podocan, a member of a new class in the small leucine-rich repeat protein family. (PMID: 15063725) Shimizu-Hirota R. … Saruta T. (FEBS Lett. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for PODN Gene

Sources for PODN Gene

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