PNKP Gene
protein-coding GIFtS: 61
GCID: GC19M050364
|
|
polynucleotide kinase 3'-phosphatase
| |
Aliases
for PNKP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Polynucleotide Kinase 3'-Phosphatase1 2 | | MCSZ2 5 | | PNK1 2 5 | | Bifunctional Polynucleotide Phosphatase/Kinase2 | | DNA 5'-Kinase/3'-Phosphatase2 3 | | Homo Sapiens Polynucleotide Kinase 3'-Phosphatase (PNKP)2 | | EIEE102 5 | | Polynucleotide Kinase-3'-Phosphatase3 |
Export aliases for PNKP gene to outside databasesPrevious GC identifers: GC19M051022 GC19M050732 GC19M055040 GC19M055056 GC19M046740 |
Summaries
for PNKP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PNKP:
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the proteinencoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locushave been associated with microcephaly, seizures, and developmental delay.(provided by RefSeq, Sep 2010)
UniProtKB/Swiss-Prot: PNKP_HUMAN, Q96T60Function: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining(NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini arecompatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groupson, the ribose sugar of the DNA backbone
Gene Wiki entry for PNKP
|
Genomic Views
for PNKP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PNKP gene promoter:
p53 Sp1 SREBP-1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for PNKP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNKP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3-q13.4 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-q13.4PNKP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M050364: view genomic region
(about GC identifiers)
Start:
|
50,364,461 bp from pter |
End:
|
50,370,818 bp from pter |
Size:
|
6,358 bases |
Orientation:
|
minus strand |
|
Proteins
for PNKP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PNKP_HUMAN, Q96T60 (See
protein sequence)Recommended Name: Bifunctional polynucleotide phosphatase/kinase Size: 521 amino acids; 57076 Da
Subunit: Monomer (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=AAD47379.1; Type=Frameshift; Positions=Several;
2 PDB 3D structures from  and Proteopedia  for PNKP:2BRF (3D)
2W3O (3D)
Secondary accessions: Q9P1V2 Q9UKU8 Q9UNF8 Q9UNI0Explore the universe of human proteins at neXtProt for PNKP: NX_Q96T60
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96T60
PNKP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009185.2
ENSEMBL proteins: ENSP00000323511
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PNKP for ontologies About GeneDecksing
PNKP Antibody Products:
Assay Products for PNKP: |
Protein
Domains /
Families
for PNKP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PNKP for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q96T60ProtoNet protein and cluster: Q96T60 1 Blocks protein family: IPB013954 Polynucleotide kinase 3 phosphatase
UniProtKB/Swiss-Prot: PNKP_HUMAN, Q96T60Domain: The FHA domain binds threonine-phosphorylated peptides from XRCC1/4, and is responsible for the recruitment ofPNKP to the sites of DNA repair. The affinity is ten times greater if peptides are also phosphorylated on the serinepreceeding the phosphothreonineSimilarity: In the N-terminal section; belongs to the DNA 3' phosphatase familySimilarity: Contains 1 FHA domain |
Function
for PNKP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PNKP_HUMAN, Q96T60Function: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining(NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini arecompatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groupson, the ribose sugar of the DNA backboneCatalytic activity: A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphateCatalytic activity: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA Genatlas biochemistry entry for PNKP:polynucleotide kinase-3 phosphatase,facilitating DNA repair of DNA strand breaks caused by oxidative damage
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNKP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNKP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PNKP (NM_007254) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNKP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNKP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNKP |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
PNKP for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PNKP:
|
Pathways & Interactions
for PNKP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Non-homologous end-joining | | | 2 | DNA Damage | | | 3 | Cell Cycle / Checkpoint Control | | | 4 | Chks in Checkpoint Regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PNKP
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PNKP
2 
Cell Signaling Technology (CST) Pathways for PNKP
1  GeneGo (Thomson Reuters) Pathway for PNKP
PNKP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PNKP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for PNKP (Q96T602, 3 ENSP000003235114) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
PNKP for ontologies About GeneDecksing
|
Drugs & Compounds
for PNKP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PNKP for compounds About GeneDecksing
 Browse Tocris compounds for PNKP
4 HMDB Compounds for PNKP About this table
5 Novoseek chemical compound relationships for PNKP gene About this table
Search CenterWatch for drugs/clinical trials and news about PNKP
|
Transcripts
for PNKP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PNKP gene: NM_007254.3 Unigene Cluster for PNKP: Polynucleotide kinase 3'-phosphatase Hs.78016 [show with all ESTs]Unigene Representative Sequence: BC0130341 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000322344(uc002pqg.3 uc002pqi.3 uc021uxx.1 uc002pqj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNKP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNKP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PNKP (NM_007254) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PNKP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNKP |
Additional cDNA sequence: AF120499.1 AF125807.1 AF126486.1 BC002519.2 BC009339.2 BC013034.2 BC033822.1 17 DOTS entries: DT.211706 DT.121429426 DT.100789769 DT.40275406 DT.100789766 DT.121429538 DT.100789779 DT.121429380 DT.100769341 DT.100789767 DT.100789780 DT.40202941 DT.95219672 DT.95219688 DT.75102180 DT.95219695 DT.121429373 24/205 AceView cDNA sequences (see all 205): CA433726 BX279591 BP870972 CB529741 CR590331 CR605495 CR612354 BU620478 BC002519 CR600664 CR621711 BM052781 BM053079 CR624604 BI765355 BU619715 BC033822 BQ008966 BI821496 BC013034 AL042657 BC009339 BM021163 BF314736
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PNKP (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17 | ^ | 18 |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for PNKP
|
Expression
for PNKP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PNKP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGGCTACA
About this image
See PNKP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PNKP
SOURCE GeneReport for Unigene cluster: Hs.78016
UniProtKB/Swiss-Prot: PNKP_HUMAN, Q96T60Tissue specificity: Expressed in many tissues with highest expression in spleen and testis, and lowest expression insmall intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels inbrain, lung and liver (PubMed:10446193)
SABiosciences Expression via Pathway-Focused PCR Arrays including PNKP: | DNA Damage Signaling Pathway in human mouse rat | | Oxidative Stress in human mouse rat | | Nitric Oxide Signaling Pathway in human mouse rat | | DNA Repair in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNKP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PNKP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNKP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNKP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNKP |
Orthologs
for PNKP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PNKP gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pnkp1 , 5 |
polynucleotide kinase 3'- phosphatase1, 5 |
79.55(n)1
81.35(a)1 |
|
7 (28.94 cM)5
590471 NM_021549.21 NP_067524.21
448571395 |
lizard
(Anolis carolinensis) |
Reptilia |
PNKP6 |
-- |
59(a) |
1 ↔ 1 |
6(79806890-79817990) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.135652 |
Xenopus laevis transcribed sequence with weak similarity more |
71.77(n) |
|
BJ070151.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1530841 |
zgc:153084 |
58.33(n)
55.44(a) |
|
569462 NM_001077578.1 NP_001071046.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG96011 , 3 |
CG96011 |
40(a)3
48.87(n)1
42.45(a)1 |
|
84F133
409941 NM_141535.31 NP_649792.31 |
worm
(Caenorhabditis elegans) |
Secernentea |
F21D5.51 , 3 |
polynucleotide kinase 3' phosphatase3
Protein F21D5.51 |
45(a)3
47.22(n)1
45.97(a)1 |
|
IV(8735986-8739560)3
1776811 NM_069102.21 NP_501503.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G148906 |
bifunctional polynucleotide phosphatase/kinase |
12(a) |
1 ↔ 1 |
3(5008742-5013265) |
rice
(Oryza sativa) |
Liliopsida |
-- |
phosphoesterase, putative, expressed |
16(a) |
1 ↔ 1 |
1(30752175-30760175) |
ENSEMBL Gene Tree for PNKP (if available)
TreeFam Gene Tree for PNKP (if available) |
Paralogs
for PNKP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PNKP gene
- APTX2
PNKP for paralogs About GeneDecksing
|
Genomic Variants
for PNKP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PNKP (50364461 - 50370818 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PNKP
2 CNVs: 5114 32261
Human Gene Mutation Database (HGMD): PNKP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNKP |
|
Disorders
/ Diseases
for PNKP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PNKP for disorders About GeneDecksing
OMIM gene information: 605610
OMIM disorders: 613402
UniProtKB/Swiss-Prot: PNKP_HUMAN, Q96T60
Defects in PNKP are the cause of epileptic encephalopathy, early infantile, type 10 (EIEE10) [MIM:613402]. Adisease characterized by microcephaly, infantile-onset seizures, severe intellectual disability and delayed motormilestones with absent speech or only achieving a few words. Most patients also have behavioral problems withhyperactivity. Microcephaly is progressive and without neuronal migration or structural abnormalities, consistent withprimary microcephaly
13  diseases for PNKP: About MalaCardsmicrocephaly, seizures, and developmental delay microcephaly ataxia-ocular apraxia seizures
graft versus host disease apraxia intellectual disability ataxia telangiectasia
west syndrome multiple sclerosis ataxia adenoma
malaria
3 diseases from the University of Copenhagen DISEASES database for PNKP:Ohtahara syndrome Apraxia DOID:4019 Human Genome Epidemiology (HuGE) Navigator: PNKP (5 documents)
Export disorders for PNKP gene to outside databases
|
Publications
for PNKP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PNKP gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with PNKP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. (PubMed id 10446192)1, 2, 3, 9 Jilani A....Lasko D.D. (1999)
- Molecular characterization of a human DNA kinase. (PubMed id 10446193)1, 2, 3 Karimi-Busheri F....Weinfeld M. (1999)
- Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. (PubMed id 19155274)1, 2, 9 Ali A.A....Oliver A.W. (2009)
- Mutations in PNKP cause microcephaly, seizures and de fects in DNA repair. (PubMed id 20118933)1, 2 Shen J....Walsh C.A. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- AP endonuclease-independent DNA base excision repair in human cells. (PubMed id 15260972)1, 9 Wiederhold L....Hazra T.K. (2004)
- Polynucleotide kinase 3' phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial. (PubMed id 18414202)1, 9 Murphy G....Lanza E. (2008)
- Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. (PubMed id 15385968)1, 9 Koch C.A....Durocher D. (2004)
|
External Searches for PNKP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PNKP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PNKP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PNKP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PNKP gene:
Search GeneIP for patents involving PNKP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PNKP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PNKP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PNKP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PNKP | | | OriGene Protein Over-expression Lysate for PNKP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PNKP | | OriGene 3'-UTR Clone for PNKP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PNKP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PNKP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PNKP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PNKP | | OriGene Custom Protein Services for PNKP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PNKP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNKP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNKP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PNKP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PNKP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PNKP |
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| | Antibodies & Assays for PNKP (Pnk1) |
| | | | Search Tocris compounds for PNKP |
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 | | | PNKP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNKP |
|  |  |  | | | | ThermoFisher Antibodies for PNKP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNKP |
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