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PNPLA7 Gene

protein-coding   GIFtS: 50
GCID: GC09M140354

Patatin-Like Phospholipase Domain Containing 7

(Previous name: chromosome 9 open reading frame 111)
(Previous symbol: C9orf111)
  Search for PNPLA7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Patatin-Like Phospholipase Domain Containing 71 2     NTEL12
C9orf1111 2 3     Patatin-Like Phospholipase Domain-Containing Protein 72
Chromosome 9 Open Reading Frame 1111     EC 3.1.1.-3
NTE-R12     EC 3.1.1.58

External Ids:    HGNC: 247681   Entrez Gene: 3757752   Ensembl: ENSG000001306537   OMIM: 6121225   UniProtKB: Q6ZV293   

Export aliases for PNPLA7 gene to outside databases

Previous GC identifers: GC09M139474 GC09M109818


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PNPLA7 Gene:
Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation
and have been induced by metabolic stimuli (Wilson et al., 2006 (PubMed 16799181)).(supplied by OMIM, Jun 2008)

GeneCards Summary for PNPLA7 Gene:
PNPLA7 (patatin-like phospholipase domain containing 7) is a protein-coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is PNPLA6.

UniProtKB/Swiss-Prot: PLPL7_HUMAN, Q6ZV29
Function: Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads
to distal axonopathy (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PNPLA7 gene promoter:
         E2F-3a   E2F-4   E2F-5   Tal-1   E2F-2   Nkx2-5   E47   NRF-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPNPLA7 promoter sequence
   Search Chromatin IP Primers for PNPLA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PNPLA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

PNPLA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNPLA7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M140354:  view genomic region     (about GC identifiers)

Start:
140,354,404 bp from pter      End:
140,444,986 bp from pter
Size:
90,583 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLPL7_HUMAN, Q6ZV29 (See protein sequence)
Recommended Name: Patatin-like phospholipase domain-containing protein 7  
Size: 1317 amino acids; 145733 Da
Sequence caution: Sequence=BAB71033.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI14579.1; Type=Erroneous gene model prediction;
Secondary accessions: B5MDD3 Q5T364 Q658X0 Q658Y3 Q6ZTS1 Q86YU8 Q8TAY5 Q96N75 Q9H7N5
Alternative splicing: 5 isoforms:  Q6ZV29-1   Q6ZV29-2   Q6ZV29-3   Q6ZV29-4   Q6ZV29-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PNPLA7: NX_Q6ZV29

Explore proteomics data for PNPLA7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn728, Asn975, Asn1014, Asn1233
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PNPLA7 (Q6ZV29) (see all 5)
     WRYVRASM  LVLGGGGARG  CVRQLEVVKSS  RQADCILIVGLGDQEP 


    See PNPLA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092007.1  NP_689499.3  

    ENSEMBL proteins: 
     ENSP00000360512   ENSP00000277531   ENSP00000400582   ENSP00000436165   ENSP00000384610  

    PNPLA7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PNPLA7

     
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    PNPLA7 Assay Products:

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    Search eBioscience for ELISAs for PNPLA7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PNPLA: Patatin-like phospholipase domain containing

    5 InterPro protein domains:
     IPR016035 Acyl_Trfase/lysoPLipase
     IPR018490 cNMP-bd-like
     IPR002641 Patatin/PLipase_A2-rel
     IPR000595 cNMP-bd_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q6ZV29

    ProtoNet protein and cluster: Q6ZV29

    1 Blocks protein domain: IPB000595 Cyclic nucleotide-binding domain

    UniProtKB/Swiss-Prot: PLPL7_HUMAN, Q6ZV29
    Similarity: Belongs to the NTE family
    Similarity: Contains 3 cyclic nucleotide-binding domains
    Similarity: Contains 1 patatin domain


    Find genes that share domains with PNPLA7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLPL7_HUMAN, Q6ZV29
    Function: Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads
    to distal axonopathy (By similarity)

         Enzyme Numbers (IUBMB): EC 3.1.1.52 EC 3.1.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with PNPLA7           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PNPLA7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PNPLA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PNPLA7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PNPLA7

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNPLA7

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLPL7_HUMAN, Q6ZV29: Membrane; Single-pass membrane protein (Potential). Nucleus membrane; Single-pass membrane
    protein (By similarity). Mitochondrion membrane; Single-pass membrane protein (By similarity). Lysosome membrane;
    Single-pass membrane protein (By similarity). Microsome membrane; Single-pass membrane protein (By similarity).
    Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    mitochondrion5
    nucleus5
    vacuole5
    endoplasmic reticulum3
    cytoskeleton1
    cytosol1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--
    GO:0031966mitochondrial membrane IEA--

    Find genes that share ontologies with PNPLA7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PNPLA7 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62


    Find genes that share SuperPaths with PNPLA7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for PNPLA7):
        Glycerophospholipid metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PNPLA7
    Interactions:

        Search GeneGlobe Interaction Network for PNPLA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PNPLA7 (Q6ZV293 ENSP000003846104) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAM2O153943I2D: score=1 
    PRKAA2P546463I2D: score=1 
    JMJD7-PLA2G4BENSP000003718864STRING: ENSP00000371886
    LCATENSP000002640054STRING: ENSP00000264005
    LPCAT3ENSP000002614074STRING: ENSP00000261407
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process IEA--
    GO:0008152metabolic process ----

    Find genes that share ontologies with PNPLA7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PNPLA7 (PLPL7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PNPLA7 gene (2 alternative transcripts): 
    NM_001098537.1  NM_152286.3  

    Unigene Cluster for PNPLA7:

    Patatin-like phospholipase domain containing 7
    Hs.294147  [show with all ESTs]
    Unigene Representative Sequence: AK122590
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371457 ENST00000492278 ENST00000469998 ENST00000277531(uc011mfa.1)
    ENST00000434090 ENST00000487228 ENST00000491019 ENST00000406427(uc010ncj.1 uc004cnf.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PNPLA7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PNPLA7
    SwitchGear 3'UTR luciferase reporter plasmidPNPLA7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PNPLA7
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PNPLA7 (NM_152286)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PNPLA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNPLA7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PNPLA7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PNPLA7
      QuantiTect SYBR Green Assays in human, mouse, rat PNPLA7
      QuantiFast Probe-based Assays in human, mouse, rat PNPLA7

    Additional mRNA sequence: 

    AK024443.1 AK055880.1 AK122590.1 AK125060.1 AK126267.1 AK127249.1 AK127340.1 AK297623.1 
    AK310060.1 AL832856.1 AL832944.1 BC025663.1 

    10 DOTS entries:

    DT.304123  DT.91832895  DT.101982754  DT.92009687  DT.101982753  DT.40196118  DT.95293772  DT.121161643 
    DT.304122  DT.91654192 

    Selected AceView cDNA sequences (see all 420):

    BM023184 AI193500 BU538804 CR595636 BQ924661 CB128829 BG820116 BM789830 
    BQ431599 BM850507 BC072412 BF516182 AK024443 CB107009 BF930109 AW250181 
    BM826052 AI027552 BQ185487 BF513129 BU902603 BU556889 CA425370 CB529512 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PNPLA7 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                                              -                                                                     
    SP2:                                                                          -                                                         
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for PNPLA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PNPLA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PNPLA7 Expression
    About this image

    PNPLA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PNPLA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.294147
        Custom PCR Arrays for PNPLA7
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNPLA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PNPLA7 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pnpla71 , 5 patatin-like phospholipase domain containing 71, 5 80.73(n)1
    82.53(a)1
      2 (16.88 cM)5
    2412741  NM_146251.41  NP_666363.31 
     249760335 
    chicken
    (Gallus gallus)
    Aves PNPLA71 patatin-like phospholipase domain containing 7 72.01(n)
    76.6(a)
      427774  NM_001130742.1  NP_001124214.1 
    lizard
    (Anolis carolinensis)
    Reptilia PNPLA76
    patatin-like phospholipase domain containing 7
    69(a)
    1 ↔ 1
    GL344697.1(887-26133)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.175122 Transcribed sequence with moderate similarity to protein more 77.76(n)    BX732921.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pnpla7b1 patatin-like phospholipase domain containing 7b 66.31(n)
    69.37(a)
      503936  XM_687184.5  XP_692276.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta sws1 swiss cheese 53.47(n)
    47.81(a)
      31716  NM_078520.3  NP_511075.3 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK370.41 ZK370.4 48.27(n)
    44.92(a)
      176225  NM_066525.2  NP_498926.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTE1(YML059C)4 Serine esterase, homolog of human neuropathy target more   --   13(158258-153219) 854943  NP_013652.1 


    ENSEMBL Gene Tree for PNPLA7 (if available)
    TreeFam Gene Tree for PNPLA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PNPLA7 gene
    PNPLA62  
    1 SIMAP similar gene for PNPLA7 using alignment to 3 protein entries:     PLPL7_HUMAN (see all proteins):
    PNPLA6

    Find genes that share paralogs with PNPLA7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PNPLA7 (see all 2366)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735697531,2
    C,F--109911220(+) TCTCAT/CGCAGA 2 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1826727161,2
    C--109911368(+) CATCCC/GCCAAA 2 -- us2k10--------
    rs727651691,2
    C,F--109911400(+) ATACAG/CAGATG 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1509428901,2
    C--109911451(+) GAAATA/GATCCG 2 -- us2k10--------
    rs586366911,2
    C,F--140355814(+) GTGGGA/GACACG 2 -- int11Minor allele frequency- G:0.03WA 118
    rs2004902561,2
    C--140355946(+) AGGAGG/TTCACG 2 -- int10--------
    rs1997829031,2
    --140355981(+) GCCTCC/TACTCA 2 -- int10--------
    rs2013178511,2
    --140356009(+) CTTGGC/TGGGCT 4 T A mis10--------
    rs1441464761,2
    F--140356010(+) TTGGCG/AGGCTC 4 /P syn11Minor allele frequency- A:0.00NA 4522
    rs1382878141,2
    C,F--140356012(+) GGCGGG/ACTCAA 4 /P /S mis11Minor allele frequency- A:0.01NA 4518

    HapMap Linkage Disequilibrium report for PNPLA7 (140354404 - 140444986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PNPLA7 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739454CNV Deletion23290073
    esv2739456CNV Deletion23290073
    esv2739455CNV Deletion23290073
    esv1491510CNV Deletion17803354
    esv2007027CNV Deletion18987734
    esv2739457CNV Deletion23290073
    esv1920878CNV Deletion18987734
    dgv1388e199CNV Deletion23128226
    esv992019CNV Insertion20482838
    nsv6772CNV Insertion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612122    OMIM disorders: --


    Find genes that share disorders with PNPLA7           About GenesLikeMe


    Export disorders for PNPLA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PNPLA7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PNPLA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. (PubMed id 19029121)1, 3 Kienesberger P.C.... Zechner R. (J. Lipid Res. 2009)
    2. Characterization of the human patatin-like phospholipase family. (PubMed id 16799181)1, 3 Wilson P.A.... Crowther D.J. (J. Lipid Res. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. (PubMed id 12640454)1, 3 Winrow C.J....Barlow C. (Nat. Genet. 2003)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375775 HGNC: 24768 AceView: NELFandC9orf111 Ensembl:ENSG00000130653 euGenes: HUgn375775
    ECgene: PNPLA7 Kegg: 375775 H-InvDB: PNPLA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PNPLA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PNPLA7 gene:
    Search GeneIP for patents involving PNPLA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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