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Aliases for PNMA1 Gene

Aliases for PNMA1 Gene

  • Paraneoplastic Ma Antigen 1 2 3
  • MA1 3 4 6
  • Neuron- And Testis-Specific Protein 1 3 4
  • Paraneoplastic Antigen MA1 2 3
  • 37 KDa Neuronal Protein 3 4
  • Paraneoplastic Neuronal Antigen MA1 3

External Ids for PNMA1 Gene

Previous GeneCards Identifiers for PNMA1 Gene

  • GC14M071683
  • GC14M067974
  • GC14M072168
  • GC14M072139
  • GC14M073248
  • GC14M074178
  • GC14M054345

Summaries for PNMA1 Gene

Entrez Gene Summary for PNMA1 Gene

  • This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014]

GeneCards Summary for PNMA1 Gene

PNMA1 (Paraneoplastic Ma Antigen 1) is a Protein Coding gene. An important paralog of this gene is ZCCHC12.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNMA1 Gene

Genomics for PNMA1 Gene

Regulatory Elements for PNMA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PNMA1 Gene

Start:
73,711,783 bp from pter
End:
73,714,425 bp from pter
Size:
2,643 bases
Orientation:
Minus strand

Genomic View for PNMA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNMA1 Gene

Proteins for PNMA1 Gene

  • Protein details for PNMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND90-PNMA1_HUMAN
    Recommended name:
    Paraneoplastic antigen Ma1
    Protein Accession:
    Q8ND90
    Secondary Accessions:
    • A8K4L5
    • O95144
    • Q8NG07

    Protein attributes for PNMA1 Gene

    Size:
    353 amino acids
    Molecular mass:
    39761 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders

neXtProt entry for PNMA1 Gene

Proteomics data for PNMA1 Gene at MOPED

Post-translational modifications for PNMA1 Gene

  • Ubiquitination at Lys62, Lys218, Lys249, Lys260, and Lys283
  • Modification sites at PhosphoSitePlus

Other Protein References for PNMA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PNMA1 Gene

Domains for PNMA1 Gene

Gene Families for PNMA1 Gene

HGNC:
  • PNMA :Paraneoplastic Ma antigens

Protein Domains for PNMA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNMA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8ND90

UniProtKB/Swiss-Prot:

PNMA1_HUMAN :
  • Q8ND90
Family:
  • Belongs to the PNMA family.
genes like me logo Genes that share domains with PNMA1: view

Function for PNMA1 Gene

Gene Ontology (GO) - Molecular Function for PNMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14676191
genes like me logo Genes that share ontologies with PNMA1: view

Phenotypes for PNMA1 Gene

GenomeRNAi human phenotypes for PNMA1:
genes like me logo Genes that share phenotypes with PNMA1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNMA1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PNMA1 Gene

Localization for PNMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNMA1 Gene

Nucleus, nucleolus. Note=In tumor cells, it is cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNMA1 Gene COMPARTMENTS Subcellular localization image for PNMA1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PNMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 10050892
GO:0005737 cytoplasm IDA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with PNMA1: view

Pathways for PNMA1 Gene

SuperPathways for PNMA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PNMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002437 inflammatory response to antigenic stimulus ISS 15201193
GO:0043065 positive regulation of apoptotic process ISS --
genes like me logo Genes that share ontologies with PNMA1: view

No data available for Pathways by source for PNMA1 Gene

Transcripts for PNMA1 Gene

mRNA/cDNA for PNMA1 Gene

(257) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNMA1 Gene

Paraneoplastic Ma antigen 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNMA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNMA1 Gene

No ASD Table

Relevant External Links for PNMA1 Gene

GeneLoc Exon Structure for
PNMA1
ECgene alternative splicing isoforms for
PNMA1

Expression for PNMA1 Gene

mRNA expression in normal human tissues for PNMA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PNMA1 Gene

This gene is overexpressed in Breast (25.4) and Bone (22.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PNMA1 Gene

SOURCE GeneReport for Unigene cluster for PNMA1 Gene Hs.194709

mRNA Expression by UniProt/SwissProt for PNMA1 Gene

Q8ND90-PNMA1_HUMAN
Tissue specificity: Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.
genes like me logo Genes that share expressions with PNMA1: view

Expression partners for PNMA1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PNMA1 Gene

Orthologs for PNMA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PNMA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNMA1 35
  • 89.33 (n)
  • 92.63 (a)
PNMA1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNMA1 35
  • 92.73 (n)
  • 96.6 (a)
PNMA1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnma1 35
  • 87.35 (n)
  • 92.07 (a)
Pnma1 16
Pnma1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PNMA1 35
  • 99.91 (n)
  • 100 (a)
PNMA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnma1 35
  • 87.63 (n)
  • 93.77 (a)
Species with no ortholog for PNMA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNMA1 Gene

ENSEMBL:
Gene Tree for PNMA1 (if available)
TreeFam:
Gene Tree for PNMA1 (if available)

Paralogs for PNMA1 Gene

Paralogs for PNMA1 Gene

Selected SIMAP similar genes for PNMA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PNMA1: view

Variants for PNMA1 Gene

Sequence variations from dbSNP and Humsavar for PNMA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7182 -- 73,712,097(+) GCACA(C/T)TTCCT utr-variant-3-prime
rs8949 -- 73,712,026(+) AAACT(G/T)GTCGA utr-variant-3-prime
rs1305033 -- 73,712,348(+) TTACC(-/TGGCATT)TTAGC utr-variant-3-prime
rs3179543 -- 73,713,370(-) AAAGT(G/T)TTATT reference, synonymous-codon
rs11545006 -- 73,712,214(+) TCGTA(A/G)TAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PNMA1 Gene

Variant ID Type Subtype PubMed ID
dgv1959n71 CNV Loss 21882294
nsv902091 CNV Gain 21882294
nsv902093 CNV Loss 21882294

Relevant External Links for PNMA1 Gene

HapMap Linkage Disequilibrium report
PNMA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNMA1 Gene

Disorders for PNMA1 Gene

(1) University of Copenhagen DISEASES for PNMA1 Gene

genes like me logo Genes that share disorders with PNMA1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for PNMA1 Gene

Publications for PNMA1 Gene

  1. Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. (PMID: 10050892) Dalmau J. … Rosenfeld M.R. (Brain 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease. (PMID: 16214224) Schueller M. … Voltz R. (J. Neuroimmunol. 2005) 3 4
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PMID: 16730941) Tsang H.T.H. … Sanderson C.M. (Genomics 2006) 3

Products for PNMA1 Gene

Sources for PNMA1 Gene

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