PNO1 Gene
protein-coding GIFtS: 47
GCID: GC02P068384
|
|
partner of NOB1 homolog (S. cerevisiae)(Previous names: KH-type RNA binding protein 1, KH-type RNA-binding protein...)
(Previous symbol: KHRBP1)
| |
Aliases
for PNO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Partner Of NOB1 Homolog (S. Cerevisiae)1 2 | | KH-Type RNA Binding Protein 11 | | KHRBP11 2 | | RNA Binding Protein2 | | RRP201 2 | | RNA-Binding Protein PNO12 | | KH-Type RNA-Binding Protein 11 2 | | |
Export aliases for PNO1 gene to outside databasesPrevious GC identifers: GC02P068238 GC02P068122 |
Summaries
for PNO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for PNO1
|
Genomic Views
for PNO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PNO1 gene promoter:
Nkx3-1 C/EBPbeta p53 Nkx3-1 v1 CUTL1 NF-kappaB Nkx3-1 v2 Nkx3-1 v3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PNO1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNO1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p14 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p14PNO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P068384: view genomic region
(about GC identifiers)
Start:
|
68,384,976 bp from pter |
End:
|
68,403,370 bp from pter |
Size:
|
18,395 bases |
Orientation:
|
plus strand |
|
Proteins
for PNO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PNO1_HUMAN, Q9NRX1 (See
protein sequence)Recommended Name: RNA-binding protein PNO1 Size: 252 amino acids; 27924 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: A8K6Q0 Q53G13 Q8WVB8Explore the universe of human proteins at neXtProt for PNO1: NX_Q9NRX1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRX1
PNO1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064528.1
ENSEMBL proteins: ENSP00000263657 ENSP00000405892
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
PNO1 for ontologies About GeneDecksing
PNO1 Antibody Products:
Assay Products for PNO1: |
Protein
Domains /
Families
for PNO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PNO1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRX1ProtoNet protein and cluster: Q9NRX1 UniProtKB/Swiss-Prot: PNO1_HUMAN, Q9NRX1Similarity: Belongs to the PNO1 familySimilarity: Contains 1 KH domain |
Function
for PNO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNO1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNO1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PNO1 (NM_020143) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNO1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNO1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNO1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- |
PNO1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PNO1:
Animal Models:
Mouse knock-out Pno1tm1Jwu for PNO1
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pno1):
PNO1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PNO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNO1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/72 Interacting proteins for PNO1 (Q9NRX12, 3 ENSP000002636574) via UniProtKB, MINT, STRING, and/or I2D (see all 72)About this table
|
Drugs & Compounds
for PNO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PNO1
Search CenterWatch for drugs/clinical trials and news about PNO1
|
Transcripts
for PNO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PNO1 gene: NM_020143.2 Unigene Cluster for PNO1: Partner of NOB1 homolog (S. cerevisiae) Hs.262858 [show with all ESTs]Unigene Representative Sequence: NM_0201433 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263657(uc002seh.3) ENST00000430742 ENST00000488728
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNO1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNO1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PNO1 (NM_020143) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNO1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNO1 |
Additional cDNA sequence: AF164799.1 AF349314.1 AK223118.1 AK225641.1 AK291715.1 AK313204.1 BC008304.1 BC018152.1 L48692.1 7 DOTS entries: DT.453079 DT.100721324 DT.95374254 DT.121612817 DT.95374256 DT.99928479 DT.121034907 24/165 AceView cDNA sequences (see all 165): AA281683 CR597643 AA338711 CR591407 AA583293 BU621762 T40124 BM452107 CN480757 BC018152 BC008304 BU182365 N74894 AA503246 BX462503 AW631351 NM_020143 BQ233496 BM918517 CD240396 AU127353 BQ217647 AI432640 BU679822
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for PNO1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PNO1
|
Expression
for PNO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PNO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCAGATTG
About this image
See PNO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PNO1
SOURCE GeneReport for Unigene cluster: Hs.262858
UniProtKB/Swiss-Prot: PNO1_HUMAN, Q9NRX1Tissue specificity: Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weaklyor not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheralblood leukocytes
SABiosciences Custom PCR Arrays for PNO1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNO1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PNO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNO1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNO1 |
Orthologs
for PNO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PNO1 gene from 10/40 species (see all 40) About this table
ENSEMBL Gene Tree for PNO1 (if available)
TreeFam Gene Tree for PNO1 (if available) |
Paralogs
for PNO1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PNO1 gene
PNO1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PNO1
PGOHUM00000247093
|
Genomic Variants
for PNO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PNO1 (68384976 - 68403370 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PNO1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNO1 |
|
Disorders
/ Diseases
for PNO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PNO1 for disorders About GeneDecksing
2  diseases for PNO1: About MalaCardsmalaria prostatitis
Export disorders for PNO1 gene to outside databases
|
Publications
for PNO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PNO1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with PNO1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel human RNA binding protein gene PNO1. (PubMed id 15497447)1, 2, 3 Zhou G.J.... Yu L. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
|
External Searches for PNO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PNO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PNO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PNO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PNO1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PNO1 gene:
Search GeneIP for patents involving PNO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PNO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PNO1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PNO1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNO1 | | | OriGene Protein Over-expression Lysate for PNO1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PNO1 | | OriGene 3'-UTR Clone for PNO1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNO1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNO1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PNO1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PNO1 | | OriGene Custom Protein Services for PNO1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PNO1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNO1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNO1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PNO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNO1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for PNO1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | PNO1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNO1 |
|  |  |  | | | | ThermoFisher Antibodies for PNO1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNO1 |
|
|
|
|
