Aliases for PNN Gene
External Ids for PNN Gene
Previous GeneCards Identifiers for PNN Gene
GeneCards Summary for PNN Gene
PNN (Pinin, Desmosome Associated Protein) is a Protein Coding gene. Diseases associated with PNN include Melanoma Metastasis and Premenstrual Tension. Among its related pathways are mRNA surveillance pathway and RNA transport. GO annotations related to this gene include poly(A) RNA binding and structural molecule activity.
UniProtKB/Swiss-Prot for PNN Gene
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5CAGGTG-3. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.