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Aliases for PNO1 Gene

Aliases for PNO1 Gene

  • Partner Of NOB1 Homolog 2 3 5
  • KH-Type RNA-Binding Protein 1 2 3
  • RNA Binding Protein 2 3
  • Partner Of NOB1 Homolog (S. Cerevisiae) 2
  • KH-Type RNA Binding Protein 1 2
  • RNA-Binding Protein PNO1 3
  • KHRBP1 3
  • RRP20 3

External Ids for PNO1 Gene

Previous HGNC Symbols for PNO1 Gene

  • KHRBP1

Previous GeneCards Identifiers for PNO1 Gene

  • GC02P068238
  • GC02P068384
  • GC02P068122

Summaries for PNO1 Gene

GeneCards Summary for PNO1 Gene

PNO1 (Partner Of NOB1 Homolog) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding.

Gene Wiki entry for PNO1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNO1 Gene

Genomics for PNO1 Gene

Regulatory Elements for PNO1 Gene

Enhancers for PNO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F068192 1.8 VISTA Ensembl ENCODE 12.8 +36.7 36697 4.7 ATF1 PKNOX1 ARNT ZNF766 ZNF143 FOS JUNB REST TBX21 ZNF518A WDR92 PPP3R1 PNO1 C1D ENSG00000273275 LOC102724389
GH02F068189 1 Ensembl ENCODE 11.9 +33.1 33056 2.6 BRD4 PKNOX1 JUN EED PRDM10 FOS MAFK ZNF197 ZNF680 ZNF362 PPP3R1 WDR92 PNO1 ENSG00000273275 LOC102724389
GH02F068190 0.2 Ensembl 11.9 +31.4 31357 0.4 WDR92 PNO1 PPP3R1 ENSG00000273275 LOC102724389
GH02F068122 1.1 Ensembl ENCODE 11.9 -35.2 -35244 0.8 ELF3 RAD21 ZNF143 CREM DEK ZNF654 CEBPB REST MIER3 SMARCA4 WDR92 PNO1 LOC100287361 LOC105374789
GH02F068120 1.1 FANTOM5 Ensembl ENCODE 11.9 -36.6 -36638 1.6 HDGF PKNOX1 ATF1 ARNT WRNIP1 SIN3A FEZF1 ELK1 GATA2 NCOA1 WDR92 PNO1 CNRIP1 LOC102724389 C1D LOC100287361 LOC105374789
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PNO1 on UCSC Golden Path with GeneCards custom track

Promoters for PNO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001543229 56 3001 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for PNO1 Gene

Chromosome:
2
Start:
68,157,844 bp from pter
End:
68,176,238 bp from pter
Size:
18,395 bases
Orientation:
Plus strand

Genomic View for PNO1 Gene

Genes around PNO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNO1 Gene

Proteins for PNO1 Gene

  • Protein details for PNO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX1-PNO1_HUMAN
    Recommended name:
    RNA-binding protein PNO1
    Protein Accession:
    Q9NRX1
    Secondary Accessions:
    • A8K6Q0
    • Q53G13
    • Q8WVB8

    Protein attributes for PNO1 Gene

    Size:
    252 amino acids
    Molecular mass:
    27924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNO1 Gene

Post-translational modifications for PNO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PNO1 Gene

No data available for DME Specific Peptides for PNO1 Gene

Domains & Families for PNO1 Gene

Protein Domains for PNO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX1

UniProtKB/Swiss-Prot:

PNO1_HUMAN :
  • Contains 1 KH domain.
  • Belongs to the PNO1 family.
Domain:
  • Contains 1 KH domain.
Family:
  • Belongs to the PNO1 family.
genes like me logo Genes that share domains with PNO1: view

No data available for Gene Families for PNO1 Gene

Function for PNO1 Gene

Gene Ontology (GO) - Molecular Function for PNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PNO1: view
genes like me logo Genes that share phenotypes with PNO1: view

Animal Models for PNO1 Gene

MGI Knock Outs for PNO1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PNO1 Gene

Localization for PNO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNO1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNO1 Gene COMPARTMENTS Subcellular localization image for PNO1 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for PNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 15497447
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PNO1: view

Pathways & Interactions for PNO1 Gene

genes like me logo Genes that share pathways with PNO1: view

Gene Ontology (GO) - Biological Process for PNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with PNO1: view

No data available for SIGNOR curated interactions for PNO1 Gene

Transcripts for PNO1 Gene

Unigene Clusters for PNO1 Gene

Partner of NOB1 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - -
SP3:

Relevant External Links for PNO1 Gene

GeneLoc Exon Structure for
PNO1
ECgene alternative splicing isoforms for
PNO1

Expression for PNO1 Gene

mRNA expression in normal human tissues for PNO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PNO1 Gene

This gene is overexpressed in Breast (45.2) and Lung (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PNO1 Gene



Protein tissue co-expression partners for PNO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PNO1 Gene:

PNO1

SOURCE GeneReport for Unigene cluster for PNO1 Gene:

Hs.262858

mRNA Expression by UniProt/SwissProt for PNO1 Gene:

Q9NRX1-PNO1_HUMAN
Tissue specificity: Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with PNO1: view

Primer Products

No data available for mRNA differential expression in normal tissues for PNO1 Gene

Orthologs for PNO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PNO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNO1 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia PNO1 34 35
  • 87.92 (n)
cow
(Bos Taurus)
Mammalia PNO1 34 35
  • 87.57 (n)
mouse
(Mus musculus)
Mammalia Pno1 34 16 35
  • 87.37 (n)
rat
(Rattus norvegicus)
Mammalia Pno1 34
  • 85.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PNO1 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNO1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNO1 34 35
  • 71.09 (n)
lizard
(Anolis carolinensis)
Reptilia PNO1 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pno1 34
  • 73.05 (n)
Str.8210 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53417 34
zebrafish
(Danio rerio)
Actinopterygii pno1 34 35
  • 66.52 (n)
zgc65782 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8532 34
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0004 34 35
  • 59.89 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004145 34
  • 59.18 (n)
worm
(Caenorhabditis elegans)
Secernentea Y53C12B.2 34 35
  • 60.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNO1 34 35 37
  • 61.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06446g 34
  • 60.37 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR390C 34
  • 57.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13230 34
  • 57.94 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10303 34
rice
(Oryza sativa)
Liliopsida Os03g0115200 34
  • 56.22 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.699 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rbp28 34
  • 57.64 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07956 34
  • 53.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11273 34
Species where no ortholog for PNO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PNO1 Gene

ENSEMBL:
Gene Tree for PNO1 (if available)
TreeFam:
Gene Tree for PNO1 (if available)

Paralogs for PNO1 Gene

Pseudogenes.org Pseudogenes for PNO1 Gene

genes like me logo Genes that share paralogs with PNO1: view

No data available for Paralogs for PNO1 Gene

Variants for PNO1 Gene

Sequence variations from dbSNP and Humsavar for PNO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10153614 -- 68,163,590(+) ttacT(C/T)AAGGG intron-variant
rs10153623 -- 68,163,778(+) GATGA(G/T)AGGGG intron-variant
rs10153740 -- 68,163,585(+) catac(A/T)tacTC intron-variant
rs10166426 -- 68,173,657(+) ggctc(A/C)ctgca intron-variant
rs10169751 -- 68,167,277(+) ccttt(C/T)ggtat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNO1 Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV loss 17160897

Variation tolerance for PNO1 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNO1 Gene

Disorders for PNO1 Gene

Relevant External Links for PNO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNO1

No disorders were found for PNO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNO1 Gene

Publications for PNO1 Gene

  1. Cloning and characterization of a novel human RNA binding protein gene PNO1. (PMID: 15497447) Zhou G.-J. … Yu L. (DNA Seq. 2004) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PNO1 Gene

Sources for PNO1 Gene

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