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Aliases for PNCK Gene

Aliases for PNCK Gene

  • Pregnancy Up-Regulated Nonubiquitous CaM Kinase 2 3
  • Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase 2 3
  • Pregnancy Up-Regulated Non-Ubiquitously-Expressed CaM Kinase 3 4
  • Pregnancy Upregulated Non-Ubiquitously Expressed CaM Kinase 2 3
  • CaM Kinase I Beta 3 4
  • CaM Kinase IB 3 4
  • EC 2.7.11.17 4 63
  • CaM-KI Beta 3 4
  • CaMKI-Beta 3 4
  • EC 2.7.11 63
  • CaMK1b 3
  • BSTK3 3

External Ids for PNCK Gene

Previous GeneCards Identifiers for PNCK Gene

  • GC0XM151404
  • GC0XM152456
  • GC0XM152590
  • GC0XM152935
  • GC0XM141592

Summaries for PNCK Gene

Entrez Gene Summary for PNCK Gene

  • PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PNCK Gene

PNCK (Pregnancy Up-Regulated Nonubiquitous CaM Kinase) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for PNCK Gene

  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNCK Gene

Genomics for PNCK Gene

Regulatory Elements for PNCK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PNCK Gene

Chromosome:
X
Start:
153,669,730 bp from pter
End:
153,689,010 bp from pter
Size:
19,281 bases
Orientation:
Minus strand

Genomic View for PNCK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNCK Gene

Proteins for PNCK Gene

  • Protein details for PNCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2M8-KCC1B_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type 1B
    Protein Accession:
    Q6P2M8
    Secondary Accessions:
    • B4DJR8
    • B4E1A6
    • B7WPG0
    • D3DWU7
    • Q8N4R0

    Protein attributes for PNCK Gene

    Size:
    343 amino acids
    Molecular mass:
    38500 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PNCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNCK Gene

Proteomics data for PNCK Gene at MOPED

Selected DME Specific Peptides for PNCK Gene

Post-translational modifications for PNCK Gene

Antibody Products

Domains & Families for PNCK Gene

Suggested Antigen Peptide Sequences for PNCK Gene

Graphical View of Domain Structure for InterPro Entry

Q6P2M8

UniProtKB/Swiss-Prot:

KCC1B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with PNCK: view

Function for PNCK Gene

Molecular function for PNCK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).

Enzyme Numbers (IUBMB) for PNCK Gene

Gene Ontology (GO) - Molecular Function for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PNCK: view
genes like me logo Genes that share phenotypes with PNCK: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNCK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PNCK Gene

Localization for PNCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNCK Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNCK Gene COMPARTMENTS Subcellular localization image for PNCK gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PNCK: view

Pathways & Interactions for PNCK Gene

SuperPathways for PNCK Gene

No Data Available

Interacting Proteins for PNCK Gene

Gene Ontology (GO) - Biological Process for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PNCK: view

No data available for Pathways by source and SIGNOR curated interactions for PNCK Gene

Drugs & Compounds for PNCK Gene

(1) Drugs for PNCK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with PNCK: view

Transcripts for PNCK Gene

Unigene Clusters for PNCK Gene

Pregnancy up-regulated non-ubiquitously expressed CaM kinase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNCK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNCK Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - - -
SP6: -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PNCK Gene

GeneLoc Exon Structure for
PNCK
ECgene alternative splicing isoforms for
PNCK

Expression for PNCK Gene

mRNA expression in normal human tissues for PNCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNCK Gene

This gene is overexpressed in Colon - Sigmoid (x4.8) and Brain - Nucleus accumbens (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for PNCK Gene

This gene is overexpressed in Plasma (57.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNCK Gene



SOURCE GeneReport for Unigene cluster for PNCK Gene Hs.436667

genes like me logo Genes that share expression patterns with PNCK: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PNCK Gene

Orthologs for PNCK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PNCK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNCK 35
  • 88.3 (n)
  • 92.69 (a)
PNCK 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNCK 35
  • 90.97 (n)
  • 94.58 (a)
PNCK 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnck 35
  • 88.34 (n)
  • 95.34 (a)
Pnck 16
Pnck 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PNCK 35
  • 99.59 (n)
  • 99.17 (a)
PNCK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnck 35
  • 89.21 (n)
  • 95.34 (a)
oppossum
(Monodelphis domestica)
Mammalia PNCK 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNCK 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PNCK 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pnck 35
  • 72.21 (n)
  • 78.77 (a)
zebrafish
(Danio rerio)
Actinopterygii pnck 35
  • 63.42 (n)
  • 64.15 (a)
pnck 36
  • 65 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7117 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEK1 38
barley
(Hordeum vulgare)
Liliopsida Hv.12128 35
rice
(Oryza sativa)
Liliopsida Os.12678 35
Os03g0789000 35
  • 52.05 (n)
  • 42.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02283 35
  • 54.6 (n)
  • 45.51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cmk1 35
  • 47.23 (n)
  • 47.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for PNCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNCK Gene

ENSEMBL:
Gene Tree for PNCK (if available)
TreeFam:
Gene Tree for PNCK (if available)

Paralogs for PNCK Gene

genes like me logo Genes that share paralogs with PNCK: view

Variants for PNCK Gene

Sequence variations from dbSNP and Humsavar for PNCK Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2314065 -- 153,684,114(+) TAAAC(G/T)AAATT intron-variant
rs5945339 -- 153,670,250(+) ACCCC(A/C)TTGCC intron-variant
rs5986919 -- 153,679,280(+) TACCT(C/T)GTCAC intron-variant
rs5986921 -- 153,685,429(+) GCCGG(A/G)AACTC intron-variant
rs5987128 -- 153,674,273(+) CCTCA(C/T)CCTCG utr-variant-5-prime, upstream-variant-2KB, intron-variant, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for PNCK Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407

Variation tolerance for PNCK Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNCK Gene

HapMap Linkage Disequilibrium report
PNCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNCK Gene

Disorders for PNCK Gene

Relevant External Links for PNCK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNCK
genes like me logo Genes that share disorders with PNCK: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNCK Gene

Publications for PNCK Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Developmental regulation of two isoforms of Ca(2+)/calmodulin-dependent protein kinase I beta in rat brain. (PMID: 10865068) LA … Gautvik K.M. (Brain Res. 2000) 23 67
  3. The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer. (PMID: 11034105) Gardner H.P. … Chodosh L.A. (Cancer Res. 2000) 23 67
  4. The multifunctional Ca2+/calmodulin-dependent protein kinases. (PMID: 8507497) Schulman H. (Curr. Opin. Cell Biol. 1993) 23 67
  5. Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma. (PMID: 23634203) Wu S. … Wang R. (PLoS ONE 2013) 67

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