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Aliases for PMPCA Gene

Aliases for PMPCA Gene

  • Peptidase (Mitochondrial Processing) Alpha 2 3
  • Inositol Polyphosphate-5-Phosphatase, 72 KD 2 3
  • EC 3.4.24.64 4 63
  • Alpha-MPP 3 4
  • KIAA0123 4 6
  • INPP5E 3 4
  • P-55 3 4
  • Mitochondrial Matrix Processing Protease, Alpha Subunit 3
  • Mitochondrial-Processing Peptidase Subunit Alpha 3
  • MPPA 4

External Ids for PMPCA Gene

Previous HGNC Symbols for PMPCA Gene

  • INPP5E

Previous GeneCards Identifiers for PMPCA Gene

  • GC09P132746
  • GC09P134662
  • GC09P136580
  • GC09P138424
  • GC09P139305
  • GC09P108764

Summaries for PMPCA Gene

GeneCards Summary for PMPCA Gene

PMPCA (Peptidase (Mitochondrial Processing) Alpha) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is UQCRC2.

UniProtKB/Swiss-Prot for PMPCA Gene

  • Cleaves presequences (transit peptides) from mitochondrial protein precursors.

Gene Wiki entry for PMPCA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PMPCA Gene

Genomics for PMPCA Gene

Regulatory Elements for PMPCA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PMPCA Gene

Start:
136,410,570 bp from pter
End:
136,423,761 bp from pter
Size:
13,192 bases
Orientation:
Plus strand

Genomic View for PMPCA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PMPCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PMPCA Gene

Proteins for PMPCA Gene

  • Protein details for PMPCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10713-MPPA_HUMAN
    Recommended name:
    Mitochondrial-processing peptidase subunit alpha
    Protein Accession:
    Q10713
    Secondary Accessions:
    • B4DKL3
    • E7ET61
    • Q16639
    • Q5SXM9
    • Q8N513

    Protein attributes for PMPCA Gene

    Size:
    525 amino acids
    Molecular mass:
    58253 Da
    Quaternary structure:
    • Heterodimer of alpha and beta subunits.
    SequenceCaution:
    • Sequence=AAH33103.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA04643.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA09472.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PMPCA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PMPCA Gene

Proteomics data for PMPCA Gene at MOPED

Post-translational modifications for PMPCA Gene

  • Ubiquitination at Lys53, Lys103, Lys232, Lys269, Lys299, and Lys488
  • Modification sites at PhosphoSitePlus

Other Protein References for PMPCA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PMPCA Gene

Graphical View of Domain Structure for InterPro Entry

Q10713

UniProtKB/Swiss-Prot:

MPPA_HUMAN :
  • Q10713
Family:
  • Belongs to the peptidase M16 family.
genes like me logo Genes that share domains with PMPCA: view

No data available for Gene Families for PMPCA Gene

Function for PMPCA Gene

Molecular function for PMPCA Gene

UniProtKB/Swiss-Prot CatalyticActivity: Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2
UniProtKB/Swiss-Prot Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors.

Enzyme Numbers (IUBMB) for PMPCA Gene

Gene Ontology (GO) - Molecular Function for PMPCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004222 metalloendopeptidase activity TAS 10942759
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PMPCA: view

Animal Model Products

CRISPR Products

miRNA for PMPCA Gene

miRTarBase miRNAs that target PMPCA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PMPCA

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PMPCA Gene

Localization for PMPCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PMPCA Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PMPCA Gene COMPARTMENTS Subcellular localization image for PMPCA gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PMPCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS 10942759
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with PMPCA: view

Pathways for PMPCA Gene

genes like me logo Genes that share pathways with PMPCA: view

Gene Ontology (GO) - Biological Process for PMPCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 10942759
GO:0006626 protein targeting to mitochondrion TAS --
GO:0008152 metabolic process --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PMPCA: view

Compounds for PMPCA Gene

(1) HMDB Compounds for PMPCA Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6
genes like me logo Genes that share compounds with PMPCA: view

Transcripts for PMPCA Gene

Unigene Clusters for PMPCA Gene

Peptidase (mitochondrial processing) alpha:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PMPCA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PMPCA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PMPCA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6: -
SP7: - - -
SP8: - - - -
SP9: - - - -
SP10: -
SP11: - - - - -
SP12:
SP13:
SP14: - -

ExUns: 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PMPCA Gene

GeneLoc Exon Structure for
PMPCA
ECgene alternative splicing isoforms for
PMPCA

Expression for PMPCA Gene

mRNA expression in normal human tissues for PMPCA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PMPCA Gene

SOURCE GeneReport for Unigene cluster for PMPCA Gene Hs.495471

genes like me logo Genes that share expressions with PMPCA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PMPCA Gene

Orthologs for PMPCA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PMPCA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PMPCA 35
  • 93.99 (n)
  • 92.79 (a)
PMPCA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PMPCA 35
  • 86.16 (n)
  • 90.67 (a)
PMPCA 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PMPCA 35
  • 85.7 (n)
  • 90.68 (a)
PMPCA 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pmpca 35
  • 85.56 (n)
  • 91.41 (a)
Pmpca 16
Pmpca 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PMPCA 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PMPCA 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pmpca 35
  • 86.13 (n)
  • 92.18 (a)
chicken
(Gallus gallus)
Aves PMPCA 35
  • 73.37 (n)
  • 82.79 (a)
PMPCA 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PMPCA 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pmpca 35
  • 75.48 (n)
  • 84.42 (a)
Str.221 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6618 35
zebrafish
(Danio rerio)
Actinopterygii pmpca 35
  • 71.79 (n)
  • 80.28 (a)
pmpca 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008086 35
  • 58.12 (n)
  • 55.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8728 35
  • 57.34 (n)
  • 53.86 (a)
CG8728 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mppa-1 35
  • 46.79 (n)
  • 41.03 (a)
mppa-1 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAS2 35
  • 48.46 (n)
  • 39.76 (a)
MAS2 36
  • 34 (a)
OneToMany
MAS2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11573g 35
  • 48.02 (n)
  • 38.37 (a)
rice
(Oryza sativa)
Liliopsida Os01g0966300 35
  • 45.18 (n)
  • 36.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06270 35
  • 51.65 (n)
  • 40.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mas2 35
  • 44.15 (n)
  • 35.31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1704 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for PMPCA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PMPCA Gene

ENSEMBL:
Gene Tree for PMPCA (if available)
TreeFam:
Gene Tree for PMPCA (if available)

Paralogs for PMPCA Gene

Paralogs for PMPCA Gene

Selected SIMAP similar genes for PMPCA Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PMPCA Gene

genes like me logo Genes that share paralogs with PMPCA: view

Variants for PMPCA Gene

Sequence variations from dbSNP and Humsavar for PMPCA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7628 -- 136,423,619(+) TATCA(A/G)AGCCT utr-variant-3-prime
rs9548 -- 136,423,371(+) ATAAA(C/T)GGTGC utr-variant-3-prime, downstream-variant-500B
rs15450 -- 136,423,576(-) CCTCC(A/T)AGGAA utr-variant-3-prime
rs1130635 -- 136,423,417(+) TCTTT(C/T)GGAAC utr-variant-3-prime, downstream-variant-500B
rs1130640 -- 136,423,527(+) GCGGT(C/T)GGTGC utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PMPCA Gene

Variant ID Type Subtype PubMed ID
nsv825173 CNV Gain 20364138
nsv894294 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
dgv8386n71 CNV Loss 21882294
dgv8389n71 CNV Loss 21882294
dgv8390n71 CNV Loss 21882294
dgv8392n71 CNV Loss 21882294
nsv894357 CNV Loss 21882294
nsv509333 CNV Insertion 20534489
nsv482928 CNV Loss 15286789
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
dgv8394n71 CNV Loss 21882294
nsv831760 CNV Loss 17160897
nsv894364 CNV Loss 21882294
nsv894365 CNV Loss 21882294
nsv894366 CNV Loss 21882294
nsv894367 CNV Loss 21882294
nsv825174 CNV Gain 20364138
nsv6766 CNV Insertion 18451855
esv2676242 CNV Deletion 23128226
dgv8395n71 CNV Loss 21882294

Relevant External Links for PMPCA Gene

HapMap Linkage Disequilibrium report
PMPCA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PMPCA Gene

Disorders for PMPCA Gene

Relevant External Links for PMPCA

Genetic Association Database (GAD)
PMPCA
Human Genome Epidemiology (HuGE) Navigator
PMPCA
genes like me logo Genes that share disorders with PMPCA: view

No data available for UniProtKB/Swiss-Prot for PMPCA Gene

Publications for PMPCA Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  3. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PMID: 11840567) Harris R.A. … Zvelebil M.J. (Proteomics 2002) 3 4
  4. Glycine-rich region of mitochondrial processing peptidase alpha-subunit is essential for binding and cleavage of the precursor proteins. (PMID: 10942759) Nagao Y. … Ito A. (J. Biol. Chem. 2000) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PMPCA Gene

Sources for PMPCA Gene

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