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Aliases for PNLIPRP1 Gene

Aliases for PNLIPRP1 Gene

  • Pancreatic Lipase Related Protein 1 2 3
  • Pancreatic Lipase-Related Protein 1 3 5
  • PLRP1 3 4
  • EC 3.1.1.3 63
  • EC 3.1.1 63
  • PL-RP1 4

External Ids for PNLIPRP1 Gene

Previous GeneCards Identifiers for PNLIPRP1 Gene

  • GC10P117269
  • GC10P117550
  • GC10P118437
  • GC10P118001
  • GC10P118015
  • GC10P118340
  • GC10P111977

Summaries for PNLIPRP1 Gene

GeneCards Summary for PNLIPRP1 Gene

PNLIPRP1 (Pancreatic Lipase Related Protein 1) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and triacylglycerol biosynthesis. GO annotations related to this gene include calcium ion binding and triglyceride lipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for PNLIPRP1 Gene

  • May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP1 Gene

Genomics for PNLIPRP1 Gene

Regulatory Elements for PNLIPRP1 Gene

Enhancers for PNLIPRP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PNLIPRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PNLIPRP1 Gene

Chromosome:
10
Start:
116,590,385 bp from pter
End:
116,609,175 bp from pter
Size:
18,791 bases
Orientation:
Plus strand

Genomic View for PNLIPRP1 Gene

Genes around PNLIPRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIPRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIPRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP1 Gene

Proteins for PNLIPRP1 Gene

  • Protein details for PNLIPRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54315-LIPR1_HUMAN
    Recommended name:
    Inactive pancreatic lipase-related protein 1
    Protein Accession:
    P54315
    Secondary Accessions:
    • Q68D83
    • Q68DR6
    • Q8TAU2
    • Q9BS82

    Protein attributes for PNLIPRP1 Gene

    Size:
    467 amino acids
    Molecular mass:
    51848 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIPRP1 Gene

    Alternative splice isoforms for PNLIPRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNLIPRP1 Gene

Proteomics data for PNLIPRP1 Gene at MOPED

Post-translational modifications for PNLIPRP1 Gene

No Post-translational modifications

Domains & Families for PNLIPRP1 Gene

Suggested Antigen Peptide Sequences for PNLIPRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54315

UniProtKB/Swiss-Prot:

LIPR1_HUMAN :
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP1: view

No data available for Gene Families for PNLIPRP1 Gene

Function for PNLIPRP1 Gene

Molecular function for PNLIPRP1 Gene

UniProtKB/Swiss-Prot Function:
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for PNLIPRP1 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PNLIPRP1: view
genes like me logo Genes that share phenotypes with PNLIPRP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PNLIPRP1

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PNLIPRP1 Gene

Localization for PNLIPRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNLIPRP1 Gene COMPARTMENTS Subcellular localization image for PNLIPRP1 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS 1379598
genes like me logo Genes that share ontologies with PNLIPRP1: view

Pathways & Interactions for PNLIPRP1 Gene

genes like me logo Genes that share pathways with PNLIPRP1: view

Interacting Proteins for PNLIPRP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351695%0d%0a9606.ENSP00000259938%0d%0a9606.ENSP00000347206%0d%0a
Selected Interacting proteins: ENSP00000351695 P54315-LIPR1_HUMAN for PNLIPRP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PNLIPRP1 Gene

None

No data available for SIGNOR curated interactions for PNLIPRP1 Gene

Drugs & Compounds for PNLIPRP1 Gene

(5) Drugs for PNLIPRP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0
arachidonic acid Experimental Nutra Activator 27

(14) Additional Compounds for PNLIPRP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PNLIPRP1: view

Transcripts for PNLIPRP1 Gene

Unigene Clusters for PNLIPRP1 Gene

Pancreatic lipase-related protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - -
SP12: - - -
SP13: - - -
SP14: - - - - -
SP15:

ExUns: 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PNLIPRP1 Gene

GeneLoc Exon Structure for
PNLIPRP1
ECgene alternative splicing isoforms for
PNLIPRP1

Expression for PNLIPRP1 Gene

mRNA expression in normal human tissues for PNLIPRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP1 Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for PNLIPRP1 Gene

This gene is overexpressed in Pancreatic juice (59.9) and Pancreas (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNLIPRP1 Gene



SOURCE GeneReport for Unigene cluster for PNLIPRP1 Gene Hs.73923

mRNA Expression by UniProt/SwissProt for PNLIPRP1 Gene

P54315-LIPR1_HUMAN
Tissue specificity: Pancreas.
genes like me logo Genes that share expression patterns with PNLIPRP1: view

Protein tissue co-expression partners for PNLIPRP1 Gene

- Elite partner

Primer Products

Orthologs for PNLIPRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNLIPRP1 35
  • 84.55 (n)
  • 79.44 (a)
dog
(Canis familiaris)
Mammalia PNLIPRP1 35
  • 87.72 (n)
  • 85.22 (a)
PNLIPRP1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnliprp1 35
  • 83.15 (n)
  • 83.73 (a)
Pnliprp1 16
Pnliprp1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnliprp1 35
  • 83.8 (n)
  • 85.22 (a)
oppossum
(Monodelphis domestica)
Mammalia PNLIPRP1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIPRP1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNLIP 35
  • 63.3 (n)
  • 61.59 (a)
PNLIP 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486161 35
  • 64.66 (n)
  • 63.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5966 37
  • 35 (a)
CG6271 37
  • 32 (a)
CG6277 37
  • 33 (a)
CG6472 37
  • 37 (a)
CG6847 37
  • 36 (a)
CG7367 37
  • 38 (a)
CG5966 36
  • 27 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007672 35
  • 49.47 (n)
  • 40.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 36
  • 40 (a)
OneToMany
Species with no ortholog for PNLIPRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIPRP1 Gene

ENSEMBL:
Gene Tree for PNLIPRP1 (if available)
TreeFam:
Gene Tree for PNLIPRP1 (if available)

Paralogs for PNLIPRP1 Gene

Paralogs for PNLIPRP1 Gene

genes like me logo Genes that share paralogs with PNLIPRP1: view

Variants for PNLIPRP1 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1049125 - 116,609,094(+) CACGC(C/T)GCTCA nc-transcript-variant, reference, missense
rs2305205 - 116,598,164(-) TACCC(A/G/T)CCCAG nc-transcript-variant, reference, missense
rs2305204 - 116,605,455(+) ATTGA(C/G)AAAGT nc-transcript-variant, reference, missense
VAR_036379 A breast cancer sample
rs11197744 - 116,591,902(+) ACACC(A/G)ATGAA nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855

Variation tolerance for PNLIPRP1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.28; 88.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PNLIPRP1 Gene

Disorders for PNLIPRP1 Gene

Relevant External Links for PNLIPRP1

Genetic Association Database (GAD)
PNLIPRP1
Human Genome Epidemiology (HuGE) Navigator
PNLIPRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNLIPRP1

No disorders were found for PNLIPRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNLIPRP1 Gene

Publications for PNLIPRP1 Gene

  1. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (PMID: 1379598) Giller T. … Hunziker W. (J. Biol. Chem. 1992) 2 3 4 67
  2. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. (PMID: 19824014) Berton A. … Crenon I. (Mol. Nutr. Food Res. 2009) 3 23
  3. Genome-wide association study of proneness to anger. (PMID: 24489884) Mick E. … Goldberg R.J. (PLoS ONE 2014) 3
  4. Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. (PMID: 23918603) Zhang G. … Hussain S.P. (Clin. Cancer Res. 2013) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for PNLIPRP1 Gene

Sources for PNLIPRP1 Gene

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