Aliases for PNPLA3 Gene
External Ids for PNPLA3 Gene
Previous HGNC Symbols for PNPLA3 Gene
Previous GeneCards Identifiers for PNPLA3 Gene
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
GeneCards Summary for PNPLA3 Gene
PNPLA3 (Patatin Like Phospholipase Domain Containing 3) is a Protein Coding gene. Diseases associated with PNPLA3 include Pnpla3-Related Susceptibility To Nonalchoholic Fatty Liver Disease and Fatty Liver Disease. Among its related pathways are Eicosanoid Synthesis and Glycerophospholipid biosynthesis. GO annotations related to this gene include phospholipase A2 activity and mono-olein transacylation activity. An important paralog of this gene is PNPLA2.
UniProtKB/Swiss-Prot for PNPLA3 Gene
Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.