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PNMA6A Gene(Protein Coding)

PNMA Family Member 6A

GCID:
GC0XP153072
GIFtS:
36
Genes Participants
UDN Logo

Aliases for PNMA6A Gene

Aliases for PNMA6A Gene

  • PNMA Family Member 6A 2 3 5
  • Paraneoplastic Ma Antigen Family Member 6C 2 3
  • Paraneoplastic Ma Antigen Family Member 6A 2 3
  • PNMA6C 3 4
  • Paraneoplastic Antigen-Like 6A Related Protein 3
  • Paraneoplastic Antigen-Like Protein 6A 3
  • Paraneoplastic Antigen-Like Protein 6C 3
  • Paraneoplastic Antigen Like 6A 2
  • Paraneoplastic Antigen Like 6C 2
  • PNMA6 3
  • MA6 3

External Ids for PNMA6A Gene

Previous HGNC Symbols for PNMA6A Gene

  • PNMA6C

Previous GeneCards Identifiers for PNMA6A Gene

  • GC0XP150859
  • GC0XP151911
  • GC0XP151991
  • GC0XP152338

Summaries for PNMA6A Gene

GeneCards Summary for PNMA6A Gene

PNMA6A (PNMA Family Member 6A) is a Protein Coding gene. Diseases associated with PNMA6A include Thyroid Gland Disease. An important paralog of this gene is PNMA6F.

Additional gene information for PNMA6A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNMA6A Gene

Genomics for PNMA6A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PNMA6A Gene

Promoters and enhancers for PNMA6A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XI153072 Promoter 1 EPDnew Ensembl 550.8 +0.1 87 1 PNMA6A PNMA6B
GH0XI153245 Enhancer 0.8 ENCODE 34.7 +173.1 173103 0.8 ARNT ZBTB40 ATF7 KLF13 ZNF362 SP3 ZNF518A SREBF1 MBD2 SP1 PNMA6A TMEM187 MAGEA1 HCFC1 ENSG00000231600 LOC105373373
GH0XI153032 Enhancer 1 Ensembl ENCODE 21.1 -39.7 -39713 1.3 HDAC1 RB1 KLF17 ZNF76 GLI4 ZNF2 RAD21 YY1 ARID2 EGR1 PNMA6A PNMA3 ENSG00000234200 GC0XM153053
GH0XI152829 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.3 -240.2 -240195 4.8 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 POLR2B GLIS2 NSDHL CETN2 ZNF185 PNMA6A GC0XM152591
GH0XI152450 Promoter/Enhancer 1 EPDnew ENCODE 6.9 -621.0 -621014 0.9 ZNF148 CTBP1 GATA2 POLR2A VEZF1 SIN3A PRDM10 GABRA3 PNMA6A KRT8P8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PNMA6A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PNMA6A gene promoter:

Genomic Locations for PNMA6A Gene

Genomic Locations for PNMA6A Gene
chrX:153,072,414-153,075,019
(GRCh38/hg38)
Size:
2,606 bases
Orientation:
Plus strand
chrX:152,240,839-152,340,864
(GRCh37/hg19)

Genomic View for PNMA6A Gene

Genes around PNMA6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNMA6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNMA6A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PNMA6A Gene

Proteins for PNMA6A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PNMA6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CW24-PNM6A_HUMAN
    Recommended name:
    Paraneoplastic antigen-like protein 6A
    Protein Accession:
    P0CW24
    Secondary Accessions:
    • A8K1G4
    • D3DWT8
    • P0CW26
    • Q96A40

    Protein attributes for PNMA6A Gene

    Size:
    399 amino acids
    Molecular mass:
    43875 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNMA6A Gene

Protein Expression for PNMA6A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PNMA6A Gene

No Post-translational modifications

Other Protein References for PNMA6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PNMA6A Gene

Domains & Families for PNMA6A Gene

Gene Families for PNMA6A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PNMA6A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNMA6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CW24

UniProtKB/Swiss-Prot:

PNM6A_HUMAN :
  • Belongs to the PNMA family.
Family:
  • Belongs to the PNMA family.
genes like me logo Genes that share domains with PNMA6A: view

Function for PNMA6A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for PNMA6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with PNMA6A: view

Phenotypes for PNMA6A Gene

GenomeRNAi human phenotypes for PNMA6A:
genes like me logo Genes that share phenotypes with PNMA6A: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PNMA6A Gene

Localization for PNMA6A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNMA6A gene
Compartment Confidence
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (1)
  • Nucleoli (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PNMA6A Gene

Pathways & Interactions for PNMA6A Gene

SuperPathways for PNMA6A Gene

PathCards logo More details on SuperPathways for PNMA6A
No Data Available

Interacting Proteins for PNMA6A Gene

Selected Interacting proteins: P0CW24-PNM6A_HUMAN for PNMA6A Gene via UniProtKB IID

Symbol External ID(s) Details
PNMA1

Gene Ontology (GO) - Biological Process for PNMA6A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PNMA6A Gene

Drugs & Compounds for PNMA6A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for PNMA6A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PNMA6A Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(41) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNMA6A Gene

Paraneoplastic Ma antigen family member 6A:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNMA6A Gene

No ASD Table

Relevant External Links for PNMA6A Gene

GeneLoc Exon Structure for
PNMA6A
ECgene alternative splicing isoforms for
PNMA6A

Expression for PNMA6A Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNMA6A Gene

mRNA expression in normal human tissues for PNMA6A Gene
mRNA expression by BioGPS for PNMA6A GenemRNA expression by GTEx for PNMA6A Gene

mRNA differential expression in normal tissues according to GTEx for PNMA6A Gene

This gene is overexpressed in Brain - Cortex (x6.8), Brain - Substantia nigra (x6.2), Brain - Frontal Cortex (BA9) (x5.5), Brain - Amygdala (x5.1), Brain - Hypothalamus (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for PNMA6A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PNMA6A Gene



Protein tissue co-expression partners for PNMA6A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PNMA6A Gene:

PNMA6A

SOURCE GeneReport for Unigene cluster for PNMA6A Gene:

Hs.721963

mRNA Expression by UniProt/SwissProt for PNMA6A Gene:

P0CW24-PNM6A_HUMAN
Tissue specificity: Expressed in the brain.

Evidence on tissue expression from TISSUES for PNMA6A Gene

  • Nervous system(3.4)
  • Thyroid gland(3.1)
genes like me logo Genes that share expression patterns with PNMA6A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNMA6A Gene

Orthologs for PNMA6A Gene

This gene was present in the common ancestor of mammals.

Orthologs for PNMA6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PNMA6C 33
  • 99.63 (n)
dog
(Canis familiaris)
 Mammalia -- 34
  • 72 (a)
 OneToMany
LOC100687496 33
  • 64.78 (n)
cow
(Bos Taurus)
 Mammalia LOC526946 33
  • 63.18 (n)
-- 34
  • 43 (a)
 OneToMany
Species where no ortholog for PNMA6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNMA6A Gene

ENSEMBL:
Gene Tree for PNMA6A (if available)
TreeFam:
Gene Tree for PNMA6A (if available)

Paralogs for PNMA6A Gene

Paralogs for PNMA6A Gene

(8) SIMAP similar genes for PNMA6A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PNMA6A: view

Variants for PNMA6A Gene

Sequence variations from dbSNP and Humsavar for PNMA6A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000176589 -- 153,075,347(+) C/T downstream_transcript_variant
rs1006487434 -- 153,074,514(+) C/T 3_prime_UTR_variant
rs1006622743 -- 153,074,707(+) G/A 3_prime_UTR_variant
rs1011150585 -- 153,074,752(+) G/A 3_prime_UTR_variant
rs1011621893 -- 153,075,138(+) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PNMA6A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
nsv1133773 CNV deletion 24896259
nsv9997 CNV gain 18304495

Additional Variant Information for PNMA6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNMA6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PNMA6A Gene

Disorders for PNMA6A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNMA6A Gene - From: DISEASES

Disorder Aliases PubMed IDs
thyroid gland disease
  • abnormality of the thyroid gland
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PNMA6A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PNMA6A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNMA6A Gene

Publications for PNMA6A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner. (PMID: 19366867) Takaji M … Yamamori T (Cerebral cortex (New York, N.Y. : 1991) 2009) 4 58

Products for PNMA6A Gene

Sources for PNMA6A Gene

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