Aliases for PMVK Gene
External Ids for PMVK Gene
Previous GeneCards Identifiers for PMVK Gene
This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]
GeneCards Summary for PMVK Gene
PMVK (Phosphomevalonate Kinase) is a Protein Coding gene. Diseases associated with PMVK include Porokeratosis Of Mibelli and Porokeratosis. Among its related pathways are Terpenoid backbone biosynthesis and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include phosphomevalonate kinase activity.