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PMP2 Gene

protein-coding   GIFtS: 53
GCID: GC08M082352

Peripheral Myelin Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peripheral Myelin Protein 21 2 3
FABP82
M-FABP2
MP22
P22
Myelin P2 Protein2

External Ids:    HGNC: 91171   Entrez Gene: 53752   Ensembl: ENSG000001475887   OMIM: 1707155   UniProtKB: P026893   

Export aliases for PMP2 gene to outside databases

Previous GC identifers: GC08M081231 GC08M082402 GC08M082075 GC08M082515 GC08M077842


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PMP2 Gene:
PMP2 (peripheral myelin protein 2) is a protein-coding gene. Diseases associated with PMP2 include microsporidiosis, and guillain-barre syndrome. GO annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: MYP2_HUMAN, P02689
Function: May play a role in lipid transport protein in Schwann cells. May bind cholesterol

Gene Wiki entry for PMP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PMP2 gene promoter:
         Sp1   POU6F1 (c2)   LUN-1   POU2F1   FOXO4   FOXJ2 (long isoform)   POU2F1a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPMP2 promoter sequence
   Search Chromatin IP Primers for PMP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.3-q22.1   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.3-q22.1

PMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMP2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082352:  view genomic region     (about GC identifiers)

Start:
82,352,561 bp from pter      End:
82,359,758 bp from pter
Size:
7,198 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYP2_HUMAN, P02689 (See protein sequence)
Recommended Name: Myelin P2 protein  
Size: 132 amino acids; 14909 Da
Subunit: Monomer
Miscellaneous: P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous
system myelin protein
6 PDB 3D structures from and Proteopedia for PMP2:
2WUT (3D)        3NR3 (3D)        4A1H (3D)        4A1Y (3D)        4A8Z (3D)        4BVM (3D)    
Secondary accessions: Q6FHL4

Explore the universe of human proteins at neXtProt for PMP2: NX_P02689

Explore proteomics data for PMP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PMP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002668.1  
    ENSEMBL proteins: 
     ENSP00000256103   ENSP00000429917  

    PMP2 Human Recombinant Protein Products:

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    Novus Biologicals PMP2 Proteins
    Novus Biologicals PMP2 Lysate
    Sino Biological Recombinant Protein for PMP2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PMP2
    Browse Proteins at Cloud-Clone Corp.

    PMP2 Antibody Products:

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    PMP2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FABP: Fatty acid binding protein family

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P02689

    ProtoNet protein and cluster: P02689

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: MYP2_HUMAN, P02689
    Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    PMP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYP2_HUMAN, P02689
    Function: May play a role in lipid transport protein in Schwann cells. May bind cholesterol

         Genatlas biochemistry entry for PMP2:
    peripheral myelin protein 2,potentially involved in the transport of fatty acids or metabolism of myelin lipids

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005504fatty acid binding IDA--
    GO:0008289lipid binding ----
    GO:0015485cholesterol binding IDA--
         
    PMP2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PMP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PMP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PMP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PMP2

    miRNA
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    miRTarBase miRNAs that target PMP2:
    hsa-mir-7-5p (MIRT025888)

    Block miRNA regulation of human, mouse, rat PMP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PMP2 (see all 11):
    hsa-miR-3689b hsa-miR-548p hsa-miR-3689a-5p hsa-miR-485-3p hsa-miR-3692 hsa-miR-646 hsa-miR-33a* hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidPMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PMP2

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    GenScript: all cDNA clones in your preferred vector: PMP2 (NM_002677)
    Sino Biological Human cDNA Clone for PMP2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMP2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PMP2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYP2_HUMAN, P02689: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    PMP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PMP2
    Interactions:

        Search GeneGlobe Interaction Network for PMP2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PMP2 (ENSP000002561034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNI3KENSP000003599284STRING: ENSP00000359928
    PLK1ENSP000003000934STRING: ENSP00000300093
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0061024membrane organization IEA--

    PMP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PMP2 (MYP2)

    4 DrugBank Compounds for PMP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Oleic Acid-- 112-80-1target--17139284 17016423 10592235
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3target--17139284 17016423 10592235
    S-Hydroxycysteine-- --target--17139284 17016423 10592235
    Lauryl Dimethylamine-N-Oxide-- --target--10592235

    2 Novoseek inferred chemical compound relationships for PMP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 18.9 3 16427315 (2), 7525873 (1)
    lipid 0 2 9584990 (1), 8288226 (1)



    PMP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PMP2 gene: 
    NM_002677.3  

    Unigene Cluster for PMP2:

    Peripheral myelin protein 2
    Hs.571512  [show with all ESTs]
    Unigene Representative Sequence: BC034997
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256103(uc003ycb.1 uc010lzv.1) ENST00000519260
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PMP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PMP2 (see all 11):
    hsa-miR-3689b hsa-miR-548p hsa-miR-3689a-5p hsa-miR-485-3p hsa-miR-3692 hsa-miR-646 hsa-miR-33a* hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidPMP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PMP2
    Predesigned siRNA for gene silencing in human, mouse, rat PMP2
    Clone
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    OriGene clones in human, mouse for PMP2 (see all 6)
    OriGene ORF clones in mouse, rat for PMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PMP2 (NM_002677)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMP2
    Primer
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    OriGene qPCR primer pairs and template standards for PMP2
    OriGene qSTAR qPCR primer pairs in human, mouse for PMP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PMP2
      QuantiTect SYBR Green Assays in human, mouse, rat PMP2
      QuantiFast Probe-based Assays in human, mouse, rat PMP2

    Additional mRNA sequence: 

    AK307118.1 AK311758.1 BC034997.1 CR541649.1 CR541738.1 DQ786226.1 X62167.1 

    3 DOTS entries:

    DT.302923  DT.120639989  DT.95240728 

    Selected AceView cDNA sequences (see all 77):

    NM_002677 AI089407 CR541649 BM676811 AI422173 AI637793 BM719957 CR541738 
    BF477477 AI986451 BI600273 BF929118 AA427843 AW298659 BU188401 BM468459 
    BC034997 BF337232 CD558190 BE894576 BI552692 AV728449 AW090041 AV725636 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PMP2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                                          
    SP2:                                          
    SP3:              -                           


    ECgene alternative splicing isoforms for PMP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PMP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGAAAAAA
    PMP2 Expression
    About this image


    PMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
    PMP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PMP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.571512
        Custom PCR Arrays for PMP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PMP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pmp21 , 5 peripheral myelin protein 21, 5 86.36(n)1
    87.12(a)1
      3 (2.54 cM)5
    188571  NM_001030305.21  NP_001025476.11 
     101798515 
    chicken
    (Gallus gallus)
    Aves PMP21 peripheral myelin protein 2 75.25(n)
    80.3(a)
      420198  NM_001199476.1  NP_001186405.1 
    lizard
    (Anolis carolinensis)
    Reptilia PMP26
    peripheral myelin protein 2
    51(a)
    1 ↔ 1
    4(24499582-24504668)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005367881 myelin P2 protein-like 62.85(n)
    53.44(a)
      100536788  XM_003200614.2  XP_003200662.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lbp-91 lbp-9 52.34(n)
    42.19(a)
      178686  NM_001038423.3  NP_001033512.1 


    ENSEMBL Gene Tree for PMP2 (if available)
    TreeFam Gene Tree for PMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PMP2 gene
    FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  FABP32  RBP12  
    RBP22  CRABP12  FABP22  FABP72  RBP72  
    15 SIMAP similar genes for PMP2 using alignment to 2 protein entries:     MYP2_HUMAN (see all proteins):
    FABP3    DKFZp547J2313    FABP9    FABP4    FABP7    FABP12
    FABP5    FABP5P3    CRABP2    RBP1    RBP5    CRABP1
    FABP2    RBP7    RBP2

    PMP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PMP2 (see all 212)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876101251,2
    --82352125(+) GGGACA/CTTTAG 1 -- ds50010--------
    rs78218771,2
    C,F,A,H--82352251(+) gccatT/Ctatgg 1 -- ds500119Minor allele frequency- C:0.43NS EA NA WA CSA 2342
    rs726844381,2
    C--82352267(+) GAAACC/GAGTCG 1 -- ds50014Minor allele frequency- G:0.06CSA WA NA EA 360
    rs1403442071,2
    --82352269(+) AACCAA/GTCGTC 1 -- ds50010--------
    rs1120760901,2
    F--82352272(+) CAGTCG/ATCACT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs751730811,2
    F--82352293(+) TCTGCC/GACACC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1475742531,2
    C--82352325(+) TCCAG-/AACTGT 1 -- ds50010--------
    rs100904071,2
    C,F,A--82352341(+) ACAAAT/ATTCTG 1 -- ds50017Minor allele frequency- A:0.45NA WA CSA EA 365
    rs1925695571,2
    --82352492(+) AAATGA/TTTATT 1 -- ds50010--------
    rs1170544021,2
    C,F--82352552(+) AAAAGC/TACTCA 1 -- ds50011Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for PMP2 (82352561 - 82359758 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PMP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891065CNV Loss21882294
    nsv465721CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PMP2
    DNA2.0 Custom Variant and Variant Library Synthesis for PMP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 170715    OMIM disorders: --

    9 diseases for PMP2:    
    About MalaCards
    microsporidiosis    guillain-barre syndrome    neuritis    polyradiculoneuropathy
    encephalomyelitis    meningitis    neuropathy    ovarian cancer
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for PMP2:
    Neuritis     Microsporidiosis

    PMP2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for PMP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuritis 85.4 5 8694832 (1), 1381167 (1), 9584990 (1), 8381954 (1) (see all 5)
    guillain-barre syndrome 62.4 2 7689591 (1), 9455979 (1)
    paralysis 17.8 1 8881424 (1)
    necrosis 0 1 7685103 (1)
    tumors 0 1 7685103 (1)

    Genetic Association Database (GAD): PMP2

    Export disorders for PMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PMP2 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with PMP2)
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    1. Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin. (PubMed id 1720307)1, 2, 3 Hayasaka K....Uyemura K. (Biochem. Biophys. Res. Commun. 1991)
    2. Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2). (PubMed id 8288226)1, 3, 9 Hayasaka K....Shimizu N. (Genomics 1993)
    3. Structural and functional characterization of human peripheral nervous system myelin protein P2. (PubMed id 20421974)1, 2, 9 Majava V.... Kursula P. (PLoS ONE 2010)
    4. Partial structure and mapping of the human myelin P2 protein gene. (PubMed id 7525873)1, 2, 9 Narayanan V....Tennekoon G. (J. Neurochem. 1994)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The complete amino acid sequence of human P2 protein. (PubMed id 6183401)1, 2 Suzuki M.... Uyemura K. (J. Neurochem. 1982)
    7. Exonic SNPs at positions 220 (A/G) and 445 (C/T) of the peripheral myelin protein 2 (PMP2). (PubMed id 11241848)1, 9 BesanAson R....Vandenberghe A. (Hum. Mutat. 2001)
    8. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    10. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5375 HGNC: 9117 AceView: PMP2 Ensembl:ENSG00000147588 euGenes: HUgn5375
    ECgene: PMP2 H-InvDB: PMP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PMP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PMP2 gene:
    Search GeneIP for patents involving PMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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