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Aliases for PNLIPRP3 Gene

Aliases for PNLIPRP3 Gene

  • Pancreatic Lipase Related Protein 3 2 3 5
  • EC 4 56
  • PL-RP3 3 4
  • Pancreatic Lipase-Related Protein 3 3
  • EC 3.1.1 56

External Ids for PNLIPRP3 Gene

Previous GeneCards Identifiers for PNLIPRP3 Gene

  • GC10P117817
  • GC10P118177
  • GC10P111814

Summaries for PNLIPRP3 Gene

GeneCards Summary for PNLIPRP3 Gene

PNLIPRP3 (Pancreatic Lipase Related Protein 3) is a Protein Coding gene. Among its related pathways are triacylglycerol degradation and Metabolism. Gene Ontology (GO) annotations related to this gene include carboxylic ester hydrolase activity and triglyceride lipase activity. An important paralog of this gene is PNLIPRP1.

Additional gene information for PNLIPRP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP3 Gene

Genomics for PNLIPRP3 Gene

GeneHancer (GH) Regulatory Elements for PNLIPRP3 Gene

Promoters and enhancers for PNLIPRP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I116426 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 550.8 +1.4 1422 4.6 FOXA2 RXRA HLF MAX FOXA1 YY1 JUND ATF3 CEBPA HNF4G PNLIPRP3 SLC18A2 HMGB3P8
GH10I116421 Enhancer 0.5 ENCODE dbSUPER 0.4 -5.8 -5825 1.2 ATF2 SLC18A2 PNLIPRP3 SNRPGP6
GH10I116440 Enhancer 0.5 ENCODE dbSUPER 0.4 +13.1 13123 1.9 L3MBTL2 HMGB3P8 PNLIPRP3 GC10P116539
GH10I116470 Enhancer 0.6 ENCODE 0.3 +42.4 42373 0.3 PKNOX1 ATF1 ZNF680 ATF2 GATA3 CREB1 ATF7 CREM MGA RNU6-1090P PNLIP HMGB3P8 PNLIPRP3 GC10P116539
GH10I116437 Enhancer 0.4 ENCODE dbSUPER 0.4 +9.5 9477 0.2 HMGB3P8 PNLIPRP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PNLIPRP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PNLIPRP3 gene promoter:

Genomic Locations for PNLIPRP3 Gene

Genomic Locations for PNLIPRP3 Gene
50,095 bases
Plus strand

Genomic View for PNLIPRP3 Gene

Genes around PNLIPRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIPRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIPRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP3 Gene

Proteins for PNLIPRP3 Gene

  • Protein details for PNLIPRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pancreatic lipase-related protein 3
    Protein Accession:

    Protein attributes for PNLIPRP3 Gene

    467 amino acids
    Molecular mass:
    52254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNLIPRP3 Gene

Selected DME Specific Peptides for PNLIPRP3 Gene


Post-translational modifications for PNLIPRP3 Gene

  • Glycosylation at isoforms=74 and Asn125

Other Protein References for PNLIPRP3 Gene

Domains & Families for PNLIPRP3 Gene

Gene Families for PNLIPRP3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PNLIPRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP3: view

Function for PNLIPRP3 Gene

Molecular function for PNLIPRP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.

Enzyme Numbers (IUBMB) for PNLIPRP3 Gene

Phenotypes From GWAS Catalog for PNLIPRP3 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PNLIPRP3: view
genes like me logo Genes that share phenotypes with PNLIPRP3: view

miRNA for PNLIPRP3 Gene

miRTarBase miRNAs that target PNLIPRP3

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PNLIPRP3 Gene

Localization for PNLIPRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNLIPRP3 gene
Compartment Confidence
extracellular 4
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PNLIPRP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PNLIPRP3 Gene

Pathways & Interactions for PNLIPRP3 Gene

genes like me logo Genes that share pathways with PNLIPRP3: view

Pathways by source for PNLIPRP3 Gene

Interacting Proteins for PNLIPRP3 Gene

Gene Ontology (GO) - Biological Process for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PNLIPRP3: view

No data available for SIGNOR curated interactions for PNLIPRP3 Gene

Drugs & Compounds for PNLIPRP3 Gene

(7) Drugs for PNLIPRP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
Myristic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(11) Additional Compounds for PNLIPRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group C
  • 1-Pentadecanoyl-3-behenoyl-sn-glycerol
  • 1-Pentadecanoyl-3-docosanoyl-sn-glycerol
  • DAG(15:0/0:0/22:0)
  • DAG(37:0)
  • DG(37:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PNLIPRP3: view

Transcripts for PNLIPRP3 Gene


(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNLIPRP3 Gene

Pancreatic lipase-related protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP3 Gene

No ASD Table

Relevant External Links for PNLIPRP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PNLIPRP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNLIPRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x19.9) and Skin - Not Sun Exposed (Suprapubic) (x17.0).

Protein differential expression in normal tissues from HIPED for PNLIPRP3 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNLIPRP3 Gene

Protein tissue co-expression partners for PNLIPRP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PNLIPRP3 Gene:


SOURCE GeneReport for Unigene cluster for PNLIPRP3 Gene:


mRNA Expression by UniProt/SwissProt for PNLIPRP3 Gene:

Tissue specificity: Overexpressed in hepatocellular carcinoma.

Evidence on tissue expression from TISSUES for PNLIPRP3 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with PNLIPRP3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PNLIPRP3 Gene

Orthologs for PNLIPRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PNLIPRP3 33 34
  • 99.36 (n)
(Canis familiaris)
Mammalia PNLIPRP3 33
  • 86.22 (n)
(Bos Taurus)
Mammalia PNLIPRP3 33 34
  • 85.8 (n)
(Ornithorhynchus anatinus)
Mammalia PNLIPRP3 34
  • 66 (a)
(Gallus gallus)
Aves PNLIPRP3 33
  • 58.92 (n)
(Anolis carolinensis)
Reptilia PNLIPRP3 34
  • 45 (a)
(Danio rerio)
Actinopterygii CABZ01090041.1 34
  • 23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6847 33
  • 45.08 (n)
CG5966 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 34
  • 34 (a)
Species where no ortholog for PNLIPRP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNLIPRP3 Gene

Gene Tree for PNLIPRP3 (if available)
Gene Tree for PNLIPRP3 (if available)

Paralogs for PNLIPRP3 Gene

Paralogs for PNLIPRP3 Gene

(6) SIMAP similar genes for PNLIPRP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PNLIPRP3: view

Variants for PNLIPRP3 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000022242 -- 116,438,304(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000025801 -- 116,467,383(+) C/A intron_variant
rs1000036491 -- 116,472,902(+) C/T intron_variant
rs1000236931 -- 116,470,615(+) T/C intron_variant
rs1000272463 -- 116,456,483(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP3 Gene

Variant ID Type Subtype PubMed ID
esv3624658 CNV loss 21293372
nsv7211 OTHER inversion 18451855
nsv819162 CNV gain 19587683
nsv832001 CNV loss 17160897
nsv948195 CNV duplication 23825009

Variation tolerance for PNLIPRP3 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.83; 86.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNLIPRP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIPRP3 Gene

Disorders for PNLIPRP3 Gene

Additional Disease Information for PNLIPRP3

No disorders were found for PNLIPRP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNLIPRP3 Gene

Publications for PNLIPRP3 Gene

  1. Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma. (PMID: 19640199) Saelee P … Karalak A (Asian Pacific journal of cancer prevention : APJCP 2009) 3 4 58
  2. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 44 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for PNLIPRP3 Gene

Sources for PNLIPRP3 Gene

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