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PNISR Gene

protein-coding GIFtS: 43
GCID: GC06M099846

PNN-Interacting Serine/Arginine-Rich Protein

(Previous names: chromosome 6 open reading frame 111, splicing factor, arginine/serine-rich...)
(Previous symbols: C6orf111, SFRS18)

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
PNN-Interacting Serine/Arginine-Rich Protein¹ ² ³		SR-Rich Protein² ³
Splicing Factor, Arginine/Serine-Rich 18¹ ² ³		Chromosome 6 Open Reading Frame 111¹
C6orf111¹ ² ³		HSPC306²
SFRS18¹ ² ³		Arginine/Serine-Rich Protein PNISR²
Serine/Arginine-Rich-Splicing Regulatory Protein 130² ³		bA98I9.2²
Splicing Factor, Arginine/Serine-Rich 130² ³		Serine-Arginine-Rich-Splicing Regulatory Protein 130²
SRrp130² ³		SR Rich Protein²
SR-Related Protein² ³		SRRP130³

External Ids:	HGNC: 21222¹	Entrez Gene: 25957²	Ensembl: ENSG00000132424⁷	UniProtKB: Q8TF01³

Export aliases for PNISR gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PNISR Gene:

PNISR (PNN-interacting serine/arginine-rich protein) is a protein-coding gene.

Gene Wiki entry for PNISR (SFRS18) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000006.12 NT_025741.16 NC_018917.2

Regulatory elements:

Search for regulatory transcription factor binding sites for PNISR
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PNISR promoter sequence

Search Chromatin IP Primers for PNISR

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PNISR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.3 Ensembl cytogenetic band: 6q16.2 HGNC cytogenetic band: 6q16.3

PNISR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNISR gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M099846: view genomic region (about GC identifiers)

Start:	99,845,927 bp from pter	End:	99,873,207 bp from pter
Size:	27,281 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PNISR_HUMAN, Q8TF01 (See protein sequence)

Recommended Name: Arginine/serine-rich protein PNISR

Size: 805 amino acids; 92577 Da

Subunit: Interacts with PNN

Sequence caution: Sequence=AAH07791.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence; Sequence=AAH19074.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence; Sequence=AAH52638.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence; Sequence=AAH64413.1; Type=Frameshift; Positions=267; Sequence=AAH64640.1; Type=Miscellaneous

discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Secondary accessions: A8K540 E1P5D2 Q5T064 Q5T065 Q6P2B4 Q6P2N4 Q6PJ93 Q6PK36 Q7Z640 Q8N2L1

Q8TF00 Q96K10 Q96SI3 Q96SM5 Q9P076 Q9P0C0 Q9Y4N3

Alternative splicing: 2 isoforms: Q8TF01-1 Q8TF01-2

Explore the universe of human proteins at neXtProt for PNISR: NX_Q8TF01

Explore proteomics data for PNISR at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See PNISR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_056306.1 NP_116259.2

ENSEMBL proteins:

ENSP00000358242 ENSP00000435246 ENSP00000387997

PNISR Human Recombinant Protein Products:

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PNISR Assay Products:

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	GenScript Custom Assay Services for PNISR
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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8TF01

UniProtKB/Swiss-Prot: PNISR_HUMAN, Q8TF01

Similarity: Belongs to the splicing factor SR family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0044822	poly(A) RNA binding	IDA	--

PNISR for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PNISR:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PNISR

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PNISR

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PNISR

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PNISR

miRNA Products:		miRTarBase miRNAs that target PNISR: hsa-mir-7-5p (MIRT047755), hsa-mir-424-5p (MIRT042438), hsa-mir-378a-3p (MIRT043914)

		Block miRNA regulation of human, mouse, rat PNISR using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate PNISR (see all 40):
		hsa-miR-323-3p hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-29b-1* hsa-miR-548l hsa-miR-1276 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: PNISR 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PNISR
		Predesigned siRNA for gene silencing in human, mouse, rat PNISR

Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PNISR
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNISR

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

PNISR_HUMAN, Q8TF01: Nucleus speckle

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0016607	nuclear speck	IEA	--

PNISR for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PNISR
Interactions:

Search GeneGlobe Interaction Network for PNISR

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

Selected Interacting proteins for PNISR (Q8TF01³ ENSP00000358242⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PNN	Q9H307³, ENSP00000216832⁴	I2D: score=4 STRING: ENSP00000216832
APC	P25054³, ENSP00000257430⁴	I2D: score=3 STRING: ENSP00000257430
USO1	ENSP00000411698⁴	STRING: ENSP00000411698
CIR1	ENSP00000339723⁴	STRING: ENSP00000339723
PRPF38B	ENSP00000359042⁴	STRING: ENSP00000359042

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for PNISR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for PNISR gene (2 alternative transcripts):

NM_015491.1 NM_032870.2

Unigene Clusters for PNISR:

PNN-interacting serine/arginine-rich protein

Hs.520287 [show with all ESTs], Hs.644863 [show with all ESTs]

Unigene Representative Sequences: NM_032870, AL080186

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369239(uc003ppo.4 uc011eag.2) ENST00000481229(uc021zdc.1)

ENST00000460600 ENST00000478777(uc003ppr.2) ENST00000476159 ENST00000463021

ENST00000492294 ENST00000498075(uc003ppt.2 uc003pps.2) ENST00000466057

ENST00000438806(uc003ppp.4)

miRNA Products:		Block miRNA regulation of human, mouse, rat PNISR using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate PNISR (see all 40):
		hsa-miR-323-3p hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-29b-1* hsa-miR-548l hsa-miR-1276 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: PNISR 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PNISR
		Predesigned siRNA for gene silencing in human, mouse, rat PNISR

Clone Products:		OriGene clones in human, mouse for PNISR (see all 11) OriGene ORF clones in mouse, rat for PNISR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for PNISR
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PNISR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PNISR

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for PNISR
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PNISR
		QuantiTect SYBR Green Assays in human, mouse, rat PNISR
		QuantiFast Probe-based Assays in human, mouse, rat PNISR

Additional mRNA sequence:

AL080186.1 BC029974.1 BC033061.1

Selected DOTS entries (see all 36):

DT.455111 DT.100826778 DT.100030918 DT.101984990 DT.99958449 DT.115812 DT.95077869 DT.121316150

DT.100826779 DT.121315834 DT.98131865 DT.91717319 DT.100826769 DT.315004 DT.100030923 DT.100826774

DT.115813 DT.121316112 DT.86851900 DT.121316145 DT.121316165 DT.121316076 DT.100826776 DT.95077851

Selected AceView cDNA sequences (see all 590):

BM970503 AI692741 AI659846 BM875325 BG697388 AI887318 AW244103 BQ478418

C01836 W88608 BF792442 BQ439976 AI620907 AA284389 CA942754 BM548909

CA313075 BM272071 AI631851 CD674790 AA196729 AV704529 AW518942 AI016207

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for PNISR (see all 17) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8a	·	8b	^	9a	·	9b	·	9c	^	10	^
SP1:																			-		-		-		-		-														-
SP2:											-								-		-		-		-		-														-
SP3:											-								-		-		-		-		-														-
SP4:
SP5:							-		-		-								-		-		-		-		-														-

ExUns:	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15
SP1:
SP2:
SP3:
SP4:					-
SP5:

ECgene alternative splicing isoforms for PNISR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PNISR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCATTCTCTT

About this image

PNISR expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 15) fully expand


Bone (Muscoskeletal System)
Bone Marrow

Brain (Nervous System)
Cerebral Cortex

Kidney (Urinary System)

Uterus (Reproductive System)

Lung (Respiratory System)

PNISR Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

PNISR Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.520287 Hs.644863

UniProtKB/Swiss-Prot: PNISR_HUMAN, Q8TF01

Tissue specificity: Expressed in heart, skeletal muscle, thymus, spleen, kidney, liver, placenta and leukocytes

Custom PCR Arrays for PNISR

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNISR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PNISR gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sfrs18^{1 , 5}	serine/arginine-rich splicing factor 18^{1, 5}	90.1(n)¹ 92.92(a)¹		4 (9.06 cM)⁵ 66625¹ NM_025669.1¹ NP_079945.1¹ 21847583⁵
chicken (Gallus gallus)	Aves	PNISR¹	PNN-interacting serine/arginine-rich protein	85.43(n) 87.66(a)		421796 NM_001031080.1 NP_001026251.1
lizard (Anolis carolinensis)	Reptilia	PNISR⁶	PNN-interacting serine/arginine-rich protein	77(a)	1 ↔ 1	1(171814889-171847107)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16792²	Xenopus laevis transcribed sequence with weak similarity more	80.19(n)		BU911171.1
zebrafish (Danio rerio)	Actinopterygii	wufb24d01²	Transcribed sequence with weak similarity to protein more	76.1(n)		CK239877.1
fruit fly (Drosophila melanogaster)	Insecta	CG31211⁶	--	21(a)	1 ↔ 1	3R(7775402-7779760)

ENSEMBL Gene Tree for PNISR (if available)
TreeFam Gene Tree for PNISR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PNISR gene

2 SIMAP similar genes for PNISR using alignment to 1 protein entry: PNISR_HUMAN:

C6orf111 SFRS18

PNISR for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62432266^1,2	C,F	--	99847378(+)	`AAAAAT/GTGTTT`	2	--	ds500¹		1		NA	2
rs141488892^1,2		--	99847409(+)	`AGTGGG/TTGACT`	2	--	ds500¹		0	--	--	--	--
rs114703059^1,2	C,F	--	99847444(+)	`TATTAC/ATGTCA`	2	--	ds500¹		1		WA	118
rs145247292^1,2		--	99847459(+)	`CAATCA/GTTCCT`	2	--	ds500¹		0	--	--	--	--
rs137981367^1,2		--	99847535(+)	`CACACA/GTTATA`	2	--	ds500¹		0	--	--	--	--
rs192769223^1,2		--	99847576(+)	`CAAAAC/TAGGAA`	2	--	ds500¹		0	--	--	--	--
rs12191620^1,2	C,F,H	--	99847586(+)	`AGAAAA/TGTTTA`	2	--	ds500¹ trp³		10		NA NS EA	686
rs149494663^1,2		--	99847593(+)	`TTTAGA/GAAGTT`	2	--	ds500¹		0	--	--	--	--
rs1128347^1,2	C,F,A,H	--	99848256(-)	`TTATTT/AAAAAT`	2	--	ut3¹		6		MN NS EA NA	708
rs144779398^1,2		--	99848298(+)	`ACTATA/GATTAT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PNISR (99845927 - 99873207 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for PNISR: About this table

Variant ID	Type	Subtype	PubMed ID
nsv527517	CNV	Loss	19592680
nsv823789	CNV	Loss	20364138
nsv886439	CNV	Loss	21882294
nsv886438	CNV	Gain	21882294
nsv886436	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PNISR

DNA2.0 Custom Variant and Variant Library Synthesis for PNISR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PNISR gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with PNISR)

Utopia: connect your pdf to the dynamic
world of online information

Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. (PubMed id 14578391)^{1, 2, 3, 9} Zimowska G.... Sugrue S.P. (Invest. Ophthalmol. Vis. Sci. 2003)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (Sci. Signal. 2010)
A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (Nat. Methods 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25957	HGNC: 21222	AceView: C6orf111	Ensembl:ENSG00000132424	euGenes: HUgn25957
ECgene: PNISR	H-InvDB: PNISR

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PNISR	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PNISR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PNISR gene:
Search GeneIP for patents involving PNISR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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PNISR Gene

PNN-Interacting Serine/Arginine-Rich Protein

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PNISR Gene

PNN-Interacting Serine/Arginine-Rich Protein

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