PNMA6A Gene
protein-coding GIFtS: 39
GCID: GC0XP152338
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paraneoplastic Ma antigen family member 6A(Previous name: paraneoplastic antigen like 6A )
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Aliases
for PNMA6A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Paraneoplastic Ma Antigen Family Member 6A1 2 | | Paraneoplastic Antigen Like 6A1 2 | | MGC158271 | | MA62 | | PNMA62 | | Paraneoplastic Antigen-Like Protein 6A2 |
Export aliases for PNMA6A gene to outside databasesPrevious GC identifers: GC0XP150859 GC0XP151911 GC0XP151991 |
Summaries
for PNMA6A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PNMA6A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PNMA6A gene promoter:
CREB SREBP-1a deltaCREB SREBP-1c MyoD NRSF form 2 SREBP-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for PNMA6A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNMA6A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28PNMA6A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP152338: view genomic region
(about GC identifiers)
Start:
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152,240,839 bp from pter |
End:
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152,340,864 bp from pter |
Size:
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100,026 bases |
Orientation:
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plus strand |
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Proteins
for PNMA6A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PNM6A_HUMAN, P0CW24 (See
protein sequence)Recommended Name: Paraneoplastic antigen-like protein 6A Size: 399 amino acids; 44006 Da
Secondary accessions: A8K1G4 D3DWT8 Q96A40Explore the universe of human proteins at neXtProt for PNMA6A: NX_P0CW24
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CW24
PNMA6A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116271.2
ENSEMBL proteins: ENSP00000405718 ENSP00000441213
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
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PNMA6A for ontologies About GeneDecksing
PNMA6A Antibody Products:
Assay Products for PNMA6A: |
Protein
Domains /
Families
for PNMA6A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PNMA6A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0CW24ProtoNet protein and cluster: P0CW24 UniProtKB/Swiss-Prot: PNM6A_HUMAN, P0CW24Similarity: Belongs to the PNMA family |
Function
for PNMA6A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA6A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA6A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNMA6A |
|
Pathways & Interactions
for PNMA6A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNMA6A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PNMA6A (P0CW243 ENSP000004057184) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for PNMA6A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PNMA6A
Search CenterWatch for drugs/clinical trials and news about PNMA6A / PNM6A
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Transcripts
for PNMA6A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PNMA6A gene: NM_032882.4 Unigene Cluster for PNMA6A: Paraneoplastic Ma antigen family member 6A Hs.721963 [show with all ESTs]Unigene Representative Sequence: NM_0328822 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000453825 ENST00000535416
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA6A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA6A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PNMA6A (NM_032882) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNMA6A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNMA6A |
1 DOTS entry: DT.91686535 24/41 AceView cDNA sequences (see all 41): N22466 CA392698 AI675171 BC007631 BG059973 CA392699 AW611713 BM698946 BM703493 AI885740 NM_032882 BX353874 AL567290 BF972760 BM669739 BX423799 BG116201 BX325209 BF508272 BM715325 AL538406 BX325210 BE311776 BX118395
GeneLoc Exon Structure
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Expression
for PNMA6A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PNMA6A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTGGGAG
About this image
See PNMA6A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.721963
SABiosciences Custom PCR Arrays for PNMA6A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNMA6A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat PNMA6A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNMA6A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNMA6A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNMA6A |
Orthologs
for PNMA6A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for PNMA6A (if available)
TreeFam Gene Tree for PNMA6A (if available) |
Paralogs
for PNMA6A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PNMA6A gene
- PNMA6B1 2 PNMA6C1 2 PNMA6D1 2 PNMA52 PNMA12 PNMA22 PNMA32 MOAP12
- PNMAL22 ZCCHC122 PNMAL12
8 SIMAP similar genes for PNMA6A using alignment to 1 protein entry: PNM6A_HUMAN:PNMA6B PNMA6C PNMA6D PNMA1 MOAP1 PNMA2
PNMA3 PNMA5
PNMA6A for paralogs About GeneDecksing
|
Genomic Variants
for PNMA6A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PNMA6A (152240839 - 152340864 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PNMA6A
1 CNV: 4178
1 Inversion: 37360
Locus Specific Mutation Databases (LSDB): PNMA6A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNMA6A |
|
Disorders
/ Diseases
for PNMA6A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PNMA6A for disorders About GeneDecksing
2  diseases for PNMA6A: About MalaCardsneurologic diseases neuronitis
Export disorders for PNMA6A gene to outside databases
|
Publications
for PNMA6A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PNMA6A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with PNMA6A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (2004)
- A functional -1 ribosomal frameshift signal in the human paraneoplastic Ma3 gene. (PubMed id 16407312)1 Wills N.M....Atkins J.F. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease. (PubMed id 16214224)1 Schueller M.... Voltz R. (2005)
- Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PubMed id 14676191)1 Brajenovic M.... Drewes G. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PNMA6A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PNMA6A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing PNMA6A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PNMA6A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PNMA6A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PNMA6A gene:
Search GeneIP for patents involving PNMA6A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PNMA6A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PNMA6A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PNMA6A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNMA6A | | | OriGene Protein Over-expression Lysate for PNMA6A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PNMA6A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA6A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA6A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PNMA6A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | PNMA6A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNMA6A |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNMA6A |
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