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Aliases for PNLIP Gene

Aliases for PNLIP Gene

  • Pancreatic Lipase 2 3 4 5
  • EC 3.1.1.3 4 63
  • PTL 3 4
  • PL 3 4
  • Triacylglycerol Acylhydrolase 3
  • PNLIPD 3

External Ids for PNLIP Gene

Previous GeneCards Identifiers for PNLIP Gene

  • GC10P117224
  • GC10P117549
  • GC10P118436
  • GC10P117970
  • GC10P118295
  • GC10P111932
  • GC10P118305

Summaries for PNLIP Gene

Entrez Gene Summary for PNLIP Gene

  • This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for PNLIP Gene

PNLIP (Pancreatic Lipase) is a Protein Coding gene. Diseases associated with PNLIP include pancreatic colipase deficiency and pancreatic lipase deficiency. Among its related pathways are Signaling by GPCR and Lipoprotein metabolism. GO annotations related to this gene include carboxylic ester hydrolase activity and triglyceride lipase activity. An important paralog of this gene is LPL.

Tocris Summary for PNLIP Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

Gene Wiki entry for PNLIP Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIP Gene

Genomics for PNLIP Gene

Regulatory Elements for PNLIP Gene

Genomic Location for PNLIP Gene

Chromosome:
10
Start:
116,545,916 bp from pter
End:
116,567,855 bp from pter
Size:
21,940 bases
Orientation:
Plus strand

Genomic View for PNLIP Gene

Genes around PNLIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIP Gene

Proteins for PNLIP Gene

  • Protein details for PNLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16233-LIPP_HUMAN
    Recommended name:
    Pancreatic triacylglycerol lipase
    Protein Accession:
    P16233
    Secondary Accessions:
    • Q5VSQ2

    Protein attributes for PNLIP Gene

    Size:
    465 amino acids
    Molecular mass:
    51157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIP Gene

neXtProt entry for PNLIP Gene

Proteomics data for PNLIP Gene at MOPED

Post-translational modifications for PNLIP Gene

  • Glycosylation at Asn 183
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PNLIP Gene

Gene Families for PNLIP Gene

Suggested Antigen Peptide Sequences for PNLIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16233

UniProtKB/Swiss-Prot:

LIPP_HUMAN :
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIP: view

Function for PNLIP Gene

Molecular function for PNLIP Gene

GENATLAS Biochemistry:
lipase,pancreatic (56kDa)
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot Induction:
By colipase/CLPS in the presence of bile salts.

Enzyme Numbers (IUBMB) for PNLIP Gene

Gene Ontology (GO) - Molecular Function for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PNLIP: view
genes like me logo Genes that share phenotypes with PNLIP: view

Human Phenotype Ontology for PNLIP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PNLIP Gene

MGI Knock Outs for PNLIP:

Animal Model Products

  • Taconic Biosciences Mouse Models for PNLIP

miRNA for PNLIP Gene

miRTarBase miRNAs that target PNLIP

No data available for Transcription Factor Targets and HOMER Transcription for PNLIP Gene

Localization for PNLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNLIP Gene COMPARTMENTS Subcellular localization image for PNLIP gene
Compartment Confidence
extracellular 5
chloroplast 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PNLIP Gene

Pathways & Interactions for PNLIP Gene

genes like me logo Genes that share pathways with PNLIP: view

Gene Ontology (GO) - Biological Process for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0016042 lipid catabolic process IEA --
GO:0044241 lipid digestion TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0061365 positive regulation of triglyceride lipase activity IDA 9631512
genes like me logo Genes that share ontologies with PNLIP: view

No data available for SIGNOR curated interactions for PNLIP Gene

Drugs & Compounds for PNLIP Gene

(27) Drugs for PNLIP Gene - From: Novoseek, DrugBank, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
Glycerol Phenylbutyrate Approved Pharma Enzyme, substrate 0
Stearic acid Experimental Pharma 0
(Hydroxyethyloxy)Tri(Ethyloxy)Octane Experimental Pharma Target 0
METHOXYUNDECYLPHOSPHINIC ACID Experimental Pharma Target 0

(48) Additional Compounds for PNLIP Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(3) Tocris Compounds for PNLIP Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
RHC 80267 Diacylglycerol lipase inhibitor 83654-05-1
genes like me logo Genes that share compounds with PNLIP: view

Transcripts for PNLIP Gene

mRNA/cDNA for PNLIP Gene

Unigene Clusters for PNLIP Gene

Pancreatic lipase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIP Gene

No ASD Table

Relevant External Links for PNLIP Gene

GeneLoc Exon Structure for
PNLIP
ECgene alternative splicing isoforms for
PNLIP

Expression for PNLIP Gene

mRNA expression in normal human tissues for PNLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIP Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for PNLIP Gene

This gene is overexpressed in Pancreatic juice (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNLIP Gene



SOURCE GeneReport for Unigene cluster for PNLIP Gene Hs.501135

genes like me logo Genes that share expression patterns with PNLIP: view

Protein tissue co-expression partners for PNLIP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PNLIP Gene

Orthologs for PNLIP Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNLIP 35
  • 85.98 (n)
  • 83.7 (a)
PNLIP 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNLIP 35
  • 87.22 (n)
  • 86.78 (a)
PNLIP 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnlip 35
  • 79.66 (n)
  • 78.85 (a)
Pnlip 16
Pnlip 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PNLIP 35
  • 99.07 (n)
  • 98.92 (a)
PNLIP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnlip 35
  • 79.88 (n)
  • 78.41 (a)
oppossum
(Monodelphis domestica)
Mammalia PNLIP 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIP 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNLIP 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17191 37
  • 33 (a)
CG17192 37
  • 31 (a)
CG5966 37
  • 36 (a)
CG6271 37
  • 34 (a)
CG6277 37
  • 32 (a)
CG6283 37
  • 31 (a)
CG6295 37
  • 37 (a)
CG6472 37
  • 34 (a)
CG6847 37
  • 29 (a)
CG7367 37
  • 33 (a)
CG5966 35
  • 48.69 (n)
  • 38.78 (a)
CG5966 36
  • 27 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000211 35
  • 45.48 (n)
  • 36.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 36
  • 43 (a)
OneToMany
Species with no ortholog for PNLIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIP Gene

ENSEMBL:
Gene Tree for PNLIP (if available)
TreeFam:
Gene Tree for PNLIP (if available)

Paralogs for PNLIP Gene

Paralogs for PNLIP Gene

(7) SIMAP similar genes for PNLIP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PNLIP Gene

genes like me logo Genes that share paralogs with PNLIP: view

Variants for PNLIP Gene

Sequence variations from dbSNP and Humsavar for PNLIP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2070772 -- 116,560,751(+) TTTTG(C/T)ATTTT intron-variant
rs2234972 -- 116,556,077(+) ATGGC(C/T)TTGCT reference, missense
rs3010492 -- 116,566,662(+) ggtac(C/T)GTTTC intron-variant
rs3010493 -- 116,567,384(+) TTAGA(C/T)TTTAT intron-variant
rs3010503 -- 116,549,731(+) ACAGC(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIP Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv832001 CNV Loss 17160897

Variation tolerance for PNLIP Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNLIP Gene

HapMap Linkage Disequilibrium report
PNLIP
Human Gene Mutation Database (HGMD)
PNLIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIP Gene

Disorders for PNLIP Gene

MalaCards: The human disease database

(25) MalaCards diseases for PNLIP Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic colipase deficiency
pancreatic lipase deficiency
  • pancreatic lipase
steatorrhea
  • fatty stool
testicular lymphoma
  • lymphoma of the testis
multicentric papillary thyroid carcinoma
  • multicentric thyroid gland papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PNLIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for PNLIP

Genetic Association Database (GAD)
PNLIP
Human Genome Epidemiology (HuGE) Navigator
PNLIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNLIP
genes like me logo Genes that share disorders with PNLIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNLIP Gene

Publications for PNLIP Gene

  1. Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits. (PMID: 11393534) Hegele R.A. … Cao H. (J. Hum. Genet. 2001) 3 23 48 67
  2. Obesity management: update on orlistat. (PMID: 18200802) Drew B.S. … Dixon J.B. (Vasc Health Risk Manag 2007) 23 25 26
  3. Orlistat: a review of its use in the management of obesity. (PMID: 16956313) Henness S. … Perry C.M. (Drugs 2006) 23 25 26
  4. The use of orlistat in the treatment of obesity, dyslipidaemia and Type 2 diabetes. (PMID: 16259579) Nelson R.H. … Miles J.M. (Expert Opin Pharmacother 2005) 23 25 26
  5. [Pharmacological treatment of obesity]. (PMID: 15382615) Gomis BarbarA! R. (Rev Med Univ Navarra 2004) 23 25 26

Products for PNLIP Gene

Sources for PNLIP Gene

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