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Aliases for PNLIPRP1 Gene

Aliases for PNLIPRP1 Gene

  • Pancreatic Lipase Related Protein 1 2 3 5
  • PLRP1 3 4
  • Inactive Pancreatic Lipase-Related Protein 1 3
  • EC 3.1.1.3 61
  • EC 3.1.1 61
  • PL-RP1 4

External Ids for PNLIPRP1 Gene

Previous GeneCards Identifiers for PNLIPRP1 Gene

  • GC10P117269
  • GC10P117550
  • GC10P118437
  • GC10P118001
  • GC10P118015
  • GC10P118340
  • GC10P111977

Summaries for PNLIPRP1 Gene

GeneCards Summary for PNLIPRP1 Gene

PNLIPRP1 (Pancreatic Lipase Related Protein 1) is a Protein Coding gene. Diseases associated with PNLIPRP1 include Common Bile Duct Disease. Among its related pathways are Fat digestion and absorption and Lipoprotein metabolism. GO annotations related to this gene include calcium ion binding and triglyceride lipase activity. An important paralog of this gene is PNLIP.

UniProtKB/Swiss-Prot for PNLIPRP1 Gene

  • May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP1 Gene

Genomics for PNLIPRP1 Gene

Regulatory Elements for PNLIPRP1 Gene

Enhancers for PNLIPRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G116614 0.6 FANTOM5 72 +23.9 23895 0.4 PKNOX1 FEZF1 ZNF384 ZIC2 JUND PRDM10 FOS ZNF548 PNLIP PNLIPRP2 PNLIPRP1
GH10G116627 0.5 Ensembl 11 +37.2 37209 0.8 CTCF HDAC2 GABPB1 KLF9 RAD21 PNLIPRP2 PNLIPRP1 C10orf82 LOC105378499
GH10G116984 0.8 FANTOM5 dbSUPER 1.6 +394.0 394013 0.1 ZNF707 ZSCAN16 CREB1 PRDM1 SHTN1 KCNK18 HSPA12A PNLIP PNLIPRP2 PNLIPRP1 VAX1 ENSG00000235742
GH10G116218 0.2 dbSUPER 4.6 -371.5 -371463 0.8 PNLIPRP1 GFRA1 GC10M115985
GH10G116589 0.9 ENCODE dbSUPER 0.7 +0.1 135 2.3 SCRT1 NFIA NFIB FEZF1 ZNF843 HHEX FOXA1 GATA3 HNF4A ZNF18 PNLIPRP2 PNLIP RNU6-1090P PNLIPRP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PNLIPRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PNLIPRP1 Gene

Chromosome:
10
Start:
116,590,385 bp from pter
End:
116,609,175 bp from pter
Size:
18,791 bases
Orientation:
Plus strand

Genomic View for PNLIPRP1 Gene

Genes around PNLIPRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIPRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIPRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP1 Gene

Proteins for PNLIPRP1 Gene

  • Protein details for PNLIPRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54315-LIPR1_HUMAN
    Recommended name:
    Inactive pancreatic lipase-related protein 1
    Protein Accession:
    P54315
    Secondary Accessions:
    • Q68D83
    • Q68DR6
    • Q8TAU2
    • Q9BS82

    Protein attributes for PNLIPRP1 Gene

    Size:
    467 amino acids
    Molecular mass:
    51848 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIPRP1 Gene

    Alternative splice isoforms for PNLIPRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNLIPRP1 Gene

Selected DME Specific Peptides for PNLIPRP1 Gene

P54315:
  • HLRSYKYY
  • LIGHSLGAH
  • NVRVVGA
  • RLDPSDA
  • CPQMGHYAD
  • DFFPNGG
  • TIEASNFQ
  • VNCICVDW
  • SILNPDGF
  • NFARWRY
  • EFDAKLDVGTIEKVKFLWNN
  • FLLYTNENPNN
  • HVAGEAG
  • FVDVIHTD
  • NNVINPTLP

Post-translational modifications for PNLIPRP1 Gene

No Post-translational modifications

Domains & Families for PNLIPRP1 Gene

Suggested Antigen Peptide Sequences for PNLIPRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54315

UniProtKB/Swiss-Prot:

LIPR1_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP1: view

No data available for Gene Families for PNLIPRP1 Gene

Function for PNLIPRP1 Gene

Molecular function for PNLIPRP1 Gene

UniProtKB/Swiss-Prot Function:
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for PNLIPRP1 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity TAS 1379598
GO:0005509 calcium ion binding ISS --
GO:0016298 NOT lipase activity IDA 19824014
GO:0046872 metal ion binding IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PNLIPRP1: view
genes like me logo Genes that share phenotypes with PNLIPRP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PNLIPRP1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PNLIPRP1 Gene

Localization for PNLIPRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNLIPRP1 gene
Compartment Confidence
extracellular 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS 1379598
GO:0005615 NOT extracellular space IDA 19824014
genes like me logo Genes that share ontologies with PNLIPRP1: view

Pathways & Interactions for PNLIPRP1 Gene

genes like me logo Genes that share pathways with PNLIPRP1: view

Gene Ontology (GO) - Biological Process for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PNLIPRP1: view

No data available for SIGNOR curated interactions for PNLIPRP1 Gene

Drugs & Compounds for PNLIPRP1 Gene

(6) Drugs for PNLIPRP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(13) Additional Compounds for PNLIPRP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PNLIPRP1: view

Transcripts for PNLIPRP1 Gene

Unigene Clusters for PNLIPRP1 Gene

Pancreatic lipase-related protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - -
SP12: - - -
SP13: - - -
SP14: - - - - -
SP15:

ExUns: 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PNLIPRP1 Gene

GeneLoc Exon Structure for
PNLIPRP1
ECgene alternative splicing isoforms for
PNLIPRP1

Expression for PNLIPRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNLIPRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP1 Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for PNLIPRP1 Gene

This gene is overexpressed in Pancreatic juice (59.9) and Pancreas (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNLIPRP1 Gene



Protein tissue co-expression partners for PNLIPRP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PNLIPRP1 Gene:

PNLIPRP1

SOURCE GeneReport for Unigene cluster for PNLIPRP1 Gene:

Hs.73923

mRNA Expression by UniProt/SwissProt for PNLIPRP1 Gene:

P54315-LIPR1_HUMAN
Tissue specificity: Pancreas.

Evidence on tissue expression from TISSUES for PNLIPRP1 Gene

  • Pancreas(4.9)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with PNLIPRP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PNLIPRP1 Gene

Orthologs for PNLIPRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PNLIPRP1 34 35
  • 87.72 (n)
cow
(Bos Taurus)
Mammalia PNLIPRP1 34
  • 84.55 (n)
rat
(Rattus norvegicus)
Mammalia Pnliprp1 34
  • 83.8 (n)
mouse
(Mus musculus)
Mammalia Pnliprp1 34 16 35
  • 83.15 (n)
oppossum
(Monodelphis domestica)
Mammalia PNLIPRP1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIPRP1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNLIP 34 35
  • 63.3 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486161 34
  • 64.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007672 34
  • 49.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7367 36
  • 38 (a)
CG6472 36
  • 37 (a)
CG6847 36
  • 36 (a)
CG5966 36 35
  • 35 (a)
CG6277 36
  • 33 (a)
CG6271 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 35
  • 40 (a)
OneToMany
Species where no ortholog for PNLIPRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIPRP1 Gene

ENSEMBL:
Gene Tree for PNLIPRP1 (if available)
TreeFam:
Gene Tree for PNLIPRP1 (if available)

Paralogs for PNLIPRP1 Gene

Paralogs for PNLIPRP1 Gene

genes like me logo Genes that share paralogs with PNLIPRP1: view

Variants for PNLIPRP1 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036379 A breast cancer sample
rs1000301278 -- 116,596,230(+) CTACC(C/T)CCCTT nc-transcript-variant, reference, missense
rs1000745637 -- 116,603,878(+) ACAGA(A/G)TGAGA intron-variant
rs1001500715 -- 116,592,135(+) AACCT(C/G)TAGCT intron-variant
rs1001598230 -- 116,591,357(+) TCTGG(G/T)GATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP1 Gene

Variant ID Type Subtype PubMed ID
esv3624660 CNV gain 21293372
nsv7211 OTHER inversion 18451855

Variation tolerance for PNLIPRP1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.28; 88.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNLIPRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNLIPRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIPRP1 Gene

Disorders for PNLIPRP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNLIPRP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
common bile duct disease
  • common bile duct diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PNLIPRP1

Genetic Association Database (GAD)
PNLIPRP1
Human Genome Epidemiology (HuGE) Navigator
PNLIPRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNLIPRP1
genes like me logo Genes that share disorders with PNLIPRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNLIPRP1 Gene

Publications for PNLIPRP1 Gene

  1. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. (PMID: 19824014) Berton A. … Crenon I. (Mol. Nutr. Food Res. 2009) 3 4 22 64
  2. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (PMID: 1379598) Giller T. … Hunziker W. (J. Biol. Chem. 1992) 2 3 4 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genome-wide association study of proneness to anger. (PMID: 24489884) Mick E. … Goldberg R.J. (PLoS ONE 2014) 3 64

Products for PNLIPRP1 Gene

Sources for PNLIPRP1 Gene