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PNLIPRP3 Gene

protein-coding   GIFtS: 52
GCID: GC10P118177

Pancreatic Lipase-Related Protein 3

  Search for PNLIPRP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pancreatic Lipase-Related Protein 31 2
PL-RP32 3
EC 3.1.1.33 8
EC 3.1.18

External Ids:    HGNC: 234921   Entrez Gene: 1195482   Ensembl: ENSG000002038377   UniProtKB: Q17RR33   

Export aliases for PNLIPRP3 gene to outside databases

Previous GC identifers: GC10P117817 GC10P111814


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PNLIPRP3 Gene:
PNLIPRP3 (pancreatic lipase-related protein 3) is a protein-coding gene. GO annotations related to this gene include triglyceride lipase activity. An important paralog of this gene is LIPH.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the PNLIPRP3 gene promoter:
         GR   GR-beta   GATA-2   PPAR-gamma1   POU2F1   POU2F1b   POU2F1a   POU2F1c   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPNLIPRP3 promoter sequence
   Search Chromatin IP Primers for PNLIPRP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PNLIPRP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.12

PNLIPRP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNLIPRP3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P118177:  view genomic region     (about GC identifiers)

Start:
118,187,379 bp from pter      End:
118,237,469 bp from pter
Size:
50,091 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LIPR3_HUMAN, Q17RR3 (See protein sequence)
Recommended Name: Pancreatic lipase-related protein 3 precursor  
Size: 467 amino acids; 52254 Da

Explore the universe of human proteins at neXtProt for PNLIPRP3: NX_Q17RR3

Explore proteomics data for PNLIPRP3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn74, Asn125
  • Selected DME Specific Peptides for PNLIPRP3 (Q17RR3) (see all 6)
     RLDPSDA  GLDPAGP  GRITGLD  DFYPNGG 


    See PNLIPRP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001011709.2  
    ENSEMBL proteins: 
     ENSP00000358232  

    PNLIPRP3 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for PNLIPRP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001024 PLAT/LH2_dom
     IPR008976 Lipase_LipOase
     IPR000734 Lipase
     IPR016272 Lipoprotein_lipase_LIPH
     IPR002331 Lipase_panc

    Graphical View of Domain Structure for InterPro Entry Q17RR3

    ProtoNet protein and cluster: Q17RR3

    3 Blocks protein domains:
    IPB000734 Lipase
    IPB002331 Pancreatic lipase signature
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: LIPR3_HUMAN, Q17RR3
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family
    Similarity: Contains 1 PLAT domain


    Find genes that share domains with PNLIPRP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPR3_HUMAN, Q17RR3
    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate

         Enzyme Numbers (IUBMB): EC 3.1.1.31 2 EC 3.1.12

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004806triglyceride lipase activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PNLIPRP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PNLIPRP3:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PNLIPRP3
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    miRNA
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    miRTarBase miRNAs that target PNLIPRP3:
    hsa-mir-335-5p (MIRT017927)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIPR3_HUMAN, Q17RR3: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with PNLIPRP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PNLIPRP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2triacylglycerol degradation
    triacylglycerol degradation
    3Glycerolipid metabolism
    Glycerolipid metabolism


    Find genes that share SuperPaths with PNLIPRP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PNLIPRP3
        triacylglycerol degradation



    2 Kegg Pathways  (Kegg details for PNLIPRP3):
        Glycerolipid metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PNLIPRP3
    Interactions:

        Search GeneGlobe Interaction Network for PNLIPRP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PNLIPRP3 (ENSP000003582324) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIPCENSP000002990224STRING: ENSP00000299022
    LIPGENSP000002612924STRING: ENSP00000261292
    LPLENSP000003097574STRING: ENSP00000309757
    PNLIPENSP000003582234STRING: ENSP00000358223
    PNLIPRP1ENSP000003516954STRING: ENSP00000351695
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016042lipid catabolic process IEA--

    Find genes that share ontologies with PNLIPRP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PNLIPRP3 (LIPR3)

    Selected HMDB Compounds for PNLIPRP3 (see all 1141)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PNLIPRP3 gene: 
    NM_001011709.2  

    Unigene Cluster for PNLIPRP3:

    Pancreatic lipase-related protein 3
    Hs.276724  [show with all ESTs]
    Unigene Representative Sequence: AL833418
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369230(uc001lcl.4)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat PNLIPRP3

    Additional mRNA sequence: 

    AL833418.1 BC015840.1 BC065752.1 BC117224.1 

    2 DOTS entries:

    DT.92028086  DT.75106615 

    11 AceView cDNA sequences:

    BG741699 AL833418 BC065752 BG741031 BC015840 BG740875 BG033763 BF976776 
    CA314648 AI350969 BF246347 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PNLIPRP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATATAGTA
    PNLIPRP3 Expression
    About this image


    PNLIPRP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
    PNLIPRP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PNLIPRP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.276724

    UniProtKB/Swiss-Prot: LIPR3_HUMAN, Q17RR3
    Tissue specificity: Overexpressed in hepatocellular carcinoma

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PNLIPRP3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia PNLIPRP31 pancreatic lipase-related protein 3 86.22(n)
    80.09(a)
      610501  XM_005637765.1  XP_005637822.1 
    chicken
    (Gallus gallus)
    Aves PNLIPRP31 pancreatic lipase-related protein 3 58.92(n)
    48.6(a)
      771374  XM_001234656.3  XP_001234657.2 
    lizard
    (Anolis carolinensis)
    Reptilia PNLIPRP36
    pancreatic lipase-related protein 3
    45(a)
    1 ↔ 1
    GL343206.1(2089487-2120129)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01090041.16
    Uncharacterized protein
    23(a)
    many ↔ many
    22(15778948-15789325) ENSDARG00000034667
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68471 CG6847 45.08(n)
    40.96(a)
      32778  NM_133031.1  NP_573259.2 


    ENSEMBL Gene Tree for PNLIPRP3 (if available)
    TreeFam Gene Tree for PNLIPRP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PNLIPRP3 gene
    LIPH2  LIPC2  LIPG2  PNLIPRP22  LPL2  PNLIP2  LIPI2  PLA1A2  
    PNLIPRP12  
    6 SIMAP similar genes for PNLIPRP3 using alignment to 1 protein entry:     LIPR3_HUMAN:
    LIPH    PNLIPRP2    PNLIP    PNLIPRP1    DKFZp779I1240    LIPC

    Find genes that share paralogs with PNLIPRP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PNLIPRP3 (see all 1137)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452668921,2
    --118185440(+) AGGAAC/TAGGGA 1 -- us2k10--------
    rs170947171,2
    C,F,H--118185623(+) CCTGTA/GTGGGA 1 -- us2k118Minor allele frequency- G:0.13NA NS EA WA 2476
    rs170947181,2
    C,F,H--118185663(+) AGCAAG/ACATTT 1 -- us2k129Minor allele frequency- A:0.14NA EA NS WA 3106
    rs1121713151,2
    C,F--118185739(+) AATGAC/TAATCT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1424675571,2
    C--118185849(+) CTATTA/GCTATG 1 -- us2k10--------
    rs1443336301,2
    --118185946(+) ATTCTA/GTAATA 1 -- us2k10--------
    rs774316111,2
    C--118186010(+) ATGTGG/TTTTTT 1 -- us2k13Minor allele frequency- T:0.21WA EA 240
    rs1487827451,2
    --118186154(+) GCTCCA/TACTGA 1 -- us2k10--------
    rs18975111,2
    C,F,O,A,H--118186269(-) CCTCTA/GAAAGC 1 -- us2k138Minor allele frequency- G:0.15NS EA NA WA CSA 3418
    rs1839557491,2
    C--118186278(+) GGGTGA/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PNLIPRP3 (118187379 - 118237469 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PNLIPRP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832001CNV Loss17160897
    nsv819162CNV Gain19587683
    nsv7211OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PNLIPRP3           About GenesLikeMe

    Genetic Association Database (GAD): PNLIPRP3

    Export disorders for PNLIPRP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PNLIPRP3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PNLIPRP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma. (PubMed id 19640199)1, 2 Saelee P.... Karalak A. (Asian Pac. J. Cancer Prev. 2009)
    2. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 119548 HGNC: 23492 AceView: PNLIPRP3 Ensembl:ENSG00000203837 euGenes: HUgn119548
    ECgene: PNLIPRP3 Kegg: 119548 H-InvDB: PNLIPRP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PNLIPRP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PNLIPRP3 gene:
    Search GeneIP for patents involving PNLIPRP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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