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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PNRC1 Gene

protein-coding   GIFtS: 52
GCID: GC06P089790

Proline-Rich Nuclear Receptor Coactivator 1

(Previous name: proline rich 2)
(Previous symbol: PROL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proline-Rich Nuclear Receptor Coactivator 11 2     PNAS-1452
PROL21 2 3 5     PRR22
Proline-Rich Protein 22 3     Proline Rich 2 Protein2
Protein B4-22 3     Proline-Rich Polypeptide 22
Proline Rich 21     Proline-Rich Protein With Nuclear Targeting Signal2
B4-22     

External Ids:    HGNC: 172781   Entrez Gene: 109572   Ensembl: ENSG000001462787   OMIM: 6067145   UniProtKB: Q127963   

Export aliases for PNRC1 gene to outside databases

Previous GC identifers: GC06P089740 GC06P089786 GC06P089847 GC06P087006


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PNRC1 Gene: 
PNRC1 (proline-rich nuclear receptor coactivator 1) is a protein-coding gene. Diseases associated with PNRC1 include uremic neuropathy, and neuropathy. GO annotations related to this gene include protein binding. An important paralog of this gene is LOC100996626.

UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796
Function: Nuclear receptor coactivator. May play a role in signal transduction

Gene Wiki entry for PNRC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PNRC1 gene promoter:
         NF-YA   IRF-1   CBF-C   CBF-A   CBF-B   STAT3   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPNRC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PNRC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q16.1

PNRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNRC1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P089790:  view genomic region     (about GC identifiers)

Start:
89,790,429 bp from pter      End:
89,794,879 bp from pter
Size:
4,451 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796 (See protein sequence)
Recommended Name: Proline-rich nuclear receptor coactivator 1  
Size: 327 amino acids; 35225 Da
Subunit: Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and
RXR. Interacts with GRB2
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=CAI16244.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R6Q0 E1P515 Q5T7J6

Explore the universe of human proteins at neXtProt for PNRC1: NX_Q12796

Explore proteomics data for PNRC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12796

  • PNRC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PNRC1 Protein Expression
    REFSEQ proteins: NP_006804.1  
    ENSEMBL proteins: 
     ENSP00000358484   ENSP00000336931   ENSP00000347000  

    Human Recombinant Protein Products for PNRC1: 
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    Cloud-Clone Corp. Proteins for PNRC1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    PNRC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026780 PNRC1/2

    Graphical View of Domain Structure for InterPro Entry Q12796

    ProtoNet protein and cluster: Q12796

    UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796
    Domain: The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif
    Similarity: Belongs to the PNRC family. PNRC1 subfamily


    PNRC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PNRC1_HUMAN, Q12796
    Function: Nuclear receptor coactivator. May play a role in signal transduction

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17612402
         
    PNRC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PNRC1:
     Decreased p24 protein expressi  Increased G1 DNA content 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidPNRC1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNRC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/17 Interacting proteins for PNRC1 (Q127961, 2, 3 ENSP000003369314) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102762, 3, ENSP000002540664MINT-5209956 I2D: score=1 STRING: ENSP00000254066
    POLR3FQ9H1D91, 3, ENSP000003668284EBI-2827376,EBI-710067 I2D: score=1 STRING: ENSP00000366828
    MAPK8P459832, 3, ENSP000003534834MINT-8262330 I2D: score=2 STRING: ENSP00000353483
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    PNRC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PNRC1

    Search CenterWatch for drugs/clinical trials and news about PNRC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PNRC1 gene: 
    NM_006813.2  

    Unigene Cluster for PNRC1:

    Proline-rich nuclear receptor coactivator 1
    Hs.75969  [show with all ESTs]
    Unigene Representative Sequence: NM_006813
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369472 ENST00000336032(uc003pmv.3 uc021zcp.1 uc003pmx.3)
    ENST00000354922
    miRNA
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    hsa-miR-4307 hsa-miR-300 hsa-miR-199a-3p hsa-miR-16-1* hsa-miR-219-5p hsa-miR-301a hsa-miR-374a hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidPNRC1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNRC1
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    Additional mRNA sequence: 

    AF279899.1 AK130046.1 AK130722.1 AK312665.1 AY303779.1 BC018112.1 BC044919.1 U03105.1 

    17 DOTS entries:

    DT.117670  DT.100732049  DT.100760315  DT.101985087  DT.95110847  DT.95110862  DT.91761323  DT.95110814 
    DT.100772474  DT.91761329  DT.95110859  DT.100878491  DT.121307369  DT.121307396  DT.413809  DT.95110818 
    DT.95110860 

    24/303 AceView cDNA sequences (see all 303):

    AW593796 BM128582 CR595339 AU133861 AA936237 CK819357 CB158460 BE644693 
    AW183338 AW514378 AW440955 AW304112 BM684751 AV709974 AA872421 AI174552 
    AL041474 CR603217 CR608318 BI493979 BU682948 CR624105 T58262 BQ959640 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PNRC1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -     -               
    SP3:                    -               
    SP4:                                    


    ECgene alternative splicing isoforms for PNRC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PNRC1 expression in normal human tissues (normalized intensities)      PNRC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTTTGTTT
    PNRC1 Expression
    About this image


    PNRC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See PNRC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PNRC1

    SOURCE GeneReport for Unigene cluster: Hs.75969

    UniProtKB/Swiss-Prot: PNRC1_HUMAN, Q12796
    Tissue specificity: Expressed in liver, lung, fat and NK/T cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PNRC1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pnrc11 , 5 proline-rich nuclear receptor coactivator 11, 5 81.82(n)1
    83.5(a)1
      4 (14.75 cM)5
    1087671  NM_001033225.21  NP_001028397.21 
     332454235 
    chicken
    (Gallus gallus)
    Aves PNRC11 proline-rich nuclear receptor coactivator 1 68.59(n)
    64.26(a)
      421817  NM_001012291.1  NP_001012291.1 
    lizard
    (Anolis carolinensis)
    Reptilia PNRC16
    Uncharacterized protein
    48(a)
    1 ↔ 1
    1(175233834-175241424)
    zebrafish
    (Danio rerio)
    Actinopterygii pnrc16
    proline-rich nuclear receptor coactivator 1
    26(a)
    1 ↔ 1
    20(1144767-1148704)


    ENSEMBL Gene Tree for PNRC1 (if available)
    TreeFam Gene Tree for PNRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PNRC1 gene
    LOC1009966262  PNRC22  
    2 SIMAP similar genes for PNRC1 using alignment to 2 protein entries:     PNRC1_HUMAN (see all proteins):
    PROL2    PNRC2

    PNRC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/169 SNPs in PNRC1 are shown (see all 169)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1174551271,2
    C,F--89788490(+) GGAAGC/TATTTT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1926118301,2
    --89788594(+) GAGGCA/GGTGAG 1 -- us2k10--------
    rs783849011,2
    C,F--89788625(+) CTGTGG/ATCTTC 1 -- us2k11Minor allele frequency- A:0.05EA 120
    rs1849487421,2
    --89788626(+) TGTGGG/TCTTCT 1 -- us2k10--------
    rs1389606341,2
    --89788627(+) GTGGTC/TTTCTA 1 -- us2k10--------
    rs1889833801,2
    --89788667(+) GACGCA/GGTGGC 1 -- us2k10--------
    rs1421851711,2
    --89788769(+) CCGTCG/TCTACT 1 -- us2k10--------
    rs347333531,2
    C,F--89788797(+) GCTGGC/GCGTGG 1 -- us2k110Minor allele frequency- G:0.48NA WA CSA EA 371
    rs1463664361,2
    C--89788871(+) CGGAGA/GTTGCA 1 -- us2k10--------
    rs1165891391,2
    F--89788925(+) TGACAC/AGCCGT 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for PNRC1 (89790429 - 89794879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PNRC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv886336CNV Loss21882294
    nsv886337CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606714    OMIM disorders: --

    3 diseases for PNRC1:    About MalaCards
    uremic neuropathy    neuropathy    prostatitis


    PNRC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PNRC1
    Human Genome Epidemiology (HuGE) Navigator: PNRC1 (2 documents)

    Export disorders for PNRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PNRC1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with PNRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning a cDNA from human NK/T cells which codes for a protein with high proline content. (PubMed id 7578250)1, 2, 3 Chen J.... Pohajdak B. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif. (PubMed id 11574675)1, 2 Zhou D. and Chen S. (2001)
    5. PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1). (PubMed id 10894149)1, 2 Zhou D.... Chen S. (2000)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. [Transcriptional regulation of the human gene coding for proline-rich nuclear receptor coactivator (pnrc) by regulatory factor x (rfx1)] (PubMed id 19334528)1 Zhang Y....Zhou D.J. (2009)
    10. Transcriptional regulation of the human PNRC promoter by NFY in HepG2 cells. (PubMed id 18281297)1 Zhang Y....Zhou D. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10957 HGNC: 17278 AceView: PNRC1 Ensembl:ENSG00000146278 euGenes: HUgn10957
    ECgene: PNRC1 H-InvDB: PNRC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PNRC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PNRC1 gene:
    Search GeneIP for patents involving PNRC1

    GeneCards and IP:
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