PNPLA8 Gene
protein-coding GIFtS: 53
GCID: GC07M108110
|
|
patatin-like phospholipase domain containing 8
| |
Aliases
for PNPLA8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Patatin-Like Phospholipase Domain Containing 81 2 | | IPLA2(GAMMA)2 | | IPLA2G1 2 3 | | Calcium-Independent Phospholipase A2-Gamma2 | | IPLA2-21 2 | | IPLA2 Gamma2 | | IPLA2gamma1 | | Membrane-Associated Calcium-Independent Phospholipase A2 Gamma2 | | Intracellular Membrane-Associated Calcium-Independent Phospholipase A2 Gamma2 3 | | EC 3.1.1.53 | | Patatin-Like Phospholipase Domain-Containing Protein 82 3 | | IPLA223 | | PNPLA-Gamma1 | | IPLA2-21 2 | | IPLA2-Gamma1 | | |
Export aliases for PNPLA8 gene to outside databasesPrevious GC identifers: GC07M107898 GC07M102480 |
Summaries
for PNPLA8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PNPLA8:
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this familyare phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene isa calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)
UniProtKB/Swiss-Prot: PLPL8_HUMAN, Q9NP80Function: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position ofglycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids
Gene Wiki entry for PNPLA8
|
Genomic Views
for PNPLA8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PNPLA8 gene promoter:
TBP AP-4 C/EBPalpha PPAR-gamma1 Ik-2 FOXO4 TFIID Sox9 PPAR-gamma2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for PNPLA8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNPLA8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31PNPLA8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M108110: view genomic region
(about GC identifiers)
Start:
|
108,110,866 bp from pter |
End:
|
108,210,110 bp from pter |
Size:
|
99,245 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 107,479,283-107,533,853 |
|
Proteins
for PNPLA8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PLPL8_HUMAN, Q9NP80 (See
protein sequence)Recommended Name: Calcium-independent phospholipase A2-gamma Size: 782 amino acids; 88477 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Golgi apparatusmembrane; Single-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity)
Sequence caution: Sequence=AAF67630.1; Type=Erroneous initiation; Sequence=BAA92090.1; Type=Erroneous initiation;Sequence=EAL24384.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D0S1 C9JZI4 O95035 Q8N3I3 Q9H7T5 Q9NR17 Q9NUN2 Q9NZ79Alternative splicing: 3 isoforms: Q9NP80-1 Q9NP80-2 Q9NP80-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PNPLA8: NX_Q9NP80
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NP80
PNPLA8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001242936.1 NP_001242937.1 NP_001242938.1 NP_001242939.1 NP_001242940.1 NP_056538.1
ENSEMBL proteins: ENSP00000394988 ENSP00000257694 ENSP00000410804 ENSP00000387789 ENSP00000406779 ENSP00000402274 ENSP00000406033 ENSP00000391872 ENSP00000373380 Reactome Protein details: Q9NP80
Human Recombinant Protein Products for PNPLA8:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
PNPLA8 for ontologies About GeneDecksing
PNPLA8 Antibody Products:
Assay Products for PNPLA8: |
Protein
Domains /
Families
for PNPLA8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PNPLA8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NP80ProtoNet protein and cluster: Q9NP80 UniProtKB/Swiss-Prot: PLPL8_HUMAN, Q9NP80Similarity: Contains 1 patatin domain |
Function
for PNPLA8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PLPL8_HUMAN, Q9NP80Function: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position ofglycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipidsCatalytic activity: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylateEnzyme regulation: Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL)Biophysicochemical properties: pH dependence: Optimum pH is 8.0; Enzyme Number (IUBMB): EC 3.1.1.51
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PNPLA8 for ontologies About GeneDecksing
Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pnpla8):
PNPLA8 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Pnpla8tm1Rigr for PNPLA8
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNPLA8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNPLA8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PNPLA8 (NM_015723) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNPLA8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNPLA8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNPLA8 |
|
Pathways & Interactions
for PNPLA8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Acyl chain remodelling of PE | | | 2 | Glycerophospholipid biosynthesis | | | 3 | Immune response CD16 signaling in NK cells | | | 4 | Metabolism | | | 5 | Arachidonic acid metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PNPLA8
1  GeneGo (Thomson Reuters) Pathway for PNPLA8
2  BioSystems Pathways for PNPLA8
5/6 
Reactome Pathways for PNPLA8 (see all 6)
PNPLA8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNPLA8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for PNPLA8 (Q9NP802 ENSP000002576944) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
PNPLA8 for ontologies About GeneDecksing
|
Drugs & Compounds
for PNPLA8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PNPLA8 for compounds About GeneDecksing
 Browse Tocris compounds for PNPLA8
10/11 HMDB Compounds for PNPLA8 (see all 11) About this table
5 Novoseek chemical compound relationships for PNPLA8 gene About this table
Search CenterWatch for drugs/clinical trials and news about PNPLA8 / PLPL8
|
Transcripts
for PNPLA8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PNPLA8 gene (6 alternative transcripts): NM_001256007.1 NM_001256008.1 NM_001256009.1 NM_001256010.1 NM_001256011.1 NM_015723.3 Unigene Cluster for PNPLA8: Patatin-like phospholipase domain containing 8 Hs.617340 [show with all ESTs]Unigene Representative Sequence: NM_01572313 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426128 ENST00000257694(uc003vfh.1 uc003vfj.1 uc003vfk.1)
ENST00000422087(uc003vff.1) ENST00000453144(uc003vfi.1) ENST00000436062
ENST00000453085 ENST00000483879 ENST00000476592 ENST00000462466 ENST00000489738
ENST00000427008 ENST00000415498 ENST00000388728
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNPLA8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNPLA8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PNPLA8 (NM_015723) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNPLA8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNPLA8 |
Additional cDNA sequence: AB041261.1 AF217519.1 AF263613.1 AF263947.1 AK002115.1 AK024335.1 AK291755.1 AL834147.1 BC005203.1 BC032999.2 BX647865.1 16 DOTS entries: DT.452540 DT.95169205 DT.40308590 DT.95221619 DT.99962051 DT.121054263 DT.100822973 DT.100822978 DT.121054186 DT.100822976 DT.100822981 DT.101962439 DT.121054254 DT.91750908 DT.100822971 DT.40270565 24/156 AceView cDNA sequences (see all 156): AK024335 BC032999 AB041261 AA489199 BQ435349 BM836713 BX419604 BU753851 CB132746 BQ011861 NM_015723 BM693651 AA429979 AI093502 CD671470 BQ420940 AA565952 BF725714 AA503094 CB242948 CB146742 CB961593 BF438996 AF263613
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PNPLA8 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PNPLA8
|
Expression
for PNPLA8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PNPLA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTATGGCA
About this image
See PNPLA8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PNPLA8
SOURCE GeneReport for Unigene cluster: Hs.617340
UniProtKB/Swiss-Prot: PLPL8_HUMAN, Q9NP80Tissue specificity: Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver andpancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscleand heart
SABiosciences Custom PCR Arrays for PNPLA8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNPLA8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PNPLA8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNPLA8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNPLA8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNPLA8 |
Orthologs
for PNPLA8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PNPLA8 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PNPLA81 |
patatin-like phospholipase domain containing 8 |
68.65(n)
62.87(a) |
|
417785 NM_001130737.1 NP_001124209.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PNPLA86 |
-- |
57(a) |
1 ↔ 1 |
5(56403078-56436209) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.121592 |
Transcribed sequence with moderate similarity to protein more |
76.87(n) |
|
BX729395.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.222882 |
Transcribed sequence with moderate similarity to protein more |
75.89(n) |
|
57062428 |
mosquito
(Anopheles gambiae) |
Insecta |
AgaP_AGAP0099561 |
AGAP009956-PA |
46.58(n)
41.75(a) |
|
1279373 XM_319089.4 XP_319089.4 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y73B6BL.41 |
Protein Y73B6BL.4 |
49.17(n)
38.66(a) |
|
177396 NM_068568.3 NP_500969.1 |
ENSEMBL Gene Tree for PNPLA8 (if available)
TreeFam Gene Tree for PNPLA8 (if available) |
Paralogs
for PNPLA8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PNPLA8 gene
- PLA2G62
PNPLA8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PNPLA8
PGOHUM00000242000
|
Genomic Variants
for PNPLA8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PNPLA8 (108110866 - 108210110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PNPLA8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNPLA8 |
|
Disorders
/ Diseases
for PNPLA8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PNPLA8 for disorders About GeneDecksing
OMIM gene information: 612123
OMIM disorders: --
2  diseases for PNPLA8: About MalaCardsschizophrenia hepatitis
Human Genome Epidemiology (HuGE) Navigator: PNPLA8 (2 documents)
Export disorders for PNPLA8 gene to outside databases
|
Publications
for PNPLA8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PNPLA8 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with PNPLA8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel intracellular membrane-bound calcium-independent phospholipase A(2). (PubMed id 10833412)1, 2, 3 Tanaka H....Sumimoto H. (2000)
- The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium- independent phospholipase A(2). (PubMed id 10744668)1, 2, 3 Mancuso D.J.... Gross R.W. (2000)
- Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2. (PubMed id 15695510)1, 2, 9 Murakami M.... Kudo I. (2005)
- Mammalian patatin domain containing proteins: a famil y with diverse lipolytic activities involved in multiple biological functions. (PubMed id 19029121)1, 3 Kienesberger P.C....Zechner R. (2009)
- Characterization of the human patatin-like phospholipase family. (PubMed id 16799181)1, 3 Wilson P.A.... Crowther D.J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. (PubMed id 17213206)1, 9 Mancuso D.J....Gross R.W. (2007)
- Identification and distribution of endoplasmic reticulum iPLA2. (PubMed id 15629460)2, 9 Kinsey G.R.... Schnellmann R.G. (2005)
- Large-scale genome-wide association study of Asian pop ulation reveals genetic factors in FRMD4A and other loci influencing smoking ini tiation and nicotine dependence. (PubMed id 22006218)1 Yoon D....Park T. (2012)
|
External Searches for PNPLA8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PNPLA8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PNPLA8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PNPLA8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PNPLA8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PNPLA8 gene:
Search GeneIP for patents involving PNPLA8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PNPLA8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PNPLA8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PNPLA8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNPLA8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PNPLA8 | | OriGene 3'-UTR Clone for PNPLA8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNPLA8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNPLA8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PNPLA8 | | OriGene Custom Protein Services for PNPLA8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PNPLA8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNPLA8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNPLA8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PNPLA8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNPLA8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNPLA8 |
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| | | | Search Tocris compounds for PNPLA8 |
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 | | | PNPLA8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNPLA8 |
|  |  |  |  | | | | ThermoFisher Antibodies for PNPLA8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNPLA8 |
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