PNLDC1 Gene
protein-coding GIFtS: 44
GCID: GC06P160221
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poly(A)-specific ribonuclease (PARN)-like domain containing...
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Aliases
for PNLDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Poly(A)-Specific Ribonuclease (PARN)-Like Domain Containing 11 2 | | FLJ402401 | | DJ195P10.21 | | Poly(A)-Specific Ribonuclease PARN-Like Domain-Containing Protein 12 |
Export aliases for PNLDC1 gene to outside databasesPrevious GC identifers: GC06P160054 GC06P160130 GC06P160191 GC06P157691 |
Summaries
for PNLDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PNLDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PNLDC1 gene promoter:
USF1 p53 Lmo2 USF-1:USF-2 IRF-1 Egr-2 SRY USF-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PNLDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNLDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25.3 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25.3PNLDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P160221: view genomic region
(about GC identifiers)
Start:
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160,221,301 bp from pter |
End:
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160,241,736 bp from pter |
Size:
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20,436 bases |
Orientation:
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plus strand |
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Proteins
for PNLDC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PNDC1_HUMAN, Q8NA58 (See
protein sequence)Recommended Name: Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 precursor Size: 520 amino acids; 60124 Da
Subcellular location: Membrane; Single-pass type IV membrane protein (Potential)
Secondary accessions: Q5TAP7 Q8N7X5Alternative splicing: 2 isoforms: Q8NA58-1 Q8NA58-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PNLDC1: NX_Q8NA58
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NA58
PNLDC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775787.1
ENSEMBL proteins: ENSP00000275275 ENSP00000376007
Human Recombinant Protein Products for PNLDC1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PNLDC1 for ontologies About GeneDecksing
PNLDC1 Antibody Products:
Assay Products for PNLDC1: |
Protein
Domains /
Families
for PNLDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PNLDC1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NA58ProtoNet protein and cluster: Q8NA58 1 Blocks protein family: IPB006941 CAF1 family ribonuclease
UniProtKB/Swiss-Prot: PNDC1_HUMAN, Q8NA58Similarity: Belongs to the CAF1 family |
Function
for PNLDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- |
PNLDC1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for PNLDC1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNLDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNLDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PNLDC1 (NM_173516) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNLDC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNLDC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNLDC1 |
|
Pathways & Interactions
for PNLDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNLDC1
|
Drugs & Compounds
for PNLDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PNLDC1
Search CenterWatch for drugs/clinical trials and news about PNLDC1 / PNDC1
|
Transcripts
for PNLDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PNLDC1 gene: NM_173516.1 Unigene Cluster for PNLDC1: Poly(A)-specific ribonuclease (PARN)-like domain containing 1 Hs.349077 [show with all ESTs]Unigene Representative Sequence: NM_1735162 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000275275(uc003qsx.1 uc003qsy.1) ENST00000392167
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNLDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNLDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PNLDC1 (NM_173516) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNLDC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNLDC1 |
Additional cDNA sequence: AK093139.1 AK097559.1 BC112246.1 6 DOTS entries: DT.100747256 DT.91995942 DT.100747254 DT.100747255 DT.100804793 DT.121404670 20 AceView cDNA sequences: AK097559 NM_173516 BE158844 BM666663 BM021530 BE158842 CK904494 BX389846 BX391855 AX747947 AK093139 BM023581 BM023285 CK904493 BX389847 BX361290 BM021248 BG697847 BX340163 BF956303
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PNLDC1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PNLDC1
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Expression
for PNLDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PNLDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTCTGGGA
About this image
See PNLDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PNLDC1
SOURCE GeneReport for Unigene cluster: Hs.349077
SABiosciences Custom PCR Arrays for PNLDC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNLDC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PNLDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNLDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNLDC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNLDC1 |
Orthologs
for PNLDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PNLDC1 gene from 7/16 species (see all 16) About this table
ENSEMBL Gene Tree for PNLDC1 (if available)
TreeFam Gene Tree for PNLDC1 (if available) |
Paralogs
for PNLDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PNLDC1 gene
- PARN2
PNLDC1 for paralogs About GeneDecksing
|
Genomic Variants
for PNLDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PNLDC1 (160221301 - 160241736 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PNLDC1
1 CNV: 3647 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNLDC1 |
|
Disorders
/ Diseases
for PNLDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PNLDC1 for disorders About GeneDecksing
2  diseases for PNLDC1: About MalaCardskidney disease malaria
Human Genome Epidemiology (HuGE) Navigator: PNLDC1 (3 documents)
Export disorders for PNLDC1 gene to outside databases
|
Publications
for PNLDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PNLDC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PNLDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
- Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1 Yoshida T....Yamada Y. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PNLDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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|
Genome Databases showing PNLDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PNLDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PNLDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PNLDC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PNLDC1 gene:
Search GeneIP for patents involving PNLDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PNLDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PNLDC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PNLDC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNLDC1 | | | OriGene Protein Over-expression Lysate for PNLDC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PNLDC1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNLDC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNLDC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PNLDC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNLDC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNLDC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PNLDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNLDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNLDC1 |
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 | | | PNLDC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNLDC1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for PNLDC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNLDC1 |
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