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Aliases for PODN Gene

Aliases for PODN Gene

  • Podocan 2 3 5
  • Podocan Proteoglycan 2 3
  • SLRR5A 3 4
  • PCAN 3

External Ids for PODN Gene

Previous GeneCards Identifiers for PODN Gene

  • GC01P052897
  • GC01P053239
  • GC01P053527
  • GC01P051643

Summaries for PODN Gene

GeneCards Summary for PODN Gene

PODN (Podocan) is a Protein Coding gene. GO annotations related to this gene include collagen binding. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for PODN Gene

  • Negatively regulates cell proliferation and cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PODN Gene

Genomics for PODN Gene

Regulatory Elements for PODN Gene

Enhancers for PODN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PODN on UCSC Golden Path with GeneCards custom track

Promoters for PODN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PODN on UCSC Golden Path with GeneCards custom track

Genomic Location for PODN Gene

53,062,052 bp from pter
53,085,502 bp from pter
23,451 bases
Plus strand

Genomic View for PODN Gene

Genes around PODN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PODN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PODN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PODN Gene

Proteins for PODN Gene

  • Protein details for PODN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DKN5
    • B4E373
    • Q5VVZ2
    • Q5VVZ3
    • Q6PIR3
    • Q6UXL8
    • Q8N641

    Protein attributes for PODN Gene

    613 amino acids
    Molecular mass:
    68976 Da
    Quaternary structure:
    • Binds to type I collagen.
    • Sequence=AAH28292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72591.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PODN Gene


neXtProt entry for PODN Gene

Proteomics data for PODN Gene at MOPED

Post-translational modifications for PODN Gene

Other Protein References for PODN Gene

Antibody Products

  • Abcam antibodies for PODN

No data available for DME Specific Peptides for PODN Gene

Domains & Families for PODN Gene

Gene Families for PODN Gene

Suggested Antigen Peptide Sequences for PODN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRNT domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.
  • Contains 20 LRR (leucine-rich) repeats.
  • Contains 1 LRRNT domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.
  • Contains 20 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PODN: view

Function for PODN Gene

Molecular function for PODN Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates cell proliferation and cell migration.

Gene Ontology (GO) - Molecular Function for PODN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with PODN: view
genes like me logo Genes that share phenotypes with PODN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PODN

miRNA for PODN Gene

miRTarBase miRNAs that target PODN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PODN Gene

Localization for PODN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PODN Gene

Isoform 1: Secreted, extracellular space, extracellular matrix.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.

Subcellular locations from

Jensen Localization Image for PODN Gene COMPARTMENTS Subcellular localization image for PODN gene
Compartment Confidence
extracellular 5
nucleus 2
peroxisome 2
cytosol 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PODN Gene

Pathways & Interactions for PODN Gene

SuperPathways for PODN Gene

No Data Available

Interacting Proteins for PODN Gene

Gene Ontology (GO) - Biological Process for PODN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030336 negative regulation of cell migration IDA 15063725
GO:0046426 negative regulation of JAK-STAT cascade IBA --
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IBA --
genes like me logo Genes that share ontologies with PODN: view

No data available for Pathways by source and SIGNOR curated interactions for PODN Gene

Drugs & Compounds for PODN Gene

No Compound Related Data Available

Transcripts for PODN Gene

Unigene Clusters for PODN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PODN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1: -
SP4: -
SP6: - -
SP8: - -

Relevant External Links for PODN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PODN Gene

mRNA expression in normal human tissues for PODN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PODN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.3).

Protein differential expression in normal tissues from HIPED for PODN Gene

This gene is overexpressed in Gallbladder (12.8) and Lung (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PODN Gene

SOURCE GeneReport for Unigene cluster for PODN Gene Hs.586141

mRNA Expression by UniProt/SwissProt for PODN Gene

Tissue specificity: Kidney, heart, liver, pancreas and vascular smooth muscle cells. Also detected in aortic intima (at protein level).
genes like me logo Genes that share expression patterns with PODN: view

Primer Products

No data available for Protein tissue co-expression partners for PODN Gene

Orthologs for PODN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PODN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PODN 35
  • 89.65 (n)
  • 91.42 (a)
  • 90 (a)
(Canis familiaris)
Mammalia PODN 35
  • 90.28 (n)
  • 95.33 (a)
  • 91 (a)
(Mus musculus)
Mammalia Podn 35
  • 87.8 (n)
  • 92.82 (a)
Podn 16
Podn 36
  • 92 (a)
(Pan troglodytes)
Mammalia PODN 35
  • 99.29 (n)
  • 99.24 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC102552895 35
  • 87.35 (n)
  • 93.13 (a)
(Ornithorhynchus anatinus)
Mammalia PODN 36
  • 78 (a)
(Gallus gallus)
Aves PODN 35
  • 70.31 (n)
  • 75.89 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia PODN 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia podn 35
  • 63.49 (n)
  • 65.42 (a)
(Danio rerio)
Actinopterygii podn 35
  • 64.05 (n)
  • 63.43 (a)
podn 36
  • 61 (a)
Species with no ortholog for PODN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PODN Gene

Gene Tree for PODN (if available)
Gene Tree for PODN (if available)

Paralogs for PODN Gene

Paralogs for PODN Gene

(5) SIMAP similar genes for PODN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PODN: view

Variants for PODN Gene

Sequence variations from dbSNP and Humsavar for PODN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12567021 - 53,078,841(+) GCACA(C/T)GCTGC reference, missense
rs1288389 - 53,078,925(+) GCTGG(C/G/T)GGGCA reference, missense
rs725509 -- 53,060,432(+) CACAC(A/G)TGGGC upstream-variant-2KB
rs725510 -- 53,060,575(+) CAGGG(C/T)TAGGA upstream-variant-2KB
rs899972 -- 53,077,121(+) TAGAG(G/T)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PODN Gene

Variant ID Type Subtype PubMed ID
nsv870582 CNV Gain 21882294
dgv51e1 CNV Complex 17122850
nsv522862 CNV Loss 19592680
essv13816 CNV CNV 17122850
nsv516780 CNV Gain+Loss 19592680
dgv226n71 CNV Loss 21882294
nsv818167 CNV Loss 17921354

Variation tolerance for PODN Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.73; 83.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PODN Gene

Disorders for PODN Gene

Relevant External Links for PODN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PODN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PODN Gene

Publications for PODN Gene

  1. Proteomics characterization of extracellular space components in the human aorta. (PMID: 20551380) Didangelos A. … Mayr M. (Mol. Cell. Proteomics 2010) 3 4 67
  2. Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. (PMID: 24043300) Hutter R. … Klotman P.E. (Circulation 2013) 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for PODN Gene

Sources for PODN Gene