Aliases for PNPLA3 Gene
External Ids for PNPLA3 Gene
Previous HGNC Symbols for PNPLA3 Gene
Previous GeneCards Identifiers for PNPLA3 Gene
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
GeneCards Summary for PNPLA3 Gene
PNPLA3 (Patatin Like Phospholipase Domain Containing 3) is a Protein Coding gene. Diseases associated with PNPLA3 include fatty liver disease, nonalcoholic 1 and pnpla3-related susceptibility to nonalchoholic fatty liver disease. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include phospholipase A2 activity and mono-olein transacylation activity. An important paralog of this gene is PNPLA4.
UniProtKB/Swiss-Prot for PNPLA3 Gene
Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.