PNRC1 Gene
protein-coding GIFtS: 49
GCID: GC06P089790
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|
proline-rich nuclear receptor coactivator 1(Previous name: proline rich 2 )
(Previous symbol: PROL2)
| |
Aliases
for PNRC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Proline-Rich Nuclear Receptor Coactivator 11 2 | | Proline Rich 21 | | PROL21 2 3 5 | | PNAS-1452 | | B4-21 2 | | Proline Rich 2 Protein2 | | PRR21 2 | | Proline-Rich Polypeptide 22 | | Proline-Rich Protein 22 3 | | Proline-Rich Protein With Nuclear Targeting Signal2 | | Protein B4-22 3 | | |
Export aliases for PNRC1 gene to outside databasesPrevious GC identifers: GC06P089740 GC06P089786 GC06P089847 GC06P087006 |
Summaries
for PNRC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796Function: Nuclear receptor coactivator. May play a role in signal transduction
Gene Wiki entry for PNRC1
|
Genomic Views
for PNRC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PNRC1 gene promoter:
NF-YA IRF-1 CBF-C CBF-A CBF-B STAT3 CP1A CP1C NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for PNRC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNRC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q16.1PNRC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P089790: view genomic region
(about GC identifiers)
Start:
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89,790,429 bp from pter |
End:
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89,794,879 bp from pter |
Size:
|
4,451 bases |
Orientation:
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plus strand |
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Proteins
for PNRC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796 (See
protein sequence)Recommended Name: Proline-rich nuclear receptor coactivator 1 Size: 327 amino acids; 35225 Da
Subunit: Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR.Interacts with GRB2
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=CAI16244.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R6Q0 E1P515 Q5T7J6Explore the universe of human proteins at neXtProt for PNRC1: NX_Q12796
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12796
PNRC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006804.1
ENSEMBL proteins: ENSP00000358484 ENSP00000336931 ENSP00000347000
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
PNRC1 for ontologies About GeneDecksing
PNRC1 Antibody Products:
Assay Products for PNRC1: |
Protein
Domains /
Families
for PNRC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PNRC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q12796ProtoNet protein and cluster: Q12796 UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796Domain: The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motifSimilarity: Belongs to the PNRC family. PNRC1 subfamily |
Function
for PNRC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796Function: Nuclear receptor coactivator. May play a role in signal transduction
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNRC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNRC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNRC1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
PNRC1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PNRC1:
|
Pathways & Interactions
for PNRC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNRC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/17 Interacting proteins for PNRC1 (Q127961, 2, 3 ENSP000003369314) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
PNRC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PNRC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PNRC1
Search CenterWatch for drugs/clinical trials and news about PNRC1
|
Transcripts
for PNRC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PNRC1 gene: NM_006813.2 Unigene Cluster for PNRC1: Proline-rich nuclear receptor coactivator 1 Hs.75969 [show with all ESTs]Unigene Representative Sequence: NM_0068133 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369472 ENST00000336032(uc003pmv.3 uc021zcp.1 uc003pmx.3)
ENST00000354922
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNRC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNRC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PNRC1 (NM_006813) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNRC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNRC1 |
Additional cDNA sequence: AF279899.1 AK130046.1 AK130722.1 AK312665.1 AY303779.1 BC018112.1 BC044919.1 U03105.1 17 DOTS entries: DT.117670 DT.100732049 DT.100760315 DT.101985087 DT.95110847 DT.95110862 DT.91761323 DT.95110814 DT.100772474 DT.91761329 DT.95110859 DT.100878491 DT.121307369 DT.121307396 DT.100878498 DT.95110818 DT.95110860 24/303 AceView cDNA sequences (see all 303): AI634530 CR602604 CR607268 AI470996 CK819358 CR608318 AV709974 BU742459 BF224012 F31774 AL041474 BM696758 BQ574784 AW298165 AI342298 AI174552 AI217377 AW183338 BM727932 BQ416734 CA307294 CR603217 AI302121 CB158460
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PNRC1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | |
| SP3: | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PNRC1
|
Expression
for PNRC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PNRC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTTTGTTT
About this image
See PNRC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PNRC1
SOURCE GeneReport for Unigene cluster: Hs.75969
UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796Tissue specificity: Expressed in liver, lung, fat and NK/T cells
SABiosciences Custom PCR Arrays for PNRC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNRC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PNRC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNRC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNRC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNRC1 |
Orthologs
for PNRC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PNRC1 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PNRC11 |
proline-rich nuclear receptor coactivator 1 |
68.59(n)
64.26(a) |
|
421817 NM_001012291.1 NP_001012291.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PNRC16 |
-- |
46(a) |
1 ↔ 1 |
1(175233834-175241424) |
zebrafish
(Danio rerio) |
Actinopterygii |
pnrc16 |
proline-rich nuclear receptor coactivator 1 |
26(a) |
1 ↔ 1 |
20(1144767-1148704) |
ENSEMBL Gene Tree for PNRC1 (if available)
TreeFam Gene Tree for PNRC1 (if available) |
Paralogs
for PNRC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PNRC1 gene
- LOC1009966262 PNRC22
2 SIMAP similar genes for PNRC1 using alignment to 2 protein entries: PNRC1_HUMAN (see all proteins):PROL2 PNRC2
PNRC1 for paralogs About GeneDecksing
|
Genomic Variants
for PNRC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PNRC1 (89790429 - 89794879 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PNRC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNRC1 |
|
Disorders
/ Diseases
for PNRC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PNRC1 for disorders About GeneDecksing
OMIM gene information: 606714
OMIM disorders: --
3  diseases for PNRC1: About MalaCardsuremic neuropathy neuropathy prostatitis
Human Genome Epidemiology (HuGE) Navigator: PNRC1 (2 documents)
Export disorders for PNRC1 gene to outside databases
|
Publications
for PNRC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PNRC1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with PNRC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning a cDNA from human NK/T cells which codes for a protein with high proline content. (PubMed id 7578250)1, 2, 3 Chen J.... Pohajdak B. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif. (PubMed id 11574675)1, 2 Zhou D. and Chen S. (2001)
- PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1). (PubMed id 10894149)1, 2 Zhou D.... Chen S. (2000)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- [Transcriptional regulation of the human gene coding for proline-rich nuclear receptor coactivator (pnrc) by regulatory factor x (rfx1)] (PubMed id 19334528)1 Zhang Y....Zhou D.J. (2009)
- Transcriptional regulation of the human PNRC promoter by NFY in HepG2 cells. (PubMed id 18281297)1 Zhang Y....Zhou D. (2008)
- Identification and characterization of PNRC splicing variants. (PubMed id 18703122)1 Wang Y....Zhou D. (2008)
|
External Searches for PNRC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PNRC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PNRC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PNRC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PNRC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PNRC1 gene:
Search GeneIP for patents involving PNRC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PNRC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PNRC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNRC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNRC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PNRC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNRC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNRC1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNRC1 |
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