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Aliases for PNLIPRP3 Gene

Aliases for PNLIPRP3 Gene

  • Pancreatic Lipase-Related Protein 3 2 3
  • EC 3.1.1.3 4 63
  • PL-RP3 3 4
  • EC 3.1.1 63

External Ids for PNLIPRP3 Gene

Previous GeneCards Identifiers for PNLIPRP3 Gene

  • GC10P117817
  • GC10P118177
  • GC10P111814

Summaries for PNLIPRP3 Gene

GeneCards Summary for PNLIPRP3 Gene

PNLIPRP3 (Pancreatic Lipase-Related Protein 3) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerolipid metabolism. GO annotations related to this gene include triglyceride lipase activity. An important paralog of this gene is LPL.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP3 Gene

Genomics for PNLIPRP3 Gene

Regulatory Elements for PNLIPRP3 Gene

Genomic Location for PNLIPRP3 Gene

Start:
116,427,867 bp from pter
End:
116,477,957 bp from pter
Size:
50,091 bases
Orientation:
Plus strand

Genomic View for PNLIPRP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNLIPRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP3 Gene

Proteins for PNLIPRP3 Gene

  • Protein details for PNLIPRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RR3-LIPR3_HUMAN
    Recommended name:
    Pancreatic lipase-related protein 3
    Protein Accession:
    Q17RR3
    Secondary Accessions:

    Protein attributes for PNLIPRP3 Gene

    Size:
    467 amino acids
    Molecular mass:
    52254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNLIPRP3 Gene

Proteomics data for PNLIPRP3 Gene at MOPED

Selected DME Specific Peptides for PNLIPRP3 Gene

Post-translational modifications for PNLIPRP3 Gene

  • Glycosylation at Asn74 and Asn125
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIPRP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for PNLIPRP3 Gene

Suggested Antigen Peptide Sequences for PNLIPRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RR3

UniProtKB/Swiss-Prot:

LIPR3_HUMAN :
  • Q17RR3
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP3: view

No data available for Gene Families for PNLIPRP3 Gene

Function for PNLIPRP3 Gene

Molecular function for PNLIPRP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate

Enzyme Numbers (IUBMB) for PNLIPRP3 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity IEA --
GO:0005515 protein binding --
GO:0052689 carboxylic ester hydrolase activity --
genes like me logo Genes that share ontologies with PNLIPRP3: view

Phenotypes for PNLIPRP3 Gene

GenomeRNAi human phenotypes for PNLIPRP3:
genes like me logo Genes that share phenotypes with PNLIPRP3: view

Animal Model Products

CRISPR Products

miRNA for PNLIPRP3 Gene

miRTarBase miRNAs that target PNLIPRP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNLIPRP3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PNLIPRP3 Gene

Localization for PNLIPRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNLIPRP3 Gene COMPARTMENTS Subcellular localization image for PNLIPRP3 gene
Compartment Confidence
extracellular 3
cytosol 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PNLIPRP3: view

Pathways for PNLIPRP3 Gene

genes like me logo Genes that share pathways with PNLIPRP3: view

Pathways by source for PNLIPRP3 Gene

1 BioSystems pathway for PNLIPRP3 Gene
2 KEGG pathways for PNLIPRP3 Gene

Interacting Proteins for PNLIPRP3 Gene

Gene Ontology (GO) - Biological Process for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PNLIPRP3: view

Compounds for PNLIPRP3 Gene

(1141) HMDB Compounds for PNLIPRP3 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
genes like me logo Genes that share compounds with PNLIPRP3: view

Transcripts for PNLIPRP3 Gene

mRNA/cDNA for PNLIPRP3 Gene

(8) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNLIPRP3 Gene

Pancreatic lipase-related protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNLIPRP3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP3 Gene

No ASD Table

Relevant External Links for PNLIPRP3 Gene

GeneLoc Exon Structure for
PNLIPRP3
ECgene alternative splicing isoforms for
PNLIPRP3

Expression for PNLIPRP3 Gene

mRNA expression in normal human tissues for PNLIPRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (19.9) and Skin - Not Sun Exposed (Suprapubic) (17.0).

Protein differential expression in normal tissues for PNLIPRP3 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PNLIPRP3 Gene

SOURCE GeneReport for Unigene cluster for PNLIPRP3 Gene Hs.276724

mRNA Expression by UniProt/SwissProt for PNLIPRP3 Gene

Q17RR3-LIPR3_HUMAN
Tissue specificity: Overexpressed in hepatocellular carcinoma.
genes like me logo Genes that share expressions with PNLIPRP3: view

Expression partners for PNLIPRP3 Gene

In Situ Assay Products

Orthologs for PNLIPRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNLIPRP3 35
  • 85.8 (n)
  • 80.35 (a)
PNLIPRP3 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNLIPRP3 35
  • 86.22 (n)
  • 80.09 (a)
chimpanzee
(Pan troglodytes)
Mammalia PNLIPRP3 35
  • 99.36 (n)
  • 98.93 (a)
PNLIPRP3 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIPRP3 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNLIPRP3 35
  • 58.92 (n)
  • 48.6 (a)
lizard
(Anolis carolinensis)
Reptilia PNLIPRP3 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01090041.1 36
  • 23 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6847 35
  • 45.08 (n)
  • 40.96 (a)
CG5966 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 36
  • 34 (a)
OneToMany
Species with no ortholog for PNLIPRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNLIPRP3 Gene

ENSEMBL:
Gene Tree for PNLIPRP3 (if available)
TreeFam:
Gene Tree for PNLIPRP3 (if available)

Paralogs for PNLIPRP3 Gene

Paralogs for PNLIPRP3 Gene

Selected SIMAP similar genes for PNLIPRP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PNLIPRP3: view

Variants for PNLIPRP3 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs721181 -- 116,467,014(+) TGCCT(C/T)GGCTG intron-variant
rs764694 -- 116,468,626(-) aaaat(G/T)gtaag intron-variant
rs764695 -- 116,468,274(-) ggtaa(A/T)gtcta intron-variant
rs891665 -- 116,459,392(+) GTCAA(C/T)GGCAA intron-variant
rs988524 -- 116,462,752(-) TCTGA(G/T)CTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP3 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv832001 CNV Loss 17160897
nsv819162 CNV Gain 19587683

Relevant External Links for PNLIPRP3 Gene

HapMap Linkage Disequilibrium report
PNLIPRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIPRP3 Gene

Disorders for PNLIPRP3 Gene

Relevant External Links for PNLIPRP3

Genetic Association Database (GAD)
PNLIPRP3

No disorders were found for PNLIPRP3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PNLIPRP3 Gene

Publications for PNLIPRP3 Gene

  1. Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma. (PMID: 19640199) Saelee P. … Karalak A. (Asian Pac. J. Cancer Prev. 2009) 3 4
  2. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 48
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PNLIPRP3 Gene

Sources for PNLIPRP3 Gene

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