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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PNISR Gene

protein-coding   GIFtS: 44
GCID: GC06M099846

PNN-interacting serine/arginine-rich protein

(Previous names: chromosome 6 open reading frame 111, splicing factor, arginine/serine-rich...)
(Previous symbols: C6orf111, SFRS18)
 Explore 1 disease affiliated with
PNISR via our new
 Human Malady Compendium 
Biological research products
for PNISR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
PNN-Interacting Serine/Arginine-Rich Protein1 2 3     DKFZp564B07691
Splicing Factor, Arginine/Serine-Rich 181 2 3     FLJ147521
C6orf1111 2 3     Chromosome 6 Open Reading Frame 1111
SFRS181 2 3     HSPC3062
SRrp1301 2 3     RP11-98I9.22
BA98I9.21     Arginine/Serine-Rich Protein PNISR2
Serine/Arginine-Rich-Splicing Regulatory Protein 1302 3     Serine-Arginine-Rich-Splicing Regulatory Protein 1302
Splicing Factor, Arginine/Serine-Rich 1302 3     SR Rich Protein2
SR-Related Protein2 3     SRRP1303
SR-Rich Protein2 3     

External Ids:    HGNC: 212221   Entrez Gene: 259572   Ensembl: ENSG000001324247   UniProtKB: Q8TF013   

Export aliases for PNISR gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for PNISR (SFRS18)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PNISR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPNISR promoter sequence
   Search SABiosciences Chromatin IP Primers for PNISR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PNISR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.3   Ensembl cytogenetic band:  6q16.2   HGNC cytogenetic band: 6q16.3

PNISR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNISR gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M099846:  view genomic region     (about GC identifiers)

Start:
99,845,927 bp from pter      End:
99,873,207 bp from pter
Size:
27,281 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PNISR_HUMAN, Q8TF01 (See protein sequence)
Recommended Name: Arginine/serine-rich protein PNISR  
Size: 805 amino acids; 92577 Da
Subunit: Interacts with PNN
Subcellular location: Nucleus speckle
Sequence caution: Sequence=AAH07791.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=AAH19074.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAH52638.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAH64413.1; Type=Frameshift; Positions=267; Sequence=AAH64640.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: A8K540 E1P5D2 Q5T064 Q5T065 Q6P2B4 Q6P2N4 Q6PJ93 Q6PK36 Q7Z640 Q8N2L1 Q8TF00
Q96K10 Q96SI3 Q96SM5 Q9P076 Q9P0C0 Q9Y4N3
Alternative splicing: 2 isoforms:  Q8TF01-1   Q8TF01-2   

Explore the universe of human proteins at neXtProt for PNISR: NX_Q8TF01

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TF01

  • PNISR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_056306.1  NP_116259.2  

    ENSEMBL proteins: 
     ENSP00000358242   ENSP00000435246   ENSP00000387997  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016607nuclear speck IEA--


    PNISR for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8TF01

    UniProtKB/Swiss-Prot: PNISR_HUMAN, Q8TF01
    Similarity: Belongs to the splicing factor SR family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-323-3p hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-29b-1* hsa-miR-548l hsa-miR-1276 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidPNISR 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNISR

    1 GenomeRNAi human phenotype for PNISR:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNISR

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PNISR (Q8TF013 ENSP000003582424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNNQ9H3073, ENSP000002168324I2D: score=4 STRING: ENSP00000216832
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    RPS24ENSP000004143214STRING: ENSP00000414321
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PNISR
    Search CenterWatch for drugs/clinical trials and news about PNISR 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PNISR gene (2 alternative transcripts): 
    NM_015491.1  NM_032870.2  

    Unigene Clusters for PNISR:

    PNN-interacting serine/arginine-rich protein
    Hs.520287  [show with all ESTs], Hs.644863  [show with all ESTs]
    Unigene Representative Sequences: NM_032870, AL080186
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369239(uc003ppo.4 uc011eag.2) ENST00000481229(uc021zdc.1)
    ENST00000460600 ENST00000478777(uc003ppr.2) ENST00000476159 ENST00000463021
    ENST00000492294 ENST00000498075(uc003ppt.2 uc003pps.2) ENST00000466057
    ENST00000438806(uc003ppp.4)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PNISR
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate PNISR (see all 40):
    hsa-miR-323-3p hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-29b-1* hsa-miR-548l hsa-miR-1276 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidPNISR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PNISR
    OriGene shRNA RFP: PNISR
    Browse OriGene siRNA
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    Additional cDNA sequence: 

    AL080186.1 BC029974.1 BC033061.1 

    24/36 DOTS entries (see all 36):

    DT.455111  DT.100826778  DT.100030918  DT.101984990  DT.115812  DT.99958449  DT.95077869  DT.121316150 
    DT.100826779  DT.121315834  DT.98131865  DT.91717319  DT.100826769  DT.315004  DT.100030923  DT.100826774 
    DT.115813  DT.86851900  DT.121316112  DT.121316145  DT.121316076  DT.121316165  DT.100826776  DT.95077851 

    24/590 AceView cDNA sequences (see all 590):

    BQ478418 BU675213 BF515967 BM505201 BQ050521 AA143791 CA849166 CA313075 
    BQ439976 CA942754 AA334274 AA284389 AI620907 N29611 BC007791 AA765561 
    BM875325 AA935381 AA805172 AA772545 AW297252 AI540119 BE674584 BC052638 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for PNISR (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^
    SP1:                                                        -     -     -     -     -                                         -                                 
    SP2:                                -                       -     -     -     -     -                                         -                                 
    SP3:                                -                       -     -     -     -     -                                         -                                 
    SP4:                                                                                                                                                            
    SP5:                    -     -     -                       -     -     -     -     -                                         -                                 

    ExUns: 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:              -                           
    SP5:                                          


    ECgene alternative splicing isoforms for PNISR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PNISR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCATTCTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PNISR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PNISR

    SOURCE GeneReport for Unigene clusters: Hs.520287 Hs.644863

    UniProtKB/Swiss-Prot: PNISR_HUMAN, Q8TF01
    Tissue specificity: Expressed in heart, skeletal muscle, thymus, spleen, kidney, liver, placenta and leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PNISR gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PNISR1 PNN-interacting serine/arginine-rich protein 85.64(n)
    88.53(a)
      421796  NM_001031080.1  NP_001026251.1 
    lizard
    (Anolis carolinensis)
    Reptilia PNISR6
    --
    73(a)
    1 ↔ 1
    1(171831657-171846724)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167922 Xenopus laevis transcribed sequence with weak similarity more 80.19(n)    BU911171.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb24d012 Transcribed sequence with weak similarity to protein more 76.1(n)    CK239877.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG312111 CG31211 39.88(n)
    31.29(a)
      41443  NM_141874.2  NP_650131.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsy-11 Protein RSY-1 43.33(n)
    34.7(a)
      173015  NM_060477.3  NP_492878.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G706201 cyclin-related protein 39.88(n)
    28.94(a)
      843399  NM_105730.3  NP_177219.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g06617001 hypothetical protein 42.46(n)
    29.11(a)
      4337289  NM_001060685.1  NP_001054150.1 


    ENSEMBL Gene Tree for PNISR (if available)
    TreeFam Gene Tree for PNISR (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PNISR gene
    SREK12  LUC7L2  SRSF112  RSRC22  LUC7L32  ZC3H132  LUC7L22  RBM252  
    PRPF38B2  TRAF3IP12  
    2 SIMAP similar genes for PNISR using alignment to 1 protein entry:     PNISR_HUMAN:
    C6orf111    SFRS18

    PNISR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/457 NCBI SNPs in PNISR are shown (see all 457    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113311241,2
    C,--97295320(+) AAAGA-/TTTTTT 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs107086161,2
    C,--97301397(+) TTTAC-/AAAAAA 1 -- int1 trp32Minor allele frequency- A:0.00NA CSA 4
    rs624322661,2
    --99847378(+) AAAAAT/GTGTTT 2 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1414888921,2
    --99847409(+) AGTGGG/TTGACT 2 -- ds50010--------
    rs1147030591,2
    C,F,--99847444(+) TATTAC/ATGTCA 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1452472921,2
    --99847459(+) CAATCA/GTTCCT 2 -- ds50010--------
    rs1379813671,2
    --99847535(+) CACACA/GTTATA 2 -- ds50010--------
    rs1927692231,2
    --99847576(+) CAAAAC/TAGGAA 2 -- ds50010--------
    rs121916201,2
    C,F,H,--99847586(+) AGAAAA/TGTTTA 2 -- ds5001 trp310Minor allele frequency- T:0.07NA NS EA 686
    rs1494946631,2
    --99847593(+) TTTAGA/GAAGTT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for PNISR (99845927 - 99873207 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PNISR: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PNISR
    DNA2.0 Custom Variant and Variant Library Synthesis for PNISR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PNISR for disorders           About GeneDecksing

    1 disease for PNISR:    About MalaCards
    malaria


    Export disorders for PNISR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PNISR gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with PNISR)
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    1. Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. (PubMed id 14578391)1, 2, 3, 9 Zimowska G.... Sugrue S.P. (2003)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25957 HGNC: 21222 AceView: C6orf111 Ensembl:ENSG00000132424 euGenes: HUgn25957
    ECgene: PNISR H-InvDB: PNISR

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PNISR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PNISR gene:
    Search GeneIP for patents involving PNISR

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