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PNLIPRP1 Gene

protein-coding   GIFtS: 61
GCID: GC10P118340

Pancreatic Lipase-Related Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Pancreatic Lipase-Related Protein 11 2
PLRP12 3 5
PL-RP12 3
Inactive Pancreatic Lipase-Related Protein 12
EC 3.1.18
EC 3.1.1.38

External Ids:    HGNC: 91561   Entrez Gene: 54072   Ensembl: ENSG000001870217   OMIM: 6044225   UniProtKB: P543153   
ORGUL members:         

Export aliases for PNLIPRP1 gene to outside databases

Previous GC identifers: GC10P117269 GC10P117550 GC10P118437 GC10P118001 GC10P118015 GC10P111977


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PNLIPRP1 Gene:
PNLIPRP1 (pancreatic lipase-related protein 1) is a protein-coding gene. Diseases associated with PNLIPRP1 include choledocholithiasis, and pancreatitis. GO annotations related to this gene include lipase activity and calcium ion binding. An important paralog of this gene is LIPH.

UniProtKB/Swiss-Prot: LIPR1_HUMAN, P54315
Function: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards
triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PNLIPRP1 gene promoter:
         Elk-1   POU3F2 (N-Oct-5a)   POU3F2   Tal-1beta   E47   C/EBPalpha   c-Ets-1   FOXL1   CHOP-10   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPNLIPRP1 promoter sequence
   Search Chromatin IP Primers for PNLIPRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PNLIPRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.12

PNLIPRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNLIPRP1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P118340:  view genomic region     (about GC identifiers)

Start:
118,349,897 bp from pter      End:
118,368,687 bp from pter
Size:
18,791 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LIPR1_HUMAN, P54315 (See protein sequence)
Recommended Name: Inactive pancreatic lipase-related protein 1 precursor  
Size: 467 amino acids; 51848 Da
1 PDB 3D structure from and Proteopedia for PNLIPRP1:
2PPL (3D)    
Secondary accessions: Q68D83 Q68DR6 Q8TAU2 Q9BS82
Alternative splicing: 3 isoforms:  P54315-1   P54315-2   P54315-3   

Explore the universe of human proteins at neXtProt for PNLIPRP1: NX_P54315

Explore proteomics data for PNLIPRP1 at MOPED

Selected DME Specific Peptides for PNLIPRP1 (P54315) (see all 15)
 DFFPNGG  RLDPSDA  HVAGEAG  NFARWRY 


See PNLIPRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006220.1  
ENSEMBL proteins: 
 ENSP00000436123   ENSP00000351695   ENSP00000433933   ENSP00000431406   ENSP00000437263  
 ENSP00000433785   ENSP00000431207   ENSP00000434159   ENSP00000434549   ENSP00000400963  
Reactome Protein details: P54315

PNLIPRP1 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for PNLIPRP1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):
 IPR001024 PLAT/LH2_dom
 IPR008976 Lipase_LipOase
 IPR000734 Lipase
 IPR016272 Lipoprotein_lipase_LIPH
 IPR002331 Lipase_panc

Graphical View of Domain Structure for InterPro Entry P54315

ProtoNet protein and cluster: P54315

4 Blocks protein domains:
IPB000734 Lipase
IPB001024 Lipoxygenase
IPB002331 Pancreatic lipase signature
IPB008262 Lipase


UniProtKB/Swiss-Prot: LIPR1_HUMAN, P54315
Similarity: Belongs to the AB hydrolase superfamily. Lipase family
Similarity: Contains 1 PLAT domain


PNLIPRP1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LIPR1_HUMAN, P54315
Function: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards
triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity)

     Enzyme Numbers (IUBMB): EC 3.1.1.32 EC 3.1.12

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004806triglyceride lipase activity TAS1379598
GO:0005509calcium ion binding ISS--
GO:0005515protein binding ----
GO:0016298NOT lipase activity IDA19824014
     
PNLIPRP1 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Pnliprp1 (no phenotypes)

PNLIPRP1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Pnliprp1tm1Lex for PNLIPRP1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PNLIPRP1
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miRNA
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Gene Editing
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GenScript: all cDNA clones in your preferred vector: PNLIPRP1 (NM_006229)
Sino Biological Human cDNA Clone for PNLIPRP1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNLIPRP1

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNLIPRP1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LIPR1_HUMAN, P54315: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS1379598
GO:0005615NOT extracellular space IDA19824014

PNLIPRP1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PNLIPRP1 About    
See pathways by source

SuperPathContained pathways About
1Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
2Fat digestion and absorption
Digestion of dietary lipid0.00
Fat digestion and absorption
3Lipoprotein metabolism
Lipid digestion, mobilization, and transport0.59
4Pancreatic secretion
Pancreatic secretion
5Glycerolipid metabolism
Glycerolipid metabolism

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for PNLIPRP1
    Digestion of dietary lipid


4 Kegg Pathways  (Kegg details for PNLIPRP1):
    Glycerolipid metabolism
Metabolic pathways
Pancreatic secretion
Fat digestion and absorption


PNLIPRP1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PNLIPRP1
Interactions:

    Search GeneGlobe Interaction Network for PNLIPRP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PNLIPRP1 (P543153 ENSP000003516954) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
InteractantInteraction Details
GeneCardExternal ID(s)
CREB3O438893I2D: score=1 
CELENSP000003611514STRING: ENSP00000361151
DGAT1ENSP000003322584STRING: ENSP00000332258
DGKHENSP000003375724STRING: ENSP00000337572
LIPCENSP000002990224STRING: ENSP00000299022
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006629lipid metabolic process IEA--

PNLIPRP1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PNLIPRP1 (LIPR1)

Selected HMDB Compounds for PNLIPRP1 (see all 1142)    About this table
CompoundSynonyms CAS #PubMed Ids
Arachidic acidArachate (see all 10)506-30-9--
Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

1 Novoseek inferred chemical compound relationship for PNLIPRP1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
phospholipid 29.4 1 9748646 (1)



PNLIPRP1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for PNLIPRP1 gene: 
NM_006229.2  

Unigene Cluster for PNLIPRP1:

Pancreatic lipase-related protein 1
Hs.73923  [show with all ESTs]
Unigene Representative Sequence: CR749524
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
ENST00000525157 ENST00000530626 ENST00000484402 ENST00000470678 ENST00000531984
ENST00000482159(uc001lcn.3) ENST00000529584 ENST00000531825(uc009xys.1)
ENST00000526223 ENST00000525820 ENST00000358834(uc001lco.1) ENST00000528052(uc001lcp.2)
ENST00000497792 ENST00000530319 ENST00000527980 ENST00000480870 ENST00000471549
ENST00000534537

miRNA
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Inhib. RNA
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PNLIPRP1
  QuantiTect SYBR Green Assays in human, mouse, rat PNLIPRP1
  QuantiFast Probe-based Assays in human, mouse, rat PNLIPRP1

Additional mRNA sequence: 

AK130236.1 AK307063.1 BC005233.1 BC025784.2 CR749299.1 CR749524.1 M93283.1 

11 DOTS entries:

DT.412084  DT.100025527  DT.91751097  DT.95369585  DT.101978120  DT.100746876  DT.121249197  DT.121249193 
DT.100737365  DT.121249194  DT.40262586 

Selected AceView cDNA sequences (see all 95):

BM504813 BX498676 CA776593 BI835931 AA366373 CA942708 CA774557 CA848509 
BX496087 AK130236 BX106949 BX497523 BX498483 CR749524 BM919705 CA868559 
AA844828 AA363715 BI838887 CD622212 BC025784 M93283 BX497657 BX498636 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP1 (see all 15)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^
SP1:                                                  -           -     -     -     -     -                 -     -                                             
SP2:              -     -     -     -                 -           -     -     -     -     -                 -     -                                             
SP3:                    -     -     -                 -           -     -     -     -     -                 -     -                                             
SP4:        -     -     -     -     -                 -           -     -     -     -     -                                                                     
SP5:              -     -     -     -                 -           -     -                                                                                       

ExUns: 13 ^ 14 ^ 15 ^ 16
SP1:                        
SP2:                        
SP3:                        
SP4:                        
SP5:                        


ECgene alternative splicing isoforms for PNLIPRP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PNLIPRP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCAAGAAAC
PNLIPRP1 Expression
About this image


PNLIPRP1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Pancreas (Endocrine System)
         Islets of Langerhans
 
 Neural Tube (Nervous System)
         Telencephalon
 
 Brain (Nervous System)
         Cerebral Cortex
PNLIPRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PNLIPRP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.73923

UniProtKB/Swiss-Prot: LIPR1_HUMAN, P54315
Tissue specificity: Pancreas

    Custom PCR Arrays for PNLIPRP1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNLIPRP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP1 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pnliprp11 , 5 pancreatic lipase related protein 11, 5 83.15(n)1
83.73(a)1
  19 (54.49 cM)5
189461  NM_018874.21  NP_061362.11 
 587288875 
chicken
(Gallus gallus)
Aves PNLIP1 pancreatic lipase 63.3(n)
61.59(a)
  423916  NM_001277382.1  NP_001264311.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
63(a)
1 → many
GL343206.1(2017129-2041833)
tropical clawed frog
(Xenopus tropicalis)
Amphibia BX713888.12   -- 74.65(n)    BX713888.1 
fruit fly
(Drosophila melanogaster)
Insecta CG73673 triacylglycerol lipase 38(a)
(best of 6)
    --


ENSEMBL Gene Tree for PNLIPRP1 (if available)
TreeFam Gene Tree for PNLIPRP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PNLIPRP1 gene
LIPH2  LIPC2  LIPG2  PNLIPRP32  PNLIPRP22  LPL2  PNLIP2  LIPI2  
PLA1A2  
10 SIMAP similar genes for PNLIPRP1 using alignment to 8 protein entries:     LIPR1_HUMAN (see all proteins):
DKFZp779I1240    PNLIPRP2    PNLIP    PNLIPRP3    LIPH    LPL
LIPG    LIPI    LOC375108    PLA1A

PNLIPRP1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PNLIPRP1 (see all 549)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0363794
A breast cancer sample4--see VAR_0363792 S C mis40--------
rs1135159291,2
Cuntested1125278737(+) AGTTTC/TGAGAG 2 F syn12Minor allele frequency- T:0.01CSA WA 218
rs781907241,2
C,F--111975808(+) GGAGCC/TAGTGC 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1471712351,2
C--111975845(+) TGCACA/GGAGTT 1 -- us2k10--------
rs1148463901,2
C,F--111975918(+) GTGAGT/GGCAAC 1 -- us2k11Minor allele frequency- G:0.02WA 118
rs1487635421,2
--111975950(+) CCAGGC/GCTGGC 1 -- us2k10--------
rs2006425031,2
--111976005(+) ACCAA-/TTCAGTG 1 -- us2k10--------
rs1424074811,2
--111976067(+) GCTGGA/GTGGTT 1 -- us2k10--------
rs1143974741,2
C,F--111976363(+) TCCCAA/GTCCAT 1 -- us2k10--------
rs775099971,2
C--111976365(+) CCAGTC/TCATCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for PNLIPRP1 (118349897 - 118368687 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PNLIPRP1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv7211OTHER Inversion18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PNLIPRP1
DNA2.0 Custom Variant and Variant Library Synthesis for PNLIPRP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604422    OMIM disorders: --

9 diseases for PNLIPRP1:    
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choledocholithiasis    pancreatitis    breast and colorectal cancer    pancreatic cancer
alzheimer's disease    cerebritis    colorectal cancer    prostate cancer
prostatitis

1 disease from the University of Copenhagen DISEASES database for PNLIPRP1:
Choledocholithiasis

PNLIPRP1 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

1 Novoseek inferred disease relationship for PNLIPRP1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pancreas exocrine 74.8 2 9720253 (1), 9726421 (1)

Genetic Association Database (GAD): PNLIPRP1
Human Genome Epidemiology (HuGE) Navigator: PNLIPRP1 (1 document)

Export disorders for PNLIPRP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PNLIPRP1 gene, integrated from 10 sources (see all 28):
(articles sorted by number of sources associating them with PNLIPRP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (PubMed id 1379598)1, 2, 3 Giller T.... Hunziker W. (J. Biol. Chem. 1992)
  2. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. (PubMed id 19824014)1, 2, 9 Berton A.... Crenon I. (Mol. Nutr. Food Res. 2009)
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Pancreatic lipase-related protein type 1: a double mutation restores a significant lipase activity. (PubMed id 9610393)9 Crenon I....Chapus C. (Biochem. Biophys. Res. Commun. 1998)
  9. Pancreatic lipase-related protein 1 (PLRP1) is present in the pancreatic juice of several species. (PubMed id 9748646)9 De Caro J....De Caro A. (Biochim. Biophys. Acta 1998)
  10. Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions. (PubMed id 16497549)9 Reboul E....Borel P. (Biochim. Biophys. Acta 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5407 HGNC: 9156 AceView: PNLIPRP1 Ensembl:ENSG00000187021 euGenes: HUgn5407
ECgene: PNLIPRP1 Kegg: 5407 H-InvDB: PNLIPRP1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PNLIPRP1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PNLIPRP1 gene:
Search GeneIP for patents involving PNLIPRP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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