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Aliases for PNPT1 Gene

Aliases for PNPT1 Gene

  • Polyribonucleotide Nucleotidyltransferase 1 2 3 5
  • Polynucleotide Phosphorylase-Like Protein 3 4
  • Polynucleotide Phosphorylase 1 3 4
  • 3-5 RNA Exonuclease OLD35 3 4
  • PNPase Old-35 3 4
  • EC 2.7.7.8 4 61
  • PNPase 1 3 4
  • PNPASE 3 4
  • Polyribonucleotide Nucleotidyltransferase 1, Mitochondrial 3
  • Deafness, Autosomal Recessive 70 2
  • Polynucleotide Phosphorylase 2
  • 3-5 RNA Exonuclease 2
  • EC 2.7.7 61
  • COXPD13 3
  • Old-35 3
  • DFNB70 3
  • OLD35 3

External Ids for PNPT1 Gene

Previous HGNC Symbols for PNPT1 Gene

  • DFNB70

Previous GeneCards Identifiers for PNPT1 Gene

  • GC02M055820
  • GC02M055837
  • GC02M055836
  • GC02M055774
  • GC02M055715
  • GC02M055861

Summaries for PNPT1 Gene

Entrez Gene Summary for PNPT1 Gene

  • The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]

GeneCards Summary for PNPT1 Gene

PNPT1 (Polyribonucleotide Nucleotidyltransferase 1) is a Protein Coding gene. Diseases associated with PNPT1 include Combined Oxidative Phosphorylation Deficiency 13 and Deafness, Autosomal Recessive 70. Among its related pathways are Purine metabolism (KEGG) and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for PNPT1 Gene

  • RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3-to-5 direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3 overhang double-stranded RNA with a 3-to-5 directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3-to-5 exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNPT1 Gene

Genomics for PNPT1 Gene

Regulatory Elements for PNPT1 Gene

Enhancers for PNPT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F055614 1.2 ENCODE 9.9 +76.6 76573 5.0 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RPS27A CFAP36 LINC01813 LOC105374667 ENSG00000203327 LOC100128027 ENSG00000272606 PNPT1 PRORSD1P PPP4R3B
GH02F055692 1.1 ENCODE 10.7 +0.3 310 1.9 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS SP3 SP5 RPS27A ENSG00000203327 CFAP36 PNPT1 GC02M055689
GH02F055608 1.1 Ensembl ENCODE 9.8 +83.8 83842 2.9 ELF3 SOX13 ZNF146 SAP130 TAL1 ARID4B ZNF48 TEAD3 YY1 POLR2A ENSG00000212175 PNPT1 GC02P055601 ENSG00000272606
GH02F055105 1.8 FANTOM5 Ensembl ENCODE 4.8 +582.3 582310 12.0 HDGF PKNOX1 ARNT MLX SIN3A ARID4B ZNF2 FOS ZNF263 SP3 RTN4 CLHC1 LOC100128027 RPS27A PNPT1 CCDC88A GC02M055111 GC02P055105
GH02F055482 0.8 Ensembl 7.6 +211.4 211410 0.6 JUN HIC1 ZNF791 POLR2A ZNF366 NR2F6 ZNF600 NR2F1 ZEB2 ATF2 RPS27A PNPT1 GC02P055475 RNU6-634P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PNPT1 on UCSC Golden Path with GeneCards custom track

Promoters for PNPT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122446 10 2600 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS SP3

Genomic Location for PNPT1 Gene

Chromosome:
2
Start:
55,634,063 bp from pter
End:
55,693,910 bp from pter
Size:
59,848 bases
Orientation:
Minus strand

Genomic View for PNPT1 Gene

Genes around PNPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNPT1 Gene

Proteins for PNPT1 Gene

  • Protein details for PNPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCS8-PNPT1_HUMAN
    Recommended name:
    Polyribonucleotide nucleotidyltransferase 1, mitochondrial
    Protein Accession:
    Q8TCS8
    Secondary Accessions:
    • Q53SU0
    • Q68CN1
    • Q7Z7D1
    • Q8IWX1
    • Q96T05
    • Q9BRU3
    • Q9BVX0

    Protein attributes for PNPT1 Gene

    Size:
    783 amino acids
    Molecular mass:
    85951 Da
    Quaternary structure:
    • Homotrimer; in free form. Homooligomer. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. Interacts with TCL1A; the interaction has no effect on PNPT1 exonuclease activity.

    Three dimensional structures from OCA and Proteopedia for PNPT1 Gene

neXtProt entry for PNPT1 Gene

Selected DME Specific Peptides for PNPT1 Gene

Q8TCS8:
  • LESNGSSS
  • RQKAAAAG
  • SNGSSSMA
  • IDRSIRP

Post-translational modifications for PNPT1 Gene

  • Ubiquitination at Lys 591
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PNPT1

Domains & Families for PNPT1 Gene

Gene Families for PNPT1 Gene

Suggested Antigen Peptide Sequences for PNPT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCS8

UniProtKB/Swiss-Prot:

PNPT1_HUMAN :
  • Contains 1 KH domain.
  • Belongs to the polyribonucleotide nucleotidyltransferase family.
Domain:
  • Contains 1 KH domain.
  • Contains 1 S1 motif domain.
Family:
  • Belongs to the polyribonucleotide nucleotidyltransferase family.
genes like me logo Genes that share domains with PNPT1: view

Function for PNPT1 Gene

Molecular function for PNPT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.
UniProtKB/Swiss-Prot Function:
RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3-to-5 direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3 overhang double-stranded RNA with a 3-to-5 directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3-to-5 exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells upon senescence and terminal differentiation. Up-regulated after treatment with IFNB1/IFN-beta.

Enzyme Numbers (IUBMB) for PNPT1 Gene

Gene Ontology (GO) - Molecular Function for PNPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IDA 19509288
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with PNPT1: view
genes like me logo Genes that share phenotypes with PNPT1: view

Human Phenotype Ontology for PNPT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PNPT1 Gene

MGI Knock Outs for PNPT1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PNPT1 Gene

Localization for PNPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNPT1 Gene

Cytoplasm. Mitochondrion. Mitochondrion intermembrane space; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNPT1 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 3
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PNPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 16055741
GO:0005739 mitochondrion IEA,IDA 16055741
GO:0005758 mitochondrial intermembrane space IEA,IDA 16966381
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with PNPT1: view

Pathways & Interactions for PNPT1 Gene

genes like me logo Genes that share pathways with PNPT1: view

Pathways by source for PNPT1 Gene

Gene Ontology (GO) - Biological Process for PNPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000957 mitochondrial RNA catabolic process IDA 18501193
GO:0000958 mitochondrial mRNA catabolic process IDA 20691904
GO:0000962 positive regulation of mitochondrial RNA catabolic process IDA 19509288
GO:0000964 mitochondrial RNA 5-end processing IMP 18083837
GO:0000965 mitochondrial RNA 3-end processing IMP 18083837
genes like me logo Genes that share ontologies with PNPT1: view

No data available for SIGNOR curated interactions for PNPT1 Gene

Drugs & Compounds for PNPT1 Gene

(7) Drugs for PNPT1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0

(9) Additional Compounds for PNPT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PNPT1: view

Transcripts for PNPT1 Gene

Unigene Clusters for PNPT1 Gene

Polyribonucleotide nucleotidyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNPT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a ·
SP1: -
SP2: - -
SP3: - -
SP4:

ExUns: 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:

Relevant External Links for PNPT1 Gene

GeneLoc Exon Structure for
PNPT1
ECgene alternative splicing isoforms for
PNPT1

Expression for PNPT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PNPT1 Gene

Protein differential expression in normal tissues from HIPED for PNPT1 Gene

This gene is overexpressed in Lymph node (15.4) and Adrenal (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PNPT1 Gene



Protein tissue co-expression partners for PNPT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PNPT1 Gene:

PNPT1

SOURCE GeneReport for Unigene cluster for PNPT1 Gene:

Hs.388733
genes like me logo Genes that share expression patterns with PNPT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PNPT1 Gene

Orthologs for PNPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PNPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNPT1 34 35
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia PNPT1 34 35
  • 91.25 (n)
dog
(Canis familiaris)
Mammalia PNPT1 34 35
  • 90.04 (n)
rat
(Rattus norvegicus)
Mammalia Pnpt1 34
  • 88.45 (n)
mouse
(Mus musculus)
Mammalia Pnpt1 34 16 35
  • 87.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PNPT1 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNPT1 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNPT1 34 35
  • 77.62 (n)
lizard
(Anolis carolinensis)
Reptilia PNPT1 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pnpt1 34
  • 74.88 (n)
Str.3686 34
zebrafish
(Danio rerio)
Actinopterygii pnpt1 34
  • 64.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010791 34
  • 55.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11337 34 35
  • 55.22 (n)
worm
(Caenorhabditis elegans)
Secernentea BE0003N10.1 34 35
  • 49.31 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14580 34
  • 50.75 (n)
Species where no ortholog for PNPT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PNPT1 Gene

ENSEMBL:
Gene Tree for PNPT1 (if available)
TreeFam:
Gene Tree for PNPT1 (if available)

Paralogs for PNPT1 Gene

Pseudogenes.org Pseudogenes for PNPT1 Gene

genes like me logo Genes that share paralogs with PNPT1: view

No data available for Paralogs for PNPT1 Gene

Variants for PNPT1 Gene

Sequence variations from dbSNP and Humsavar for PNPT1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs397514598 Combined oxidative phosphorylation deficiency 13 (COXPD13) [MIM:614932], Pathogenic 55,667,007(-) ATTTC(A/G)AAGAG nc-transcript-variant, reference, missense
rs397514599 Deafness, autosomal recessive, 70 (DFNB70) [MIM:614934], Pathogenic 55,656,148(-) ATCTG(A/G)AGTCC nc-transcript-variant, reference, missense
rs778100619 Pathogenic 55,672,999(+) TATTT(A/G)TTGGG nc-transcript-variant, reference, stop-gained
rs780383722 Pathogenic 55,684,952(+) TATTC(A/G)ACTTG nc-transcript-variant, reference, stop-gained
rs879255657 Pathogenic 55,647,421(-) GCGTA(C/G)CAATA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PNPT1 Gene

Variant ID Type Subtype PubMed ID
esv22582 CNV gain 19812545
esv2759050 CNV gain 17122850
esv2760573 CNV gain 21179565
esv2762645 CNV loss 21179565
esv3575244 CNV gain 25503493
esv3590859 CNV gain 21293372
nsv442740 CNV gain 18776908
nsv514069 CNV gain 21397061
nsv520581 CNV loss 19592680
nsv834080 CNV loss 17160897
nsv9791 CNV gain 18304495
nsv9802 CNV gain 18304495

Variation tolerance for PNPT1 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.01; 93.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNPT1 Gene

Human Gene Mutation Database (HGMD)
PNPT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNPT1 Gene

Disorders for PNPT1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PNPT1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 13
  • coxpd13
deafness, autosomal recessive 70
  • autosomal recessive nonsyndromic deafness 70
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
dfnb70 nonsyndromic hearing loss and deafness
  • deafness, autosomal recessive 70
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
- elite association - COSMIC cancer census association via MalaCards
Search PNPT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PNPT1_HUMAN
  • Combined oxidative phosphorylation deficiency 13 (COXPD13) [MIM:614932]: A mitochondrial disorder characterized by early onset severe encephalomyopathy, dystonia, choreoathetosis, bucofacial dyskinesias and combined mitochondrial respiratory chain deficiency. Nerve conductions velocities are decreased. Levels of plasma and cerebrospinal fluid lactate are increased. {ECO:0000269 PubMed:23084291}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Deafness, autosomal recessive, 70 (DFNB70) [MIM:614934]: A form of non-syndromic deafness characterized by severe, bilateral hearing impairment with prelingual onset, resulting in inability to acquire normal speech. {ECO:0000269 PubMed:23084290}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PNPT1

Genetic Association Database (GAD)
PNPT1
Human Genome Epidemiology (HuGE) Navigator
PNPT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNPT1
genes like me logo Genes that share disorders with PNPT1: view

No data available for Genatlas for PNPT1 Gene

Publications for PNPT1 Gene

  1. Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330- kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. (PMID: 19509288) Wang D.D. … Lee W.H. (J. Biol. Chem. 2009) 3 4 22 64
  2. Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts. (PMID: 18083836) Portnoy V. … Schuster G. (RNA 2008) 3 4 22 64
  3. Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA. (PMID: 18083837) Slomovic S. … Schuster G. (RNA 2008) 3 4 22 64
  4. Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis. (PMID: 16966381) Chen H.W. … French S.W. (Mol. Cell. Biol. 2006) 3 4 22 64
  5. Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence. (PMID: 16055741) Sarkar D. … Fisher P.B. (Mol. Cell. Biol. 2005) 3 4 22 64

Products for PNPT1 Gene

Sources for PNPT1 Gene

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