PNMA3 Gene
protein-coding GIFtS: 48
GCID: GC0XP152224
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paraneoplastic Ma antigen 3(Previous name: paraneoplastic antigen MA3 )
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Aliases
for PNMA3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Paraneoplastic Ma Antigen 31 2 | | MGC1327561 | | MA31 2 3 | | MGC1327581 | | MA51 2 | | Paraneoplastic Cancer-Testis-Brain Antigen2 | | Paraneoplastic Antigen MA31 2 | | |
Export aliases for PNMA3 gene to outside databasesPrevious GC identifers: GC0XP146564 GC0XP148882 GC0XP149972 GC0XP150843 GC0XP151895 GC0XP151975 GC0XP141026 |
Summaries
for PNMA3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PNMA3:
This gene is a member of the paraneoplastic antigen MA (PNMA) gene family, whose protein products share homology withretroviral Gag proteins. They are highly expressed in the brain and also in a range of tumors associated with seriousneurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consistingof a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shiftedproduct has not been characterized. (provided by RefSeq, Jul 2008)
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Genomic Views
for PNMA3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PNMA3 gene promoter:
E2F-3a E2F-4 E2F-5 SREBP-1c E2F-2 SREBP-1b E2F-1 E2F SREBP-1a HOXA5
Other transcription factors
Search SABiosciences Chromatin IP Primers for PNMA3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNMA3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28PNMA3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP152224: view genomic region
(about GC identifiers)
Start:
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152,224,766 bp from pter |
End:
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152,228,827 bp from pter |
Size:
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4,062 bases |
Orientation:
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plus strand |
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Proteins
for PNMA3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PNMA3_HUMAN, Q9UL41 (See
protein sequence)Recommended Name: Paraneoplastic antigen Ma3 Size: 463 amino acids; 52404 Da
Subcellular location: Nucleus, nucleolus (By similarity)
Miscellaneous: Antibodies against PNMA3 are present in sera from patients suffering of paraneoplastic neurologicaldisorders
Secondary accessions: D3DWT7 Q9H0A4Alternative splicing: 2 isoforms: Q9UL41-1 Q9UL41-2 Explore the universe of human proteins at neXtProt for PNMA3: NX_Q9UL41
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UL41
PNMA3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037496.3
ENSEMBL proteins: ENSP00000359288 ENSP00000390576 ENSP00000359286 ENSP00000407642
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
PNMA3 for ontologies About GeneDecksing
PNMA3 Antibody Products:
Assay Products for PNMA3: |
Protein
Domains /
Families
for PNMA3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PNMA3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UL41ProtoNet protein and cluster: Q9UL41 1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature
UniProtKB/Swiss-Prot: PNMA3_HUMAN, Q9UL41Similarity: Belongs to the PNMA familySimilarity: Contains 1 CCHC-type zinc finger |
Function
for PNMA3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PNMA3 (NM_013364) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNMA3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNMA3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNMA3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
PNMA3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PNMA3:
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Pathways & Interactions
for PNMA3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNMA3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PNMA3 (Q9UL413 ENSP000003592864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
PNMA3 for ontologies About GeneDecksing
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Drugs & Compounds
for PNMA3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PNMA3
Search CenterWatch for drugs/clinical trials and news about PNMA3
|
Transcripts
for PNMA3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PNMA3 gene: NM_013364.4 Unigene Clusters for PNMA3: Paraneoplastic Ma antigen 3 Hs.449627 [show with all ESTs], Hs.744496 [show with all ESTs]Unigene Representative Sequences: BC030761, NM_0133644 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370265 ENST00000424805(uc004fhd.3) ENST00000370264(uc022cho.1)
ENST00000447306(uc004fhc.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PNMA3 (NM_013364) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNMA3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNMA3 |
Additional cDNA sequence: AF083116.1 AK312299.1 AL136878.1 BC105096.1 BC105098.1 5 DOTS entries: DT.445726 DT.100751391 DT.91683288 DT.121306744 DT.100741065 24/57 AceView cDNA sequences (see all 57): CB134357 BM544400 AA322434 CB153962 BX494239 AL040126 H67501 BM728249 AF083116 BM544075 AI828763 AL042615 BG713993 BC030761 NM_013364 AL136878 AI026957 BP361636 BE463973 BM661597 AL538003 CA449774 BI753094 AI198567
GeneLoc Exon Structure
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Expression
for PNMA3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PNMA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCAGTTTC
About this image
See PNMA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PNMA3
SOURCE GeneReport for Unigene clusters: Hs.449627 Hs.744496
UniProtKB/Swiss-Prot: PNMA3_HUMAN, Q9UL41Tissue specificity: Expressed at high levels in the brain and testis. Expressed at lower levels in the heart, tracheaand kidney
SABiosciences Custom PCR Arrays for PNMA3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNMA3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PNMA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNMA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNMA3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNMA3 |
Orthologs
for PNMA3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for PNMA3 (if available)
TreeFam Gene Tree for PNMA3 (if available) |
Paralogs
for PNMA3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PNMA3 gene
- PNMA6A2 PNMA52 PNMA12 PNMA6D2 PNMA22 PNMA6C2 MOAP12 PNMAL22
- ZCCHC122 PNMAL12 PNMA6B2
8 SIMAP similar genes for PNMA3 using alignment to 1 protein entry: PNMA3_HUMAN:PNMA2 PNMA1 MOAP1 PNMA6A PNMA6B PNMA6C
PNMA6D PNMA5
PNMA3 for paralogs About GeneDecksing
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Genomic Variants
for PNMA3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PNMA3 (152224766 - 152228827 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PNMA3
1 CNV: 4178
1 Inversion: 37360
Locus Specific Mutation Databases (LSDB): PNMA3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNMA3 |
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Disorders
/ Diseases
for PNMA3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PNMA3 for disorders About GeneDecksing
OMIM gene information: 300675
OMIM disorders: --
5  diseases for PNMA3: About MalaCardsmammary duct ectasia paraneoplastic neurologic disorders bronchitis neurologic diseases
neuronitis
Export disorders for PNMA3 gene to outside databases
|
Publications
for PNMA3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PNMA3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PNMA3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular and clinical diversity in paraneoplastic immunity to Ma proteins. (PubMed id 11558790)1, 2, 3 Rosenfeld M.R.... Dalmau J. (2001)
- The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease. (PubMed id 16214224)1, 2 Schueller M.... Voltz R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A functional -1 ribosomal frameshift signal in the human paraneoplastic Ma3 gene. (PubMed id 16407312)1, 9 Wills N.M....Atkins J.F. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PubMed id 14676191)1 Brajenovic M.... Drewes G. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)2 Wiemann S.... Poustka A. (2001)
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External Searches for PNMA3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PNMA3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing PNMA3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PNMA3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PNMA3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PNMA3 gene:
Search GeneIP for patents involving PNMA3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PNMA3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | OriGene Antibodies for PNMA3 | | OriGene shRNA RFP for PNMA3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PNMA3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNMA3 | | | OriGene Protein Over-expression Lysate for PNMA3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PNMA3 | | OriGene 3'-UTR Clone for PNMA3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNMA3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PNMA3 | | OriGene Custom Protein Services for PNMA3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PNMA3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNMA3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNMA3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PNMA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNMA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNMA3 |
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 | | | PNMA3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNMA3 |
|  |  |  | | | | Search ThermoFisher Antibodies for PNMA3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNMA3 |
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