Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PMPCB Gene

protein-coding   GIFtS: 61
GCID: GC07P102937

Peptidase (Mitochondrial Processing) Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidase (Mitochondrial Processing) Beta1 2     MPP112
MPPB2 3 5     MPPP522
Beta-MPP2 3     Mitochondrial Processing Peptidase Beta Subunit2
P-522 3     Mitochondrial-Processing Peptidase Subunit Beta2
EC 3.4.24.643 8     

External Ids:    HGNC: 91191   Entrez Gene: 95122   Ensembl: ENSG000001058197   OMIM: 6031315   UniProtKB: O754393   

Export aliases for PMPCB gene to outside databases

Previous GC identifers: GC07P101421 GC07P102484 GC07P102498 GC07P102532 GC07P102725 GC07P097300


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PMPCB Gene:
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is
located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly
imported into the mitochondria, though it only functions as part of a heterodimeric complex. (provided by RefSeq,
Jul 2008)

GeneCards Summary for PMPCB Gene: 
PMPCB (peptidase (mitochondrial processing) beta) is a protein-coding gene. Diseases associated with PMPCB include filariasis, and acute lymphoblastic leukemia, and among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include metalloendopeptidase activity and zinc ion binding. An important paralog of this gene is UQCRC1.

UniProtKB/Swiss-Prot: MPPB_HUMAN, O75439
Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity)

Gene Wiki entry for PMPCB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PMPCB gene promoter:
         p53   AML1a   GCNF   Tal-1beta   POU2F1   POU2F1a   GCNF-1   c-Myb   ITF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PMPCB promoter sequence
   Search SABiosciences Chromatin IP Primers for PMPCB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PMPCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

PMPCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMPCB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102937:  view genomic region     (about GC identifiers)

Start:
102,937,869 bp from pter      End:
102,969,958 bp from pter
Size:
32,090 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 102,298,239-102,315,499     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MPPB_HUMAN, O75439 (See protein sequence)
Recommended Name: Mitochondrial-processing peptidase subunit beta precursor  
Size: 489 amino acids; 54366 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Heterodimer of alpha and beta subunits (By similarity)
Subcellular location: Mitochondrion matrix (By similarity)
Secondary accessions: O60416 Q96FV4

Explore the universe of human proteins at neXtProt for PMPCB: NX_O75439

Explore proteomics data for PMPCB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75439

  • 4/12 DME Specific Peptides for PMPCB (O75439) (see all 12)
     WIDAGSR  LGRTILGP  ILADIIQNS  QVVLNVPET 

    PMPCB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PMPCB Protein Expression
    REFSEQ proteins: NP_004270.2  
    ENSEMBL proteins: 
     ENSP00000249269   ENSP00000390035   ENSP00000397884   ENSP00000402859   ENSP00000388934  
     ENSP00000408682   ENSP00000410393  
    Reactome Protein details: O75439
    Human Recombinant Protein Products for PMPCB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PMPCB
    OriGene Protein Over-expression Lysate for PMPCB
    OriGene MassSpec for PMPCB 
    OriGene Custom Protein Services for PMPCB
    GenScript Custom Purified and Recombinant Proteins Services for PMPCB
    Novus Biologicals PMPCB Proteins
    Novus Biologicals PMPCB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix IEA--

    PMPCB for ontologies           About GeneDecksing



    PMPCB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PMPCB
    GenScript Custom Superior Antibodies Services for PMPCB
    Novus Biologicals PMPCB Antibodies
    Abcam antibodies for PMPCB
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for PMPCB
    LSBio Antibodies in human, mouse, rat for PMPCB 

    Assay Products for PMPCB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PMPCB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PMPCB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001431 Pept_M16_Zn_BS
     IPR011765 Pept_M16_N
     IPR011237 Pept_M16_dom
     IPR007863 Peptidase_M16_C
     IPR011249 Metalloenz_LuxS/M16

    Graphical View of Domain Structure for InterPro Entry O75439

    ProtoNet protein and cluster: O75439

    1 Blocks protein domain: IPB001431 Insulinase-like peptidase

    UniProtKB/Swiss-Prot: MPPB_HUMAN, O75439
    Similarity: Belongs to the peptidase M16 family


    PMPCB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPPB_HUMAN, O75439
    Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity)
    Catalytic activity: Release of N-terminal transit peptides from precursor proteins imported into the
    mitochondrion, typically with Arg in position P2

         Genatlas biochemistry entry for PMPCB:
    peptidase (mitochondrial processing) beta,M phase phosphoprotein

         Enzyme Number (IUBMB): EC 3.4.24.641 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004222metalloendopeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    PMPCB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PMPCB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PMPCB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PMPCB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PMPCB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PMPCB
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PMPCB (see all 16):
    hsa-miR-429 hsa-miR-374a hsa-miR-548a-3p hsa-miR-629* hsa-miR-1183 hsa-miR-200b hsa-miR-384 hsa-miR-1298
    SwitchGear 3'UTR luciferase reporter plasmidPMPCB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PMPCB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PMPCB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PMPCB
    Sirion Biotech Customized adenovirus for overexpression of PMPCB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PMPCB (see all 7)
    OriGene ORF clones in mouse, rat for PMPCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PMPCB (NM_004279)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PMPCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMPCB
    Sirion Biotech Customized lentivirus for stable overexpression of PMPCB 
                         Customized lentivirus expression plasmids for stable overexpression of PMPCB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PMPCB
    Search LifeMap BioReagents cell lines for PMPCB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMPCB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PMPCB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for PMPCB
        Mitochondrial Protein Import
    Metabolism of proteins



    PMPCB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PMPCB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/314 Interacting proteins for PMPCB (O754392, 3 ENSP000002492694) via UniProtKB, MINT, STRING, and/or I2D (see all 314)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK3P274482, 3MINT-63617 I2D: score=5 
    PMPCAQ107132, 3, ENSP000003607824MINT-8079030 I2D: score=9 STRING: ENSP00000360782
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MRPL3P090012, 3, ENSP000002649954MINT-8079030 I2D: score=1 STRING: ENSP00000264995
    FXNQ165953, ENSP000003664824I2D: score=4 STRING: ENSP00000366482
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0044267cellular protein metabolic process TAS--

    PMPCB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PMPCB (MPPB)

    Search CenterWatch for drugs/clinical trials and news about PMPCB / MPPB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PMPCB gene: 
    NM_004279.2  

    Unigene Cluster for PMPCB:

    Peptidase (mitochondrial processing) beta
    Hs.184211  [show with all ESTs]
    Unigene Representative Sequence: NM_004279
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249269(uc003vbl.3) ENST00000428154(uc003vbk.1 uc011klm.1)
    ENST00000456433 ENST00000443722 ENST00000498530(uc010liu.1) ENST00000444457
    ENST00000453466 ENST00000469560 ENST00000420236(uc011kll.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PMPCB
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PMPCB (see all 16):
    hsa-miR-429 hsa-miR-374a hsa-miR-548a-3p hsa-miR-629* hsa-miR-1183 hsa-miR-200b hsa-miR-384 hsa-miR-1298
    SwitchGear 3'UTR luciferase reporter plasmidPMPCB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PMPCB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PMPCB
    Clone
    Products:
         
    OriGene clones in human, mouse for PMPCB (see all 7)
    OriGene ORF clones in mouse, rat for PMPCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PMPCB (NM_004279)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PMPCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMPCB
    Sirion Biotech Customized lentivirus for stable overexpression of PMPCB 
                         Customized lentivirus expression plasmids for stable overexpression of PMPCB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PMPCB
    OriGene qSTAR qPCR primer pairs in human, mouse for PMPCB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PMPCB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PMPCB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PMPCB

    Additional mRNA sequence: 

    AF054182.1 AF520796.1 AK000994.1 AK098616.1 AK289864.1 AK297354.1 AK309928.1 AL050216.1 
    BC014079.2 

    24/27 DOTS entries (see all 27):

    DT.456141  DT.101970896  DT.95367648  DT.40278493  DT.101986355  DT.85105588  DT.91641719  DT.316090 
    DT.405874  DT.75123444  DT.417083  DT.121065765  DT.97855617  DT.100838046  DT.100888013  DT.100888022 
    DT.102838904  DT.121065760  DT.95367654  DT.99932231  DT.100888012  DT.121065709  DT.121065718  DT.92454563 

    24/524 AceView cDNA sequences (see all 524):

    AI338838 CB130360 BM979970 BU072520 CB160027 BM453089 CR602907 CB113001 
    BF222585 BQ671195 CB114728 BM450626 AL559982 BQ049045 BQ931102 BM929907 
    CD107140 AW299807 BM742928 BM995830 BM562784 BM785525 BM763691 AV659416 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PMPCB (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                    -                                               -                       -     -                                 
    SP2:                    -                                               -                       -     -                                 
    SP3:                    -                                               -     -                                                         
    SP4:                    -                       -                                                                                       
    SP5:                    -                       -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for PMPCB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PMPCB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATACATT
    PMPCB Expression
    About this image


    See PMPCB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PMPCB

    SOURCE GeneReport for Unigene cluster: Hs.184211
        SABiosciences Custom PCR Arrays for PMPCB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PMPCB
    OriGene qSTAR qPCR primer pairs in human, mouse for PMPCB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PMPCB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PMPCB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PMPCB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMPCB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PMPCB gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pmpcb1 , 5 peptidase (mitochondrial processing) beta1, 5 85.48(n)1
    90.18(a)1
      5 (9.97 cM)5
    730781  NM_028431.21  NP_082707.11 
     217371415 
    chicken
    (Gallus gallus)
    Aves PMPCB1 peptidase (mitochondrial processing) beta 76.36(n)
    82.27(a)
      417718  NM_001199472.1  NP_001186401.1 
    lizard
    (Anolis carolinensis)
    Reptilia PMPCB6
    peptidase (mitochondrial processing) beta
    80(a)
    1 ↔ 1
    5(95364737-95380667)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA789443.12   -- 77.35(n)    CA789443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pmpcb1 peptidase (mitochondrial processing) beta 71.31(n)
    84.04(a)
      503532  NM_001012496.1  NP_001012514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37311 , 3 mitochondrial processing peptidase3
    CG37311
    70(a)3
    60.67(n)1
    71.01(a)1
      88D63
    418001  NM_142144.21  NP_650401.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC410.23
    mppb-11
    mitochondrial processing peptidase3
    Protein MPPB-11
    50(a)
    (best of 2)3
    55.84(n)1
    50.23(a)1
      IV(9074536-9076682)3
    1777251  NM_069175.51  NP_501576.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAS1(YLR163C)4
    MAS11
    Smaller subunit of the mitochondrial processing protease more4
    Mas1p1
    52.27(n)1
    45.91(a)1
      12(493254-491866)4
    8508601, 4  NP_013264.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPPBETA1 mitochondrial processing peptidase 55.53(n)
    52.17(a)
      821084  NM_111075.2  NP_186858.1 
    rice
    (Oryza sativa)
    Liliopsida Os.41242 Oryza sativa C3meo4 mRNA, complete cds 75.5(n)    NM_191703.1 


    ENSEMBL Gene Tree for PMPCB (if available)
    TreeFam Gene Tree for PMPCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PMPCB gene
    UQCRC12  
    3 SIMAP similar genes for PMPCB using alignment to 8 protein entries:     MPPB_HUMAN (see all proteins):
    DKFZp586I1223    UQCRC1    PMPCA

    PMPCB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/384 SNPs in PMPCB are shown (see all 384)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1181693771,2
    F--102936063(+) AAATTC/ATTGCT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1914280511,2
    --102936262(+) GAGGGA/CGATGA 1 -- us2k10--------
    rs1824574851,2
    --102936364(+) GGATTC/TTTCAT 1 -- us2k10--------
    rs1870855801,2
    --102936382(+) CTGCCC/GTAACA 1 -- us2k10--------
    rs37575071,2
    C,F,H--102936409(+) ATCCTA/GTAGGT 1 -- us2k119Minor allele frequency- G:0.08NA NS EA WA 2476
    rs1911443971,2
    C--102936463(+) AGGCAC/GGAAAG 1 -- us2k10--------
    rs37575081,2
    C,F,H--102936527(+) TTGGAT/GTTTTG 1 -- us2k124Minor allele frequency- G:0.18NS EA NA WA CSA 2351
    rs69719481,2
    H--102936623(+) tgataT/Ctgagt 1 -- us2k14Minor allele frequency- C:0.00NS EA 416
    rs1504631071,2
    C--102936786(+) AAACAC/TCAACT 1 -- us2k10--------
    rs176805231,2
    C,F,H--102936821(+) CAGCAC/TAGTCT 1 -- us2k120Minor allele frequency- T:0.06NA EA NS 2438

    HapMap Linkage Disequilibrium report for PMPCB (102937869 - 102969958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PMPCB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831084CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PMPCB
    DNA2.0 Custom Variant and Variant Library Synthesis for PMPCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603131    OMIM disorders: --

    5 diseases for PMPCB:    About MalaCards
    filariasis    acute lymphoblastic leukemia    lymphoblastic leukemia    tuberculosis
    leukemia


    PMPCB for disorders           About GeneDecksing

    Genetic Association Database (GAD): PMPCB
    Human Genome Epidemiology (HuGE) Navigator: PMPCB (1 document)

    Export disorders for PMPCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PMPCB gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with PMPCB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (1998)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Maturation of wild-type and mutated frataxin by the mitochondrial processing peptidase. (PubMed id 9700204)1, 9 Koutnikova H....Koenig M. (1998)
    5. Mitochondrial processing peptidase regulates PINK1 pro cessing, import and Parkin recruitment. (PubMed id 22354088)1 Greene A.W....Fon E.A. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9512 HGNC: 9119 AceView: PMPCB Ensembl:ENSG00000105819 euGenes: HUgn9512
    ECgene: PMPCB H-InvDB: PMPCB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PMPCB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PMPCB gene:
    Search GeneIP for patents involving PMPCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PMPCB  
     OriGene qPCR primer pairs and template standards for PMPCB   OriGene Protein Over-expression Lysate for PMPCB  
     OriGene MassSpec something-or-other for PMPCB   OriGene clones in human, mouse for PMPCB  
     OriGene qSTAR qPCR primer pairs in human, mouse for PMPCB   OriGene Purified Protein for PMPCB  
     OriGene ORF clones in mouse, rat for PMPCB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PMPCB   OriGene Custom Protein Services for PMPCB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PMPCB
     QIAGEN SeqTarget long-range PCR primers for resequencing PMPCB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PMPCB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PMPCB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PMPCB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PMPCB
     GenScript Custom Purified and Recombinant Proteins Services for PMPCB GenScript cDNA clones with any tag delivered in your preferred vector for PMPCB
     GenScript Custom Assay Services for PMPCB GenScript Custom Superior Antibodies Services for PMPCB
     GenScript Custom overexpressing Cell Line Services for PMPCB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PMPCB promoter
     Search Chromatin IP Primers for PMPCB
     RT2 qPCR Primer Assay in human, mouse, rat PMPCB
     GNC Network for PMPCB
     SABiosciences Custom PCR Arrays for PMPCB
     Search Tocris compounds for PMPCB (MPPB)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PMPCB antibodies
     PMPCB proteins
     PMPCB lysates
     Antibodies for PMPCB
     See all of Abcam's Antibodies, Kits and Proteins for PMPCB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PMPCB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMPCB
     SwitchGear 3'UTR luciferase reporter plasmids for PMPCB
     SwitchGear Promoter luciferase reporter plasmids for PMPCB
     ThermoFisher Antibody for PMPCB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMPCB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PMPCB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PMPCB
    Customized:
     lentivirus for stable overexpression of PMPCB
     lentivirus expression plasmids for stable overexpression of PMPCB
     adenovirus for overexpression of PMPCB
     LSBio Antibodies in human, mouse, rat for PMPCB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PMPCB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4