Aliases for PNMA6A Gene
Aliases for PNMA6A Gene
External Ids for PNMA6A Gene
- HGNC: 28248
- Entrez Gene: 84968
- Ensembl: ENSG00000235961
- OMIM: 300917
- UniProtKB: P0CW24
Previous HGNC Symbols for PNMA6A Gene
- PNMA6C
Previous GeneCards Identifiers for PNMA6A Gene
- GC0XP150859
- GC0XP151911
- GC0XP151991
- GC0XP152338
Summaries for PNMA6A Gene
GeneCards Summary for PNMA6A Gene
PNMA6A (PNMA Family Member 6A) is a Protein Coding gene. Diseases associated with PNMA6A include Thyroid Gland Disease. An important paralog of this gene is PNMA6F.
Additional gene information for PNMA6A Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNMA6A Gene
Genomics for PNMA6A Gene
GeneHancer (GH) Regulatory Elements for PNMA6A Gene
Promoters and enhancers for PNMA6A Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XI153072 | Promoter | 1 | EPDnew Ensembl | 550.8 | +0.1 | 87 | 1 | PNMA6A PNMA6B | ||
GH0XI153245 | Enhancer | 0.8 | ENCODE | 34.7 | +173.1 | 173103 | 0.8 | ARNT ZBTB40 ATF7 KLF13 ZNF362 SP3 ZNF518A SREBF1 MBD2 SP1 | PNMA6A TMEM187 MAGEA1 HCFC1 ENSG00000231600 LOC105373373 | |
GH0XI153032 | Enhancer | 1 | Ensembl ENCODE | 21.1 | -39.7 | -39713 | 1.3 | HDAC1 RB1 KLF17 ZNF76 GLI4 ZNF2 RAD21 YY1 ARID2 EGR1 | PNMA6A PNMA3 ENSG00000234200 GC0XM153053 | |
GH0XI152829 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 4.3 | -240.2 | -240195 | 4.8 | HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 POLR2B GLIS2 | NSDHL CETN2 ZNF185 PNMA6A GC0XM152591 | |
GH0XI152450 | Promoter/Enhancer | 1 | EPDnew ENCODE | 6.9 | -621.0 | -621014 | 0.9 | ZNF148 CTBP1 GATA2 POLR2A VEZF1 SIN3A PRDM10 | GABRA3 PNMA6A KRT8P8 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PNMA6A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PNMA6A Gene
Genomic Locations for PNMA6A Gene
- chrX:153,072,414-153,075,019
- (GRCh38/hg38)
- Size:
- 2,606 bases
- Orientation:
- Plus strand
- chrX:152,240,839-152,340,864
- (GRCh37/hg19)
Genomic View for PNMA6A Gene
Genes around PNMA6A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq28 by Ensembl
- Xq28 by Entrez Gene
- Xq28 by HGNC
PNMA6A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for PNMA6A Gene
Proteins for PNMA6A Gene
-
Protein details for PNMA6A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0CW24-PNM6A_HUMAN
- Recommended name:
- Paraneoplastic antigen-like protein 6A
- Protein Accession:
- P0CW24
- A8K1G4
- D3DWT8
- P0CW26
- Q96A40
Protein attributes for PNMA6A Gene
- Size:
- 399 amino acids
- Molecular mass:
- 43875 Da
- Quaternary structure:
- No Data Available
Protein Expression for PNMA6A Gene
Post-translational modifications for PNMA6A Gene
No Post-translational modifications
Other Protein References for PNMA6A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Custom Antibody ServicesOriGene Antibodies for PNMA6A
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Protein Products
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Assay Products
No data available for DME Specific Peptides for PNMA6A Gene
Domains & Families for PNMA6A Gene
Gene Families for PNMA6A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for PNMA6A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0CW24- Family:
-
- Belongs to the PNMA family.
Function for PNMA6A Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16169070 |
Phenotypes for PNMA6A Gene
- GenomeRNAi human phenotypes for PNMA6A:
Animal Model Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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Cell Line Products
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Horizon Cell Lines for PNMA6A
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PNMA6A Gene
Localization for PNMA6A Gene
- Mitochondria (1)
- Nucleoli (1)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PNMA6A Gene
Pathways & Interactions for PNMA6A Gene
No data available for Pathways by source and SIGNOR curated interactions for PNMA6A Gene
Transcripts for PNMA6A Gene
mRNA/cDNA for PNMA6A Gene
- (1) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (41) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PNMA6A Gene
CRISPR Products
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-
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-
ViGene Biosciences ready-to-package AAV shRNAs for PNMA6A gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PNMA6A gene related products
- orf clones - Search results for available PNMA6A gene related products
- Applied Biological Materials Clones for PNMA6A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PNMA6A Gene
mRNA differential expression in normal tissues according to GTEx for PNMA6A Gene
This gene is overexpressed in Brain - Cortex (x6.8), Brain - Substantia nigra (x6.2), Brain - Frontal Cortex (BA9) (x5.5), Brain - Amygdala (x5.1), Brain - Hypothalamus (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.2).
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PNMA6A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PNMA6A Gene:
PNMA6ASOURCE GeneReport for Unigene cluster for PNMA6A Gene:
Hs.721963mRNA Expression by UniProt/SwissProt for PNMA6A Gene:
P0CW24-PNM6A_HUMAN
Tissue specificity:
Expressed in the brain.
Evidence on tissue expression from TISSUES for PNMA6A Gene
- Nervous system(3.4)
- Thyroid gland(3.1)
Primer Products
-
OriGene qPCR primer pairs for PNMA6A
-
OriGene qPCR primer pairs and template standards for PNMA6A
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNMA6A Gene
Orthologs for PNMA6A Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PNMA6C 33 |
|
||
dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
LOC100687496 33 |
|
||||
cow (Bos Taurus) |
Mammalia | LOC526946 33 |
|
||
-- 34 |
|
OneToMany |
- Species where no ortholog for PNMA6A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for PNMA6A Gene
Paralogs for PNMA6A Gene
(8) SIMAP similar genes for PNMA6A Gene using alignment to 1 proteins:
Variants for PNMA6A Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000176589 | -- | 153,075,347(+) | C/T | downstream_transcript_variant | |
rs1006487434 | -- | 153,074,514(+) | C/T | 3_prime_UTR_variant | |
rs1006622743 | -- | 153,074,707(+) | G/A | 3_prime_UTR_variant | |
rs1011150585 | -- | 153,074,752(+) | G/A | 3_prime_UTR_variant | |
rs1011621893 | -- | 153,075,138(+) | G/C | downstream_transcript_variant |
Additional Variant Information for PNMA6A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PNMA6A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PNMA6A Gene
Disorders for PNMA6A Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
thyroid gland disease |
|
|
Search PNMA6A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PNMA6A
No data available for UniProtKB/Swiss-Prot and Genatlas for PNMA6A Gene
Publications for PNMA6A Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
- Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner. (PMID: 19366867) Takaji M … Yamamori T (Cerebral cortex (New York, N.Y. : 1991) 2009) 4 58
Products for PNMA6A Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available PNMA6C related products ranked by validation data
- antibodies-online: Search results for available PNMA6C related products ranked by validation data
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Sources for PNMA6A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew