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Aliases for PNCK Gene

Aliases for PNCK Gene

  • Pregnancy Up-Regulated Nonubiquitous CaM Kinase 2 3 5
  • Pregnancy Up-Regulated Non-Ubiquitously-Expressed CaM Kinase 3 4
  • Pregnancy Upregulated Non-Ubiquitously Expressed CaM Kinase 2 3
  • CaM Kinase I Beta 3 4
  • CaM Kinase IB 3 4
  • EC 2.7.11.17 4 58
  • CaM-KI Beta 3 4
  • CaMKI-Beta 3 4
  • Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase 2
  • Calcium/Calmodulin-Dependent Protein Kinase Type 1B 3
  • EC 2.7.11 58
  • CaMK1b 3
  • BSTK3 3

External Ids for PNCK Gene

Previous GeneCards Identifiers for PNCK Gene

  • GC0XM151404
  • GC0XM152456
  • GC0XM152590
  • GC0XM152935
  • GC0XM141592

Summaries for PNCK Gene

Entrez Gene Summary for PNCK Gene

  • PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PNCK Gene

PNCK (Pregnancy Up-Regulated Nonubiquitous CaM Kinase) is a Protein Coding gene. Diseases associated with PNCK include Jervell And Lange-Nielsen Syndrome and Tetanus Neonatorum. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Development ERBB-family signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK1D.

UniProtKB/Swiss-Prot for PNCK Gene

  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).

Additional gene information for PNCK Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNCK Gene

Genomics for PNCK Gene

Regulatory Elements for PNCK Gene

Enhancers for PNCK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH153721 1.1 ENCODE 32.9 -36.6 -36584 7 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 SP3 SP5 ZHX2 MXD4 REST PNCK SLC6A8 KRT18P48 PDZD4 ABCD1 PLXNB3
GH0XH153683 1.2 Ensembl ENCODE 28.7 +3.0 3002 4 HDGF TBP ATF1 NFRKB NFXL1 ZNF2 GLIS2 CBX5 ZNF366 ATF7 PNCK ABCD1 SLC6A8 PDZD4 RN7SL687P
GH0XH153741 1 Ensembl ENCODE 28.9 -54.5 -54458 3 HDAC1 CTCF PKNOX1 KLF1 ATF1 RB1 E2F1 ZFHX2 MTA3 POLR2A PNCK LOC102723591 ABCD1 PLXNB3
GH0XH153730 1.3 FANTOM5 Ensembl ENCODE 19.7 -42.7 -42650 2 SOX13 SAP130 CEBPG BATF ZSCAN29 FOS GATAD2A SOX5 HLF JUNB PNCK PLXNB3 LOC102723591 SLC6A8 ABCD1 MECP2 TMEM187 IKBKG ARHGAP4 IRAK1
GH0XH153688 0.8 ENCODE 30.7 -0.3 -338 1 CTCF HDGF MXI1 KLF1 TAL1 ZSCAN4 HIC1 TCF12 GLIS2 MTA3 PNCK LOC102723591 BCAP31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PNCK on UCSC Golden Path with GeneCards custom track

Promoters for PNCK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249586 510 2201 HDGF TBP ZSCAN4 KLF17 NFXL1 ZNF2 GLIS2 ZNF366 SCRT2 SMARCA5

Genomic Location for PNCK Gene

Chromosome:
X
Start:
153,669,730 bp from pter
End:
153,689,010 bp from pter
Size:
19,281 bases
Orientation:
Minus strand

Genomic View for PNCK Gene

Genes around PNCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNCK Gene

Proteins for PNCK Gene

  • Protein details for PNCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2M8-KCC1B_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type 1B
    Protein Accession:
    Q6P2M8
    Secondary Accessions:
    • B4DJR8
    • B4E1A6
    • B7WPG0
    • D3DWU7
    • Q8N4R0

    Protein attributes for PNCK Gene

    Size:
    343 amino acids
    Molecular mass:
    38500 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PNCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNCK Gene

Selected DME Specific Peptides for PNCK Gene

Q6P2M8:
  • KCIPKKAL
  • YVAPELL
  • VTGGELF
  • GGELFDR
  • ENEIAVL
  • LKPENLL
  • RDLKPEN
  • VHRDLKP
  • IVHRDLK

Post-translational modifications for PNCK Gene

Domains & Families for PNCK Gene

Gene Families for PNCK Gene

Suggested Antigen Peptide Sequences for PNCK Gene

Graphical View of Domain Structure for InterPro Entry

Q6P2M8

UniProtKB/Swiss-Prot:

KCC1B_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with PNCK: view

Function for PNCK Gene

Molecular function for PNCK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).

Enzyme Numbers (IUBMB) for PNCK Gene

Phenotypes From GWAS Catalog for PNCK Gene

Gene Ontology (GO) - Molecular Function for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004683 calmodulin-dependent protein kinase activity IBA,IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PNCK: view
genes like me logo Genes that share phenotypes with PNCK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PNCK

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PNCK
  • Applied Biological Materials Clones for PNCK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PNCK Gene

Localization for PNCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNCK Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNCK gene
Compartment Confidence
cytosol 4
plasma membrane 3
nucleus 3
mitochondrion 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PNCK: view

Pathways & Interactions for PNCK Gene

genes like me logo Genes that share pathways with PNCK: view

Pathways by source for PNCK Gene

2 Sino Biological pathways for PNCK Gene

Gene Ontology (GO) - Biological Process for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with PNCK: view

No data available for SIGNOR curated interactions for PNCK Gene

Drugs & Compounds for PNCK Gene

(1) Drugs for PNCK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PNCK: view

Transcripts for PNCK Gene

Unigene Clusters for PNCK Gene

Pregnancy up-regulated non-ubiquitously expressed CaM kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PNCK
  • Applied Biological Materials Clones for PNCK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PNCK Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - - -
SP6: -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PNCK Gene

GeneLoc Exon Structure for
PNCK
ECgene alternative splicing isoforms for
PNCK

Expression for PNCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNCK Gene

This gene is overexpressed in Colon - Sigmoid (x4.8) and Brain - Nucleus accumbens (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for PNCK Gene

This gene is overexpressed in Plasma (57.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNCK Gene



NURSA nuclear receptor signaling pathways regulating expression of PNCK Gene:

PNCK

SOURCE GeneReport for Unigene cluster for PNCK Gene:

Hs.436667

Evidence on tissue expression from TISSUES for PNCK Gene

  • Nervous system(4.8)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with PNCK: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNCK Gene

Orthologs for PNCK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PNCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNCK 34 33
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PNCK 34 33
  • 90.97 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnck 33
  • 89.21 (n)
mouse
(Mus musculus)
Mammalia Pnck 16 34 33
  • 88.34 (n)
cow
(Bos Taurus)
Mammalia PNCK 34 33
  • 88.3 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNCK 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNCK 34
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PNCK 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pnck 33
  • 72.21 (n)
zebrafish
(Danio rerio)
Actinopterygii pnck 33 34
  • 63.42 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7117 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEK1 36
rice
(Oryza sativa)
Liliopsida Os03g0789000 33
  • 52.05 (n)
Os.12678 33
barley
(Hordeum vulgare)
Liliopsida Hv.12128 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02283 33
  • 54.6 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cmk1 33
  • 47.23 (n)
Species where no ortholog for PNCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNCK Gene

ENSEMBL:
Gene Tree for PNCK (if available)
TreeFam:
Gene Tree for PNCK (if available)

Paralogs for PNCK Gene

genes like me logo Genes that share paralogs with PNCK: view

Variants for PNCK Gene

Sequence variations from dbSNP and Humsavar for PNCK Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs122453115 Pathogenic 153,688,833(+) ACGGC(A/G)GAGGT upstream-variant-2KB, reference, missense
rs782373793 Likely benign 153,688,661(+) GACGG(A/G)GCCCC upstream-variant-2KB, reference, synonymous-codon
rs878853039 Uncertain significance 153,688,842(+) GTGAG(C/T)TCCCC intron-variant, upstream-variant-2KB
rs384573 Benign 153,688,570(+) CGCCG(A/G)GGCCA upstream-variant-2KB, utr-variant-5-prime
rs1000329399 -- 153,670,074(+) GGGAC(C/T)GAAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PNCK Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
nsv1144323 CNV deletion 24896259

Variation tolerance for PNCK Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNCK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNCK Gene

Disorders for PNCK Gene

MalaCards: The human disease database

(2) MalaCards diseases for PNCK Gene - From: DISEASES

Disorder Aliases PubMed IDs
jervell and lange-nielsen syndrome
  • jervell-lange nielsen syndrome
tetanus neonatorum
  • neonatal tetanus
- elite association - COSMIC cancer census association via MalaCards
Search PNCK in MalaCards View complete list of genes associated with diseases

Relevant External Links for PNCK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNCK
genes like me logo Genes that share disorders with PNCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNCK Gene

Publications for PNCK Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer. (PMID: 11034105) Gardner HP … Chodosh LA (Cancer research 2000) 3 22 60
  4. Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process. (PMID: 25773930) Deb TB … Johnson MD (Breast cancer research and treatment 2015) 3 60
  5. Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma. (PMID: 23634203) Wu S … Wang R (PloS one 2013) 3 60

Products for PNCK Gene

  • Addgene plasmids for PNCK

Sources for PNCK Gene

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