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POC1A Gene

protein-coding   GIFtS: 45
GCID: GC03M052109

POC1 Centriolar Protein A

(Previous names: WD repeat domain 51A, POC1 centriolar protein homolog A...)
(Previous symbol: WDR51A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POC1 Centriolar Protein A1 2     PIX22 5
WDR51A1 2 3     SOFT2 5
WD Repeat Domain 51A1 2     POC1 Centriolar Protein Homolog A (Chlamydomonas)1
Proteome Of Centriole Protein 1A2 3     POC1 Centriolar Protein Homolog A2
WD Repeat-Containing Protein 51A2 3     Pix23

External Ids:    HGNC: 244881   Entrez Gene: 258862   Ensembl: ENSG000001640877   OMIM: 6147835   UniProtKB: Q8NBT03   

Export aliases for POC1A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POC1A Gene:
POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes.
They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins
found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and
hypotrichosis (SOFT) syndrome. (provided by RefSeq, Sep 2012)

GeneCards Summary for POC1A Gene:
POC1A (POC1 centriolar protein A) is a protein-coding gene. Diseases associated with POC1A include short stature, onychodysplasia, facial dysmorphism, and hypotrichosis, and short stature. An important paralog of this gene is NLE1.

UniProtKB/Swiss-Prot: POC1A_HUMAN, Q8NBT0
Function: Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps
of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B
to ensure centriole integrity and proper mitotic spindle formation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for POC1A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOC1A promoter sequence
   Search Chromatin IP Primers for POC1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POC1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.2

POC1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POC1A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052109:  view genomic region     (about GC identifiers)

Start:
52,109,249 bp from pter      End:
52,188,706 bp from pter
Size:
79,458 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: POC1A_HUMAN, Q8NBT0 (See protein sequence)
Recommended Name: POC1 centriolar protein homolog A  
Size: 407 amino acids; 45009 Da
Subunit: Interacts with POC1B
Sequence caution: Sequence=AAI19694.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAB56021.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4FUW4 E9PFC6 Q0VDF8 Q2TAK6 Q96IK6 Q9UFJ8
Alternative splicing: 3 isoforms:  Q8NBT0-1   Q8NBT0-2   Q8NBT0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for POC1A: NX_Q8NBT0

Explore proteomics data for POC1A at MOPED


See POC1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001155052.1  NP_001155053.1  NP_056241.3  

ENSEMBL proteins: 
 ENSP00000296484   ENSP00000378421   ENSP00000418968  

POC1A Human Recombinant Protein Products:

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Cloud-Clone Corp. ELISAs for POC1A
Cloud-Clone Corp. CLIAs for POC1A


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
WDR: WD repeat domain containing

5 InterPro protein domains:
 IPR019775 WD40_repeat_CS
 IPR001680 WD40_repeat
 IPR020472 G-protein_beta_WD-40_rep
 IPR017986 WD40_repeat_dom
 IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q8NBT0

ProtoNet protein and cluster: Q8NBT0

UniProtKB/Swiss-Prot: POC1A_HUMAN, Q8NBT0
Similarity: Belongs to the WD repeat POC1 family
Similarity: Contains 7 WD repeats


POC1A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: POC1A_HUMAN, Q8NBT0
Function: Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps
of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B
to ensure centriole integrity and proper mitotic spindle formation

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
     
POC1A for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POC1A
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miRNA
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Block miRNA regulation of human, mouse, rat POC1A using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate POC1A:
hsa-miR-188-3p hsa-miR-605 hsa-miR-3176 hsa-miR-3922-3p
SwitchGear 3'UTR luciferase reporter plasmidPOC1A 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat POC1A

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 3): POC1A (NM_015426)
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
POC1A_HUMAN, Q8NBT0: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm,
cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and
daughter centrioles
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton5
cytosol3
nucleus2

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000922spindle pole IDA--
GO:0005737cytoplasm ----
GO:0005813centrosome IDA--
GO:0005814centriole IDA--
GO:0036064ciliary basal body IDA--

POC1A for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POC1A
Interactions:

    Search GeneGlobe Interaction Network for POC1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for POC1A (Q8NBT03 ENSP000002964844) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
InteractantInteraction Details
GeneCardExternal ID(s)
AXIN1O151693I2D: score=1 
AAR2ENSP000003136744STRING: ENSP00000313674
DDX6ENSP000002640184STRING: ENSP00000264018
LSM1ENSP000003105964STRING: ENSP00000310596
LSM3ENSP000003021604STRING: ENSP00000302160
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030030cell projection organization IEA--

POC1A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for POC1A



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for POC1A gene (3 alternative transcripts): 
NM_001161580.1  NM_001161581.1  NM_015426.4  

Unigene Cluster for POC1A:

POC1 centriolar protein homolog A (Chlamydomonas)
Hs.476306  [show with all ESTs]
Unigene Representative Sequence: NM_001161581
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296484 ENST00000394970(uc003dcv.3 uc003dcu.3 uc003dcw.3)
ENST00000474012
miRNA
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Block miRNA regulation of human, mouse, rat POC1A using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate POC1A:
hsa-miR-188-3p hsa-miR-605 hsa-miR-3176 hsa-miR-3922-3p
SwitchGear 3'UTR luciferase reporter plasmidPOC1A 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat POC1A
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GenScript: all cDNA clones in your preferred vector (see all 3): POC1A (NM_015426)
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Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POC1A
  QuantiTect SYBR Green Assays in human, mouse, rat POC1A
  QuantiFast Probe-based Assays in human, mouse, rat POC1A

Additional mRNA sequence: 

AF088072.1 AK075289.1 AK315688.1 AL117629.1 BC007417.2 BC110877.1 BC119692.2 BC119693.2 

3 DOTS entries:

DT.100786330  DT.310232  DT.100786331 

Selected AceView cDNA sequences (see all 144):

CD243955 BG750211 BX366124 CR603119 BC007417 CR617280 BQ072102 CR611109 
CR611523 BQ072005 BQ053484 BU957068 AA705518 AI754571 AL046820 AW001089 
AI754568 BX394024 CR617463 CR608071 BM701085 BU857901 BU857837 CR607157 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for POC1A    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:              -                                                                           
SP2:                                                                          -               
SP3:                                                                                          
SP4:                                                                                          


ECgene alternative splicing isoforms for POC1A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POC1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
POC1A Expression
About this image

POC1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

POC1A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.476306
    Custom PCR Arrays for POC1A
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POC1A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for POC1A gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Poc1a1 , 5 POC1 centriolar protein homolog A (Chlamydomonas)1, 5 89.05(n)1
90.86(a)1
  9 (57.46 cM)5
702351  NM_027354.21  NP_081630.21 
 1062810615 
chicken
(Gallus gallus)
Aves POC1A1 POC1 centriolar protein homolog A (Chlamydomonas) 70.49(n)
75.56(a)
  415889  XM_004944376.1  XP_004944433.1 
lizard
(Anolis carolinensis)
Reptilia POC1A6
POC1 centriolar protein A
69(a)
1 ↔ 1
2(153674332-153713909)
African clawed frog
(Xenopus laevis)
Amphibia MGC691112 hypothetical protein MGC69111 76.49(n)    BC056099.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.210582 Danio rerio cDNA clone MGC56055 IMAGE3820440, complete more 77.66(n)    BC045888.1 
fruit fly
(Drosophila melanogaster)
Insecta Poc11 Proteome of centrioles 1 53.44(n)
46.33(a)
  39502  NM_140383.2  NP_648640.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSA46
WD-repeat protein involved in ribosome biogenesis;...
17(a)
1 → many
III(240805-242352) YCR072C


ENSEMBL Gene Tree for POC1A (if available)
TreeFam Gene Tree for POC1A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for POC1A gene
NLE12  WDR832  POC1B2  WDR52  ATG16L12  SNRNP402  WDR5B2  PAFAH1B12  
SMU12  DAW12  WDR382  ATG16L22  
12 SIMAP similar genes for POC1A using alignment to 1 protein entry:     POC1A_HUMAN:
DKFZp762M0115    POC1B    POC1B-GALNT4    WDR51B    PF20    WDR5B
TUWD12    WDR5    WDR48    WSB1    DAW1    GNB2

POC1A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for POC1A (see all 1335)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0688844
Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT)4--see VAR_0688842 L P mis40--------
rs1448770011,2
C--52041287(+) CAAGAA/GGCTGA 3 -- int10--------
rs759855981,2
C,F--52041336(+) CATTTG/CTCCTG 3 -- int11Minor allele frequency- C:0.03WA 118
rs1124199191,2
F--52041478(+) TGCAAG/AGGCTC 3 -- int12Minor allele frequency- A:0.02CSA WA 119
rs751019461,2
C--52041532(+) GGGGTA/CCTGGC 3 -- int10--------
rs1174905411,2
C,F--52041732(+) AACACG/ATGTGG 3 -- ut311Minor allele frequency- A:0.03EA 120
rs1814542711,2
--52041766(+) AGCCAA/CCACCC 3 -- ut310--------
rs7473431,2
C,F,A,H--52041790(+) TGTTCT/CCAACA 3 -- ut3125Minor allele frequency- C:0.36MN NS EA NA WA CSA 2887
rs783226061,2
C,F--52041879(+) TCAATT/CTCTAC 3 -- ut311Minor allele frequency- C:0.03WA 118
rs8930561,2
C,F,A,H--52041947(+) GCATCG/ATGGAG 3 -- ut31 ese325Minor allele frequency- A:0.14MN NS EA NA WA CSA 2886

HapMap Linkage Disequilibrium report for POC1A (52109249 - 52188706 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for POC1A:    About this table    
Variant IDTypeSubtypePubMed ID
nsv508923CNV Insertion20534489
nsv508926CNV Insertion20534489
nsv876786CNV Loss21882294
nsv460537CNV Loss19166990
nsv508218CNV Loss20534489
nsv470572CNV Loss18288195
nsv834694CNV Gain17160897
nsv520211CNV Gain19592680
nsv519445CNV Gain+Loss19592680

Human Gene Mutation Database (HGMD): POC1A
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing POC1A
DNA2.0 Custom Variant and Variant Library Synthesis for POC1A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614783   
OMIM disorders: 614813  
UniProtKB/Swiss-Prot: POC1A_HUMAN, Q8NBT0
  • Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) [MIM:614813]: A syndrome
    characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies.
    Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected
    individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is
    present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is
    normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected
    individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and
    fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include
    short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis
    and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped
    epiphyses. Vertebral body ossification is also delayed. Note=The disease is caused by mutations affecting the
    gene represented in this entry. Cells derived from affected individuals have abnormal mitotic mechanics with
    multipolar spindles, in addition to clearly impaired ciliogenesis

  • 7 diseases for POC1A:    
    About MalaCards
    short stature, onychodysplasia, facial dysmorphism, and hypotrichosis    short stature    hypotrichosis    dwarfism
    brachydactyly    multiple myeloma    myeloma


    POC1A for disorders           About GeneDecksing


    Export disorders for POC1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POC1A gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with POC1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. (PubMed id 19109428)1, 2, 3 Keller L.C....Marshall W.F. (Mol. Biol. Cell 2009)
    2. Poc1A and Poc1B act together in human cells to ensure centriole integrity. (PubMed id 23015594)1, 2 Venoux M....Fry A.M. (J. Cell. Sci. 2013)
    3. Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis syndrome is caused by a POC1A mutation. (PubMed id 22840363)1, 2 Sarig O....Sprecher E. (Am. J. Hum. Genet. 2012)
    4. POC1A truncation mutation causes a ciliopathy in humans characterized by primordial dwarfism. (PubMed id 22840364)1, 2 Shaheen R.... Alkuraya F.S. (Am. J. Hum. Genet. 2012)
    5. Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells. (PubMed id 18068700)1, 2 Hames R.S.... Fry A.M. (Exp. Cell Res. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25886 HGNC: 24488 AceView: DKFZP434C245 Ensembl:ENSG00000164087 euGenes: HUgn25886
    ECgene: POC1A H-InvDB: POC1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POC1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POC1A gene:
    Search GeneIP for patents involving POC1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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