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Aliases for PNISR Gene

Aliases for PNISR Gene

  • PNN-Interacting Serine/Arginine-Rich Protein 2 3 4
  • Splicing Factor, Arginine/Serine-Rich 18 2 3 4
  • Serine/Arginine-Rich-Splicing Regulatory Protein 130 3 4
  • Splicing Factor, Arginine/Serine-Rich 130 3 4
  • SR-Related Protein 3 4
  • SR-Rich Protein 3 4
  • C6orf111 3 4
  • SRrp130 3 4
  • SFRS18 3 4
  • Serine-Arginine-Rich-Splicing Regulatory Protein 130 3
  • Chromosome 6 Open Reading Frame 111 2
  • Arginine/Serine-Rich Protein PNISR 3
  • SR Rich Protein 3
  • BA98I9.2 3
  • HSPC306 3

External Ids for PNISR Gene

Previous HGNC Symbols for PNISR Gene

  • C6orf111
  • SFRS18

Previous GeneCards Identifiers for PNISR Gene

  • GC06M099846

Summaries for PNISR Gene

GeneCards Summary for PNISR Gene

PNISR (PNN-Interacting Serine/Arginine-Rich Protein) is a Protein Coding gene.

Gene Wiki entry for PNISR Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNISR Gene

Genomics for PNISR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PNISR Gene

Start:
99,398,051 bp from pter
End:
99,425,395 bp from pter
Size:
27,345 bases
Orientation:
Minus strand

Genomic View for PNISR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNISR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNISR Gene

No data available for Regulatory Elements for PNISR Gene

Proteins for PNISR Gene

  • Protein details for PNISR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF01-PNISR_HUMAN
    Recommended name:
    Arginine/serine-rich protein PNISR
    Protein Accession:
    Q8TF01
    Secondary Accessions:
    • A8K540
    • E1P5D2
    • Q5T064
    • Q5T065
    • Q6P2B4
    • Q6P2N4
    • Q6PJ93
    • Q6PK36
    • Q7Z640
    • Q8N2L1
    • Q8TF00
    • Q96K10
    • Q96SI3
    • Q96SM5
    • Q9P076
    • Q9P0C0
    • Q9Y4N3

    Protein attributes for PNISR Gene

    Size:
    805 amino acids
    Molecular mass:
    92577 Da
    Quaternary structure:
    • Interacts with PNN.
    SequenceCaution:
    • Sequence=AAH07791.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH19074.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH52638.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH64413.1; Type=Frameshift; Positions=267; Evidence={ECO:0000305}; Sequence=AAH64640.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PNISR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNISR Gene

Proteomics data for PNISR Gene at MOPED

Post-translational modifications for PNISR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PNISR Gene

No data available for DME Specific Peptides for PNISR Gene

Domains for PNISR Gene

Protein Domains for PNISR Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PNISR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF01

UniProtKB/Swiss-Prot:

PNISR_HUMAN :
  • Q8TF01
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with PNISR: view

No data available for Gene Families for PNISR Gene

Function for PNISR Gene

Gene Ontology (GO) - Molecular Function for PNISR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PNISR: view

Phenotypes for PNISR Gene

GenomeRNAi human phenotypes for PNISR:
genes like me logo Genes that share phenotypes with PNISR: view

Animal Model Products

CRISPR Products

miRNA for PNISR Gene

miRTarBase miRNAs that target PNISR

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNISR

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PNISR Gene

Localization for PNISR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNISR Gene

Nucleus speckle.

Gene Ontology (GO) - Cellular Components for PNISR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with PNISR: view

No data available for Subcellular locations from COMPARTMENTS for PNISR Gene

Pathways for PNISR Gene

SuperPathways for PNISR Gene

No Data Available

Gene Ontology (GO) - Biological Process for PNISR Gene

None

No data available for Pathways by source for PNISR Gene

Transcripts for PNISR Gene

Unigene Clusters for PNISR Gene

PNN-interacting serine/arginine-rich protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNISR

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PNISR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNISR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4:
SP5: - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - - - - - - -
SP12: -
SP13: - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - - - - - - - - -
SP16: - - -
SP17:

ExUns: 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PNISR Gene

GeneLoc Exon Structure for
PNISR
ECgene alternative splicing isoforms for
PNISR

Expression for PNISR Gene

mRNA expression in normal human tissues for PNISR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PNISR Gene

SOURCE GeneReport for Unigene cluster for PNISR Gene Hs.520287

mRNA Expression by UniProt/SwissProt for PNISR Gene

Q8TF01-PNISR_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, thymus, spleen, kidney, liver, placenta and leukocytes.
genes like me logo Genes that share expressions with PNISR: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PNISR Gene

Orthologs for PNISR Gene

This gene was present in the common ancestor of animals.

Orthologs for PNISR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFRS18 35
  • 99.88 (n)
  • 99.88 (a)
SFRS18 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS18 35
  • 95.13 (n)
  • 96.59 (a)
SFRS18 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNISR 35
  • 96.4 (n)
  • 99.25 (a)
PNISR 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfrs18 35
  • 90.1 (n)
  • 92.92 (a)
Sfrs18 16
Sfrs18 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNISR 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNISR 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnisr 35
  • 90.48 (n)
  • 94.16 (a)
chicken
(Gallus gallus)
Aves PNISR 35
  • 85.43 (n)
  • 87.66 (a)
PNISR 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PNISR 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16792 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pnisr 35
  • 73.24 (n)
  • 75.7 (a)
Str.10739 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9974 35
zebrafish
(Danio rerio)
Actinopterygii pnisr 36
  • 56 (a)
OneToOne
wufb24d01 35
fruit fly
(Drosophila melanogaster)
Insecta CG31211 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for PNISR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNISR Gene

ENSEMBL:
Gene Tree for PNISR (if available)
TreeFam:
Gene Tree for PNISR (if available)

Paralogs for PNISR Gene

Selected SIMAP similar genes for PNISR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PNISR: view

No data available for Paralogs for PNISR Gene

Variants for PNISR Gene

Sequence variations from dbSNP and Humsavar for PNISR Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13608 -- 99,411,947(+) TGATT(A/C)CTCCA intron-variant, utr-variant-5-prime
rs1128347 -- 99,400,380(-) TTATT(A/T)AAAAT utr-variant-3-prime, intron-variant, downstream-variant-500B
rs1135676 -- 99,408,465(-) TAAAT(C/T)AGATG intron-variant
rs3811072 -- 99,404,101(+) AATGT(C/T)GACAG intron-variant
rs4144165 -- 99,399,384(+) TGTCA(G/T)GAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PNISR Gene

Variant ID Type Subtype PubMed ID
nsv886436 CNV Gain 21882294
nsv886438 CNV Gain 21882294
nsv527517 CNV Loss 19592680
nsv886439 CNV Loss 21882294
nsv823789 CNV Loss 20364138

Relevant External Links for PNISR Gene

HapMap Linkage Disequilibrium report
PNISR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNISR Gene

Disorders for PNISR Gene

No disorders were found for PNISR Gene.

No data available for UniProtKB/Swiss-Prot for PNISR Gene

Publications for PNISR Gene

  1. Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. (PMID: 14578391) Zimowska G. … Sugrue S.P. (Invest. Ophthalmol. Vis. Sci. 2003) 2 3 4 23
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for PNISR Gene

Sources for PNISR Gene

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