Aliases for PNRC2 Gene
External Ids for PNRC2 Gene
Previous GeneCards Identifiers for PNRC2 Gene
GeneCards Summary for PNRC2 Gene
PNRC2 (Proline Rich Nuclear Receptor Coactivator 2) is a Protein Coding gene. An important paralog of this gene is PNRC1.
UniProtKB/Swiss-Prot for PNRC2 Gene
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5 UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).