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Aliases for PNMA6A Gene

Aliases for PNMA6A Gene

  • Paraneoplastic Ma Antigen Family Member 6A 2 3
  • Paraneoplastic Ma Antigen Family Member 6C 2 3
  • PNMA6 3 6
  • Paraneoplastic Antigen-Like 6A Related Protein 3
  • Paraneoplastic Antigen-Like Protein 6A 3
  • Paraneoplastic Antigen-Like Protein 6C 3
  • Paraneoplastic Antigen Like 6A 2
  • Paraneoplastic Antigen Like 6C 2
  • PNMA6C 3
  • MA6 3

External Ids for PNMA6A Gene

Previous HGNC Symbols for PNMA6A Gene

  • PNMA6C

Previous GeneCards Identifiers for PNMA6A Gene

  • GC0XP150859
  • GC0XP151911
  • GC0XP151991
  • GC0XP152338

Summaries for PNMA6A Gene

GeneCards Summary for PNMA6A Gene

PNMA6A (Paraneoplastic Ma Antigen Family Member 6A) is a Protein Coding gene. An important paralog of this gene is ZCCHC12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNMA6A Gene

Genomics for PNMA6A Gene

Regulatory Elements for PNMA6A Gene

Genomic Location for PNMA6A Gene

Start:
153,072,456 bp from pter
End:
153,075,018 bp from pter
Size:
2,563 bases
Orientation:
Plus strand

Genomic View for PNMA6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNMA6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNMA6A Gene

Proteins for PNMA6A Gene

  • Protein details for PNMA6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CW24-PNM6A_HUMAN
    Recommended name:
    Paraneoplastic antigen-like protein 6A
    Protein Accession:
    P0CW24
    Secondary Accessions:
    • A8K1G4
    • D3DWT8
    • Q96A40

    Protein attributes for PNMA6A Gene

    Size:
    399 amino acids
    Molecular mass:
    44006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNMA6A Gene

Proteomics data for PNMA6A Gene at MOPED

Post-translational modifications for PNMA6A Gene

  • Ubiquitination at Lys244
  • Modification sites at PhosphoSitePlus

Other Protein References for PNMA6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PNMA6A Gene

Domains for PNMA6A Gene

Gene Families for PNMA6A Gene

HGNC:
  • PNMA :Paraneoplastic Ma antigens

Protein Domains for PNMA6A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNMA6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CW24

UniProtKB/Swiss-Prot:

PNM6A_HUMAN :
  • P0CW24
Family:
  • Belongs to the PNMA family.
genes like me logo Genes that share domains with PNMA6A: view

Function for PNMA6A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PNMA6A Gene

Localization for PNMA6A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNMA6A Gene COMPARTMENTS Subcellular localization image for PNMA6A gene
Compartment Confidence
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PNMA6A Gene

Pathways for PNMA6A Gene

SuperPathways for PNMA6A Gene

No Data Available

Interacting Proteins for PNMA6A Gene

Selected Interacting proteins: P0CW24-PNM6A_HUMAN for PNMA6A Gene via I2D

Symbol External ID(s) Details
PNMA1

Gene Ontology (GO) - Biological Process for PNMA6A Gene

None

No data available for Pathways by source for PNMA6A Gene

Transcripts for PNMA6A Gene

mRNA/cDNA for PNMA6A Gene

(41) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNMA6A Gene

Paraneoplastic Ma antigen family member 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNMA6A Gene

No ASD Table

Relevant External Links for PNMA6A Gene

GeneLoc Exon Structure for
PNMA6A
ECgene alternative splicing isoforms for
PNMA6A

Expression for PNMA6A Gene

mRNA expression in normal human tissues for PNMA6A Gene

mRNA differential expression in normal tissues according to GTEx for PNMA6A Gene

This gene is overexpressed in Brain - Cortex (6.8), Brain - Substantia nigra (6.2), Brain - Frontal Cortex (BA9) (5.5), Brain - Amygdala (5.1), Brain - Hypothalamus (4.8), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PNMA6A Gene

SOURCE GeneReport for Unigene cluster for PNMA6A Gene Hs.721963

mRNA Expression by UniProt/SwissProt for PNMA6A Gene

P0CW24-PNM6A_HUMAN
Tissue specificity: Expressed in the brain.
genes like me logo Genes that share expressions with PNMA6A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PNMA6A Gene

Orthologs for PNMA6A Gene

This gene was present in the common ancestor of mammals.

Orthologs for PNMA6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNMA6C 35
  • 99.63 (n)
  • 98.9 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
OneToMany
LOC526946 35
  • 63.18 (n)
  • 49.83 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
OneToMany
LOC100687496 35
  • 64.78 (n)
  • 52.65 (a)
Species with no ortholog for PNMA6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNMA6A Gene

ENSEMBL:
Gene Tree for PNMA6A (if available)
TreeFam:
Gene Tree for PNMA6A (if available)

Paralogs for PNMA6A Gene

Paralogs for PNMA6A Gene

Selected SIMAP similar genes for PNMA6A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PNMA6A: view

Variants for PNMA6A Gene

Sequence variations from dbSNP and Humsavar for PNMA6A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs41311368 -- 153,074,687(+) CCCCA(G/T)CGCAG utr-variant-3-prime
rs112035433 -- 153,074,603(+) TTTCC(C/T)TGCGT utr-variant-3-prime
rs115813242 -- 153,075,478(+) GACTC(C/G)GCGGG downstream-variant-500B
rs143034040 -- 153,074,580(+) CGTAT(C/G)GTGAG utr-variant-3-prime
rs149587401 -- 153,074,812(+) CTGAG(G/T)TTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PNMA6A Gene

Variant ID Type Subtype PubMed ID
nsv7467 OTHER Inversion 18451855
essv6402 CNV CNV 17122850
dgv2494e1 CNV Complex 17122850
nsv9997 CNV Gain 18304495
esv33199 CNV Gain+Loss 17666407

Relevant External Links for PNMA6A Gene

HapMap Linkage Disequilibrium report
PNMA6A
Locus Specific Mutation Databases (LSDB)
PNMA6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNMA6A Gene

Disorders for PNMA6A Gene

No disorders were found for PNMA6A Gene.

No data available for UniProtKB/Swiss-Prot for PNMA6A Gene

Publications for PNMA6A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  2. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease. (PMID: 16214224) Schueller M. … Voltz R. (J. Neuroimmunol. 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PNMA6A Gene

Sources for PNMA6A Gene

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