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Aliases for PNMA1 Gene

Aliases for PNMA1 Gene

  • Paraneoplastic Ma Antigen 1 2 3 5
  • Neuron- And Testis-Specific Protein 1 3 4
  • 37 KDa Neuronal Protein 3 4
  • MA1 3 4
  • Paraneoplastic Neuronal Antigen MA1 3
  • Paraneoplastic Antigen MA1 2

External Ids for PNMA1 Gene

Previous GeneCards Identifiers for PNMA1 Gene

  • GC14M071683
  • GC14M067974
  • GC14M072168
  • GC14M072139
  • GC14M073248
  • GC14M074178
  • GC14M054345

Summaries for PNMA1 Gene

Entrez Gene Summary for PNMA1 Gene

  • This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014]

GeneCards Summary for PNMA1 Gene

PNMA1 (Paraneoplastic Ma Antigen 1) is a Protein Coding gene. Diseases associated with PNMA1 include Paraneoplastic Syndromes. An important paralog of this gene is ZCCHC12.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNMA1 Gene

Genomics for PNMA1 Gene

Regulatory Elements for PNMA1 Gene

Enhancers for PNMA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PNMA1 on UCSC Golden Path with GeneCards custom track

Promoters for PNMA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PNMA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PNMA1 Gene

73,711,783 bp from pter
73,714,425 bp from pter
2,643 bases
Minus strand

Genomic View for PNMA1 Gene

Genes around PNMA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNMA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNMA1 Gene

Proteins for PNMA1 Gene

  • Protein details for PNMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Paraneoplastic antigen Ma1
    Protein Accession:
    Secondary Accessions:
    • A8K4L5
    • O95144
    • Q8NG07

    Protein attributes for PNMA1 Gene

    353 amino acids
    Molecular mass:
    39761 Da
    Quaternary structure:
    No Data Available
    • Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.

neXtProt entry for PNMA1 Gene

Proteomics data for PNMA1 Gene at MOPED

Post-translational modifications for PNMA1 Gene

  • Ubiquitination at Lys 62, Lys 218, Lys 249, Lys 260, and Lys 283
  • Modification sites at PhosphoSitePlus

Other Protein References for PNMA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PNMA1 Gene

Domains & Families for PNMA1 Gene

Gene Families for PNMA1 Gene

Protein Domains for PNMA1 Gene


Suggested Antigen Peptide Sequences for PNMA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PNMA family.
  • Belongs to the PNMA family.
genes like me logo Genes that share domains with PNMA1: view

Function for PNMA1 Gene

genes like me logo Genes that share phenotypes with PNMA1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PNMA1 Gene

Localization for PNMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNMA1 Gene

Nucleus, nucleolus. Note=In tumor cells, it is cytoplasmic.

Subcellular locations from

Jensen Localization Image for PNMA1 Gene COMPARTMENTS Subcellular localization image for PNMA1 gene
Compartment Confidence
nucleus 5
cytosol 3
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PNMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 10050892
GO:0005737 cytoplasm IDA 10050892
genes like me logo Genes that share ontologies with PNMA1: view

Pathways & Interactions for PNMA1 Gene

SuperPathways for PNMA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PNMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002437 inflammatory response to antigenic stimulus ISS 15201193
genes like me logo Genes that share ontologies with PNMA1: view

No data available for Pathways by source and SIGNOR curated interactions for PNMA1 Gene

Drugs & Compounds for PNMA1 Gene

No Compound Related Data Available

Transcripts for PNMA1 Gene

mRNA/cDNA for PNMA1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(257) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNMA1 Gene

Paraneoplastic Ma antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNMA1 Gene

No ASD Table

Relevant External Links for PNMA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PNMA1 Gene

mRNA expression in normal human tissues for PNMA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PNMA1 Gene

This gene is overexpressed in Breast (25.4) and Bone (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PNMA1 Gene

SOURCE GeneReport for Unigene cluster for PNMA1 Gene Hs.194709

mRNA Expression by UniProt/SwissProt for PNMA1 Gene

Tissue specificity: Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.
genes like me logo Genes that share expression patterns with PNMA1: view

Protein tissue co-expression partners for PNMA1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for PNMA1 Gene

Orthologs for PNMA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PNMA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PNMA1 35
  • 89.33 (n)
  • 92.63 (a)
PNMA1 36
  • 93 (a)
(Canis familiaris)
Mammalia PNMA1 35
  • 92.73 (n)
  • 96.6 (a)
PNMA1 36
  • 97 (a)
(Mus musculus)
Mammalia Pnma1 35
  • 87.35 (n)
  • 92.07 (a)
Pnma1 16
Pnma1 36
  • 92 (a)
(Pan troglodytes)
Mammalia PNMA1 35
  • 99.91 (n)
  • 100 (a)
PNMA1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pnma1 35
  • 87.63 (n)
  • 93.77 (a)
Species with no ortholog for PNMA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNMA1 Gene

Gene Tree for PNMA1 (if available)
Gene Tree for PNMA1 (if available)

Paralogs for PNMA1 Gene

(11) SIMAP similar genes for PNMA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PNMA1: view

Variants for PNMA1 Gene

Sequence variations from dbSNP and Humsavar for PNMA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs35129712 - 73,713,480(+) GAACA(C/T)TCTCC reference, missense
rs34413931 - 73,712,996(+) GGATG(C/G)GAATA reference, missense
rs7182 -- 73,712,097(+) GCACA(C/T)TTCCT utr-variant-3-prime
rs8949 -- 73,712,026(+) AAACT(G/T)GTCGA utr-variant-3-prime
rs1305033 -- 73,712,348(+) TTACC(-/TGGCATT)TTAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PNMA1 Gene

Variant ID Type Subtype PubMed ID
dgv1959n71 CNV Loss 21882294
nsv902091 CNV Gain 21882294
nsv902093 CNV Loss 21882294

Variation tolerance for PNMA1 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PNMA1 Gene

Disorders for PNMA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNMA1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
paraneoplastic syndromes
- elite association - COSMIC cancer census association via MalaCards
Search PNMA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PNMA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PNMA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNMA1 Gene

Publications for PNMA1 Gene

  1. Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. (PMID: 10050892) Dalmau J. … Rosenfeld M.R. (Brain 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma. (PMID: 25120759) Jiang S.H. … Zhang Z.G. (Int J Clin Exp Pathol 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle J.J. … Zoghbi H.Y. (Hum. Mol. Genet. 2011) 3

Products for PNMA1 Gene

Sources for PNMA1 Gene