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PNCK Gene

protein-coding   GIFtS: 52
GCID: GC0XM152935

Pregnancy Up-Regulated Nonubiquitous CaM Kinase

(Previous names: pregnancy upregulated non-ubiquitously expressed CaM kinase,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pregnancy Up-Regulated Nonubiquitous CaM Kinase1 2     BSTK32 5
Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase1 2     CaMK1b2
Pregnancy Upregulated Non-Ubiquitously Expressed CaM Kinase1 2     caMKI-beta2
CaM Kinase I Beta2 3     Calcium/Calmodulin-Dependent Protein Kinase Type 1B2
CaM Kinase IB2 3     CaMKI-beta3
CaM-KI Beta2 3     CAMK1B5
Pregnancy Up-Regulated Non-Ubiquitously-Expressed CaM Kinase2 3     EC 2.7.118
EC 2.7.11.173 8     

External Ids:    HGNC: 134151   Entrez Gene: 1397282   Ensembl: ENSG000001308227   OMIM: 3006805   UniProtKB: Q6P2M83   

Export aliases for PNCK gene to outside databases

Previous GC identifers: GC0XM151404 GC0XM152456 GC0XM152590 GC0XM141592


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PNCK Gene:
PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases
(see CAMK1; MIM 604998) (Gardner et al., 2000 (PubMed 10673339)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PNCK Gene:
PNCK (pregnancy up-regulated nonubiquitous CaM kinase) is a protein-coding gene. Diseases associated with PNCK include cerebritis, and breast cancer. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is CAMK1G.

UniProtKB/Swiss-Prot: KCC1B_HUMAN, Q6P2M8
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade.
In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PNCK gene promoter:
         STAT1   HSF2   STAT1beta   STAT1alpha   Egr-4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PNCK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PNCK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

PNCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PNCK gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM152935:  view genomic region     (about GC identifiers)

Start:
152,935,185 bp from pter      End:
152,954,465 bp from pter
Size:
19,281 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCC1B_HUMAN, Q6P2M8 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type 1B  
Size: 343 amino acids; 38500 Da
Secondary accessions: B4DJR8 B4E1A6 B7WPG0 D3DWU7 Q8N4R0
Alternative splicing: 5 isoforms:  Q6P2M8-1   Q6P2M8-2   Q6P2M8-3   Q6P2M8-5   Q6P2M8-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PNCK: NX_Q6P2M8

Explore proteomics data for PNCK at MOPED

Post-translational modifications: 

  • Phosphorylated by CAMKK1 (Probable)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PNCK (Q6P2M8) (see all 9)
     GGELFDR  ENEIAVL  YVAPELL  VTGGELF 


    See PNCK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034671.3  NP_001129212.1  

    ENSEMBL proteins: 
     ENSP00000340586   ENSP00000359169   ENSP00000390812   ENSP00000359161   ENSP00000359164  
     ENSP00000405950   ENSP00000415770   ENSP00000397085   ENSP00000391772   ENSP00000391264  
     ENSP00000400671   ENSP00000401542   ENSP00000411267   ENSP00000396128   ENSP00000407173  
     ENSP00000395360   ENSP00000377417  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: pregnancy up-regulated non-ubiquitously expressed CaM kinase
    CAMK1 family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q6P2M8

    ProtoNet protein and cluster: Q6P2M8

    UniProtKB/Swiss-Prot: KCC1B_HUMAN, Q6P2M8
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    PNCK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC1B_HUMAN, Q6P2M8
    Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade.
    In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005516calmodulin binding IEA--
         
    PNCK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PNCK:
     Decreased CYP1A1 activity afte 

         1 MGI phenotypic allele for Pnck (no phenotypes)

    PNCK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PNCK
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCC1B_HUMAN, Q6P2M8: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    PNCK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PNCK
    Interactions:

        Search GeneGlobe Interaction Network for PNCK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for PNCK (ENSP000004059504) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CETN3ENSP000002831224STRING: ENSP00000283122
    FHENSP000003555184STRING: ENSP00000355518
    EPS15ENSP000003607984STRING: ENSP00000360798
    EPS15L1ENSP000002480704STRING: ENSP00000248070
    FOXE1ENSP000003642654STRING: ENSP00000364265
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    PNCK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PNCK (KCC1B)

    1 HMDB Compound for PNCK    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PNCK gene (3 alternative transcripts): 
    NM_198452.1  NM_001039582.3  NM_001135740.1  

    Unigene Cluster for PNCK:

    Pregnancy up-regulated non-ubiquitously expressed CaM kinase
    Hs.436667  [show with all ESTs]
    Unigene Representative Sequence: NM_001039582
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000340888 ENST00000370150 ENST00000466074 ENST00000438984 ENST00000472324(uc010nuh.2)
    ENST00000370142 ENST00000370145(uc011myt.2) ENST00000447676 ENST00000488994(uc011myw.2)
    ENST00000473680 ENST00000439087 ENST00000433470 ENST00000422811 ENST00000466638(uc011myv.2)
    ENST00000489536 ENST00000411968 ENST00000488168 ENST00000475172
    miRNA
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    hsa-miR-661 hsa-miR-3116 hsa-miR-1286 hsa-miR-455-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PNCK
      QuantiTect SYBR Green Assays in human, mouse, rat PNCK
      QuantiFast Probe-based Assays in human, mouse, rat PNCK

    Additional mRNA sequence: 

    AK296203.1 AK303746.1 AK316402.1 

    16 DOTS entries:

    DT.97824487  DT.91910310  DT.121313465  DT.95091773  DT.100759913  DT.97826019  DT.97838045  DT.101954388 
    DT.102825841  DT.102864  DT.121313418  DT.95069334  DT.99950762  DT.121313471  DT.95119444  DT.121313422 

    Selected AceView cDNA sequences (see all 68):

    BM980401 CF890832 BI756289 NM_198452 CB152704 BC033746 CR611192 BQ639668 
    BC064422 AI813403 BI829739 BF447169 BI915442 BI545446 AI125938 BG701103 
    AI986390 BG702279 BE536669 BI915449 BI757461 BI668490 BG715227 BX361051 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PNCK (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^
    SP1:                                -     -     -     -     -     -                 -                                                                           
    SP2:                                      -     -     -     -     -                 -                                                                           
    SP3:                                                                                                                                                            
    SP4:                    -     -     -     -     -     -     -     -                                                                                             
    SP5:                                                  -     -     -                 -                                                                           

    ExUns: 15 ^ 16a · 16b ^ 17
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PNCK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PNCK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTCCAGC
    PNCK Expression
    About this image


    PNCK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    PNCK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PNCK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436667
        Custom PCR Arrays for PNCK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PNCK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PNCK gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pnck1 , 5 pregnancy upregulated non-ubiquitously expressed CaM kinase less1, 5 88.34(n)1
    95.34(a)1
      X (37.38 cM)5
    938431  NM_001199351.11  NP_001186280.11 
     736559945 
    lizard
    (Anolis carolinensis)
    Reptilia PNCK6
    pregnancy up-regulated nonubiquitous CaM kinase
    75(a)
    1 ↔ 1
    2(87014719-87044271)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB098710.12   -- 75.53(n)    AB098710.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pnck1 pregnancy up-regulated non-ubiquitously expressed CaM kinase less 63.42(n)
    64.15(a)
      567480  XM_690776.3  XP_695868.2 
    rice
    (Oryza sativa)
    Liliopsida Os.126782 Oryza sativa (japonica cultivar-group) cDNA cloneJ023054K20, full insert sequence less 76.41(n)    AK070346.1 


    ENSEMBL Gene Tree for PNCK (if available)
    TreeFam Gene Tree for PNCK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PNCK gene
    CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  PSKH12  
    CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    Selected SIMAP similar genes for PNCK using alignment to 9 protein entries:     KCC1B_HUMAN (see all proteins) (see all similar genes):
    CAMK1D    CAMK1    CAMK1G    MAP4K3    PSKH2    CAMK4
    PSKH1    SGK1    BRSK2    DCLK1    MGC45428    PRKAA1
    SGK2    CAMK2D    CAMK2G    CAMK2A    DKFZp781N0293    MAPK7

    PNCK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PNCK (see all 175)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878767541,2
    --152935001(+) GGCCAC/TGCTGC 2 -- int10--------
    rs1932053861,2
    --152935096(+) GTGGGC/TGAAGC 2 -- int10--------
    rs1161323711,2
    C--152935197(+) TGTATA/CTTTCT 2 -- ut310--------
    rs1496965321,2
    C--152935423(+) TGGGGA/TCAGAC 2 -- ut310--------
    rs1855876791,2
    --152935500(+) GCCAGA/CCCCAG 2 -- ut310--------
    rs128488401,2
    C,A--152935655(+) CCCCCT/CGCCTC 2 -- int15Minor allele frequency- C:0.12NA CSA 8
    rs59453391,2
    C,F,A,H--152935705(+) ACCCCA/CTTGCC 2 -- int119Minor allele frequency- C:0.31NS EA NA CSA 1988
    rs2015062391,2
    C--152935882(+) TGGGCA/GTGCAG 2 -- int10--------
    rs78904681,2
    C,F--152935938(+) AGCACG/AGAGGC 4 /R /C mis1 ese32Minor allele frequency- A:0.00NA 3696
    rs1497856031,2
    F--152935942(+) CGGAGG/ACCTGA 4 /G syn11Minor allele frequency- A:0.00NA 3646

    HapMap Linkage Disequilibrium report for PNCK (152935185 - 152954465 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PNCK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33199CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PNCK
    DNA2.0 Custom Variant and Variant Library Synthesis for PNCK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300680    OMIM disorders: --

    2 diseases for PNCK:    
    About MalaCards
    cerebritis    breast cancer


    PNCK for disorders           About GeneDecksing


    Export disorders for PNCK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PNCK gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with PNCK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer. (PubMed id 11034105)1, 9 Gardner H.P....Chodosh L.A. (Cancer Res. 2000)
    4. Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma. (PubMed id 23634203)1 Wu S....Wang R. (PLoS ONE 2013)
    5. Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex. (PubMed id 21325639)1 Deb T.B....Johnson M.D. (Am. J. Physiol., Cell Physiol. 2011)
    6. Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation. (PubMed id 18562482)1 Deb T.B....Johnson M.D. (Am. J. Physiol., Cell Physiol. 2008)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 139728 HGNC: 13415 AceView: PNCK Ensembl:ENSG00000130822 euGenes: HUgn139728
    ECgene: PNCK H-InvDB: PNCK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PNCK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PNCK gene:
    Search GeneIP for patents involving PNCK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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