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Aliases for PNLIPRP2 Gene

Aliases for PNLIPRP2 Gene

  • Pancreatic Lipase-Related Protein 2 2 3
  • Galactolipase 3 4
  • EC 3.1.1.3 4 63
  • PL-RP2 3 4
  • PLRP2 3 4
  • EC 3.1.1.26 4
  • EC 3.1.1 63

External Ids for PNLIPRP2 Gene

Previous GeneCards Identifiers for PNLIPRP2 Gene

  • GC10P117299
  • GC10P117624
  • GC10P118511
  • GC10P118045
  • GC10P118370
  • GC10P112007

Summaries for PNLIPRP2 Gene

Entrez Gene Summary for PNLIPRP2 Gene

  • This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]

GeneCards Summary for PNLIPRP2 Gene

PNLIPRP2 (Pancreatic Lipase-Related Protein 2) is a Protein Coding gene. Among its related pathways are Metabolism and Pancreatic secretion. GO annotations related to this gene include calcium ion binding and phospholipase activity.

UniProtKB/Swiss-Prot for PNLIPRP2 Gene

  • Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP2 Gene

Genomics for PNLIPRP2 Gene

Regulatory Elements for PNLIPRP2 Gene

Genomic Location for PNLIPRP2 Gene

Chromosome:
10
Start:
116,620,953 bp from pter
End:
116,645,143 bp from pter
Size:
24,191 bases
Orientation:
Plus strand

Genomic View for PNLIPRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNLIPRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP2 Gene

Proteins for PNLIPRP2 Gene

  • Protein details for PNLIPRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54317-LIPR2_HUMAN
    Recommended name:
    Pancreatic lipase-related protein 2
    Protein Accession:
    P54317
    Secondary Accessions:
    • A8K627
    • Q6IB55

    Protein attributes for PNLIPRP2 Gene

    Size:
    469 amino acids
    Molecular mass:
    51947 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIPRP2 Gene

neXtProt entry for PNLIPRP2 Gene

Proteomics data for PNLIPRP2 Gene at MOPED

Post-translational modifications for PNLIPRP2 Gene

  • Glycosylation at Asn 353 and Asn 428

Other Protein References for PNLIPRP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PNLIPRP2 Gene

Gene Families for PNLIPRP2 Gene

HGNC:

Suggested Antigen Peptide Sequences for PNLIPRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54317

UniProtKB/Swiss-Prot:

LIPR2_HUMAN :
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP2: view

Function for PNLIPRP2 Gene

Molecular function for PNLIPRP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.
UniProtKB/Swiss-Prot Function:
Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.

Enzyme Numbers (IUBMB) for PNLIPRP2 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IDA 18702514
GO:0004806 triglyceride lipase activity IEA --
GO:0005509 calcium ion binding IDA 18702514
GO:0005515 protein binding --
GO:0047372 acylglycerol lipase activity IDA 18702514
genes like me logo Genes that share ontologies with PNLIPRP2: view
genes like me logo Genes that share phenotypes with PNLIPRP2: view

Animal Model Products

CRISPR Products

miRNA for PNLIPRP2 Gene

miRTarBase miRNAs that target PNLIPRP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNLIPRP2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PNLIPRP2 Gene

Localization for PNLIPRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18702514
genes like me logo Genes that share ontologies with PNLIPRP2: view

No data available for Subcellular locations from COMPARTMENTS for PNLIPRP2 Gene

Pathways & Interactions for PNLIPRP2 Gene

genes like me logo Genes that share pathways with PNLIPRP2: view

Pathways by source for PNLIPRP2 Gene

Interacting Proteins for PNLIPRP2 Gene

Selected Interacting proteins: P54317-LIPR2_HUMAN for PNLIPRP2 Gene via I2D

Symbol External ID(s) Details
CLPS

Gene Ontology (GO) - Biological Process for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006641 triglyceride metabolic process TAS 1379598
GO:0006968 cellular defense response --
GO:0007586 digestion --
GO:0009395 phospholipid catabolic process IDA 18702514
genes like me logo Genes that share ontologies with PNLIPRP2: view

No data available for SIGNOR curated interactions for PNLIPRP2 Gene

Drugs & Compounds for PNLIPRP2 Gene

(6) Drugs for PNLIPRP2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Decylamine-N,N-Dimethyl-N-Oxide Experimental Pharma Target 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(15) Additional Compounds for PNLIPRP2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PNLIPRP2: view

Transcripts for PNLIPRP2 Gene

mRNA/cDNA for PNLIPRP2 Gene

Unigene Clusters for PNLIPRP2 Gene

Pancreatic lipase-related protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNLIPRP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP2 Gene

No ASD Table

Relevant External Links for PNLIPRP2 Gene

GeneLoc Exon Structure for
PNLIPRP2
ECgene alternative splicing isoforms for
PNLIPRP2

Expression for PNLIPRP2 Gene

mRNA expression in normal human tissues for PNLIPRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP2 Gene

This gene is overexpressed in Pancreas (x52.6).

Protein differential expression in normal tissues from HIPED for PNLIPRP2 Gene

This gene is overexpressed in Pancreatic juice (56.5) and Pancreas (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PNLIPRP2 Gene



SOURCE GeneReport for Unigene cluster for PNLIPRP2 Gene Hs.423598

mRNA Expression by UniProt/SwissProt for PNLIPRP2 Gene

P54317-LIPR2_HUMAN
Tissue specificity: Pancreas
genes like me logo Genes that share expression patterns with PNLIPRP2: view

Protein tissue co-expression partners for PNLIPRP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PNLIPRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNLIPRP2 35
  • 82.66 (n)
  • 76.55 (a)
dog
(Canis familiaris)
Mammalia PNLIPRP2 35
  • 83.08 (n)
  • 77.52 (a)
mouse
(Mus musculus)
Mammalia Pnliprp2 35
  • 79.63 (n)
  • 75.85 (a)
Pnliprp2 16
chimpanzee
(Pan troglodytes)
Mammalia PNLIPRP2 35
  • 98.94 (n)
  • 98.51 (a)
rat
(Rattus norvegicus)
Mammalia Pnliprp2 35
  • 79.84 (n)
  • 77.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17192 37
  • 32 (a)
CG5966 37
  • 35 (a)
CG6271 37
  • 34 (a)
CG6277 37
  • 33 (a)
CG6283 37
  • 32 (a)
CG6472 37
  • 36 (a)
CG6847 37
  • 35 (a)
CG7367 37
  • 34 (a)
Species with no ortholog for PNLIPRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIPRP2 Gene

ENSEMBL:
Gene Tree for PNLIPRP2 (if available)
TreeFam:
Gene Tree for PNLIPRP2 (if available)

Paralogs for PNLIPRP2 Gene

(10) SIMAP similar genes for PNLIPRP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PNLIPRP2: view

No data available for Paralogs for PNLIPRP2 Gene

Variants for PNLIPRP2 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1900504 -- 116,625,761(+) attaa(C/T)taaaa intron-variant
rs1992824 -- 116,635,787(+) TGTTC(A/T)CTTAT intron-variant
rs2286774 -- 116,621,189(+) TTGCG(A/G)GGCGT intron-variant
rs2286775 -- 116,621,273(+) GCATG(C/G)GTCTG intron-variant
rs2286776 -- 116,624,192(+) CTGCC(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP2 Gene

Variant ID Type Subtype PubMed ID
esv1523619 CNV Insertion 17803354

Relevant External Links for PNLIPRP2 Gene

HapMap Linkage Disequilibrium report
PNLIPRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PNLIPRP2 Gene

Disorders for PNLIPRP2 Gene

Relevant External Links for PNLIPRP2

Genetic Association Database (GAD)
PNLIPRP2
Human Genome Epidemiology (HuGE) Navigator
PNLIPRP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNLIPRP2
genes like me logo Genes that share disorders with PNLIPRP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNLIPRP2 Gene

Publications for PNLIPRP2 Gene

  1. Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2. (PMID: 20083229) Amara S. … Carriere F. (Biochim. Biophys. Acta 2010) 23 67
  2. Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis. (PMID: 20512995) McGuire B.M. … Scharschmidt B.F. (Hepatology 2010) 23 67
  3. Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate. (PMID: 19447192) Amara S. … De Caro A. (Biochim. Biophys. Acta 2009) 23 67
  4. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. (PMID: 19824014) Berton A. … Crenon I. (Mol. Nutr. Food Res. 2009) 23 67
  5. Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). (PMID: 19548271) Alves B.N. … Hudig D. (Cell Biochem. Funct. 2009) 23 67

Products for PNLIPRP2 Gene

Sources for PNLIPRP2 Gene

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