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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PNLIPRP3 Gene

protein-coding   GIFtS: 52
GCID: GC10P118177

Pancreatic Lipase-Related Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pancreatic Lipase-Related Protein 31 2
PL-RP32 3
EC 3.1.1.33 8
EC 3.1.18

External Ids:    HGNC: 234921   Entrez Gene: 1195482   Ensembl: ENSG000002038377   UniProtKB: Q17RR33   

Export aliases for PNLIPRP3 gene to outside databases

Previous GC identifers: GC10P117817 GC10P111814


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PNLIPRP3 Gene: 
PNLIPRP3 (pancreatic lipase-related protein 3) is a protein-coding gene. Diseases associated with PNLIPRP3 include pancreatitis, and hepatocellular carcinoma, and among its related super-pathways are Metabolism. GO annotations related to this gene include retinyl-palmitate esterase activity and triglyceride lipase activity. An important paralog of this gene is LIPH.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PNLIPRP3 gene promoter:
         GR   GR-beta   GATA-2   PPAR-gamma1   POU2F1   POU2F1b   POU2F1a   POU2F1c   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPNLIPRP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PNLIPRP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNLIPRP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.12

PNLIPRP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNLIPRP3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P118177:  view genomic region     (about GC identifiers)

Start:
118,187,379 bp from pter      End:
118,237,469 bp from pter
Size:
50,091 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIPR3_HUMAN, Q17RR3 (See protein sequence)
Recommended Name: Pancreatic lipase-related protein 3 precursor  
Size: 467 amino acids; 52254 Da
Subcellular location: Secreted (Potential)

Explore the universe of human proteins at neXtProt for PNLIPRP3: NX_Q17RR3

Explore proteomics data for PNLIPRP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q17RR3

  • 4/6 DME Specific Peptides for PNLIPRP3 (Q17RR3) (see all 6)
     RLDPSDA  GLDPAGP  GRITGLD  DFYPNGG 

    PNLIPRP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PNLIPRP3 Protein Expression
    REFSEQ proteins: NP_001011709.2  
    ENSEMBL proteins: 
     ENSP00000358232  

    Human Recombinant Protein Products for PNLIPRP3: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for PNLIPRP3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    PNLIPRP3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR001024 LipOase_LH2
     IPR008976 Lipase_LipOase
     IPR000734 Lipase
     IPR016272 Lipoprotein_lipase_LIPH
     IPR002331 Lipase_panc

    Graphical View of Domain Structure for InterPro Entry Q17RR3

    ProtoNet protein and cluster: Q17RR3

    3 Blocks protein domains:
    IPB000734 Lipase
    IPB002331 Pancreatic lipase signature
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: LIPR3_HUMAN, Q17RR3
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family
    Similarity: Contains 1 PLAT domain


    PNLIPRP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPR3_HUMAN, Q17RR3
    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate

         Enzyme Numbers (IUBMB): EC 3.1.1.31 2 EC 3.1.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004806triglyceride lipase activity IEA--
    GO:0005515protein binding ----
    GO:0050253retinyl-palmitate esterase activity ----
         
    PNLIPRP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PNLIPRP3:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PNLIPRP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PNLIPRP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PNLIPRP3 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PNLIPRP3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2triacylglycerol degradation
    triacylglycerol degradation
    3Glycerolipid metabolism
    Glycerolipid metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PNLIPRP3
        triacylglycerol degradation



    2         Kegg Pathways  (Kegg details for PNLIPRP3):
        Glycerolipid metabolism
    Metabolic pathways


    PNLIPRP3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNLIPRP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for PNLIPRP3 (ENSP000003582324) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CELENSP000003611514STRING: ENSP00000361151
    LIPCENSP000002990224STRING: ENSP00000299022
    LIPGENSP000002612924STRING: ENSP00000261292
    LPLENSP000003097574STRING: ENSP00000309757
    MGLLENSP000002650524STRING: ENSP00000265052
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016042lipid catabolic process IEA--

    PNLIPRP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PNLIPRP3 (LIPR3)

    10/1141 HMDB Compounds for PNLIPRP3 (see all 1141)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    Search CenterWatch for drugs/clinical trials and news about PNLIPRP3 / LIPR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PNLIPRP3 gene: 
    NM_001011709.2  

    Unigene Cluster for PNLIPRP3:

    Pancreatic lipase-related protein 3
    Hs.276724  [show with all ESTs]
    Unigene Representative Sequence: AL833418
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369230(uc001lcl.4)
    miRNA
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    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNLIPRP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNLIPRP3

    Additional mRNA sequence: 

    AL833418.1 BC015840.1 BC065752.1 BC117224.1 

    2 DOTS entries:

    DT.92028086  DT.75106615 

    11 AceView cDNA sequences:

    BG741699 BC015840 BG740875 AL833418 BG741031 BC065752 BG033763 AI350969 
    BF976776 CA314648 BF246347 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PNLIPRP3 expression in normal human tissues (normalized intensities)      PNLIPRP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATATAGTA
    PNLIPRP3 Expression
    About this image


    PNLIPRP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Basal Cells Respiratory Bronchioles
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Human EpiDermal Keratinocytes (HEK)   
     
     Breast (Uncategorized)
             Human Mammary Epithelial Cells (HMEpiC)   
     
     Esophagus
             Human Esophageal Epithelial Cells (HEEpiC)   

    See PNLIPRP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PNLIPRP3

    SOURCE GeneReport for Unigene cluster: Hs.276724

    UniProtKB/Swiss-Prot: LIPR3_HUMAN, Q17RR3
    Tissue specificity: Overexpressed in hepatocellular carcinoma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PNLIPRP3 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia PNLIPRP31 pancreatic lipase-related protein 3 86.04(n)
    80.48(a)
      610501  XM_848020.2  XP_853113.2 
    chicken
    (Gallus gallus)
    Aves PNLIPRP31 pancreatic lipase-related protein 3 58.92(n)
    48.6(a)
      771374  XM_001234656.2  XP_001234657.2 
    lizard
    (Anolis carolinensis)
    Reptilia PNLIPRP36
    pancreatic lipase-related protein 3
    45(a)
    1 ↔ 1
    GL343206.1(2089487-2120129)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68471 CG6847 44.38(n)
    39.53(a)
      32778  NM_133031.1  NP_573259.2 


    ENSEMBL Gene Tree for PNLIPRP3 (if available)
    TreeFam Gene Tree for PNLIPRP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PNLIPRP3 gene
    LIPH2  LIPC2  LIPG2  PNLIPRP22  LPL2  PNLIP2  LIPI2  PLA1A2  
    PNLIPRP12  
    6 SIMAP similar genes for PNLIPRP3 using alignment to 1 protein entry:     LIPR3_HUMAN:
    LIPH    PNLIPRP2    PNLIP    PNLIPRP1    DKFZp779I1240    LIPC

    PNLIPRP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1137 SNPs in PNLIPRP3 are shown (see all 1137)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452668921,2
    --118185440(+) AGGAAC/TAGGGA 1 -- us2k10--------
    rs170947171,2
    C,F,H--118185623(+) CCTGTA/GTGGGA 1 -- us2k118Minor allele frequency- G:0.13NA NS EA WA 2476
    rs170947181,2
    C,F,H--118185663(+) AGCAAG/ACATTT 1 -- us2k129Minor allele frequency- A:0.14NA EA NS WA 3106
    rs1121713151,2
    C,F--118185739(+) AATGAC/TAATCT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1424675571,2
    C--118185849(+) CTATTA/GCTATG 1 -- us2k10--------
    rs1443336301,2
    --118185946(+) ATTCTA/GTAATA 1 -- us2k10--------
    rs774316111,2
    C--118186010(+) ATGTGG/TTTTTT 1 -- us2k13Minor allele frequency- T:0.21WA EA 240
    rs1487827451,2
    --118186154(+) GCTCCA/TACTGA 1 -- us2k10--------
    rs18975111,2
    C,F,O,A,H--118186269(-) CCTCTA/GAAAGC 1 -- us2k138Minor allele frequency- G:0.15NS EA NA WA CSA 3418
    rs1839557491,2
    C--118186278(+) GGGTGA/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PNLIPRP3 (118187379 - 118237469 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PNLIPRP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832001CNV Loss17160897
    nsv819162CNV Gain19587683
    nsv7211OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for PNLIPRP3:    About MalaCards
    pancreatitis    hepatocellular carcinoma


    PNLIPRP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PNLIPRP3

    Export disorders for PNLIPRP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PNLIPRP3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PNLIPRP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma. (PubMed id 19640199)1, 2 Saelee P.... Karalak A. (2009)
    2. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (2007)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 119548 HGNC: 23492 AceView: PNLIPRP3 Ensembl:ENSG00000203837 euGenes: HUgn119548
    ECgene: PNLIPRP3 Kegg: 119548 H-InvDB: PNLIPRP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PNLIPRP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PNLIPRP3 gene:
    Search GeneIP for patents involving PNLIPRP3

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