Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PNLIPRP3 Gene

Aliases for PNLIPRP3 Gene

  • Pancreatic Lipase Related Protein 3 2 3
  • EC 3.1.1.3 4 63
  • PL-RP3 3 4
  • Pancreatic Lipase-Related Protein 3 5
  • EC 3.1.1 63

External Ids for PNLIPRP3 Gene

Previous GeneCards Identifiers for PNLIPRP3 Gene

  • GC10P117817
  • GC10P118177
  • GC10P111814

Summaries for PNLIPRP3 Gene

GeneCards Summary for PNLIPRP3 Gene

PNLIPRP3 (Pancreatic Lipase Related Protein 3) is a Protein Coding gene. Diseases associated with PNLIPRP3 include Hepatocellular Carcinoma. Among its related pathways are triacylglycerol biosynthesis and Metabolism. GO annotations related to this gene include carboxylic ester hydrolase activity and triglyceride lipase activity. An important paralog of this gene is LPL.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP3 Gene

Genomics for PNLIPRP3 Gene

Regulatory Elements for PNLIPRP3 Gene

Enhancers for PNLIPRP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PNLIPRP3 on UCSC Golden Path with GeneCards custom track

Promoters for PNLIPRP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PNLIPRP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PNLIPRP3 Gene

Chromosome:
10
Start:
116,427,867 bp from pter
End:
116,477,961 bp from pter
Size:
50,095 bases
Orientation:
Plus strand

Genomic View for PNLIPRP3 Gene

Genes around PNLIPRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIPRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIPRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP3 Gene

Proteins for PNLIPRP3 Gene

  • Protein details for PNLIPRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RR3-LIPR3_HUMAN
    Recommended name:
    Pancreatic lipase-related protein 3
    Protein Accession:
    Q17RR3

    Protein attributes for PNLIPRP3 Gene

    Size:
    467 amino acids
    Molecular mass:
    52254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNLIPRP3 Gene

Proteomics data for PNLIPRP3 Gene at MOPED

Selected DME Specific Peptides for PNLIPRP3 Gene

Post-translational modifications for PNLIPRP3 Gene

  • Glycosylation at Asn 74 and Asn 125
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIPRP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PNLIPRP3 Gene

Gene Families for PNLIPRP3 Gene

Suggested Antigen Peptide Sequences for PNLIPRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RR3

UniProtKB/Swiss-Prot:

LIPR3_HUMAN :
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP3: view

Function for PNLIPRP3 Gene

Molecular function for PNLIPRP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.

Enzyme Numbers (IUBMB) for PNLIPRP3 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PNLIPRP3: view
genes like me logo Genes that share phenotypes with PNLIPRP3: view

Animal Model Products

CRISPR Products

miRNA for PNLIPRP3 Gene

miRTarBase miRNAs that target PNLIPRP3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PNLIPRP3 Gene

Localization for PNLIPRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNLIPRP3 Gene COMPARTMENTS Subcellular localization image for PNLIPRP3 gene
Compartment Confidence
extracellular 4
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PNLIPRP3 Gene

Pathways & Interactions for PNLIPRP3 Gene

genes like me logo Genes that share pathways with PNLIPRP3: view

Pathways by source for PNLIPRP3 Gene

Interacting Proteins for PNLIPRP3 Gene

Gene Ontology (GO) - Biological Process for PNLIPRP3 Gene

None

No data available for SIGNOR curated interactions for PNLIPRP3 Gene

Drugs & Compounds for PNLIPRP3 Gene

(5) Drugs for PNLIPRP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0
arachidonic acid Experimental Nutra Activator 27

(12) Additional Compounds for PNLIPRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PNLIPRP3: view

Transcripts for PNLIPRP3 Gene

mRNA/cDNA for PNLIPRP3 Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNLIPRP3 Gene

Pancreatic lipase-related protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP3 Gene

No ASD Table

Relevant External Links for PNLIPRP3 Gene

GeneLoc Exon Structure for
PNLIPRP3
ECgene alternative splicing isoforms for
PNLIPRP3

Expression for PNLIPRP3 Gene

mRNA expression in normal human tissues for PNLIPRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x19.9) and Skin - Not Sun Exposed (Suprapubic) (x17.0).

Protein differential expression in normal tissues from HIPED for PNLIPRP3 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNLIPRP3 Gene



SOURCE GeneReport for Unigene cluster for PNLIPRP3 Gene Hs.276724

mRNA Expression by UniProt/SwissProt for PNLIPRP3 Gene

Q17RR3-LIPR3_HUMAN
Tissue specificity: Overexpressed in hepatocellular carcinoma.
genes like me logo Genes that share expression patterns with PNLIPRP3: view

Protein tissue co-expression partners for PNLIPRP3 Gene

Primer Products

Orthologs for PNLIPRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNLIPRP3 35
  • 85.8 (n)
  • 80.35 (a)
PNLIPRP3 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNLIPRP3 35
  • 86.22 (n)
  • 80.09 (a)
chimpanzee
(Pan troglodytes)
Mammalia PNLIPRP3 35
  • 99.36 (n)
  • 98.93 (a)
PNLIPRP3 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIPRP3 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNLIPRP3 35
  • 58.92 (n)
  • 48.6 (a)
lizard
(Anolis carolinensis)
Reptilia PNLIPRP3 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01090041.1 36
  • 23 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6847 35
  • 45.08 (n)
  • 40.96 (a)
CG5966 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 36
  • 34 (a)
OneToMany
Species with no ortholog for PNLIPRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNLIPRP3 Gene

ENSEMBL:
Gene Tree for PNLIPRP3 (if available)
TreeFam:
Gene Tree for PNLIPRP3 (if available)

Paralogs for PNLIPRP3 Gene

Paralogs for PNLIPRP3 Gene

(6) SIMAP similar genes for PNLIPRP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PNLIPRP3: view

Variants for PNLIPRP3 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10885929 - 116,428,016(+) AGATG(C/T)TTGGA reference, missense, utr-variant-5-prime
rs7077408 - 116,469,251(+) TTCAC(C/T)TCAAA intron-variant, reference, missense
rs2116286 - 116,477,098(-) TACAG(A/T)AGGTA downstream-variant-500B, reference, missense
rs10736251 - 116,471,848(+) GGGCA(A/G/T)TTAGG reference, missense, utr-variant-3-prime
rs1897519 - 116,471,851(-) TTTCC(C/T)AACTG reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP3 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv832001 CNV Loss 17160897
nsv819162 CNV Gain 19587683

Variation tolerance for PNLIPRP3 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.83; 86.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PNLIPRP3 Gene

Disorders for PNLIPRP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNLIPRP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PNLIPRP3

Genetic Association Database (GAD)
PNLIPRP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNLIPRP3
genes like me logo Genes that share disorders with PNLIPRP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNLIPRP3 Gene

Publications for PNLIPRP3 Gene

  1. Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma. (PMID: 19640199) Saelee P. … Karalak A. (Asian Pac. J. Cancer Prev. 2009) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PNLIPRP3 Gene

Sources for PNLIPRP3 Gene

Content