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PNRC2 Gene

protein-coding   GIFtS: 50
GCID: GC01P024285

Proline-Rich Nuclear Receptor Coactivator 2

  Search for PNRC2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proline-Rich Nuclear Receptor Coactivator 21 2

External Ids:    HGNC: 231581   Entrez Gene: 556292   Ensembl: ENSG000001892667   OMIM: 6118825   UniProtKB: Q9NPJ43   

Export aliases for PNRC2 gene to outside databases

Previous GC identifers: GC01P023346 GC01M117667 GC01P9A0092 GC01P9A4031 GC01P024031 GC01P024158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PNRC2 Gene:
PNRC2 (proline-rich nuclear receptor coactivator 2) is a protein-coding gene. An important paralog of this gene is PNRC1.

UniProtKB/Swiss-Prot: PNRC2_HUMAN, Q9NPJ4
Function: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex
and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping
machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor
coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure

Gene Wiki entry for PNRC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PNRC2 gene promoter:
         RP58   MEF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Cdc5   Evi-1   MEF-2A   Nkx6-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPNRC2 promoter sequence
   Search Chromatin IP Primers for PNRC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PNRC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

PNRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNRC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024285:  view genomic region     (about GC identifiers)

Start:
24,285,599 bp from pter      End:
24,289,952 bp from pter
Size:
4,354 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PNRC2_HUMAN, Q9NPJ4 (See protein sequence)
Recommended Name: Proline-rich nuclear receptor coactivator 2  
Size: 139 amino acids; 15591 Da
Subunit: Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form. Interacts with DCP1A.
Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR
1 PDB 3D structure from and Proteopedia for PNRC2:
4B6H (3D)    
Secondary accessions: B4DU72
Alternative splicing: 2 isoforms:  Q9NPJ4-1   Q9NPJ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PNRC2: NX_Q9NPJ4

Explore proteomics data for PNRC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys86
  • Modification sites at PhosphoSitePlus

  • See PNRC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060231.1  
    ENSEMBL proteins: 
     ENSP00000464216   ENSP00000334840   ENSP00000363592   ENSP00000462379  

    PNRC2 Human Recombinant Protein Products:

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    Novus Biologicals PNRC2 Protein
    Novus Biologicals PNRC2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PNRC2

     
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    LSBio Antibodies in human, mouse, rat for PNRC2

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    Cloud-Clone Corp. ELISAs for PNRC2
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    Search eBioscience for ELISAs for PNRC2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR028322 PNRC
     IPR026781 PNRC2

    Graphical View of Domain Structure for InterPro Entry Q9NPJ4

    ProtoNet protein and cluster: Q9NPJ4

    UniProtKB/Swiss-Prot: PNRC2_HUMAN, Q9NPJ4
    Domain: The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif
    Similarity: Belongs to the PNRC family. PNRC2 subfamily


    Find genes that share domains with PNRC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PNRC2_HUMAN, Q9NPJ4
    Function: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex
    and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping
    machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor
    coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19150429
         
    Find genes that share ontologies with PNRC2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PNRC2:
     Increased circadian period len  Synthetic lethal with c-Myc af 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pnrc2):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  liver/biliary system 

    Find genes that share phenotypes with PNRC2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pnrc2tm1Shch for PNRC2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PNRC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PNRC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PNRC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PNRC2

    miRNA
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    Block miRNA regulation of human, mouse, rat PNRC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PNRC2 (see all 38):
    hsa-miR-4291 hsa-miR-3146 hsa-miR-15a hsa-miR-503 hsa-miR-128 hsa-miR-550a* hsa-miR-424 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidPNRC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PNRC2
    Predesigned siRNA for gene silencing in human, mouse, rat PNRC2

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    GenScript: all cDNA clones in your preferred vector: PNRC2 (NM_017761)
    Sino Biological Human cDNA Clone for PNRC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PNRC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNRC2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for PNRC2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNRC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PNRC2_HUMAN, Q9NPJ4: Nucleus. Cytoplasm, P-body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA19150429
    GO:0005634nucleus IDA19150429

    Find genes that share ontologies with PNRC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PNRC2
    Interactions:

        Search GeneGlobe Interaction Network for PNRC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for PNRC2 (Q9NPJ41, 2, 3 ENSP000003348404) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR5A1Q132852, 3, ENSP000003626904MINT-15668 MINT-15669 I2D: score=2 STRING: ENSP00000362690
    RARAP102762, 3, ENSP000002540664MINT-14834 I2D: score=2 STRING: ENSP00000254066
    SPAG9O602712, 3, ENSP000002620134MINT-8267030 I2D: score=2 STRING: ENSP00000262013
    ZBTB48P100742, 3, ENSP000003669024MINT-8267052 I2D: score=2 STRING: ENSP00000366902
    XRCC6P129562, 3MINT-8267041 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA19150429
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0031087deadenylation-independent decapping of nuclear-transcribed mRNA TAS19150429

    Find genes that share ontologies with PNRC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PNRC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PNRC2 gene: 
    NM_017761.3  

    Unigene Clusters for PNRC2:

    Proline-rich nuclear receptor coactivator 2
    Hs.7862  [show with all ESTs], Hs.512636  [show with all ESTs]
    Unigene Representative Sequences: XM_003846416, NM_017761
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471915 ENST00000334351(uc001big.3) ENST00000374468 ENST00000579103

    miRNA
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    Block miRNA regulation of human, mouse, rat PNRC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PNRC2 (see all 38):
    hsa-miR-4291 hsa-miR-3146 hsa-miR-15a hsa-miR-503 hsa-miR-128 hsa-miR-550a* hsa-miR-424 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidPNRC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PNRC2
    Predesigned siRNA for gene silencing in human, mouse, rat PNRC2
    Clone
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    OriGene ORF clones in mouse, rat for PNRC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PNRC2 (NM_017761)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNRC2
    Primer
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    OriGene qPCR primer pairs and template standards for PNRC2
    OriGene qSTAR qPCR primer pairs in human, mouse for PNRC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PNRC2
      QuantiTect SYBR Green Assays in human, mouse, rat PNRC2
      QuantiFast Probe-based Assays in human, mouse, rat PNRC2

    Additional mRNA sequence: 

    AF151042.1 AF374386.1 AK000319.1 AK024774.1 AK311305.1 BC001959.1 BC078177.1 

    22 DOTS entries:

    DT.100827894  DT.316990  DT.91765350  DT.121431718  DT.121431747  DT.100827890  DT.95250263  DT.121463832 
    DT.99995595  DT.121431734  DT.99946394  DT.101954646  DT.91765355  DT.91854560  DT.99940840  DT.100827889 
    DT.100827897  DT.121431710  DT.121431720  DT.121463877  DT.91765351  DT.121431737 

    Selected AceView cDNA sequences (see all 378):

    BQ436222 BM476917 BE350743 CK430974 BM788490 CF139535 AA769205 AI273653 
    AI624702 BI711159 BQ423903 AW840173 BQ892943 BM786565 BF001737 CB163074 
    AI829468 AA040037 BE407789 BG287639 BP367350 AI240994 AW614414 R71244 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PNRC2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                          -                                             
    SP2:        -     -     -     -                                             
    SP3:                          -                                             
    SP4:                          -                                             
    SP5:                          -                                             


    ECgene alternative splicing isoforms for PNRC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PNRC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGAAGCA
    PNRC2 Expression
    About this image


    PNRC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    PNRC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PNRC2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.7862 Hs.512636

    UniProtKB/Swiss-Prot: PNRC2_HUMAN, Q9NPJ4
    Tissue specificity: Expressed in heart, lung, muscle and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNRC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PNRC2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pnrc21 , 5 proline-rich nuclear receptor coactivator 21, 5 86.33(n)1
    82.73(a)1
      4 (68.01 cM)5
    528301  NM_026383.31  NP_080659.11 
     1358709185 
    chicken
    (Gallus gallus)
    Aves PNRC21 proline-rich nuclear receptor coactivator 2 79.38(n)
    75.54(a)
      419688  NM_001006315.1  NP_001006315.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    1 → many
    GL343498.1(55272-55682)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA988100.12   -- 80.17(n)    CA988100.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pnrc21 proline-rich nuclear receptor coactivator 2 58.59(n)
    54.55(a)
      565522  NM_001130192.1  NP_001123664.1 


    ENSEMBL Gene Tree for PNRC2 (if available)
    TreeFam Gene Tree for PNRC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PNRC2 gene
    PNRC12  ENSG000002157002  
    2 SIMAP similar genes for PNRC2 using alignment to 2 protein entries:     PNRC2_HUMAN (see all proteins):
    PNRC1    PROL2

    Find genes that share paralogs with PNRC2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for PNRC2 (see all 7)
    PGOHUM00000235354 PGOHUM00000263143 PGOHUM00000236270 PGOHUM00000263226 PGOHUM00000263240


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PNRC2 (see all 84)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439173871,2
    C--24284358(+) GTTTTC/GCCATG 1 -- us2k10--------
    rs1145681871,2
    C--24284706(+) ACCACA/GTACTT 1 -- us2k10--------
    rs1512965691,2
    C--24284805(+) ATGCAA/GTAACT 1 -- us2k10--------
    rs2014055751,2
    C--24285122(+) GGAGGC/TGGAGG 1 -- us2k10--------
    rs1499929211,2
    C--24285318(+) CCCAG-/AATT  
            
    ATTCA
    1 -- us2k10--------
    rs1446950011,2
    C--24285371(+) GGGTTA/GCTTAT 1 -- us2k10--------
    rs1165889511,2
    C--24285521(+) CAAACG/TTACTG 1 -- us2k10--------
    rs1405841921,2
    C--24286067(+) TCGGCA/GGGCCA 1 -- us2k10--------
    rs3762529641,2
    C--24286071(+) CGGGCC/TGGGGC 1 -- us2k10--------
    rs1438083411,2
    C--24286082(+) CGCGGA/GGAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PNRC2 (24285599 - 24289952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PNRC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676255CNV Deletion23128226
    esv2662136CNV Deletion23128226
    nsv6742CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PNRC2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611882    OMIM disorders: --


    Find genes that share disorders with PNRC2           About GenesLikeMe


    Export disorders for PNRC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PNRC2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with PNRC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif. (PubMed id 11574675)1, 2, 3 Zhou D. and Chen S. (Nucleic Acids Res. 2001)
    2. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PubMed id 14651967)1, 2, 9 Hentschke M. and Borgmeyer U. (Biochem. Biophys. Res. Commun. 2003)
    3. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PubMed id 19150429)1, 2 Cho H.... Kim Y.K. (Mol. Cell 2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    8. Structural basis of the PNRC2-mediated link between mrna surveillance and decapping. (PubMed id 23085078)1 Lai T....Song H. (Structure 2012)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55629 HGNC: 23158 AceView: PNRC2 Ensembl:ENSG00000189266 euGenes: HUgn55629
    ECgene: PNRC2 H-InvDB: PNRC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PNRC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PNRC2 gene:
    Search GeneIP for patents involving PNRC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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