Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PMPCB Gene

protein-coding   GIFtS: 62
GCID: GC07P102937

Peptidase (Mitochondrial Processing) Beta

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Peptidase (Mitochondrial Processing) Beta1 2     MPP112
MPPB2 3 5     MPPP522
Beta-MPP2 3     Mitochondrial Processing Peptidase Beta Subunit2
P-522 3     Mitochondrial-Processing Peptidase Subunit Beta2
EC 3.4.24.643 8     

External Ids:    HGNC: 91191   Entrez Gene: 95122   Ensembl: ENSG000001058197   OMIM: 6031315   UniProtKB: O754393   

Export aliases for PMPCB gene to outside databases

Previous GC identifers: GC07P101421 GC07P102484 GC07P102498 GC07P102532 GC07P102725 GC07P097300


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PMPCB Gene:
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is
located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly
imported into the mitochondria, though it only functions as part of a heterodimeric complex. (provided by RefSeq,
Jul 2008)

GeneCards Summary for PMPCB Gene:
PMPCB (peptidase (mitochondrial processing) beta) is a protein-coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is UQCRC1.

UniProtKB/Swiss-Prot: MPPB_HUMAN, O75439
Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity)

Gene Wiki entry for PMPCB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PMPCB gene promoter:
         p53   AML1a   GCNF   Tal-1beta   POU2F1   POU2F1a   GCNF-1   c-Myb   ITF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PMPCB promoter sequence
   Search Chromatin IP Primers for PMPCB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PMPCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

PMPCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMPCB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102937:  view genomic region     (about GC identifiers)

Start:
102,937,869 bp from pter      End:
102,969,958 bp from pter
Size:
32,090 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 102,298,239-102,315,499     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MPPB_HUMAN, O75439 (See protein sequence)
Recommended Name: Mitochondrial-processing peptidase subunit beta precursor  
Size: 489 amino acids; 54366 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Heterodimer of alpha and beta subunits (By similarity)
Secondary accessions: O60416 Q96FV4

Explore the universe of human proteins at neXtProt for PMPCB: NX_O75439

Explore proteomics data for PMPCB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys95, Lys224, Lys235, Lys472
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PMPCB (O75439) (see all 12)
     WIDAGSR  LGRTILGP  ILADIIQNS  QVVLNVPET 


    See PMPCB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004270.2  
    ENSEMBL proteins: 
     ENSP00000249269   ENSP00000390035   ENSP00000397884   ENSP00000402859   ENSP00000388934  
     ENSP00000408682   ENSP00000410393  
    Reactome Protein details: O75439

    PMPCB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PMPCB
    OriGene Protein Over-expression Lysate for PMPCB
    OriGene MassSpec for PMPCB
    OriGene Custom Protein Services for PMPCB
    GenScript Custom Purified and Recombinant Proteins Services for PMPCB
    Novus Biologicals PMPCB Proteins
    Novus Biologicals PMPCB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PMPCB 

     
    antibodies-online proteins for PMPCB (7 products) 

     
    antibodies-online peptides for PMPCB

    PMPCB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PMPCB
    Novus Biologicals PMPCB Antibodies
    Abcam antibodies for PMPCB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PMPCB
    antibodies-online antibodies for PMPCB (26 products) 

    PMPCB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PMPCB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PMPCB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PMPCB 
    antibodies-online kits for PMPCB (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR001431 Pept_M16_Zn_BS
     IPR011765 Pept_M16_N
     IPR011237 Pept_M16_dom
     IPR007863 Peptidase_M16_C
     IPR011249 Metalloenz_LuxS/M16

    Graphical View of Domain Structure for InterPro Entry O75439

    ProtoNet protein and cluster: O75439

    1 Blocks protein domain: IPB001431 Insulinase-like peptidase

    UniProtKB/Swiss-Prot: MPPB_HUMAN, O75439
    Similarity: Belongs to the peptidase M16 family


    Find genes that share domains with PMPCB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPPB_HUMAN, O75439
    Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity)
    Catalytic activity: Release of N-terminal transit peptides from precursor proteins imported into the
    mitochondrion, typically with Arg in position P2

         Genatlas biochemistry entry for PMPCB:
    peptidase (mitochondrial processing) beta,M phase phosphoprotein

         Enzyme Number (IUBMB): EC 3.4.24.641 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004222metalloendopeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PMPCB           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PMPCB

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PMPCB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PMPCB (see all 16):
    hsa-miR-429 hsa-miR-374a hsa-miR-548a-3p hsa-miR-629* hsa-miR-1183 hsa-miR-200b hsa-miR-384 hsa-miR-1298
    SwitchGear 3'UTR luciferase reporter plasmidPMPCB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PMPCB
    Predesigned siRNA for gene silencing in human, mouse, rat PMPCB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PMPCB

    Clone
    Products:
         
    OriGene clones in human, mouse for PMPCB (see all 6)
    OriGene ORF clones in mouse, rat for PMPCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PMPCB (NM_004279)
    Sino Biological Human cDNA Clone for PMPCB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PMPCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMPCB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PMPCB
    Browse ESI BIO Cell Lines and PureStem Progenitors for PMPCB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMPCB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MPPB_HUMAN, O75439: Mitochondrion matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with PMPCB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PMPCB About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import


    Find genes that share SuperPaths with PMPCB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PMPCB
        Mitochondrial protein import


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PMPCB
    Interactions:

        GeneGlobe Interaction Network for PMPCB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PMPCB (O754392, 3 ENSP000002492694) via UniProtKB, MINT, STRING, and/or I2D (see all 400)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK3P274482, 3MINT-63617 I2D: score=5 
    PMPCAQ107132, 3, ENSP000003607824MINT-8079030 I2D: score=9 STRING: ENSP00000360782
    MRPL3P090012, 3, ENSP000002649954MINT-8079030 I2D: score=1 STRING: ENSP00000264995
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    DIS3Q9Y2L13, ENSP000003669974I2D: score=4 STRING: ENSP00000366997
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with PMPCB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PMPCB (MPPB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PMPCB gene: 
    NM_004279.2  

    Unigene Cluster for PMPCB:

    Peptidase (mitochondrial processing) beta
    Hs.184211  [show with all ESTs]
    Unigene Representative Sequence: NM_004279
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249269(uc003vbl.3) ENST00000428154(uc003vbk.1 uc011klm.1)
    ENST00000456433 ENST00000443722 ENST00000498530(uc010liu.1) ENST00000444457
    ENST00000453466 ENST00000469560 ENST00000420236(uc011kll.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PMPCB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PMPCB (see all 16):
    hsa-miR-429 hsa-miR-374a hsa-miR-548a-3p hsa-miR-629* hsa-miR-1183 hsa-miR-200b hsa-miR-384 hsa-miR-1298
    SwitchGear 3'UTR luciferase reporter plasmidPMPCB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PMPCB
    Predesigned siRNA for gene silencing in human, mouse, rat PMPCB
    Clone
    Products:
         
    OriGene clones in human, mouse for PMPCB (see all 6)
    OriGene ORF clones in mouse, rat for PMPCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PMPCB (NM_004279)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PMPCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMPCB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PMPCB
    OriGene qSTAR qPCR primer pairs in human, mouse for PMPCB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PMPCB
      QuantiTect SYBR Green Assays in human, mouse, rat PMPCB
      QuantiFast Probe-based Assays in human, mouse, rat PMPCB

    Additional mRNA sequence: 

    AF054182.1 AF520796.1 AK000994.1 AK098616.1 AK289864.1 AK297354.1 AK309928.1 AL050216.1 
    BC014079.2 

    Selected DOTS entries (see all 27):

    DT.456141  DT.101970896  DT.95367648  DT.40278493  DT.101986355  DT.85105588  DT.91641719  DT.316090 
    DT.405874  DT.75123444  DT.417083  DT.121065765  DT.97855617  DT.100838046  DT.100888013  DT.100888022 
    DT.102838904  DT.121065760  DT.95367654  DT.99932231  DT.100888012  DT.121065709  DT.121065718  DT.92454563 

    Selected AceView cDNA sequences (see all 524):

    BC014079 W60629 AU099027 CR611191 BU687263 CR599164 BM752626 BG762556 
    BM763896 CR617716 AU104067 AL571034 BM786742 CR602907 BM907156 AI478435 
    BF438567 CR595035 CB142093 AA319032 BU783957 AI928082 AI700006 AU104064 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PMPCB (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                    -                                               -                       -     -                                 
    SP2:                    -                                               -                       -     -                                 
    SP3:                    -                                               -     -                                                         
    SP4:                    -                       -                                                                                       
    SP5:                    -                       -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for PMPCB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PMPCB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATACATT
    PMPCB Expression
    About this image


    PMPCB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    PMPCB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PMPCB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.184211
        Custom PCR Arrays for PMPCB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PMPCB
    OriGene qSTAR qPCR primer pairs in human, mouse for PMPCB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PMPCB
    QuantiTect SYBR Green Assays in human, mouse, rat PMPCB
    QuantiFast Probe-based Assays in human, mouse, rat PMPCB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMPCB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PMPCB gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pmpcb1 , 5 peptidase (mitochondrial processing) beta1, 5 85.48(n)1
    90.18(a)1
      5 (9.97 cM)5
    730781  NM_028431.21  NP_082707.11 
     217371415 
    chicken
    (Gallus gallus)
    Aves PMPCB1 peptidase (mitochondrial processing) beta 76.36(n)
    82.27(a)
      417718  NM_001199472.1  NP_001186401.1 
    lizard
    (Anolis carolinensis)
    Reptilia PMPCB6
    peptidase (mitochondrial processing) beta
    79(a)
    1 ↔ 1
    5(95364737-95380667)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA789443.12   -- 77.35(n)    CA789443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pmpcb1 peptidase (mitochondrial processing) beta 70.54(n)
    83.33(a)
      503532  NM_001012496.2  NP_001012514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37311 , 3 mitochondrial processing peptidase3
    CG37311
    70(a)3
    60.67(n)1
    71.01(a)1
      88D63
    418001  NM_169607.11  NP_731954.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC410.23
    mppb-11
    mitochondrial processing peptidase3
    mppb-11
    50(a)
    (best of 2)3
    55.56(n)1
    49.77(a)1
      IV(9074536-9076682)3
    1777251  NM_069175.61  NP_501576.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAS1(YLR163C)4
    MAS11
    Smaller subunit of the mitochondrial processing protease more4
    MAS11
    52.94(n)1
    47.06(a)1
      12(493254-491866)4
    8508601, 4  NP_013264.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPPBETA1 MPPBETA 56.04(n)
    52.98(a)
      821084  NM_111075.2  NP_186858.1 
    rice
    (Oryza sativa)
    Liliopsida Os.41242 Oryza sativa C3meo4 mRNA, complete cds 75.5(n)    NM_191703.1 


    ENSEMBL Gene Tree for PMPCB (if available)
    TreeFam Gene Tree for PMPCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PMPCB gene
    UQCRC12  
    3 SIMAP similar genes for PMPCB using alignment to 8 protein entries:     MPPB_HUMAN (see all proteins):
    DKFZp586I1223    UQCRC1    PMPCA

    Find genes that share paralogs with PMPCB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PMPCB (see all 384)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1181693771,2
    F--102936063(+) AAATTC/ATTGCT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1914280511,2
    --102936262(+) GAGGGA/CGATGA 1 -- us2k10--------
    rs1824574851,2
    --102936364(+) GGATTC/TTTCAT 1 -- us2k10--------
    rs1870855801,2
    --102936382(+) CTGCCC/GTAACA 1 -- us2k10--------
    rs37575071,2
    C,F,H--102936409(+) ATCCTA/GTAGGT 1 -- us2k119Minor allele frequency- G:0.08NA NS EA WA 2476
    rs1911443971,2
    C--102936463(+) AGGCAC/GGAAAG 1 -- us2k10--------
    rs37575081,2
    C,F,H--102936527(+) TTGGAT/GTTTTG 1 -- us2k124Minor allele frequency- G:0.18NS EA NA WA CSA 2351
    rs69719481,2
    H--102936623(+) tgataT/Ctgagt 1 -- us2k14Minor allele frequency- C:0.00NS EA 416
    rs1504631071,2
    C--102936786(+) AAACAC/TCAACT 1 -- us2k10--------
    rs176805231,2
    C,F,H--102936821(+) CAGCAC/TAGTCT 1 -- us2k120Minor allele frequency- T:0.06NA EA NS 2438

    HapMap Linkage Disequilibrium report for PMPCB (102937869 - 102969958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PMPCB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831084CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PMPCB
    DNA2.0 Custom Variant and Variant Library Synthesis for PMPCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603131    OMIM disorders: --


    Find genes that share disorders with PMPCB           About GenesLikeMe

    Genetic Association Database (GAD): PMPCB
    Human Genome Epidemiology (HuGE) Navigator: PMPCB (1 document)

    Export disorders for PMPCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PMPCB gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with PMPCB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    4. Maturation of wild-type and mutated frataxin by the mitochondrial processing peptidase. (PubMed id 9700204)1, 9 Koutnikova H....Koenig M. (Hum. Mol. Genet. 1998)
    5. Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. (PubMed id 22354088)1 Greene A.W....Fon E.A. (EMBO Rep. 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9512 HGNC: 9119 AceView: PMPCB Ensembl:ENSG00000105819 euGenes: HUgn9512
    ECgene: PMPCB H-InvDB: PMPCB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PMPCB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PMPCB gene:
    Search GeneIP for patents involving PMPCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PMPCB  
     OriGene qPCR primer pairs and template standards for PMPCB   OriGene Protein Over-expression Lysate for PMPCB  
     OriGene MassSpec for PMPCB   OriGene clones in human, mouse for PMPCB  
     OriGene qSTAR qPCR primer pairs in human, mouse for PMPCB   OriGene Purified Protein for PMPCB  
     OriGene ORF clones in mouse, rat for PMPCB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PMPCB   OriGene Custom Protein Services for PMPCB  

     
     
     Block miRNA regulation of human, mouse, rat PMPCB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PMPCB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PMPCB Predesigned siRNA for gene silencing in human, mouse, rat PMPCB
     QuantiFast Probe-based Assays in human, mouse, rat PMPCB QuantiTect SYBR Green Assays in human, mouse, rat PMPCB
     Custom PCR Arrays for PMPCB Search Chromatin IP Primers for PMPCB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PMPCB  GeneGlobe Interaction Network for PMPCB
     Regulatory tfbs in PMPCB promoter
     GenScript Custom Purified and Recombinant Proteins Services for PMPCB GenScript cDNA clones with any tag delivered in your preferred vector for PMPCB
     GenScript Custom Assay Services for PMPCB GenScript Custom overexpressing Cell Line Services for PMPCB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PMPCB (MPPB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PMPCB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PMPCB antibodies
     PMPCB proteins
     PMPCB lysates
     Antibodies for PMPCB
     See all of Abcam's Antibodies, Kits and Proteins for PMPCB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PMPCB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMPCB
     SwitchGear 3'UTR luciferase reporter plasmids for PMPCB
     SwitchGear Promoter luciferase reporter plasmids for PMPCB
     ThermoFisher Antibody for PMPCB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMPCB
     Browse compounds at ApexBio
     Search Addgene for plasmids for PMPCB
      Search eBioscience for proteins for PMPCB
      Search eBioscience for elisas for PMPCB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PMPCB
     antibodies-online antibodies for PMPCB (26 products)
     antibodies-online kits for PMPCB (8 products)
     antibodies-online peptides for PMPCB
     antibodies-online proteins for PMPCB (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PMPCB gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4