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POC1B-GALNT4 Gene

protein-coding   GIFtS: 22
GCID: GC12M089914

POC1B-GALNT4 Readthrough

  Search for POC1B-GALNT4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POC1B-GALNT4 Readthrough1 2
POC1B-GALNT4 Fusion2
POC1B-GALNT4 Protein2

External Ids:    HGNC: 429571   Entrez Gene: 1005280302   Ensembl: ENSG000002590757   UniProtKB: F8VUJ34   UniProtKB: F8VZB34   

Export aliases for POC1B-GALNT4 gene to outside databases

Previous GC identifer: GC12U901524


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POC1B-GALNT4 Gene:
This locus represents naturally occurring transcripts that splice the 5' exons of the POC1B (POC1 centriolar
protein homolog B) gene on chromosome 12 to the GALNT4 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide
N-acetylgalactosaminyltransferase 4) gene, which is located within a POC1B intron. Alternative splicing results
in two transcript variants, one of which encodes a fusion isoform that shares sequence identity with the products
of each individual gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for POC1B-GALNT4 Gene:
POC1B-GALNT4 (POC1B-GALNT4 readthrough) is a protein-coding gene. An important paralog of this gene is GALNT12.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for POC1B-GALNT4
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POC1B-GALNT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q21.33

POC1B-GALNT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POC1B-GALNT4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M089914:  view genomic region     (about GC identifiers)

Start:
89,913,185 bp from pter      End:
89,920,039 bp from pter
Size:
6,855 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/TrEMBL: F8VUJ3 (See protein sequence)
Recommended Name: Protein POC1B-GALNT4  
Size: 575 amino acids; 66238 Da
Cofactor: Manganese (By similarity)
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F8VZB3 (See protein sequence)

Recommended Name: Protein POC1B-GALNT4  
Size: 42 amino acids; 4501 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

REFSEQ proteins (2 alternative transcripts): 
NP_001186710.1  NP_001186711.1  

ENSEMBL proteins: 
 ENSP00000447852   ENSP00000447754  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR000772 Ricin_B_lectin
 IPR001173 Glyco_trans_2

Graphical View of Domain Structure for InterPro Entry F8VUJ3
Graphical View of Domain Structure for InterPro Entry F8VZB3

ProtoNet protein and cluster: F8VUJ3

UniProtKB/TrEMBL: F8VUJ3
Similarity: Contains ricin B-type lectin domain


Find genes that share domains with POC1B-GALNT4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0016757transferase activity, transferring glycosyl groups ----
     
Find genes that share ontologies with POC1B-GALNT4           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005794Golgi apparatus ----
GO:0016021integral component of membrane ----

Find genes that share ontologies with POC1B-GALNT4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for POC1B-GALNT4 About    
See pathways by source

SuperPathContained pathways About
1O-linked glycosylation of mucins
O-linked glycosylation of mucins0.47
Mucin type O-Glycan biosynthesis0.47
2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Post-translational protein modification0.43
Metabolism of proteins0.30
3Metabolism
Metabolic pathways0.38


Find genes that share SuperPaths with POC1B-GALNT4           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2 Kegg Pathways  (Kegg details for POC1B-GALNT4):
    Mucin type O-Glycan biosynthesis
Metabolic pathways

UniProtKB/TrEMBL: F8VZB3
Pathway: Protein modification; protein glycosylation

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Interactions:

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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006486protein glycosylation ----

Find genes that share ontologies with POC1B-GALNT4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for POC1B-GALNT4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for POC1B-GALNT4 gene (2 alternative transcripts): 
NM_001199781.1  NM_001199782.1  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000548729(uc001tbe.3 uc010suo.2) ENST00000547474
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POC1B-GALNT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
POC1B-GALNT4 Expression
About this image

POC1B-GALNT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for POC1B-GALNT4 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
74(a)
1 → many
GL343332.1(1361662-1363413)
zebrafish
(Danio rerio)
Actinopterygii poc1bl6
POC1 centriolar protein homolog B (Chlamydomonas),...
70(a)
1 → many
19(35717415-35769609) ENSDARG00000012745
        Species with no ortholog for POC1B-GALNT4

ENSEMBL Gene Tree for POC1B-GALNT4 (if available)
TreeFam Gene Tree for POC1B-GALNT4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for POC1B-GALNT4 gene
GALNT122  GALNT12  GALNTL62  GALNT32  GALNT102  GALNT22  GALNT132  GALNT62  
GALNT152  GALNT72  GALNT52  GALNT142  GALNTL52  GALNT42  GALNT162  GALNT112  
Selected SIMAP similar genes for POC1B-GALNT4 using alignment to 2 protein entries:     F8VUJ3_HUMAN (see all proteins) (see all similar genes):
GALNT4    POC1B    WDR51B    GalNAc-T10    POC1A    GALNTL6
GALNT15    GALNT12    GALNT6    GALNT3    GALNT1    GALNTL5
GALNT11    GalNAc-T16    GALNT2    GALNT13    GALNT14    GALNT16

Find genes that share paralogs with POC1B-GALNT4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 1 variation for POC1B-GALNT4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832479CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for POC1B-GALNT4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with POC1B-GALNT4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100528030 HGNC: 42957 Ensembl:ENSG00000259075 euGenes: HUgn100528030 ECgene: POC1B-GALNT4 Kegg: 100528030
H-InvDB: POC1B-GALNT4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for POC1B-GALNT4 gene:
Search GeneIP for patents involving POC1B-GALNT4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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