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Aliases for PMPCB Gene

Aliases for PMPCB Gene

  • Peptidase, Mitochondrial Processing Beta Subunit 2 3
  • Peptidase (Mitochondrial Processing) Beta 2 3 5
  • EC 3.4.24.64 4 63
  • Beta-MPP 3 4
  • MPPB 3 4
  • P-52 3 4
  • Mitochondrial Processing Peptidase Beta Subunit 3
  • MPPP52 3
  • MPP11 3

External Ids for PMPCB Gene

Previous GeneCards Identifiers for PMPCB Gene

  • GC07P101421
  • GC07P102484
  • GC07P102498
  • GC07P102532
  • GC07P102725
  • GC07P102937
  • GC07P097300

Summaries for PMPCB Gene

Entrez Gene Summary for PMPCB Gene

  • This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for PMPCB Gene

PMPCB (Peptidase, Mitochondrial Processing Beta Subunit) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is UQCRC1.

UniProtKB/Swiss-Prot for PMPCB Gene

  • Cleaves presequences (transit peptides) from mitochondrial protein precursors.

Gene Wiki entry for PMPCB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PMPCB Gene

Genomics for PMPCB Gene

Regulatory Elements for PMPCB Gene

Promoters for PMPCB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PMPCB on UCSC Golden Path with GeneCards custom track

Genomic Location for PMPCB Gene

Chromosome:
7
Start:
103,297,422 bp from pter
End:
103,329,902 bp from pter
Size:
32,481 bases
Orientation:
Plus strand

Genomic View for PMPCB Gene

Genes around PMPCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PMPCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PMPCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PMPCB Gene

Proteins for PMPCB Gene

  • Protein details for PMPCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75439-MPPB_HUMAN
    Recommended name:
    Mitochondrial-processing peptidase subunit beta
    Protein Accession:
    O75439
    Secondary Accessions:
    • O60416
    • Q96FV4

    Protein attributes for PMPCB Gene

    Size:
    489 amino acids
    Molecular mass:
    54366 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Heterodimer of alpha and beta subunits.

neXtProt entry for PMPCB Gene

Proteomics data for PMPCB Gene at MOPED

Post-translational modifications for PMPCB Gene

  • Ubiquitination at Lys 95, Lys 224, Lys 235, and Lys 472
  • Modification sites at PhosphoSitePlus

Other Protein References for PMPCB Gene

Antibody Products

Domains & Families for PMPCB Gene

Graphical View of Domain Structure for InterPro Entry

O75439

UniProtKB/Swiss-Prot:

MPPB_HUMAN :
  • Belongs to the peptidase M16 family.
Family:
  • Belongs to the peptidase M16 family.
genes like me logo Genes that share domains with PMPCB: view

No data available for Gene Families for PMPCB Gene

Function for PMPCB Gene

Molecular function for PMPCB Gene

GENATLAS Biochemistry:
peptidase (mitochondrial processing) beta,M phase phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity:
Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
UniProtKB/Swiss-Prot Function:
Cleaves presequences (transit peptides) from mitochondrial protein precursors.

Enzyme Numbers (IUBMB) for PMPCB Gene

genes like me logo Genes that share phenotypes with PMPCB: view

Animal Model Products

miRNA for PMPCB Gene

miRTarBase miRNAs that target PMPCB

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PMPCB Gene

Localization for PMPCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PMPCB Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PMPCB Gene COMPARTMENTS Subcellular localization image for PMPCB gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for PMPCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with PMPCB: view

Pathways & Interactions for PMPCB Gene

genes like me logo Genes that share pathways with PMPCB: view

Pathways by source for PMPCB Gene

2 Reactome pathways for PMPCB Gene

Gene Ontology (GO) - Biological Process for PMPCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0016485 protein processing IBA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PMPCB: view

No data available for SIGNOR curated interactions for PMPCB Gene

Drugs & Compounds for PMPCB Gene

No Compound Related Data Available

Transcripts for PMPCB Gene

Unigene Clusters for PMPCB Gene

Peptidase (mitochondrial processing) beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PMPCB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7:
SP8:

Relevant External Links for PMPCB Gene

GeneLoc Exon Structure for
PMPCB
ECgene alternative splicing isoforms for
PMPCB

Expression for PMPCB Gene

mRNA expression in normal human tissues for PMPCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PMPCB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PMPCB Gene



SOURCE GeneReport for Unigene cluster for PMPCB Gene Hs.184211

genes like me logo Genes that share expression patterns with PMPCB: view

Protein tissue co-expression partners for PMPCB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PMPCB Gene

Orthologs for PMPCB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PMPCB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PMPCB 35
  • 92.64 (n)
  • 94.37 (a)
PMPCB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PMPCB 35
  • 90.42 (n)
  • 92.71 (a)
PMPCB 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pmpcb 35
  • 85.48 (n)
  • 90.18 (a)
Pmpcb 16
Pmpcb 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PMPCB 35
  • 99.52 (n)
  • 99.18 (a)
PMPCB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pmpcb 35
  • 83.71 (n)
  • 89.37 (a)
oppossum
(Monodelphis domestica)
Mammalia PMPCB 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PMPCB 35
  • 76.36 (n)
  • 82.27 (a)
PMPCB 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PMPCB 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pmpcb 35
  • 75.65 (n)
  • 85.26 (a)
Str.15357 35
zebrafish
(Danio rerio)
Actinopterygii pmpcb 35
  • 70.54 (n)
  • 83.33 (a)
pmpcb 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10147 35
fruit fly
(Drosophila melanogaster)
Insecta CG3731 37
  • 70 (a)
CG3731 35
  • 60.67 (n)
  • 71.01 (a)
CG3731 36
  • 68 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000935 35
  • 58.66 (n)
  • 69.16 (a)
worm
(Caenorhabditis elegans)
Secernentea F56D2.1 37
  • 38 (a)
ZC410.2 37
  • 50 (a)
mppb-1 35
  • 55.56 (n)
  • 49.77 (a)
mppb-1 36
  • 48 (a)
ManyToMany
ucr-1 36
  • 38 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL138C 35
  • 51.69 (n)
  • 47.76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18095g 35
  • 54.21 (n)
  • 46.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAS1 35
  • 52.94 (n)
  • 47.06 (a)
MAS1 36
  • 43 (a)
OneToMany
MAS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MPPBETA 35
  • 56.04 (n)
  • 52.98 (a)
soybean
(Glycine max)
eudicotyledons Gma.1751 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6917 35
barley
(Hordeum vulgare)
Liliopsida Hv.5304 35
rice
(Oryza sativa)
Liliopsida Os.4124 35
Os03g0212700 35
  • 55 (n)
  • 53.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27578 35
corn
(Zea mays)
Liliopsida Zm.5860 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4874 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02549 35
  • 53.68 (n)
  • 53.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes qcr1 35
  • 54.36 (n)
  • 51.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3431 36
  • 63 (a)
OneToMany
Species with no ortholog for PMPCB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PMPCB Gene

ENSEMBL:
Gene Tree for PMPCB (if available)
TreeFam:
Gene Tree for PMPCB (if available)

Paralogs for PMPCB Gene

Paralogs for PMPCB Gene

(3) SIMAP similar genes for PMPCB Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PMPCB: view

Variants for PMPCB Gene

Sequence variations from dbSNP and Humsavar for PMPCB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3087615 - 103,311,676(-) GCAAC(A/C)TCACT nc-transcript-variant, reference, missense
rs1057797 -- 103,309,037(-) TGAGA(A/C/T)AGATT nc-transcript-variant, reference, missense
rs1060201 -- 103,297,505(+) GCGCG(A/C)GGCGG nc-transcript-variant, reference, synonymous-codon
rs2023926 -- 103,304,495(-) ATTGA(A/C)TAACC intron-variant
rs2301861 -- 103,297,437(-) TAGAG(A/G)ATGAA nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PMPCB Gene

Variant ID Type Subtype PubMed ID
nsv831084 CNV Gain 17160897

Variation tolerance for PMPCB Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PMPCB Gene

HapMap Linkage Disequilibrium report
PMPCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PMPCB Gene

Disorders for PMPCB Gene

Relevant External Links for PMPCB

Genetic Association Database (GAD)
PMPCB
Human Genome Epidemiology (HuGE) Navigator
PMPCB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PMPCB

No disorders were found for PMPCB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PMPCB Gene

Publications for PMPCB Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. Maturation of wild-type and mutated frataxin by the mitochondrial processing peptidase. (PMID: 9700204) Koutnikova H. … Koenig M. (Hum. Mol. Genet. 1998) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase. (PMID: 24903103) Pandey D. … Romer L.H. (Circ. Res. 2014) 3

Products for PMPCB Gene

Sources for PMPCB Gene

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