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Aliases for PNLIP Gene

Aliases for PNLIP Gene

  • Pancreatic Lipase 2 3 4
  • EC 4 63
  • PTL 3 4
  • PL 3 4
  • Triacylglycerol Acylhydrolase 3
  • PNLIPD 3

External Ids for PNLIP Gene

Previous GeneCards Identifiers for PNLIP Gene

  • GC10P117224
  • GC10P117549
  • GC10P118436
  • GC10P117970
  • GC10P118295
  • GC10P111932
  • GC10P118305

Summaries for PNLIP Gene

Entrez Gene Summary for PNLIP Gene

  • This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for PNLIP Gene

PNLIP (Pancreatic Lipase) is a Protein Coding gene. Diseases associated with PNLIP include pancreatic colipase deficiency and pancreatic lipase deficiency. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include carboxylic ester hydrolase activity and triglyceride lipase activity. An important paralog of this gene is LPL.

Tocris Summary for PNLIP Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

Gene Wiki entry for PNLIP Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIP Gene

Genomics for PNLIP Gene

Regulatory Elements for PNLIP Gene

Genomic Location for PNLIP Gene

116,545,916 bp from pter
116,567,855 bp from pter
21,940 bases
Plus strand

Genomic View for PNLIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIP Gene

Proteins for PNLIP Gene

  • Protein details for PNLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pancreatic triacylglycerol lipase
    Protein Accession:
    Secondary Accessions:
    • Q5VSQ2

    Protein attributes for PNLIP Gene

    465 amino acids
    Molecular mass:
    51157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIP Gene

neXtProt entry for PNLIP Gene

Proteomics data for PNLIP Gene at MOPED

Post-translational modifications for PNLIP Gene

  • Glycosylation at Asn 183
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PNLIP Gene

Gene Families for PNLIP Gene


Suggested Antigen Peptide Sequences for PNLIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIP: view

Function for PNLIP Gene

Molecular function for PNLIP Gene

GENATLAS Biochemistry:
lipase,pancreatic (56kDa)
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot Induction:
By colipase/CLPS in the presence of bile salts

Enzyme Numbers (IUBMB) for PNLIP Gene

Gene Ontology (GO) - Molecular Function for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
GO:0052689 carboxylic ester hydrolase activity --
genes like me logo Genes that share ontologies with PNLIP: view
genes like me logo Genes that share phenotypes with PNLIP: view

Animal Models for PNLIP Gene

MGI Knock Outs for PNLIP:

Animal Model Products

miRNA for PNLIP Gene

miRTarBase miRNAs that target PNLIP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNLIP

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PNLIP Gene

Localization for PNLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIP Gene


Subcellular locations from

Jensen Localization Image for PNLIP Gene COMPARTMENTS Subcellular localization image for PNLIP gene
Compartment Confidence
extracellular 5
chloroplast 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PNLIP: view

Pathways & Interactions for PNLIP Gene

genes like me logo Genes that share pathways with PNLIP: view

Gene Ontology (GO) - Biological Process for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process --
GO:0007603 phototransduction, visible light TAS --
GO:0016042 lipid catabolic process IEA --
GO:0030299 intestinal cholesterol absorption IEA --
genes like me logo Genes that share ontologies with PNLIP: view

No data available for SIGNOR curated interactions for PNLIP Gene

Drugs & Compounds for PNLIP Gene

(27) Drugs for PNLIP Gene - From: NovoSeek, DrugBank, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 49
Glycerol Phenylbutyrate Approved Pharma Enzyme, substrate 0
cholic acid Approved Pharma Full agonist, Agonist 0
deoxycholic acid Approved Pharma Antagonist 40
Ethanol Approved Pharma 1708

(47) Additional Compounds for PNLIP Gene - From: NovoSeek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PNLIP: view

Transcripts for PNLIP Gene

mRNA/cDNA for PNLIP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(725) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNLIP Gene

Pancreatic lipase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNLIP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIP Gene

No ASD Table

Relevant External Links for PNLIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PNLIP Gene

mRNA expression in normal human tissues for PNLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIP Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for PNLIP Gene

This gene is overexpressed in Pancreatic juice (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNLIP Gene

SOURCE GeneReport for Unigene cluster for PNLIP Gene Hs.501135

genes like me logo Genes that share expression patterns with PNLIP: view

Protein tissue co-expression partners for PNLIP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PNLIP Gene

Orthologs for PNLIP Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PNLIP 35
  • 85.98 (n)
  • 83.7 (a)
  • 81 (a)
(Canis familiaris)
Mammalia PNLIP 35
  • 87.22 (n)
  • 86.78 (a)
  • 88 (a)
(Mus musculus)
Mammalia Pnlip 35
  • 79.66 (n)
  • 78.85 (a)
Pnlip 16
Pnlip 36
  • 78 (a)
(Pan troglodytes)
Mammalia PNLIP 35
  • 99.07 (n)
  • 98.92 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pnlip 35
  • 79.88 (n)
  • 78.41 (a)
(Monodelphis domestica)
Mammalia PNLIP 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia PNLIP 36
  • 68 (a)
(Gallus gallus)
Aves PNLIP 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17191 37
  • 33 (a)
CG17192 37
  • 31 (a)
CG5966 37
  • 36 (a)
CG6271 37
  • 34 (a)
CG6277 37
  • 32 (a)
CG6283 37
  • 31 (a)
CG6295 37
  • 37 (a)
CG6472 37
  • 34 (a)
CG6847 37
  • 29 (a)
CG7367 37
  • 33 (a)
CG5966 35
  • 48.69 (n)
  • 38.78 (a)
CG5966 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000211 35
  • 45.48 (n)
  • 36.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 36
  • 43 (a)
Species with no ortholog for PNLIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIP Gene

Gene Tree for PNLIP (if available)
Gene Tree for PNLIP (if available)

Paralogs for PNLIP Gene

Paralogs for PNLIP Gene

(7) SIMAP similar genes for PNLIP Gene using alignment to 1 proteins: Pseudogenes for PNLIP Gene

genes like me logo Genes that share paralogs with PNLIP: view

Variants for PNLIP Gene

Sequence variations from dbSNP and Humsavar for PNLIP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2070772 -- 116,560,751(+) TTTTG(C/T)ATTTT intron-variant
rs2234972 -- 116,556,077(+) ATGGC(C/T)TTGCT missense, reference
rs2915748 -- 116,553,753(-) TGCAC(A/G/T)TTGGA missense, reference, synonymous-codon
rs2915749 -- 116,553,604(-) aaagt(A/G)tattt intron-variant
rs2915769 -- 116,565,481(-) tccat(C/T)tcaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIP Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv832001 CNV Loss 17160897

Variation tolerance for PNLIP Gene

Residual Variation Intolerance Score: 30.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNLIP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIP Gene

Disorders for PNLIP Gene

MalaCards: The human disease database

(25) MalaCards diseases for PNLIP Gene - From: OMIM, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic colipase deficiency
pancreatic lipase deficiency
  • pancreatic lipase
  • fatty stool
testicular lymphoma
  • lymphoma of the testis
lipoprotein lipase deficiency
  • lipoprotein lipase
- elite association
Search PNLIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for PNLIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PNLIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNLIP Gene

Publications for PNLIP Gene

  1. Obesity management: update on orlistat. (PMID: 18200802) Drew B.S. … Dixon J.B. (Vasc Health Risk Manag 2007) 23 25 26 67
  2. Orlistat: a review of its use in the management of obesity. (PMID: 16956313) Henness S. … Perry C.M. (Drugs 2006) 23 25 26 67
  3. The use of orlistat in the treatment of obesity, dyslipidaemia and Type 2 diabetes. (PMID: 16259579) Nelson R.H. … Miles J.M. (Expert Opin Pharmacother 2005) 23 25 26 67
  4. [Pharmacological treatment of obesity]. (PMID: 15382615) Gomis BarbarA! R. (Rev Med Univ Navarra 2004) 23 25 26 67
  5. Orlistat. (PMID: 11728255) Wong N.N. … Cheng-Lai A. (Heart Dis 2000) 23 25 26 67

Products for PNLIP Gene

Sources for PNLIP Gene

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