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Aliases for PNO1 Gene

Aliases for PNO1 Gene

  • Partner Of NOB1 Homolog 2 3 5
  • KH-Type RNA-Binding Protein 1 2 3
  • RNA Binding Protein 2 3
  • Partner Of NOB1 Homolog (S. Cerevisiae) 2
  • KH-Type RNA Binding Protein 1 2
  • KHRBP1 3
  • RRP20 3

External Ids for PNO1 Gene

Previous HGNC Symbols for PNO1 Gene

  • KHRBP1

Previous GeneCards Identifiers for PNO1 Gene

  • GC02P068238
  • GC02P068384
  • GC02P068122

Summaries for PNO1 Gene

GeneCards Summary for PNO1 Gene

PNO1 (Partner Of NOB1 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include nucleic acid binding and RNA binding.

Gene Wiki entry for PNO1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNO1 Gene

Genomics for PNO1 Gene

Regulatory Elements for PNO1 Gene

Promoters for PNO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PNO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PNO1 Gene

Chromosome:
2
Start:
68,157,844 bp from pter
End:
68,176,238 bp from pter
Size:
18,395 bases
Orientation:
Plus strand

Genomic View for PNO1 Gene

Genes around PNO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNO1 Gene

Proteins for PNO1 Gene

  • Protein details for PNO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX1-PNO1_HUMAN
    Recommended name:
    RNA-binding protein PNO1
    Protein Accession:
    Q9NRX1
    Secondary Accessions:
    • A8K6Q0
    • Q53G13
    • Q8WVB8

    Protein attributes for PNO1 Gene

    Size:
    252 amino acids
    Molecular mass:
    27924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNO1 Gene

Proteomics data for PNO1 Gene at MOPED

Post-translational modifications for PNO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PNO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PNO1 Gene

Domains & Families for PNO1 Gene

Protein Domains for PNO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX1

UniProtKB/Swiss-Prot:

PNO1_HUMAN :
  • Contains 1 KH domain.
  • Belongs to the PNO1 family.
Domain:
  • Contains 1 KH domain.
Family:
  • Belongs to the PNO1 family.
genes like me logo Genes that share domains with PNO1: view

No data available for Gene Families for PNO1 Gene

Function for PNO1 Gene

Gene Ontology (GO) - Molecular Function for PNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PNO1: view
genes like me logo Genes that share phenotypes with PNO1: view

Animal Models for PNO1 Gene

MGI Knock Outs for PNO1:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PNO1 Gene

Localization for PNO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNO1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNO1 Gene COMPARTMENTS Subcellular localization image for PNO1 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for PNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PNO1: view

Pathways & Interactions for PNO1 Gene

genes like me logo Genes that share pathways with PNO1: view

Pathways by source for PNO1 Gene

Gene Ontology (GO) - Biological Process for PNO1 Gene

None

No data available for SIGNOR curated interactions for PNO1 Gene

Drugs & Compounds for PNO1 Gene

No Compound Related Data Available

Transcripts for PNO1 Gene

mRNA/cDNA for PNO1 Gene

Unigene Clusters for PNO1 Gene

Partner of NOB1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - -
SP3:

Relevant External Links for PNO1 Gene

GeneLoc Exon Structure for
PNO1
ECgene alternative splicing isoforms for
PNO1

Expression for PNO1 Gene

mRNA expression in normal human tissues for PNO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PNO1 Gene

This gene is overexpressed in Breast (45.2) and Lung (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PNO1 Gene



SOURCE GeneReport for Unigene cluster for PNO1 Gene Hs.262858

mRNA Expression by UniProt/SwissProt for PNO1 Gene

Q9NRX1-PNO1_HUMAN
Tissue specificity: Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with PNO1: view

Protein tissue co-expression partners for PNO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PNO1 Gene

Orthologs for PNO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PNO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNO1 35
  • 87.57 (n)
  • 93.65 (a)
PNO1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNO1 35
  • 87.92 (n)
  • 93.23 (a)
PNO1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pno1 35
  • 87.37 (n)
  • 92.74 (a)
Pno1 16
Pno1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PNO1 35
  • 99.34 (n)
  • 99.21 (a)
PNO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pno1 35
  • 85.73 (n)
  • 93.2 (a)
oppossum
(Monodelphis domestica)
Mammalia PNO1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNO1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNO1 35
  • 71.09 (n)
  • 81.33 (a)
PNO1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PNO1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pno1 35
  • 73.05 (n)
  • 82.13 (a)
Str.8210 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53417 35
zebrafish
(Danio rerio)
Actinopterygii pno1 35
  • 66.52 (n)
  • 74.46 (a)
zgc65782 35
pno1 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8532 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004145 35
  • 59.18 (n)
  • 62.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0004 35
  • 59.89 (n)
  • 69.23 (a)
l(1)G0004 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y53C12B.2 35
  • 60.96 (n)
  • 66.3 (a)
Y53C12B.2 36
  • 45 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR390C 35
  • 57.09 (n)
  • 64.09 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06446g 35
  • 60.37 (n)
  • 61.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNO1 35
  • 61.33 (n)
  • 64.64 (a)
PNO1 36
  • 44 (a)
OneToOne
PNO1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13230 35
  • 57.94 (n)
  • 57.07 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10303 35
barley
(Hordeum vulgare)
Liliopsida Hv.699 35
rice
(Oryza sativa)
Liliopsida Os03g0115200 35
  • 56.22 (n)
  • 56.68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11273 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07956 35
  • 53.33 (n)
  • 54.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rbp28 35
  • 57.64 (n)
  • 58.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for PNO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PNO1 Gene

ENSEMBL:
Gene Tree for PNO1 (if available)
TreeFam:
Gene Tree for PNO1 (if available)

Paralogs for PNO1 Gene

Pseudogenes.org Pseudogenes for PNO1 Gene

genes like me logo Genes that share paralogs with PNO1: view

No data available for Paralogs for PNO1 Gene

Variants for PNO1 Gene

Sequence variations from dbSNP and Humsavar for PNO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_029814 -
VAR_029815 -
rs1060842 -- 68,174,880(+) AACCA(G/T)CTGAA utr-variant-3-prime
rs1137930 -- 68,161,691(+) TGTAA(A/G)GAAAC reference, synonymous-codon
rs1448924 -- 68,173,110(+) tttAA(A/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNO1 Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV Loss 17160897
nsv874249 CNV Loss 21882294

Variation tolerance for PNO1 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNO1 Gene

HapMap Linkage Disequilibrium report
PNO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNO1 Gene

Disorders for PNO1 Gene

Relevant External Links for PNO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNO1

No disorders were found for PNO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNO1 Gene

Publications for PNO1 Gene

  1. Cloning and characterization of a novel human RNA binding protein gene PNO1. (PMID: 15497447) Zhou G.-J. … Yu L. (DNA Seq. 2004) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3

Products for PNO1 Gene

Sources for PNO1 Gene

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