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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PMPCA Gene

protein-coding   GIFtS: 59
GCID: GC09P139305

Peptidase (Mitochondrial Processing) Alpha

(Previous names: inositol polyphosphate-5-phosphatase, 72 kD)
(Previous symbol: INPP5E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidase (Mitochondrial Processing) Alpha1 2     EC 3.4.24.643 8
INPP5E1 2 3     KIAA01233 5
Inositol Polyphosphate-5-Phosphatase, 72 KD1 2     Mitochondrial Matrix Processing Protease, Alpha Subunit2
Alpha-MPP2 3     Mitochondrial-Processing Peptidase Subunit Alpha2
P-552 3     MPPA3

External Ids:    HGNC: 186671   Entrez Gene: 232032   Ensembl: ENSG000001656887   OMIM: 6130365   UniProtKB: Q107133   

Export aliases for PMPCA gene to outside databases

Previous GC identifers: GC09P132746 GC09P134662 GC09P136580 GC09P138424 GC09P108764


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PMPCA Gene: 
PMPCA (peptidase (mitochondrial processing) alpha) is a protein-coding gene. Diseases associated with PMPCA include filariasis, and tuberculosis, and among its related super-pathways are Post-translational protein modification and D-myo-inositol (1,3,4)-trisphosphate biosynthesis. GO annotations related to this gene include metalloendopeptidase activity and metal ion binding. An important paralog of this gene is UQCRC2.

UniProtKB/Swiss-Prot: MPPA_HUMAN, Q10713
Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity)

Gene Wiki entry for PMPCA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_024000.16  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PMPCA gene promoter:
         Pbx1a   p53   Pax-6   MyoD   Lmo2   NRF-2   c-Myb   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PMPCA promoter sequence
   Search SABiosciences Chromatin IP Primers for PMPCA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PMPCA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

PMPCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMPCA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P139305:  view genomic region     (about GC identifiers)

Start:
139,305,110 bp from pter      End:
139,318,213 bp from pter
Size:
13,104 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MPPA_HUMAN, Q10713 (See protein sequence)
Recommended Name: Mitochondrial-processing peptidase subunit alpha precursor  
Size: 525 amino acids; 58253 Da
Subunit: Heterodimer of alpha and beta subunits (By similarity)
Subcellular location: Mitochondrion matrix (By similarity)
Mass spectrometry: Mass=54624.57; Method=MALDI; Range=33-525; Source=PubMed:11840567;
Caution: Does not seem to have a protease activity as it lack the zinc-binding site
Sequence caution: Sequence=AAH33103.2; Type=Erroneous initiation; Sequence=BAA04643.1; Type=Erroneous initiation;
Sequence=BAA09472.2; Type=Erroneous initiation;
Secondary accessions: Q16639 Q5SXM9 Q8N513

Explore the universe of human proteins at neXtProt for PMPCA: NX_Q10713

Explore proteomics data for PMPCA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q10713

  • 4/6 DME Specific Peptides for PMPCA (Q10713) (see all 6)
     GLESCSFLE  FSAGGPGKGM  RENTVGLHRFCP  YPNIPLSSPLPGVPKP 

    PMPCA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PMPCA Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269873.1  NP_001269875.1  NP_055975.1  

    ENSEMBL proteins: 
     ENSP00000360785   ENSP00000360782   ENSP00000408393   ENSP00000416702  
    Reactome Protein details: Q10713
    Human Recombinant Protein Products for PMPCA: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS10942759
    GO:0005759mitochondrial matrix IEA--

    PMPCA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001431 Pept_M16_Zn_BS
     IPR011765 Pept_M16_N
     IPR011237 Pept_M16_dom
     IPR007863 Peptidase_M16_C
     IPR011249 Metalloenz_LuxS/M16

    Graphical View of Domain Structure for InterPro Entry Q10713

    ProtoNet protein and cluster: Q10713

    1 Blocks protein domain: IPB001431 Insulinase-like peptidase

    UniProtKB/Swiss-Prot: MPPA_HUMAN, Q10713
    Similarity: Belongs to the peptidase M16 family


    PMPCA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPPA_HUMAN, Q10713
    Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity)
    Catalytic activity: Release of N-terminal transit peptides from precursor proteins imported into the
    mitochondrion, typically with Arg in position P2

         Enzyme Number (IUBMB): EC 3.4.24.641 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004222metalloendopeptidase activity TAS10942759
    GO:0046872metal ion binding IEA--
         
    PMPCA for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PMPCA 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PMPCA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    3-phosphoinositide degradation0.33
    3Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PMPCA
        3-phosphoinositide degradation

    2        Reactome Pathways for PMPCA
        Mitochondrial Protein Import
    Metabolism of proteins



    PMPCA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PMPCA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/291 Interacting proteins for PMPCA (Q107132, 3 ENSP000003607824) via UniProtKB, MINT, STRING, and/or I2D (see all 291)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PMPCBO754392, 3, ENSP000002492694MINT-8079030 I2D: score=9 STRING: ENSP00000249269
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    HSPD1P108092, 3, ENSP000003400194MINT-8079030 I2D: score=1 STRING: ENSP00000340019
    DPH5Q9H2P93, ENSP000003591274I2D: score=2 STRING: ENSP00000359127
    MARK2Q7KZI73, ENSP000003891844I2D: score=2 STRING: ENSP00000389184
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10942759
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0044267cellular protein metabolic process TAS--

    PMPCA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PMPCA (MPPA)

    1 HMDB Compound for PMPCA    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    Search CenterWatch for drugs/clinical trials and news about PMPCA / MPPA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PMPCA gene (3 alternative transcripts): 
    NM_001282944.1  NM_001282946.1  NM_015160.2  

    Unigene Cluster for PMPCA:

    Peptidase (mitochondrial processing) alpha
    Hs.495471  [show with all ESTs]
    Unigene Representative Sequence: AK091455
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371720(uc011mdy.1 uc010nbk.2) ENST00000371717(uc004chl.3 uc010nbl.3 uc011mdz.2)
    ENST00000462616(uc004chm.1) ENST00000444897 ENST00000399219(uc004chn.1)

    miRNA
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    Additional mRNA sequence: 

    AK091455.1 AK129769.1 AK296617.1 AK299304.1 AK307206.1 AK308104.1 BC004342.1 BC022949.1 
    BC033103.1 BC111399.1 BC114360.1 BC132724.1 BC136599.1 D21064.1 D50913.2 

    18 DOTS entries:

    DT.87017052  DT.100811261  DT.100811258  DT.97860538  DT.100767920  DT.102832211  DT.99937015  DT.97860540 
    DT.91767290  DT.100830975  DT.121153895  DT.40112890  DT.75139177  DT.121153856  DT.121153859  DT.121153894 
    DT.91767293  DT.95325840 

    24/427 AceView cDNA sequences (see all 427):

    AI792120 BU675960 BE535418 BM840126 BC033103 BQ892023 BP338214 NM_015160 
    BE513845 BU167118 CN482525 AL529462 BP374852 BQ709389 BM556395 BQ068144 
    BM766731 BC022949 BG820234 CA307958 BP343886 BM712261 CR592081 CB163620 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PMPCA (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^
    SP1:        -     -                             -                             -     -     -                                                                 -   
    SP2:        -     -                             -                                                                                                               
    SP3:        -     -                             -     -                       -     -     -                                                                     
    SP4:              -                             -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 15a · 15b · 15c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for PMPCA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PMPCA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCCGCA
    PMPCA Expression
    About this image


    See PMPCA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PMPCA

    SOURCE GeneReport for Unigene cluster: Hs.495471
        SABiosciences Custom PCR Arrays for PMPCA
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PMPCA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMPCA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PMPCA gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pmpca1 , 5 peptidase (mitochondrial processing) alpha1, 5 85.56(n)1
    91.41(a)1
      2 (18.88 cM)5
    668651  NM_173180.31  NP_775272.11 
     263893395 
    chicken
    (Gallus gallus)
    Aves PMPCA1 peptidase (mitochondrial processing) alpha 73.37(n)
    82.79(a)
      417134  NM_001006197.1  NP_001006197.1 
    lizard
    (Anolis carolinensis)
    Reptilia PMPCA6
    peptidase (mitochondrial processing) alpha
    81(a)
    1 ↔ 1
    GL344440.1(1458-18055)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF286299.12   -- 81.8(n)    CF286299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pmpca1 peptidase (mitochondrial processing) alpha 71.98(n)
    80.48(a)
      492801  NM_001007442.1  NP_001007443.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87281 CG8728 57.48(n)
    53.86(a)
      35748  NM_136489.2  NP_610333.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mppa-11 Protein MPPA-1 46.64(n)
    41.26(a)
      171737  NM_058487.4  NP_490888.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAS2(YHR024C)4 Larger subunit of the mitochondrial processing protease more   --   8(159192-157744) 856419  NP_011889.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPPalpha1 mitochondrial processing peptidase 43.27(n)
    33.63(a)
      820896  NM_112519.3  NP_566548.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07390001 hypothetical protein 42.74(n)
    34.83(a)
      4327198  NM_001050728.1  NP_001044193.1 


    ENSEMBL Gene Tree for PMPCA (if available)
    TreeFam Gene Tree for PMPCA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PMPCA gene
    UQCRC22  
    1 SIMAP similar gene for PMPCA using alignment to 6 protein entries:     MPPA_HUMAN (see all proteins):
    PMPCB

    PMPCA for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PMPCA
    PGOHUM00000242597 PGOHUM00000245623


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/389 SNPs in PMPCA are shown (see all 389)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385235701,2
    C--139307070(+) GATGTC/TTGAGA 1 -- int10--------
    rs1467331701,2
    --139307112(+) ATTATC/GAAGTT 1 -- int10--------
    rs111459351,2
    F--139307160(+) GATAAG/TTTTTG 1 -- int10--------
    rs38412021,2
    C--139307194(+) AAAAA-/ATTGTG 1 -- int10--------
    rs569784601,2
    C--139307195(+) AAAAA-/ATTGTG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1177101361,2
    C,F--139307215(+) TTCAGG/AGATAG 1 -- int12Minor allele frequency- A:0.01NA EU 713
    rs1389082761,2
    C--139307224(+) AGCCTA/GGATTG 1 -- int10--------
    rs1879515101,2
    C--139307271(+) CTGCTC/TGATTT 2 R * stg10--------
    rs2000197501,2
    --139307315(+) AAGCAC/TGGGGG 2 H syn10--------
    rs1493770261,2
    C--139307379(+) TTGGGG/TCCTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PMPCA (139305110 - 139318213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for PMPCA (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676242CNV Deletion23128226
    nsv509333CNV Insertion20534489
    nsv6766CNV Insertion18451855
    nsv894367CNV Loss21882294
    nsv894364CNV Loss21882294
    nsv894366CNV Loss21882294
    nsv894294CNV Loss21882294
    dgv8395n71CNV Loss21882294
    nsv894365CNV Loss21882294
    dgv8390n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613036    OMIM disorders: --

    3 diseases for PMPCA:    About MalaCards
    filariasis    tuberculosis    breast cancer


    PMPCA for disorders           About GeneDecksing

    Genetic Association Database (GAD): PMPCA
    Human Genome Epidemiology (HuGE) Navigator: PMPCA (1 document)

    Export disorders for PMPCA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PMPCA gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with PMPCA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T....Nomura N. (1995)
    2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T....Kotani H. (1995)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (2002)
    6. Glycine-rich region of mitochondrial processing peptidase alpha-subunit is essential for binding and cleavage of the precursor proteins. (PubMed id 10942759)1, 9 Nagao Y....Ito A. (2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23203 HGNC: 18667 AceView: PMPCA Ensembl:ENSG00000165688 euGenes: HUgn23203
    ECgene: PMPCA H-InvDB: PMPCA

    (According to HUGE)
    About This Section
    HUGE: KIAA0123

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PMPCA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PMPCA gene:
    Search GeneIP for patents involving PMPCA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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