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Aliases for PNLIPRP2 Gene

Aliases for PNLIPRP2 Gene

  • Pancreatic Lipase-Related Protein 2 2 3
  • PLRP2 3 4 6
  • Galactolipase 3 4
  • EC 3.1.1.3 4 64
  • PL-RP2 3 4
  • EC 3.1.1.26 4
  • EC 3.1.1 64

External Ids for PNLIPRP2 Gene

Summaries for PNLIPRP2 Gene

GeneCards Summary for PNLIPRP2 Gene

PNLIPRP2 (Pancreatic Lipase-Related Protein 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include calcium ion binding and phospholipase activity.

UniProtKB/Swiss-Prot for PNLIPRP2 Gene

  • Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP2 Gene

Genomics for PNLIPRP2 Gene

Genomic Location for PNLIPRP2 Gene

Start:
116,620,953 bp from pter
End:
116,645,143 bp from pter
Size:
24,191 bases
Orientation:
Plus strand

Genomic View for PNLIPRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNLIPRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP2 Gene

Regulatory Elements for PNLIPRP2 Gene

Proteins for PNLIPRP2 Gene

  • Protein details for PNLIPRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54317-LIPR2_HUMAN
    Recommended name:
    Pancreatic lipase-related protein 2
    Protein Accession:
    P54317
    Secondary Accessions:
    • A8K627
    • Q6IB55

    Protein attributes for PNLIPRP2 Gene

    Size:
    469 amino acids
    Molecular mass:
    51947 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIPRP2 Gene

neXtProt entry for PNLIPRP2 Gene

Proteomics data for PNLIPRP2 Gene at MOPED

Post-translational modifications for PNLIPRP2 Gene

  • Glycosylation at Asn353 and Asn428

Other Protein References for PNLIPRP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PNLIPRP2 Gene

UniProtKB/Swiss-Prot:

LIPR2_HUMAN
Domain:
  • Contains 1 PLAT domain.:
    • P54317
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.:
    • P54317
genes like me logo Genes that share domains with PNLIPRP2: view

No data available for Gene Families for PNLIPRP2 Gene

Function for PNLIPRP2 Gene

Molecular function for PNLIPRP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.
UniProtKB/Swiss-Prot Function: Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.

Enzyme Numbers (IUBMB) for PNLIPRP2 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IDA 18702514
GO:0004806 triglyceride lipase activity IEA --
GO:0005509 calcium ion binding IDA 18702514
GO:0005515 protein binding --
GO:0047372 acylglycerol lipase activity IDA 18702514
genes like me logo Genes that share ontologies with PNLIPRP2: view
genes like me logo Genes that share phenotypes with PNLIPRP2: view

miRNA for PNLIPRP2 Gene

miRTarBase miRNAs that target PNLIPRP2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PNLIPRP2 Gene

Localization for PNLIPRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18702514
genes like me logo Genes that share ontologies with PNLIPRP2: view

Pathways for PNLIPRP2 Gene

genes like me logo Genes that share pathways with PNLIPRP2: view

Pathways by source for PNLIPRP2 Gene

Interacting Proteins for PNLIPRP2 Gene

Selected Interacting proteins: P54317-LIPR2_HUMAN for PNLIPRP2 Gene via I2D

Symbol External ID(s) Details
CLPS

Gene Ontology (GO) - Biological Process for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006641 triglyceride metabolic process TAS 1379598
GO:0006968 cellular defense response --
GO:0007586 digestion --
GO:0009395 phospholipid catabolic process IDA 18702514
genes like me logo Genes that share ontologies with PNLIPRP2: view

Compounds for PNLIPRP2 Gene

(1142) HMDB Compounds for PNLIPRP2 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available

(1) Drugbank Compounds for PNLIPRP2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Decylamine-N,N-Dimethyl-N-Oxide
target

(1) Novoseek inferred chemical compound relationships for PNLIPRP2 Gene

Compound -log(P) Hits PubMed IDs
lipid 33.3 8
genes like me logo Genes that share compounds with PNLIPRP2: view

Transcripts for PNLIPRP2 Gene

mRNA/cDNA for PNLIPRP2 Gene

Unigene Clusters for PNLIPRP2 Gene

Pancreatic lipase-related protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:
SP3:
SP4:

Relevant External Links for PNLIPRP2 Gene

GeneLoc Exon Structure for
PNLIPRP2
ECgene alternative splicing isoforms for
PNLIPRP2

Expression for PNLIPRP2 Gene

mRNA expression in normal human tissues for PNLIPRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP2 Gene

This gene is overexpressed in Pancreas (52.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PNLIPRP2 Gene

SOURCE GeneReport for Unigene cluster for PNLIPRP2 Gene Hs.423598

mRNA Expression by UniProt/SwissProt for PNLIPRP2 Gene

P54317-LIPR2_HUMAN
Tissue specificity: Pancreas
genes like me logo Genes that share expressions with PNLIPRP2: view

Orthologs for PNLIPRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNLIPRP2 36
  • 98.94 (n)
  • 98.51 (a)
cow
(Bos Taurus)
Mammalia PNLIPRP2 36
  • 82.66 (n)
  • 76.55 (a)
dog
(Canis familiaris)
Mammalia PNLIPRP2 36
  • 83.08 (n)
  • 77.52 (a)
mouse
(Mus musculus)
Mammalia Pnliprp2 36
  • 79.63 (n)
  • 75.85 (a)
Pnliprp2 16
rat
(Rattus norvegicus)
Mammalia Pnliprp2 36
  • 79.84 (n)
  • 77.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6271 38
  • 34 (a)
CG7367 38
  • 34 (a)
CG6283 38
  • 32 (a)
CG6472 38
  • 36 (a)
CG5966 38
  • 35 (a)
CG6847 38
  • 35 (a)
CG6277 38
  • 33 (a)
CG17192 38
  • 32 (a)
Species with no ortholog for PNLIPRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIPRP2 Gene

ENSEMBL:
Gene Tree for PNLIPRP2 (if available)
TreeFam:
Gene Tree for PNLIPRP2 (if available)

Paralogs for PNLIPRP2 Gene

Selected SIMAP similar genes for PNLIPRP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PNLIPRP2: view

No data available for Paralogs for PNLIPRP2 Gene

Variants for PNLIPRP2 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1900504 -- 116,625,761(+) attaa(C/T)taaaa intron-variant
rs1900506 -- 116,637,873(+) agaaa(A/T)gtatt intron-variant
rs1900507 -- 116,639,611(+) tcttg(C/T)tgatt intron-variant
rs1992824 -- 116,635,787(+) TGTTC(A/T)CTTAT intron-variant
rs2286774 -- 116,621,189(+) TTGCG(A/G)GGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP2 Gene

Variant ID Type Subtype PubMed ID
esv1523619 CNV Insertion 17803354

Relevant External Links for PNLIPRP2 Gene

HapMap Linkage Disequilibrium report
PNLIPRP2

Disorders for PNLIPRP2 Gene

Relevant External Links for PNLIPRP2

Genetic Association Database (GAD)
PNLIPRP2
Human Genome Epidemiology (HuGE) Navigator
PNLIPRP2
genes like me logo Genes that share disorders with PNLIPRP2: view

No data available for UniProtKB/Swiss-Prot for PNLIPRP2 Gene

Publications for PNLIPRP2 Gene

  1. Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation. (PMID: 18702514) Eydoux C. … Carriere F. (Biochemistry 2008) 3 4 23
  2. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (PMID: 1379598) Giller T. … Hunziker W. (J. Biol. Chem. 1992) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). (PMID: 19548271) Alves B.N. … Hudig D. (Cell Biochem. Funct. 2009) 3 23

Products for PNLIPRP2 Gene

Sources for PNLIPRP2 Gene

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