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Aliases for PNPLA7 Gene

Aliases for PNPLA7 Gene

  • Patatin-Like Phospholipase Domain Containing 7 2 3
  • C9orf111 3 4
  • Patatin-Like Phospholipase Domain-Containing Protein 7 3
  • Chromosome 9 Open Reading Frame 111 2
  • EC 3.1.1.5 64
  • EC 3.1.1.- 4
  • NTE-R1 3
  • NTEL1 3

External Ids for PNPLA7 Gene

Previous Symbols for PNPLA7 Gene

  • C9orf111

Summaries for PNPLA7 Gene

Entrez Gene Summary for PNPLA7 Gene

  • Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]).[supplied by OMIM, Jun 2008]

GeneCards Summary for PNPLA7 Gene

PNPLA7 (Patatin-Like Phospholipase Domain Containing 7) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is PNPLA6.

UniProtKB/Swiss-Prot for PNPLA7 Gene

  • Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNPLA7 Gene

Genomics for PNPLA7 Gene

Genomic Location for PNPLA7 Gene

Start:
137,459,952 bp from pter
End:
137,550,613 bp from pter
Size:
90,662 bases
Orientation:
Minus strand

Genomic View for PNPLA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNPLA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNPLA7 Gene

Regulatory Elements for PNPLA7 Gene

Proteins for PNPLA7 Gene

  • Protein details for PNPLA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZV29-PLPL7_HUMAN
    Recommended name:
    Patatin-like phospholipase domain-containing protein 7
    Protein Accession:
    Q6ZV29
    Secondary Accessions:
    • B5MDD3
    • Q5T364
    • Q658X0
    • Q658Y3
    • Q6ZTS1
    • Q86YU8
    • Q8TAY5
    • Q96N75
    • Q9H7N5

    Protein attributes for PNPLA7 Gene

    Size:
    1317 amino acids
    Molecular mass:
    145733 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71033.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI14579.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PNPLA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNPLA7 Gene

Proteomics data for PNPLA7 Gene at MOPED

Selected DME Specific Peptides for PNPLA7 Gene

Post-translational modifications for PNPLA7 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn728, Asn975, Asn1014, and Asn1233

Other Protein References for PNPLA7 Gene

Domains for PNPLA7 Gene

Gene Families for PNPLA7 Gene

HGNC:
  • PNPLA :Patatin-like phospholipase domain containing

UniProtKB/Swiss-Prot:

PLPL7_HUMAN
Domain:
  • Contains 3 cyclic nucleotide-binding domains.:
    • Q6ZV29
  • Contains 1 patatin domain.:
    • Q6ZV29
Family:
  • Belongs to the NTE family.:
    • Q6ZV29
genes like me logo Genes that share domains with PNPLA7: view

Function for PNPLA7 Gene

Molecular function for PNPLA7 Gene

UniProtKB/Swiss-Prot Function: Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.

Enzyme Numbers (IUBMB) for PNPLA7 Gene

Gene Ontology (GO) - Molecular Function for PNPLA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity IBA --
genes like me logo Genes that share ontologies with PNPLA7: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PNPLA7 Gene

Localization for PNPLA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNPLA7 Gene

Membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNPLA7 Gene COMPARTMENTS Subcellular localization image for PNPLA7 gene
Compartment Confidence
lysosome 5
mitochondrion 5
nucleus 5
vacuole 5
endoplasmic reticulum 3
cytoskeleton 1
cytosol 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PNPLA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005739 mitochondrion --
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with PNPLA7: view

Pathways for PNPLA7 Gene

SuperPathways for PNPLA7 Gene

genes like me logo Genes that share pathways with PNPLA7: view

Pathways by source for PNPLA7 Gene

1 KEGG pathway for PNPLA7 Gene

Interacting Proteins for PNPLA7 Gene

Gene Ontology (GO) - Biological Process for PNPLA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0008152 metabolic process --
GO:0032502 developmental process IBA --
genes like me logo Genes that share ontologies with PNPLA7: view

Transcripts for PNPLA7 Gene

Unigene Clusters for PNPLA7 Gene

Patatin-like phospholipase domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNPLA7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for PNPLA7 Gene

GeneLoc Exon Structure for
PNPLA7
ECgene alternative splicing isoforms for
PNPLA7

Expression for PNPLA7 Gene

mRNA expression in normal human tissues for PNPLA7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PNPLA7 Gene

SOURCE GeneReport for Unigene cluster for PNPLA7 Gene Hs.294147

genes like me logo Genes that share expressions with PNPLA7: view

Orthologs for PNPLA7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PNPLA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNPLA7 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PNPLA7 36
  • 84.13 (n)
  • 82.08 (a)
PNPLA7 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNPLA7 36
  • 84.66 (n)
  • 85.19 (a)
PNPLA7 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnpla7 36
  • 80.73 (n)
  • 82.53 (a)
Pnpla7 16
Pnpla7 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNPLA7 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNPLA7 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnpla7 36
  • 81.09 (n)
  • 82.79 (a)
chicken
(Gallus gallus)
Aves PNPLA7 36
  • 72.01 (n)
  • 76.6 (a)
PNPLA7 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PNPLA7 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pnpla6 36
  • 72.61 (n)
  • 74.87 (a)
Str.17512 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8816 36
zebrafish
(Danio rerio)
Actinopterygii pnpla7a 37
  • 67 (a)
OneToMany
pnpla7b 36
  • 66.31 (n)
  • 69.37 (a)
pnpla7b 37
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000467 36
  • 57 (n)
  • 48.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta sws 36
  • 53.47 (n)
  • 47.81 (a)
sws 37
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M110.7 37
  • 33 (a)
ManyToMany
ZK370.4 36
  • 48.27 (n)
  • 44.92 (a)
ZK370.4 37
  • 33 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTE1 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for PNPLA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PNPLA7 Gene

ENSEMBL:
Gene Tree for PNPLA7 (if available)
TreeFam:
Gene Tree for PNPLA7 (if available)

Paralogs for PNPLA7 Gene

Paralogs for PNPLA7 Gene

Selected SIMAP similar genes for PNPLA7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PNPLA7: view

Variants for PNPLA7 Gene

Sequence variations from dbSNP and Humsavar for PNPLA7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12788 - 137,522,823(-) CGTCC(A/G)CGCGG missense, reference
rs821303 -- 137,514,985(+) CCCTG(A/C)GGGGA intron-variant
rs821304 -- 137,524,225(-) GTCAC(A/C)CCGCT intron-variant
rs821305 -- 137,534,899(-) CGGTT(C/G)GAGGG intron-variant
rs821306 -- 137,534,886(-) TTGGT(C/G)CTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNPLA7 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
nsv894645 CNV Loss 21882294
dgv8460n71 CNV Loss 21882294
nsv894659 CNV Loss 21882294
nsv894660 CNV Loss 21882294
dgv8461n71 CNV Loss 21882294
nsv831762 CNV Loss 17160897
esv1920878 CNV Deletion 18987734
esv2739454 CNV Deletion 23290073
dgv1388e199 CNV Deletion 23128226
dgv1248n67 CNV Gain 20364138
esv2007027 CNV Deletion 18987734
nsv894663 CNV Loss 21882294
nsv6772 CNV Insertion 18451855
esv992019 CNV Insertion 20482838
dgv1249n67 CNV Gain 20364138
esv2739455 CNV Deletion 23290073
esv1491510 CNV Deletion 17803354
esv2739456 CNV Deletion 23290073
esv2739457 CNV Deletion 23290073
nsv831763 CNV Loss 17160897
nsv894664 CNV Loss 21882294

Relevant External Links for PNPLA7 Gene

HapMap Linkage Disequilibrium report
PNPLA7

Disorders for PNPLA7 Gene

No disorders were found for PNPLA7 Gene.

No data available for UniProtKB/Swiss-Prot for PNPLA7 Gene

Publications for PNPLA7 Gene

  1. Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. (PMID: 12640454) Winrow C.J. … Barlow C. (Nat. Genet. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Characterization of the human patatin-like phospholipase family. (PMID: 16799181) Wilson P.A. … Crowther D.J. (J. Lipid Res. 2006) 2 3
  4. Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. (PMID: 19029121) Kienesberger P.C. … Zechner R. (J. Lipid Res. 2009) 2 3
  5. Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility. (PMID: 25015289) Renaudin X. … Rosselli F. (J. Cell. Sci. 2014) 3

Products for PNPLA7 Gene

Sources for PNPLA7 Gene

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