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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PNPLA1 Gene

protein-coding   GIFtS: 46
GCID: GC06P036337

Patatin-Like Phospholipase Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Patatin-Like Phospholipase Domain Containing 11 2
ARCI102
dJ50J22.12
Patatin-Like Phospholipase Domain-Containing Protein 12
EC 3.1.1.-3

External Ids:    HGNC: 212461   Entrez Gene: 2858482   Ensembl: ENSG000001803167   OMIM: 6121215   UniProtKB: Q8N8W43   

Export aliases for PNPLA1 gene to outside databases

Previous GC identifers: GC06P036212 GC06P036257 GC06P036318 GC06P035930


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PNPLA1 Gene:
The protein encoded by this gene belongs to the patatin-like phospholipase (PNPLA) family, which is characterized
by the presence of a highly conserved patatin domain. PNPLA family members have diverse lipolytic and
acyltransferase activities, and are key elements in lipid metabolism. While other members of this family have
been well characterized, the function of this gene remained an enigma. However, recent studies show that this
gene is expressed in the skin epidermal keratinocytes, and has a role in glycerophospholipid metabolism in the
cutaneous barrier. Consistent with these observations, mutations in this gene are associated with ichthyosis in
human (autosomal recessive congenital ichthyoses, ARCI) and dog. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2012)

GeneCards Summary for PNPLA1 Gene: 
PNPLA1 (patatin-like phospholipase domain containing 1) is a protein-coding gene. Diseases associated with PNPLA1 include pnpla1-related autosomal recessive congenital ichthyosis, and autosomal recessive congenital ichthyosis. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is PNPLA2.

UniProtKB/Swiss-Prot: PLPL1_HUMAN, Q8N8W4
Function: Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in
glycerophospholipid metabolism




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PNPLA1 gene promoter:
         AREB6   Spz1   FOXD3   MyoD   AP-4   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPNPLA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PNPLA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNPLA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

PNPLA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNPLA1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036337:  view genomic region     (about GC identifiers)

Start:
36,210,945 bp from pter      End:
36,276,372 bp from pter
Size:
65,428 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLPL1_HUMAN, Q8N8W4 (See protein sequence)
Recommended Name: Patatin-like phospholipase domain-containing protein 1  
Size: 532 amino acids; 57875 Da
Subcellular location: Cytoplasm. Note=Clearly distributed in the cytoplasm of keratinocytes
Sequence caution: Sequence=CAI21612.2; Type=Erroneous gene model prediction;
Secondary accessions: A3RMU3 J3JS20 Q2A6N1 Q3SY95 Q3SY96 Q5R3L2
Alternative splicing: 3 isoforms:  Q8N8W4-1   Q8N8W4-2   Q8N8W4-3   (Inactive. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PNPLA1: NX_Q8N8W4

Explore proteomics data for PNPLA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N8W4

  • PNPLA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PNPLA1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001139188.1  NP_001139189.2  NP_775947.2  

    ENSEMBL proteins: 
     ENSP00000321116   ENSP00000373367   ENSP00000391868   ENSP00000378072  

    Human Recombinant Protein Products for PNPLA1: 
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    Cloud-Clone Corp. Proteins for PNPLA1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    PNPLA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PNPLA: Patatin-like phospholipase domain containing

    2 InterPro protein domains:
     IPR016035 Acyl_Trfase/lysoPLipase
     IPR002641 Patatin/PLipase_A2-rel

    Graphical View of Domain Structure for InterPro Entry Q8N8W4

    ProtoNet protein and cluster: Q8N8W4

    UniProtKB/Swiss-Prot: PLPL1_HUMAN, Q8N8W4
    Similarity: Contains 1 patatin domain


    PNPLA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLPL1_HUMAN, Q8N8W4
    Function: Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in
    glycerophospholipid metabolism

         Enzyme Number (IUBMB): EC 3.1.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    PNPLA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PNPLA1:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PNPLA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PNPLA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PNPLA1 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PNPLA1:
    hsa-miR-3907
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNPLA1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0008152metabolic process ----
    GO:0016042lipid catabolic process IEA--

    PNPLA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PNPLA1 (PLPL1)

    Search CenterWatch for drugs/clinical trials and news about PNPLA1 / PLPL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PNPLA1 gene (4 alternative transcripts): 
    NM_001145716.2  NM_001145717.1  NM_173676.2  NM_001039725.1  

    Unigene Cluster for PNPLA1:

    Patatin-like phospholipase domain containing 1
    Hs.407002  [show with all ESTs]
    Unigene Representative Sequence: NM_001145717
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312917 ENST00000388715(uc010jwe.1 uc003olw.1) ENST00000457797
    ENST00000394571(uc010jwf.2)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PNPLA1:
    hsa-miR-3907
    SwitchGear 3'UTR luciferase reporter plasmidPNPLA1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene qSTAR qPCR primer pairs in human, mouse for PNPLA1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNPLA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNPLA1

    Additional mRNA sequence: 

    AK096074.1 AM182887.1 BC103905.1 BC103906.1 BC103907.1 FJ457781.1 

    3 DOTS entries:

    DT.100001216  DT.91652339  DT.121324988 

    4 AceView cDNA sequences:

    AK096074 NM_173676 BI257213 BG194684 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PNPLA1 expression in normal human tissues (normalized intensities)      PNPLA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PNPLA1 Expression
    About this image


    PNPLA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood

    See PNPLA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PNPLA1

    SOURCE GeneReport for Unigene cluster: Hs.407002

    UniProtKB/Swiss-Prot: PLPL1_HUMAN, Q8N8W4
    Tissue specificity: Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly
    expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in
    the region of keratin filament bundles, which is more pronounced in upper epidermal layers and in the lower
    cornified layers

        SABiosciences Custom PCR Arrays for PNPLA1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNPLA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PNPLA1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pnpla11 , 5 patatin-like phospholipase domain containing 11, 5 68.88(n)1
    64.9(a)1
      17 (15.03 cM)5
    4330911  NM_001034885.31  NP_001030057.11 
     288584115 
    chicken
    (Gallus gallus)
    Aves PNPLA11 patatin-like phospholipase domain containing 1 63.66(n)
    55.69(a)
      428259  XM_425818.3  XP_425818.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    PNPLA16
    patatin-like phospholipase domain containing 1
    45(a)
    43(a)
    possible ortholog
    1 ↔ 1
    4(124411201-124434859)
    4(124435422-124445704)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01030033.16
    Uncharacterized protein
    16(a)
    1 ↔ 1
    23(5218512-5229309)
    fruit fly
    (Drosophila melanogaster)
    Insecta dob6
    bmm6
    brummer
    25(a)
    21(a)
    many ↔ many
    many ↔ many
    X(14961036-14963124)
    3L(14769596-14779512)
    worm
    (Caenorhabditis elegans)
    Secernentea C05D11.76
    Uncharacterized protein C05D11.7
    14(a)
    1 → many
    III(6415772-6421712)


    ENSEMBL Gene Tree for PNPLA1 (if available)
    TreeFam Gene Tree for PNPLA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PNPLA1 gene
    PNPLA22  PNPLA42  PNPLA52  PNPLA32  
    3 SIMAP similar genes for PNPLA1 using alignment to 1 protein entry:     PLPL1_HUMAN:
    ATGL    PNPLA2    PNPLA4

    PNPLA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1698 SNPs in PNPLA1 are shown (see all 1698)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0695664
    Ichthyosis, congenital, autosomal recessive 10 (ARCI10)4--see VAR_0695662 A V mis40--------
    rs1427094371,2
    --36120218(+) CCTCCA/GGCCTC 2 -- us2k10--------
    rs1152031521,2
    F--36120260(+) GATTAC/TAGGCA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs117563321,2
    H--36120460(+) aatttA/Taaaaa 2 -- us2k10--------
    rs771033021,2
    --36120561(+) TTTTTG/TTAGAT 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs47139391,2
    C,F,A,H--36120668(+) GTTCCG/ATATCA 2 -- us2k125Minor allele frequency- A:0.24NS EA NA WA 2940
    rs1836943201,2
    --36120794(+) TTTTGC/TAGTCG 2 -- us2k10--------
    rs1879904911,2
    --36120853(+) GTGGGG/TGTGTG 2 -- us2k10--------
    rs1142067011,2
    C,F--36121027(+) CATCTC/TTTCTC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs734155361,2
    C--36121093(+) AGACTC/TCTCAG 2 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for PNPLA1 (36210945 - 36276372 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PNPLA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33691CNV Gain+Loss17666407


    Human Gene Mutation Database (HGMD): PNPLA1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PNPLA1
    DNA2.0 Custom Variant and Variant Library Synthesis for PNPLA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612121    OMIM disorders: --

    UniProtKB/Swiss-Prot: PLPL1_HUMAN, Q8N8W4
  • Ichthyosis, congenital, autosomal recessive 10 (ARCI10) [MIM:615024]: A form of autosomal recessive
    congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the
    epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar
    ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within
    the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often
    associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the
    entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on
    an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 5 diseases for PNPLA1:    About MalaCards
    pnpla1-related autosomal recessive congenital ichthyosis    autosomal recessive congenital ichthyosis    ichthyosis    congenital ichthyosiform erythroderma
    obesity

    1 disease from the University of Copenhagen DISEASES database for PNPLA1:
    Congenital ichthyosiform erythroderma

    PNPLA1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PNPLA1
    Human Genome Epidemiology (HuGE) Navigator: PNPLA1 (2 documents)

    Export disorders for PNPLA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PNPLA1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PNPLA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human patatin-like phospholipase family. (PubMed id 16799181)1, 2, 3 Wilson P.A.... Crowther D.J. (2006)
    2. PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. (PubMed id 22246504)1, 2 Grall A....Fischer J. (2012)
    3. Genetic variance in the adiponutrin gene family and childhood obesity. (PubMed id 19390624)1, 4 Johansson L.E....RidderstrAYle M. (2009)
    4. Mammalian patatin domain containing proteins: a famil y with diverse lipolytic activities involved in multiple biological functions. (PubMed id 19029121)1, 3 Kienesberger P.C....Zechner R. (2009)
    5. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione s-transferase omega genes. (PubMed id 18414634)1, 4 De Chaudhuri S....Giri A.K. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285848 HGNC: 21246 AceView: PNPLA1 Ensembl:ENSG00000180316 euGenes: HUgn285848
    ECgene: PNPLA1 H-InvDB: PNPLA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PNPLA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PNPLA1 gene:
    Search GeneIP for patents involving PNPLA1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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