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Aliases for PNLIPRP1 Gene

Aliases for PNLIPRP1 Gene

  • Pancreatic Lipase-Related Protein 1 2 3
  • PLRP1 3 4 6
  • Inactive Pancreatic Lipase-Related Protein 1 3
  • EC 3.1.1.3 64
  • EC 3.1.1 64
  • PL-RP1 4

External Ids for PNLIPRP1 Gene

Summaries for PNLIPRP1 Gene

GeneCards Summary for PNLIPRP1 Gene

PNLIPRP1 (Pancreatic Lipase-Related Protein 1) is a Protein Coding gene. Diseases associated with PNLIPRP1 include choledocholithiasis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include calcium ion binding and lipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for PNLIPRP1 Gene

  • May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP1 Gene

Genomics for PNLIPRP1 Gene

Genomic Location for PNLIPRP1 Gene

Start:
116,590,385 bp from pter
End:
116,609,175 bp from pter
Size:
18,791 bases
Orientation:
Plus strand

Genomic View for PNLIPRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNLIPRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP1 Gene

Regulatory Elements for PNLIPRP1 Gene

Proteins for PNLIPRP1 Gene

  • Protein details for PNLIPRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54315-LIPR1_HUMAN
    Recommended name:
    Inactive pancreatic lipase-related protein 1
    Protein Accession:
    P54315
    Secondary Accessions:
    • Q68D83
    • Q68DR6
    • Q8TAU2
    • Q9BS82

    Protein attributes for PNLIPRP1 Gene

    Size:
    467 amino acids
    Molecular mass:
    51848 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIPRP1 Gene

    Alternative splice isoforms for PNLIPRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNLIPRP1 Gene

Proteomics data for PNLIPRP1 Gene at MOPED

Post-translational modifications for PNLIPRP1 Gene

No Post-translational modifications

Other Protein References for PNLIPRP1 Gene

Domains for PNLIPRP1 Gene

UniProtKB/Swiss-Prot:

LIPR1_HUMAN
Domain:
  • Contains 1 PLAT domain.:
    • P54315
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.:
    • P54315
genes like me logo Genes that share domains with PNLIPRP1: view

No data available for Gene Families for PNLIPRP1 Gene

Function for PNLIPRP1 Gene

Molecular function for PNLIPRP1 Gene

UniProtKB/Swiss-Prot Function: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for PNLIPRP1 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity TAS 1379598
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding --
GO:0016298 NOT lipase activity IDA 19824014
GO:0052689 carboxylic ester hydrolase activity --
genes like me logo Genes that share ontologies with PNLIPRP1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PNLIPRP1 Gene

Localization for PNLIPRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNLIPRP1 Gene COMPARTMENTS Subcellular localization image for PNLIPRP1 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 1379598
GO:0005615 NOT extracellular space IDA 19824014
genes like me logo Genes that share ontologies with PNLIPRP1: view

Pathways for PNLIPRP1 Gene

genes like me logo Genes that share pathways with PNLIPRP1: view

Interacting Proteins for PNLIPRP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351695%0d%0a9606.ENSP00000259938%0d%0a9606.ENSP00000347206%0d%0a
Selected Interacting proteins: ENSP00000351695 P54315-LIPR1_HUMAN for PNLIPRP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with PNLIPRP1: view

Compounds for PNLIPRP1 Gene

(1142) HMDB Compounds for PNLIPRP1 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available

(1) Novoseek inferred chemical compound relationships for PNLIPRP1 Gene

Compound -log(P) Hits PubMed IDs
phospholipid 29.4 1
genes like me logo Genes that share compounds with PNLIPRP1: view

Transcripts for PNLIPRP1 Gene

Unigene Clusters for PNLIPRP1 Gene

Pancreatic lipase-related protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - -
SP12: - - -
SP13: - - -
SP14: - - - - -
SP15:

ExUns: 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PNLIPRP1 Gene

GeneLoc Exon Structure for
PNLIPRP1
ECgene alternative splicing isoforms for
PNLIPRP1

Expression for PNLIPRP1 Gene

mRNA expression in normal human tissues for PNLIPRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP1 Gene

This gene is overexpressed in Pancreas (52.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PNLIPRP1 Gene

SOURCE GeneReport for Unigene cluster for PNLIPRP1 Gene Hs.73923

mRNA Expression by UniProt/SwissProt for PNLIPRP1 Gene

P54315-LIPR1_HUMAN
Tissue specificity: Pancreas.
genes like me logo Genes that share expressions with PNLIPRP1: view

Orthologs for PNLIPRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNLIPRP1 36
  • 84.55 (n)
  • 79.44 (a)
dog
(Canis familiaris)
Mammalia PNLIPRP1 36
  • 87.72 (n)
  • 85.22 (a)
PNLIPRP1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnliprp1 36
  • 83.15 (n)
  • 83.73 (a)
Pnliprp1 16
Pnliprp1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNLIPRP1 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIPRP1 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnliprp1 36
  • 83.8 (n)
  • 85.22 (a)
chicken
(Gallus gallus)
Aves PNLIP 36
  • 63.3 (n)
  • 61.59 (a)
PNLIP 37
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486161 36
  • 64.66 (n)
  • 63.09 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007672 36
  • 49.47 (n)
  • 40.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5966 37
  • 27 (a)
OneToMany
CG6271 38
  • 32 (a)
CG7367 38
  • 38 (a)
CG6472 38
  • 37 (a)
CG5966 38
  • 35 (a)
CG6847 38
  • 36 (a)
CG6277 38
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 37
  • 40 (a)
OneToMany
Species with no ortholog for PNLIPRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIPRP1 Gene

ENSEMBL:
Gene Tree for PNLIPRP1 (if available)
TreeFam:
Gene Tree for PNLIPRP1 (if available)

Paralogs for PNLIPRP1 Gene

Paralogs for PNLIPRP1 Gene

genes like me logo Genes that share paralogs with PNLIPRP1: view

Variants for PNLIPRP1 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs729587 -- 116,594,987(+) TACTT(C/T)TAAAA intron-variant
rs1049125 - 116,609,094(+) CACGC(C/T)GCTCA missense, reference
rs1867991 -- 116,592,393(-) GTGCT(G/T)CATGT intron-variant
rs1900510 -- 116,600,648(-) TGGCT(C/T)TCGTG intron-variant
rs2234973 -- 116,591,807(+) CTTTT(C/T)TGACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855

Relevant External Links for PNLIPRP1 Gene

HapMap Linkage Disequilibrium report
PNLIPRP1

Disorders for PNLIPRP1 Gene

(1) MalaCards Diseases for PNLIPRP1 Gene

Search for PNLIPRP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PNLIPRP1 Gene

(1) Novoseek inferred disease relationships for PNLIPRP1 Gene

Disease -log(P) Hits PubMed IDs
pancreas exocrine 74.8 2

Relevant External Links for PNLIPRP1

Genetic Association Database (GAD)
PNLIPRP1
Human Genome Epidemiology (HuGE) Navigator
PNLIPRP1
genes like me logo Genes that share disorders with PNLIPRP1: view

No data available for UniProtKB/Swiss-Prot for PNLIPRP1 Gene

Publications for PNLIPRP1 Gene

  1. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. (PMID: 19824014) Berton A. … Crenon I. (Mol. Nutr. Food Res. 2009) 3 4 23
  2. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (PMID: 1379598) Giller T. … Hunziker W. (J. Biol. Chem. 1992) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. (PMID: 23918603) Zhang G. … Hussain S.P. (Clin. Cancer Res. 2013) 3

Products for PNLIPRP1 Gene

Sources for PNLIPRP1 Gene

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