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Aliases for PNOC Gene

Aliases for PNOC Gene

  • Prepronociceptin 2 3 5
  • Orphanin FQ 2 3
  • Nocistatin 2 3
  • OFQ 3 4
  • Pre-Pro-N/OFQ 3
  • Pronociceptin 3
  • Nociceptin 3
  • PpN/OFQ 3
  • N/OFQ 3
  • PPNOC 3
  • NOP 3

External Ids for PNOC Gene

Previous GeneCards Identifiers for PNOC Gene

  • GC08P027957
  • GC08P028679
  • GC08P028196
  • GC08P028230
  • GC08P028174
  • GC08P026719

Summaries for PNOC Gene

Entrez Gene Summary for PNOC Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

GeneCards Summary for PNOC Gene

PNOC (Prepronociceptin) is a Protein Coding gene. Diseases associated with PNOC include myoclonus, familial cortical and pain agnosia. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include neuropeptide hormone activity and opioid peptide activity.

UniProtKB/Swiss-Prot for PNOC Gene

  • Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.

  • Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.

  • Orphanin FQ2: Has potent analgesic activity.

Tocris Summary for PNOC Gene

  • The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and mu receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNOC Gene

Genomics for PNOC Gene

Regulatory Elements for PNOC Gene

Genomic Location for PNOC Gene

Chromosome:
8
Start:
28,316,986 bp from pter
End:
28,343,355 bp from pter
Size:
26,370 bases
Orientation:
Plus strand

Genomic View for PNOC Gene

Genes around PNOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNOC Gene

Proteins for PNOC Gene

  • Protein details for PNOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13519-PNOC_HUMAN
    Recommended name:
    Prepronociceptin
    Protein Accession:
    Q13519
    Secondary Accessions:
    • B7Z749
    • Q6FH16

    Protein attributes for PNOC Gene

    Size:
    176 amino acids
    Molecular mass:
    20295 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PNOC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNOC Gene

Proteomics data for PNOC Gene at MOPED

Post-translational modifications for PNOC Gene

  • Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
  • The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PNOC Gene

Antibody Products

No data available for DME Specific Peptides for PNOC Gene

Domains & Families for PNOC Gene

Gene Families for PNOC Gene

Protein Domains for PNOC Gene

Graphical View of Domain Structure for InterPro Entry

Q13519

UniProtKB/Swiss-Prot:

PNOC_HUMAN :
  • Belongs to the opioid neuropeptide precursor family.
Family:
  • Belongs to the opioid neuropeptide precursor family.
genes like me logo Genes that share domains with PNOC: view

Function for PNOC Gene

Molecular function for PNOC Gene

GENATLAS Biochemistry:
prepronociceptin,precursor of the natural agonist of opioid receptor-like receptor,expressed in the central nervous system and (weakly) ovary
UniProtKB/Swiss-Prot Function:
Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
UniProtKB/Swiss-Prot Function:
Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
UniProtKB/Swiss-Prot Function:
Orphanin FQ2: Has potent analgesic activity.

Gene Ontology (GO) - Molecular Function for PNOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001515 opioid peptide activity IEA --
genes like me logo Genes that share ontologies with PNOC: view
genes like me logo Genes that share phenotypes with PNOC: view

Animal Models for PNOC Gene

MGI Knock Outs for PNOC:

Animal Model Products

miRNA for PNOC Gene

miRTarBase miRNAs that target PNOC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PNOC Gene

Localization for PNOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNOC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNOC Gene COMPARTMENTS Subcellular localization image for PNOC gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PNOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with PNOC: view

Pathways & Interactions for PNOC Gene

genes like me logo Genes that share pathways with PNOC: view

Gene Ontology (GO) - Biological Process for PNOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9521323
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with PNOC: view

No data available for SIGNOR curated interactions for PNOC Gene

Drugs & Compounds for PNOC Gene

(38) Drugs for PNOC Gene - From: Novoseek and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nociceptin Pharma Endogenous NOP agonist 5

(25) Additional Compounds for PNOC Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[(pF)Phe4]Nociceptin(1-13)NH2
380620-88-2
[Phe1psi(CH2-NH)Gly2]Nociceptin(1-13)NH2
213130-17-7
Ac-RYYRWK-NH2
200959-47-3
Nociceptin (1-13)NH2
178064-02-3
genes like me logo Genes that share compounds with PNOC: view

Transcripts for PNOC Gene

Unigene Clusters for PNOC Gene

Prepronociceptin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNOC Gene

No ASD Table

Relevant External Links for PNOC Gene

GeneLoc Exon Structure for
PNOC
ECgene alternative splicing isoforms for
PNOC

Expression for PNOC Gene

mRNA expression in normal human tissues for PNOC Gene

mRNA differential expression in normal tissues according to GTEx for PNOC Gene

This gene is overexpressed in Spleen (x4.9).

SOURCE GeneReport for Unigene cluster for PNOC Gene Hs.88218

mRNA Expression by UniProt/SwissProt for PNOC Gene

Q13519-PNOC_HUMAN
Tissue specificity: Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
genes like me logo Genes that share expression patterns with PNOC: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PNOC Gene

Orthologs for PNOC Gene

This gene was present in the common ancestor of chordates.

Orthologs for PNOC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNOC 36
  • 100 (a)
OneToOne
PNOC 35
  • 99.81 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PNOC 35
  • 85.81 (n)
  • 85.81 (a)
PNOC 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNOC 36
  • 86 (a)
OneToOne
PNOC 35
  • 86.27 (n)
  • 86.93 (a)
mouse
(Mus musculus)
Mammalia Pnoc 16
Pnoc 36
  • 78 (a)
OneToOne
Pnoc 35
  • 85.31 (n)
  • 82.89 (a)
oppossum
(Monodelphis domestica)
Mammalia PNOC 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNOC 36
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnoc 35
  • 83.88 (n)
  • 79.08 (a)
chicken
(Gallus gallus)
Aves PNOC 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PNOC 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pnoc 35
  • 58.28 (n)
  • 44.76 (a)
zebrafish
(Danio rerio)
Actinopterygii pnoca 35
  • 50 (n)
  • 41.55 (a)
pnoca 36
  • 23 (a)
OneToMany
pnocb 36
  • 28 (a)
OneToMany
Species with no ortholog for PNOC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNOC Gene

ENSEMBL:
Gene Tree for PNOC (if available)
TreeFam:
Gene Tree for PNOC (if available)

Paralogs for PNOC Gene

(1) SIMAP similar genes for PNOC Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PNOC: view

No data available for Paralogs for PNOC Gene

Variants for PNOC Gene

Sequence variations from dbSNP and Humsavar for PNOC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs351774 -- 28,333,284(+) CCAAA(A/T)GGCCA intron-variant
rs351776 -- 28,333,789(+) CAGAA(A/C)AATTC intron-variant
rs189509 -- 28,334,189(+) AACTC(A/G)ACAGG intron-variant
rs240573 -- 28,337,446(-) gatgg(C/G)tgcct intron-variant, upstream-variant-2KB
rs1563945 -- 28,317,369(+) AACTG(A/C)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNOC Gene

Variant ID Type Subtype PubMed ID
nsv6134 CNV Insertion 18451855
dgv456n21 CNV Gain 19592680
nsv819240 CNV Gain 19587683

Variation tolerance for PNOC Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNOC Gene

HapMap Linkage Disequilibrium report
PNOC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNOC Gene

Disorders for PNOC Gene

MalaCards: The human disease database

(5) MalaCards diseases for PNOC Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
myoclonus, familial cortical
  • familial cortical myoclonus
pain agnosia
  • analgesia
agnosia
  • alexia
specific developmental disorder
neonatal abstinence syndrome
  • drug withdrawal syndrome in newborn
- elite association - COSMIC cancer census association via MalaCards
Search PNOC in MalaCards View complete list of genes associated with diseases

Relevant External Links for PNOC

Genetic Association Database (GAD)
PNOC
Human Genome Epidemiology (HuGE) Navigator
PNOC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNOC
genes like me logo Genes that share disorders with PNOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNOC Gene

Publications for PNOC Gene

  1. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. (PMID: 8710928) Mollereau C. … Parmentier M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23 67
  2. Plasma nociceptin/orphanin FQ levels in response to the hyperventilation test in healthy subjects. (PMID: 20100531) Fontana F. … Spampinato S. (Peptides 2010) 3 23
  3. Assessment of nociceptin/orphanin FQ and micro-opioid receptor mRNA in the human right atrium. (PMID: 20413378) McDonald J. … Lambert D.G. (Br J Anaesth 2010) 3 23
  4. Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex. (PMID: 19573600) Rocha L. … Borsodi A. (Neurobiol. Dis. 2009) 3 23
  5. Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes. (PMID: 18247127) Kaminsky D.E. … Rogers T.J. (J Neuroimmune Pharmacol 2008) 3 23

Products for PNOC Gene

Sources for PNOC Gene

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