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Aliases for PNCK Gene

Aliases for PNCK Gene

  • Pregnancy Up-Regulated Nonubiquitous CaM Kinase 2 3
  • Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase 2 3
  • Pregnancy Up-Regulated Non-Ubiquitously-Expressed CaM Kinase 3 4
  • Pregnancy Upregulated Non-Ubiquitously Expressed CaM Kinase 2 3
  • CaM Kinase I Beta 3 4
  • CaM Kinase IB 3 4
  • EC 2.7.11.17 4 64
  • CaM-KI Beta 3 4
  • CaMKI-Beta 3 4
  • CaMK1b 3 6
  • BSTK3 3 6
  • Calcium/Calmodulin-Dependent Protein Kinase Type 1B 3
  • EC 2.7.11 64

External Ids for PNCK Gene

Summaries for PNCK Gene

Entrez Gene Summary for PNCK Gene

  • PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PNCK Gene

PNCK (Pregnancy Up-Regulated Nonubiquitous CaM Kinase) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for PNCK Gene

  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNCK Gene

Genomics for PNCK Gene

Genomic Location for PNCK Gene

Start:
153,669,730 bp from pter
End:
153,689,010 bp from pter
Size:
19,281 bases
Orientation:
Minus strand

Genomic View for PNCK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNCK Gene

Regulatory Elements for PNCK Gene

Proteins for PNCK Gene

  • Protein details for PNCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2M8-KCC1B_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type 1B
    Protein Accession:
    Q6P2M8
    Secondary Accessions:
    • B4DJR8
    • B4E1A6
    • B7WPG0
    • D3DWU7
    • Q8N4R0

    Protein attributes for PNCK Gene

    Size:
    343 amino acids
    Molecular mass:
    38500 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PNCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNCK Gene

Proteomics data for PNCK Gene at MOPED

Selected DME Specific Peptides for PNCK Gene

Post-translational modifications for PNCK Gene

Domains for PNCK Gene

UniProtKB/Swiss-Prot:

KCC1B_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q6P2M8
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.:
    • Q6P2M8
genes like me logo Genes that share domains with PNCK: view

Function for PNCK Gene

Molecular function for PNCK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by Ca(2+)/calmodulin.
UniProtKB/Swiss-Prot Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).

Enzyme Numbers (IUBMB) for PNCK Gene

Gene Ontology (GO) - Molecular Function for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with PNCK: view

Phenotypes for PNCK Gene

GenomeRNAi human phenotypes for PNCK:
genes like me logo Genes that share phenotypes with PNCK: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PNCK Gene

Localization for PNCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNCK Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNCK Gene COMPARTMENTS Subcellular localization image for PNCK gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PNCK: view

Pathways for PNCK Gene

SuperPathways for PNCK Gene

No Data Available

Interacting Proteins for PNCK Gene

Gene Ontology (GO) - Biological Process for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PNCK: view

No data available for Pathways by source for PNCK Gene

Compounds for PNCK Gene

(1) HMDB Compounds for PNCK Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PNCK: view

Transcripts for PNCK Gene

Unigene Clusters for PNCK Gene

Pregnancy up-regulated non-ubiquitously expressed CaM kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNCK Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - - -
SP6: -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PNCK Gene

GeneLoc Exon Structure for
PNCK
ECgene alternative splicing isoforms for
PNCK

Expression for PNCK Gene

mRNA expression in normal human tissues for PNCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNCK Gene

This gene is overexpressed in Colon - Sigmoid (4.8) and Brain - Nucleus accumbens (basal ganglia) (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PNCK Gene

SOURCE GeneReport for Unigene cluster for PNCK Gene Hs.436667

genes like me logo Genes that share expressions with PNCK: view

Orthologs for PNCK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PNCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNCK 36
  • 99.59 (n)
  • 99.17 (a)
PNCK 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PNCK 36
  • 88.3 (n)
  • 92.69 (a)
PNCK 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNCK 36
  • 90.97 (n)
  • 94.58 (a)
PNCK 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnck 36
  • 88.34 (n)
  • 95.34 (a)
Pnck 16
Pnck 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNCK 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNCK 37
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnck 36
  • 89.21 (n)
  • 95.34 (a)
lizard
(Anolis carolinensis)
Reptilia PNCK 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pnck 36
  • 72.21 (n)
  • 78.77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7117 36
zebrafish
(Danio rerio)
Actinopterygii pnck 36
  • 63.42 (n)
  • 64.15 (a)
pnck 37
  • 65 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEK1 39
barley
(Hordeum vulgare)
Liliopsida Hv.12128 36
rice
(Oryza sativa)
Liliopsida Os.12678 36
Os03g0789000 36
  • 52.05 (n)
  • 42.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02283 36
  • 54.6 (n)
  • 45.51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cmk1 36
  • 47.23 (n)
  • 47.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 56 (a)
OneToMany
Species with no ortholog for PNCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNCK Gene

ENSEMBL:
Gene Tree for PNCK (if available)
TreeFam:
Gene Tree for PNCK (if available)

Paralogs for PNCK Gene

genes like me logo Genes that share paralogs with PNCK: view

Variants for PNCK Gene

Sequence variations from dbSNP and Humsavar for PNCK Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2314065 -- 153,684,114(+) TAAAC(G/T)AAATT intron-variant
rs4275390 -- 153,675,039(+) ACTCA(A/G)AAACT upstream-variant-2KB, intron-variant
rs5945339 -- 153,670,250(+) ACCCC(A/C)TTGCC intron-variant
rs5986919 -- 153,679,280(+) TACCT(C/T)GTCAC intron-variant
rs5986921 -- 153,685,429(+) GCCGG(A/G)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNCK Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407

Relevant External Links for PNCK Gene

HapMap Linkage Disequilibrium report
PNCK

Disorders for PNCK Gene

No disorders were found for PNCK Gene.

No data available for UniProtKB/Swiss-Prot for PNCK Gene

Publications for PNCK Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer. (PMID: 11034105) Gardner H.P. … Chodosh L.A. (Cancer Res. 2000) 3 23
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase. (PMID: 10673339) Gardner H.P. … Chodosh L.A. (Genomics 2000) 3

Products for PNCK Gene

  • Addgene plasmids for PNCK

Sources for PNCK Gene

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