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PML Gene

protein-coding   GIFtS: 69
GCID: GC15P074287

Promyelocytic Leukemia

  See PML-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Promyelocytic Leukemia1 2     TRIM192 3
MYL2 3 5     RING Finger Protein 712 3
Promyelocytic Leukemia Protein2 3     Probable Transcription Factor PML2
Tripartite Motif-Containing Protein 192 3     Promyelocytic Leukemia, Inducer Of2
PP86752 3     Protein PML2
RNF712 3     Tripartite Motif Protein TRIM192

External Ids:    HGNC: 91131   Entrez Gene: 53712   Ensembl: ENSG000001404647   OMIM: 1025785   UniProtKB: P295903   

Export aliases for PML gene to outside databases

Previous GC identifers: GC15P070307 GC15P067403 GC15P071862 GC15P072002 GC15P072074 GC15P051118


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PML Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein
localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is
cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the
translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL).
Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal
regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different
isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PML Gene:
PML (promyelocytic leukemia) is a protein-coding gene. Diseases associated with PML include leukemia, acute promyelocytic, pml/rara type, and acute promyelocytic leukemia. GO annotations related to this gene include transcription coactivator activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: PML_HUMAN, P29590
Function: Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular
processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response,
and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a
process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role
in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1
and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN,
and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation
and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of
TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex,
regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with
WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization
and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The
nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with
SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform
PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic
PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of
ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell
network formation and migration
Function: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or
several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of
p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of
virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus
particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis.
The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral
E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human
cytomegalovirus (HCMV) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and
isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear
sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against
poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the
PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator,
bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV)
production and isoform PML-2 may enhance adenovirus transcription

Gene Wiki entry for PML (Promyelocytic leukemia protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PML gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PML promoter sequence
   Search Chromatin IP Primers for PML

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PML


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

PML Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PML gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P074287:  view genomic region     (about GC identifiers)

Start:
74,287,014 bp from pter      End:
74,340,160 bp from pter
Size:
53,147 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PML_HUMAN, P29590 (See protein sequence)
Recommended Name: Protein PML  
Size: 882 amino acids; 97551 Da
Subunit: Key component of PML bodies. PML bodies are formed by the interaction of PML homodimers (via SUMO-binding
motif) with sumoylated PML, leading to the assembly of higher oligomers. Several types of PML bodies have been
observed. PML bodies can form hollow spheres that can sequester target proteins inside. Interacts (via
SUMO-binding motif) with sumoylated proteins. Interacts (via C-terminus) with p53/TP53. Recruits p53/TP53 and
CHEK2 into PML bodies, which promotes p53/TP53 phosphorylation at 'Ser-20' and prevents its proteasomal
degradation. Interacts with MDM2, and sequesters MDM2 in the nucleolus, thereby preventing ubiquitination of
p53/TP53. Interaction with PML-RARA oncoprotein and certain viral proteins causes disassembly of PML bodies and
abolishes the normal PML function. Interacts with HIPK2, TERT, SIRT1, TOPBP1, TRIM27 and TRIM69. Interacts with
ELF4 (via C-terminus). Interacts with Lassa virus Z protein and rabies virus phosphoprotein. Interacts with
ITPR3. Interacts (in the cytoplasm) with TGFBR1, TGFBR2 and PKM. Interacts (via the coiled-coil domain and when
sumoylated) with SATB1. Interacts with UBE2I; the interaction is enhanced by arsenic binding. Interacts (PML-RARA
oncoprotein, via the coiled-coil domain) with UBE2I; the interaction is enhanced by arsenic binding and is
required for PML-RARA oncoprotein sumoylation and inhibition of RARA transactivational activity. Interacts with
RB1, PPP1A, SMAD2, SMAD3, DAXX, RPL11 and MTOR. Interacts with PPARGC1A and KAT2A. Interacts with CSNK2A1 and
CSNK2A3. Interacts with ANKRD2; the interaction is direct. Isoform PML-1, isoform PML-2, isoform PML-3, isoform
PML-4, isoform PML-5 and isoform PML-6 interact with RNF4. Isoform PML-1 interacts with NLRP3. Isoform PML-1,
isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5 interact with MAGEA2, RBL2, PER2 and E2F4. Isoform
PML-2 interacts with CIITA. Isoform PML-2, isoform PML-3 and isoform PML-4 interact with TBX2. Isoform PML-4
interacts with RANBP2, HDAC7, KAT6A, WRN, PIN1, TBX3 and phosphorylated MAPK1/ERK2. Isoform PML-4 interacts with
the CTNNB1 and TCF7L2/TCF4 complex. Isoform PML-4 preferentially interacts with MAPK7/BMK1 although other
isoforms (isoform PML-1, isoform PML-2, isoform PML-3 and isoform PML-6) also interact with it. Isoform PML-12
interacts with PIAS1, PIAS2 (isoform PIAS2-alpha) and CSNK2A1/CK2. Isoform PML-3 interacts with HFV bel1/tas and
bet. Isoform PML-4 interacts with VZV capsid protein VP26/ORF23 capsid protein. Ths sumoylated isoform PML-4
interacts with encephalomyocarditis virus (EMCV) RNA-directed RNA polymerase 3D-POL (P3D-POL). Isoform PML-1
interacts with herpes simplex virus-1 (HHV-1) ICP0. Isoform PML-2 interacts with human adenovirus 2 E1A and this
interaction stimulates E1A-dependent transcriptional activation. Isoform PML-6 interacts with moloney murine
leukemia virus (MoMLV) integrase (IN) and reverse transcriptase (RT)
Sequence caution: Sequence=AAA60351.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA60352.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA60388.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA60390.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAB62809.1; Type=Miscellaneous discrepancy;
Note=Chimeric cDNA; Sequence=BAD92648.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for PML:
1BOR (3D)    
Secondary accessions: E9PBR7 P29591 P29592 P29593 Q00755 Q15959 Q59FP9 Q8WUA0 Q96S41 Q9BPW2
Q9BWP7 Q9BZX6 Q9BZX7 Q9BZX8 Q9BZX9 Q9BZY0 Q9BZY2 Q9BZY3
Alternative splicing: 12 isoforms:  P29590-1   P29590-8   P29590-9   P29590-5   P29590-2   P29590-4   P29590-10   P29590-3   
P29590-11   P29590-12   P29590-13   P29590-14   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PML: NX_P29590

Explore proteomics data for PML at MOPED

Post-translational modifications: 

  • Ubiquitinated; mediated by RNF4, UHRF1, UBE3A/E6AP, KLHL20-based E3 ligase complex, SIAH1 or SIAH2 and leading to
    subsequent proteasomal degradation. Ubiquitination by KLHL20-based E3 ligase complex requires CDK1/2-mediated
    phosphorylation at Ser-518 which in turn is recognized by prolyl-isopeptidase PIN1 and PIN1-catalyzed
    isomerization further potentiates PML interaction with KLHL20. 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked
    polyubiquitination by RNF4 is polysumoylation-dependent1
  • Sumoylation regulates PML's: stability in response to extracellular or intracellular stimuli, transcription
    directly and indirectly, through sequestration of or dissociation of the transcription factors from PML-NBs,
    ability to regulate apoptosis and its anti-viral activities. It is also essential for: maintaining proper PML
    nuclear bodies (PML-NBs) structure and normal function, recruitment of components of PML-NBs, the turnover and
    retention of PML in PML-NBs and the integrity of PML-NBs. Undergoes 'Lys-11'-linked sumoylation. Sumoylation on
    all three sites (Lys-65, Lys-160 and Lys-490) is required for nuclear body formation. Sumoylation on Lys-160 is a
    prerequisite for sumoylation on Lys-65. Lys-65 and Lys-160 are sumoylated by PISA1 and PIAS2. PIAS1-mediated
    sumoylation of PML promotes its interaction with CSNK2A1/CK2 and phosphorylation at Ser-565 which in turn
    triggers its ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML-RARA promotes its
    ubiquitin-mediated degradation. The PML-RARA fusion protein requires the coiled-coil domain for sumoylation.
    Sumoylation at Lys-490 by RANBP2 is essential for the proper assembly of PML-NBs. DNA damage triggers its
    sumoylation while some but not all viral infections can abolish sumoylation. Desumoylated by SENP1, SENP2, SENP3,
    SENP5 and SENP6. Arsenic induces PML and PML-RARA polysumoylation and their subsequent RNF4-dependent
    ubiquitination and proteasomal degradation, and is used as treatment in acute promyelocytic leukemia (APL). The
    nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6)
    show an increased sumoylation in response to arsenic trioxide. The cytoplasmic isoform PML-7 is not sumoylated1
  • Phosphorylation is a major regulatory mechanism that controls PML protein abundance and the number and size of PML
    nuclear bodies (PML-NBs). Phosphorylated in response to DNA damage, probably by ATR. HIPK2-mediated
    phosphorylation at Ser-8, Ser-36 and Ser-38 leads to increased accumulation of PML protein and its sumoylation
    and is required for the maximal pro-apoptotic activity of PML after DNA damage. CHEK2-mediated phosphorylation at
    Ser-117 is important for PML-mediated apopotosis following DNA damage. MAPK1-mediated phosphorylations at
    Ser-403, Ser-505, Ser-527 and Ser-530 and CDK1/2-mediated phosphorylation at Ser-518 promote PIN1-dependent PML
    degradation. CK2-mediated phosphorylation at Ser-565 primes PML ubiquitination via an unidentified ubiquitin
    ligase1
  • Acetylation at Lys-487 is essential for its nuclear localization. Deacetylated at Lys-487 by SIRT1 and this
    deacetylation promotes PML control of PER2 nuclear localization1
  • Ubiquitination2 at Lys380, Lys394, Lys400, Lys401, Lys426, Lys476, Lys623
  • Modification sites at PhosphoSitePlus

  • See PML Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_002666.1  NP_150241.2  NP_150242.1  NP_150243.2  NP_150247.2  NP_150249.1  NP_150250.2  NP_150252.1  
    NP_150253.2  

    ENSEMBL proteins: 
     ENSP00000378567   ENSP00000378564   ENSP00000268059   ENSP00000315434   ENSP00000268058  
     ENSP00000455838   ENSP00000455612   ENSP00000456486   ENSP00000456277   ENSP00000394642  
     ENSP00000395576   ENSP00000457023   ENSP00000353004   ENSP00000457032   ENSP00000456989  
     ENSP00000457669   ENSP00000458061   ENSP00000456329  
    Reactome Protein details: P29590

    PML Human Recombinant Protein Products:

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    Novus Biologicals PML Protein
    Novus Biologicals PML Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PML

     
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    antibodies-online proteins for PML (5 products) 

     
    antibodies-online peptides for PML

    PML Antibody Products:

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    Abcam antibodies for PML (P29590, P10276)
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    ThermoFisher Antibodies for PML
    antibodies-online antibodies for PML (123 products) 

    PML Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PML
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    Search eBioscience for ELISAs for PML 
    antibodies-online kits for PML (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR021978 DUF3583
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry P29590

    ProtoNet protein and cluster: P29590

    2 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: PML_HUMAN, P29590
    Domain: The coiled-coil domain mediates a strong homo/multidimerization activity essential for core assembly of
    PML-NBs. Interacts with PKM via its coiled-coil domain (PubMed:18298799)
    Domain: The B box-type zinc binding domain and the coiled-coil domain mediate its interaction with PIAS1
    (PubMed:22406621)
    Domain: Binds arsenic via the RING-type zinc finger. The RING-type zinc finger is essential for its interaction
    with HFV bel1/tas (PubMed:11432836)
    Domain: The unique C-terminal domains of isoform PML-2 and isoform PML-5 play an important role in regulating the
    localization, assembly dynamics, and functions of PML-NBs (PubMed:22773875)
    Domain: The Sumo interaction motif (SIM) is required for efficient ubiquitination, recruitment of proteasome
    components within PML-NBs and PML degradation in response to arsenic trioxide (PubMed:23028697)
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with PML           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PML_HUMAN, P29590
    Function: Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular
    processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response,
    and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a
    process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role
    in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1
    and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN,
    and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation
    and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of
    TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex,
    regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with
    WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization
    and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The
    nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with
    SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform
    PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic
    PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of
    ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell
    network formation and migration
    Function: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or
    several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of
    p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of
    virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus
    particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis.
    The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral
    E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human
    cytomegalovirus (HCMV) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and
    isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear
    sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against
    poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the
    PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator,
    bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV)
    production and isoform PML-2 may enhance adenovirus transcription
    Induction: By interferons alpha, beta and gamma. Up-regulated by IRF3 and p53/TP53

         Genatlas biochemistry entry for PML:
    POD (promyelocytic oncogenic domain),nuclear matrix protein,B box family, colocalizing and interacting with
    CREBBP,TIF2A and with DAXX in special (PML/SP100) nuclear bodies(NB/POD), to form a retinoic acid (RA) dependent
    growth suppressive RRXA,RARA nuclear complex,involved in development,recombinaison,DNA repair,and in early
    hematopoiesis and late erythropoiesis,recruiting the nuclear corepressor histone deacetylase complex,essential
    for multiple apoptotic pathways,putative controller of genes devoted to MHC class I antigen presentation.

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity IDA11080164
    GO:0005515protein binding IPI10597310
    GO:0008270zinc ion binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI12915590
         
    Find genes that share ontologies with PML           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PML:
     Decreased viability of wild-ty  Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pml):
     cellular  hematopoietic system  immune system  mortality/aging  no phenotypic analysis 
     normal  tumorigenesis 

    Find genes that share phenotypes with PML           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pmltm1Ppp for PML

       genOway: Develop your customized and physiologically relevant rodent model for PML

    miRNA
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    miRTarBase miRNAs that target PML:
    hsa-mir-378a-3p (MIRT043919), hsa-mir-423-3p (MIRT042535), hsa-mir-335-5p (MIRT018318)

    Block miRNA regulation of human, mouse, rat PML using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PML (see all 14):
    hsa-miR-1266 hsa-miR-323b-3p hsa-miR-133b hsa-miR-221* hsa-miR-124 hsa-miR-214 hsa-miR-149 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidPML 3' UTR sequence
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    eBioscience FlowRNA Probe Sets ( VA1-12243) for PML 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PML_HUMAN, P29590: Nucleus. Nucleus, nucleoplasm. Cytoplasm. Nucleus, PML body. Nucleus, nucleolus. Endoplasmic
    reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Early endosome membrane;
    Peripheral membrane protein; Cytoplasmic side. Note=Isoform PML-1 can shuttle between the nucleus and cytoplasm.
    Isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform
    PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms. Detected in the
    nucleolus after DNA damage. Acetylation at Lys-487 is essential for its nuclear localization. Within the nucleus,
    most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in
    the matrix-associated nuclear bodies (PML-NBs). The transfer of PML from the nucleoplasm to PML-NBs depends on
    its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the localization in
    PML-NBs. Also found in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect
    the endoplasmic reticulum (ER) and the mitochondria. Sequestered in the cytoplasm by interaction with rabies
    virus phosphoprotein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA16778193

    Find genes that share ontologies with PML           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PML About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Proteolysis Putative SUMO 1 pathway
    DNA damage Role of SUMO in p53 regulation0.33
    Proteolysis Putative SUMO 1 pathway0.33
    3Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    4Apoptotic Pathways in Synovial Fibroblasts
    Cellular Apoptosis Pathway0.85
    5Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69


    Find genes that share SuperPaths with PML           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PML
        p53 Signaling
    Cellular Apoptosis Pathway
    SUMO Pathway

    3 GeneGo (Thomson Reuters) Pathways for PML
        Proteolysis Putative SUMO-1 pathway
    DNA damage Role of SUMO in p53 regulation
    Immune response IFN alpha/beta signaling pathway

    Selected BioSystems Pathways for PML (see all 7)
        DNA damage response
    Integrated Breast Cancer Pathway
    TNF-alpha/NF-kB Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    mTOR signaling pathway

    1 Reactome Pathway for PML
        Interferon gamma signaling


    Selected Kegg Pathways  (Kegg details for PML) (see all 7):
        Ubiquitin mediated proteolysis
    Endocytosis
    Influenza A
    Herpes simplex infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PML: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PML

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PML (P295901, 2, 3 ENSP000002680584) via UniProtKB, MINT, STRING, and/or I2D (see all 218)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-295890,EBI-389668 MINT-4793330 MINT-4793420 MINT-4793448 I2D: score=5 STRING: ENSP00000417281
    TP53P046371, 2, 3, ENSP000002693054EBI-295890,EBI-366083 MINT-4793478 MINT-4793489 I2D: score=5 STRING: ENSP00000269305
    ENSG00000231617Q9UER71, 3, ENSP000004046234EBI-295890,EBI-77321 I2D: score=6 STRING: ENSP00000404623
    ENSG00000206206Q9UER71, 3EBI-295890,EBI-77321 I2D: score=6 
    ENSG00000206279Q9UER71, 3EBI-295890,EBI-77321 I2D: score=6 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 58):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA16915281
    GO:0001932regulation of protein phosphorylation ISS--
    GO:0002230positive regulation of defense response to virus by host IMP16873256
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IMP--

    Find genes that share ontologies with PML           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PML

    Selected Novoseek inferred chemical compound relationships for PML gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 87.5 151 16740359 (5), 8400236 (4), 15529177 (3), 7784078 (3) (see all 99)
    alpha-retinoic acid 81.6 3 8396481 (1), 8207983 (1), 7815831 (1)
    arsenite 72 10 16891316 (3), 12667397 (2), 19380586 (1), 18413806 (1)
    pic 1 68.3 3 9658103 (2), 10187798 (1)
    retinoid 65.1 3 8916959 (1), 8649787 (1), 8704214 (1)
    glutamine 21.4 4 12430715 (2), 16409557 (1), 15977647 (1)
    zinc 17.2 9 12794076 (2), 12759344 (1), 17988991 (1), 10938104 (1) (see all 8)
    etoposide 14.5 4 9209367 (1)
    lysine 13 2 20205709 (1)
    bromodeoxyuridine 11.5 1 12773567 (1)

    2 PharmGKB related drug/compound annotations for PML gene    About this table
    Drug/compound PharmGKB Annotation
    arsenic trioxide
    tretinoin



    Find genes that share compounds with PML           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PML gene (9 alternative transcripts): 
    NM_002675.3  NM_033238.2  NM_033239.2  NM_033240.2  NM_033244.3  NM_033246.2  NM_033247.2  NM_033249.2  
    NM_033250.2  

    Unigene Cluster for PML:

    Promyelocytic leukemia
    Hs.526464  [show with all ESTs]
    Unigene Representative Sequence: NM_033238
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000395135(uc002awq.3 uc002awr.3 uc002aws.3 uc002awt.3)
    ENST00000395132(uc002awp.3) ENST00000268059(uc002awk.3 uc002awn.3)
    ENST00000354026(uc002awo.3) ENST00000268058 ENST00000565898(uc002awu.3 uc002awv.3 uc010ule.2)
    ENST00000569477 ENST00000569965 ENST00000567543 ENST00000436891(uc002awx.3)
    ENST00000435786(uc002awm.3 uc002awl.3) ENST00000564428 ENST00000359928
    ENST00000563500(uc002awj.1 uc002awy.3) ENST00000564725(uc002aww.1)
    ENST00000569161 ENST00000565239 ENST00000567606
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PML (see all 14):
    hsa-miR-1266 hsa-miR-323b-3p hsa-miR-133b hsa-miR-221* hsa-miR-124 hsa-miR-214 hsa-miR-149 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidPML 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PML
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    OriGene ORF clones in mouse, rat for PML
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    GenScript: all cDNA clones in your preferred vector (see all 9): PML (NM_033244)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PML
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PML
    Addgene plasmids for PML 
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    OriGene qSTAR qPCR primer pairs in human, mouse for PML
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PML
      QuantiTect SYBR Green Assays in human, mouse, rat PML
      QuantiFast Probe-based Assays in human, mouse, rat PML
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12243) for PML 

    Additional mRNA sequence: 

    AB067754.1 AB208950.1 AB209051.1 AB209411.1 AF230401.1 AF230402.1 AF230403.1 AF230404.1 
    AF230405.1 AF230406.1 AF230407.1 AF230408.1 AF230409.1 AF230410.1 AF230411.1 AF370432.1 
    AF388193.1 AF388194.1 AK026871.1 AK300256.1 AK300951.1 BC000080.2 BC020994.2 BC034251.1 
    BC139795.1 BT009911.1 BX647287.1 M73778.1 M79462.1 M79463.1 M79464.1 M80185.1 
    S50913.1 X63131.1 

    24 DOTS entries:

    DT.97791923  DT.447813  DT.100792863  DT.100792859  DT.91792314  DT.91783610  DT.97787374  DT.210086 
    DT.317724  DT.102827730  DT.91836290  DT.100792858  DT.92352534  DT.100792875  DT.91722067  DT.100792857 
    DT.101959716  DT.97772804  DT.100718623  DT.100792873  DT.100792874  DT.92011830  DT.92362935  DT.99993975 

    Selected AceView cDNA sequences (see all 298):

    BU753248 BQ642940 CA487430 BI793248 BX647287 CF272229 BE336744 BI757312 
    BQ642937 CR602508 NM_033249 AI160099 BQ919042 NM_033240 BM917894 BM469516 
    BI962511 BI963945 BQ438276 NM_002675 AI469853 AA312138 BI962969 AI146508 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PML (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^
    SP1:                                                                                      -           -     -     -     -     -     -     -           -     -   
    SP2:                                                                                      -           -     -     -     -     -     -     -                     
    SP3:                                                                          -           -           -     -     -     -     -     -     -           -     -   
    SP4:                                                                                      -           -                                                         
    SP5:                                                                                                  -     -     -     -     -     -     -                     

    ExUns: 10a · 10b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for PML

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PML expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PML Expression
    About this image


    PML expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    PML Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PML Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.526464
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PML: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PML
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PML

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PML gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pml1 , 5 promyelocytic leukemia1, 5 77.71(n)1
    71.33(a)1
      9 (31.63 cM)5
    188541  NM_178087.41  NP_835188.21 
     582180765 
    chicken
    (Gallus gallus)
    Aves LOC1008575631 protein PML-like 54.29(n)
    40.29(a)
      100857563  XM_004943698.1  XP_004943755.1 


    ENSEMBL Gene Tree for PML (if available)
    TreeFam Gene Tree for PML (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PML gene
    2 SIMAP similar genes for PML using alignment to 8 protein entries:     PML_HUMAN (see all proteins):
    promyelocytic leukemia protein    PML-RAR

    Find genes that share paralogs with PML           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PML (see all 1092)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903575291,2
    --51117006(+) ATCTTC/TTCCAG 9 -- us2k10--------
    rs792336081,2
    C,F--51117012(+) TCCAGG/AATCAA 9 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1810660111,2
    --51117091(+) CTTTGC/GGTTTC 9 -- us2k10--------
    rs1379040231,2
    --51117113(+) GTCTGC/TAAATT 9 -- us2k10--------
    rs780071071,2
    C,F--51117201(+) GGCCTG/AGCCAG 9 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1424398641,2
    C--51117204(+) CTGGCC/GAGGTC 9 -- us2k10--------
    rs734397051,2
    C,F--51117322(+) CAGAGC/TTACAT 9 -- us2k13Minor allele frequency- T:0.14WA CSA 122
    rs1853131801,2
    --51117365(+) AGGCCA/CTCAGT 9 -- us2k10--------
    rs1459762681,2
    --51117661(+) TTTGGC/TTTTCA 9 -- us2k10--------
    rs2012290761,2
    --51117870(+) GTACA-/CA    
       GGAGC
    CAGCA
    9 -- us2k10--------

    HapMap Linkage Disequilibrium report for PML (74287014 - 74340160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PML:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509575CNV Insertion20534489
    nsv457203CNV Loss19166990
    nsv469619CNV Loss16826518
    nsv510666CNV Loss20534489
    nsv518316CNV Gain19592680
    nsv817697CNV Gain17921354
    nsv833052CNV Gain+Loss17160897
    nsv428308CNV Gain+Loss18775914
    dgv756e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): PML
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PML
    DNA2.0 Custom Variant and Variant Library Synthesis for PML

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 102578    OMIM disorders: --

    UniProtKB/Swiss-Prot: PML_HUMAN, P29590
  • Note=A chromosomal aberration involving PML may be a cause of acute promyelocytic leukemia (APL).
    Translocation t(15;17)(q21;q21) with RARA. The PML breakpoints (type A and type B) lie on either side of an
    alternatively spliced exon

  • 4 diseases for PML:    
    About MalaCards
    leukemia, acute promyelocytic, pml/rara type    acute promyelocytic leukemia    leukemia    neuronal intranuclear inclusion disease

    1 disease from the University of Copenhagen DISEASES database for PML:
    Leukemia

    Find genes that share disorders with PML           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PML gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 96.3 303 11511788 (3), 16154611 (2), 19380586 (2), 8550548 (2) (see all 99)
    leukemia promyelocytic acute 95.6 154 1310060 (2), 1353379 (2), 9452416 (2), 11068554 (2) (see all 99)
    leukemogenesis 72.4 8 8580793 (1), 18809579 (1), 8609713 (1), 8400236 (1) (see all 7)
    leukemia 68.7 64 19088278 (2), 9591778 (2), 9734655 (2), 18716620 (2) (see all 45)
    minimal residual disease 60.9 4 1310060 (1), 1375840 (1), 8180596 (1), 9260053 (1)
    bloom syndrome 58.3 2 10637504 (1)
    drpla 43.3 1 12901837 (1)
    biliary cirrhosis primary 31.8 6 9362351 (2), 8986606 (1), 9193756 (1), 8749719 (1)
    tumors 30.2 88 14970276 (8), 18566754 (6), 18856066 (3), 19652541 (2) (see all 32)
    herpes simplex 29.4 11 19279115 (2), 10574707 (1), 10233977 (1), 9151854 (1) (see all 9)

    Genatlas disease: PML
    acute promyelocytic leukemia (APL) with translocation t(15;17)(q22;q12) and with poor prognosis,may be associated
    with a hemorrhagic diathesis,secundary to an overexpression of annexin II with a secundary itinease of plasmin
    (see RARA)

    Genetic Association Database (GAD): PML
    Human Genome Epidemiology (HuGE) Navigator: PML (24 documents)
    Tumor Gene Database (TGDB): PML

    Export disorders for PML gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PML gene, integrated from 10 sources (see all 716) (see top 10):
    (articles sorted by number of sources associating them with PML)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PML colocalizes with and stabilizes the DNA damage response protein TopBP1. (PubMed id 12773567)1, 2, 9 Xu Z.-X.... Chang K.-S. (Mol. Cell. Biol. 2003)
    2. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. (PubMed id 10684855)1, 2, 9 Zhong S....Pandolfi P.P. (J. Exp. Med. 2000)
    3. PML protein isoforms and the RBCC/TRIM motif. (PubMed id 11704850)1, 2, 9 Jensen K.... Freemont P.S. (Oncogene 2001)
    4. The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. (PubMed id 12810724)1, 2, 9 Louria-Hayon I....Haupt Y. (J. Biol. Chem. 2003)
    5. Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. (PubMed id 1311253)1, 2, 9 Kastner P.... Chambon P. (EMBO J. 1992)
    6. Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. (PubMed id 9570750)1, 2, 9 Cao T.... Etkin L.D. (J. Cell Sci. 1998)
    7. PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. (PubMed id 15467728)1, 2, 9 Daniels M.J.... Venkitaraman A.R. (Nat. Struct. Mol. Biol. 2004)
    8. The function of PML in p53-dependent apoptosis. (PubMed id 11025664)1, 2, 9 Guo A.... Pandolfi P.P. (Nat. Cell Biol. 2000)
    9. Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection. (PubMed id 17942542)1, 2, 9 Tavalai N.... Stamminger T. (J. Virol. 2008)
    10. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. (PubMed id 18716620)1, 2, 9 Song M.S.... Pandolfi P.P. (Nature 2008)
    11. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. (PubMed id 15136035)1, 2, 9 Kojic S....Faulkner G. (J. Mol. Biol. 2004)
    12. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. (PubMed id 12006491)1, 2, 9 Langley E.... Kouzarides T. (EMBO J. 2002)
    13. Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein. (PubMed id 14976184)1, 2, 9 Suico M.A.... Kai H. (J. Biol. Chem. 2004)
    14. Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants. (PubMed id 1312695)1, 2, 9 Tong J.H.... Berger R. (Oncogene 1992)
    15. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. (PubMed id 1720570)1, 2, 9 Goddard A.D.... Solomon E. (Science 1991)
    16. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. (PubMed id 1652368)1, 2, 9 Kakizuka A.... Evans R.M. (Cell 1991)
    17. Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human. (PubMed id 23430110)1, 2 Lo Y.H.... Lai M.Z. (Blood 2013)
    18. The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription. (PubMed id 23135708)1, 2 Berscheminski J.... Schreiner S. (J. Virol. 2013)
    19. PML tumor suppressor protein is required for HCV production. (PubMed id 23219818)1, 2 Kuroki M.... Kato N. (Biochem. Biophys. Res. Commun. 2013)
    20. The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. (PubMed id 22945642)1, 2 Guan D.... Kao H.Y. (Oncogene 2012)
    21. The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. (PubMed id 22406621)1, 2 Rabellino A....Scaglioni P.P. (Cancer Res. 2012)
    22. Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms. (PubMed id 23028697)1, 2 Maroui M.A....Chelbi-Alix M.K. (PLoS ONE 2012)
    23. Contribution of the C-terminal regions of promyelocytic leukemia protein (PML) isoforms II and V to PML nuclear body formation. (PubMed id 22773875)1, 2 Geng Y.... Tang J. (J. Biol. Chem. 2012)
    24. Beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. (PubMed id 22155184)1, 2 Satow R.... Yamada T. (Gastroenterology 2012)
    25. MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs. (PubMed id 22117195)1, 2 Peche L.Y.... Schneider C. (Cell Death Differ. 2012)
    26. Herpes simplex virus 1 ubiquitin ligase ICP0 interacts with PML isoform I and induces its SUMO-independent degradation. (PubMed id 22875967)1, 2 Cuchet-Lourenco D.... Everett R.D. (J. Virol. 2012)
    27. A metabolic prosurvival role for PML in breast cancer. (PubMed id 22886304)1, 2 Carracedo A.... Pandolfi P.P. (J. Clin. Invest. 2012)
    28. Role of the promyelocytic leukaemia protein in cell death regulation. (PubMed id 22237204)1, 2 Salomoni P.... Michod D. (Cell Death Dis. 2012)
    29. Promyelocytic leukemia protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor alpha (TNFalpha) and interferon alpha (IFNalpha). (PubMed id 22589541)1, 2 Cheng X.... Kao H.Y. (J. Biol. Chem. 2012)
    30. PML promotes MHC class II gene expression by stabilizing the class II transactivator. (PubMed id 23007646)1, 2 Ulbricht T.... Hemmerich P. (J. Cell Biol. 2012)
    31. The role of PML in the nervous system. (PubMed id 21161613)1, 2 Salomoni P. and Betts-Henderson J. (Mol. Neurobiol. 2011)
    32. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. (PubMed id 21148299)1, 2 Hattersley N.... Hay R.T. (Mol. Biol. Cell 2011)
    33. Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against Varicella-Zoster virus. (PubMed id 21304940)1, 2 Reichelt M.... Arvin A.M. (PLoS Pathog. 2011)
    34. Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in gamma- irradiation-induced DNA damage responses. (PubMed id 21639834)1, 2 Liu J.... Sun Z. (Biokhimiia 2011)
    35. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. (PubMed id 21623375)1, 4 Albagha O.M....Ralston S.H. (Nat. Genet. 2011)
    36. Role of promyelocytic leukemia protein in host antiviral defense. (PubMed id 21198351)1, 2 Geoffroy M.C. and Chelbi-Alix M.K. (J. Interferon Cytokine Res. 2011)
    37. PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication. (PubMed id 21172801)1, 2 Cuchet D.... Everett R.D. (J. Cell Sci. 2011)
    38. Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies. (PubMed id 21994459)1, 2 Maroui M.A.... Chelbi-Alix M.K. (J. Virol. 2011)
    39. Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover. (PubMed id 22033920)1, 2 Lim J.H.... Kao H.Y. (J. Biol. Chem. 2011)
    40. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    41. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. (PubMed id 20625391)1, 2 Hung M.S.... You L. (PLoS ONE 2010)
    42. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    43. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    44. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    45. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    46. PML-IV functions as a negative regulator of telomerase by interacting with TERT. (PubMed id 19567472)1, 2 Oh W.... Song J. (J. Cell Sci. 2009)
    47. Differential suppressive effect of promyelocytic leukemia protein on the replication of different subtypes/strains of influenza A virus. (PubMed id 19703418)1, 2 Li W.... Li K. (Biochem. Biophys. Res. Commun. 2009)
    48. PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage. (PubMed id 19015637)1, 2 Gresko E.... Schmitz M.L. (Oncogene 2009)
    49. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    50. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. (PubMed id 18408734)1, 2 Tatham M.H.... Hay R.T. (Nat. Cell Biol. 2008)
    51. Acetylation of PML is involved in histone deacetylase inhibitor- mediated apoptosis. (PubMed id 18621739)1, 2 Hayakawa F.... Naoe T. (J. Biol. Chem. 2008)
    52. Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein. (PubMed id 18298799)1, 2 Shimada N.... Ishii S. (Genes Cells 2008)
    53. Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. (PubMed id 17173041)1, 2 Kumar P.P....Galande S. (Nat. Cell Biol. 2007)
    54. Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense. (PubMed id 16912307)1, 2 Pampin M.... Chelbi-Alix M.K. (J. Virol. 2006)
    55. Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. (PubMed id 17030982)1, 2 Dellaire G....Bazett-Jones D.P. (J. Cell Biol. 2006)
    56. The mechanisms of PML-nuclear body formation. (PubMed id 17081985)1, 2 Shen T.H.... Pandolfi P.P. (Mol. Cell 2006)
    57. Characterization of endogenous human promyelocytic leukemia isoforms. (PubMed id 16778193)1, 2 Condemine W.... de The H. (Cancer Res. 2006)
    58. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    59. [Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia]. (PubMed id 15968309)1, 4 Zhu Y.L....Liu J. (Beijing Da Xue Xue Bao 2005)
    60. Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation. (PubMed id 15809060)1, 2 Kim Y.E.... Ahn J.H. (Biochem. Biophys. Res. Commun. 2005)
    61. Cytoplasmic PML function in TGF-beta signalling. (PubMed id 15356634)1, 2 Lin H.K.... Pandolfi P.P. (Nature 2004)
    62. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. (PubMed id 15195100)1, 2 Bernardi R....Pandolfi P.P. (Nat. Cell Biol. 2004)
    63. The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome. (PubMed id 14645235)1, 2 Fanelli M.... Minucci S. (J. Biol. Chem. 2004)
    64. Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: structure of the fusion point in a case lacking classic t(15;17) translocation. (PubMed id 12691149)1, 2 Fujita K....Omine M. (Leuk. Lymphoma 2003)
    65. SUMO-1 protease-1 regulates gene transcription through PML. (PubMed id 12419228)1, 2 Best J.L.... Zon L.I. (Mol. Cell 2002)
    66. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. (PubMed id 12402044)1, 2 Yang S.... Kim M.K. (Nat. Cell Biol. 2002)
    67. PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator. (PubMed id 11432836)1, 2 Regad T....Chelbi-Alix M.K. (EMBO J. 2001)
    68. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2 Reymond A.... Ballabio A. (EMBO J. 2001)
    69. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. (PubMed id 10669754)1, 2 Li H.... Chen J.D. (Mol. Cell. Biol. 2000)
    70. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. (PubMed id 10610177)1, 2 Zhong S.... Pandolfi P.P. (Nat. Genet. 1999)
    71. Identification of three major sentrinization sites in PML. (PubMed id 9756909)1, 2 Kamitani T....Yeh E.T.H. (J. Biol. Chem. 1998)
    72. An arenavirus RING (zinc-binding) protein binds the oncoprotein promyelocyte leukemia protein (PML) and relocates PML nuclear bodies to the cytoplasm. (PubMed id 9420283)1, 2 Borden K.L.... Salvato M.S. (J. Virol. 1998)
    73. The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. (PubMed id 7729428)1, 2 Borden K.L.B.... Freemont P.S. (EMBO J. 1995)
    74. The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. (PubMed id 1652369)1, 2 de The H.... Dejean A. (Cell 1991)
    75. Role of SUMO in RNF4-mediated promyelocytic leukemia protein (PML) degradation: sumoylation of PML and phospho-switch control of its SUMO binding domain dissected in living cells. (PubMed id 19380586)1, 9 Percherancier Y....Aubry M. (J. Biol. Chem. 2009)
    76. Loss of the tumor suppressor PML in human cancers of multiple histologic origins. (PubMed id 14970276)1, 9 Gurrieri C....Pandolfi P.P. (J. Natl. Cancer Inst. 2004)
    77. The PML gene is not involved in the regulation of MHC class I expression in human cell lines. (PubMed id 12506025)1, 9 Bruno S....Ciccone E. (Blood 2003)
    78. Physical and functional interactions between PML and MDM2. (PubMed id 12759344)1, 9 Wei X....Maki C.G. (J. Biol. Chem. 2003)
    79. Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins. (PubMed id 12186918)1, 9 Lopez P....Roizman B. (J. Virol. 2002)
    80. Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells. (PubMed id 18039859)1, 9 Reineke E.L....Kao H.Y. (Mol. Cell. Biol. 2008)
    81. Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase. (PubMed id 15273249)1, 9 Shin J....Ahn K. (J. Biol. Chem. 2004)
    82. Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1. (PubMed id 20100838)1, 9 Reineke E.L....Kao H.Y. (J. Biol. Chem. 2010)
    83. Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation. (PubMed id 18625722)1, 9 Gao C....Kao H.Y. (Mol. Cell. Biol. 2008)
    84. PML enhances the regulation of p53 by CK1 in response to DNA damage. (PubMed id 18246126)1, 9 Alsheich-Bartok O....Haupt Y. (Oncogene 2008)
    85. Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3. (PubMed id 15940266)1, 9 Fu C....Yao X. (Oncogene 2005)
    86. Opposing effects of PML and PML/RAR alpha on STAT3 activity. (PubMed id 12506013)1, 9 Kawasaki A....Kanakura Y. (Blood 2003)
    87. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. (PubMed id 10525530)1, 9 Ishov A.M....Maul G.G. (J. Cell Biol. 1999)
    88. PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells. (PubMed id 17428679)1, 9 JanderovA!-RossmeislovA! L....HodnA1 Z. (J. Struct. Biol. 2007)
    89. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. (PubMed id 9452416)1, 9 Kamitani T....Yeh E.T. (J. Biol. Chem. 1998)
    90. Cell-cycle regulation and dynamics of cytoplasmic compartments containing the promyelocytic leukemia protein and nucleoporins. (PubMed id 19339552)1, 9 Jul-Larsen A....e S.O. (J. Cell. Sci. 2009)
    91. The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. (PubMed id 11575918)1, 9 Kentsis A....Borden K.L. (J. Mol. Biol. 2001)
    92. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. (PubMed id 11259576)1, 9 Wu W.S....Chang K.S. (Mol. Cell. Biol. 2001)
    93. REGgamma/PA28gamma proteasome activator interacts with PML and Chk2 and affects PML nuclear bodies number. (PubMed id 19556897)1, 9 Zannini L....Delia D. (Cell Cycle 2009)
    94. CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor. (PubMed id 18566754)1, 9 Scaglioni P.P....Pandolfi P.P. (Mol. Cell. Biochem. 2008)
    95. PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PubMed id 18809579)1, 9 Shima Y....Kitabayashi I. (Mol. Cell. Biol. 2008)
    96. Serum-dependent expression of promyelocytic leukemia protein suppresses propagation of influenza virus. (PubMed id 16154611)1, 9 Iki S....Fujii N. (Virology 2005)
    97. Isoforms of the promyelocytic leukemia protein differ in their effects on ND10 organization. (PubMed id 15922731)1, 9 Beech S.J....Leppard K.N. (Exp. Cell Res. 2005)
    98. Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus. (PubMed id 9427741)1, 9 MA1ller S....Dejean A. (EMBO J. 1998)
    99. Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis. (PubMed id 9583681)1, 9 Le X.F....Chang K.S. (Oncogene 1998)
    100. Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms. (PubMed id 1594241)1, 9 Fagioli M....Pelicci P.G. (Oncogene 1992)
    101. Three-dimensional organization of promyelocytic leukemia nuclear bodies. (PubMed id 20130140)1, 9 Lang M....Rippe K. (J. Cell. Sci. 2010)
    102. Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizations. (PubMed id 20097304)1, 9 Ho C.L....Huang S.M. (amp 2010)
    103. Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies. (PubMed id 18463162)1, 9 Gao C....Kao H.Y. (Mol. Biol. Cell 2008)
    104. Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells. (PubMed id 15855159)1, 9 Kruse M.L....SchAofer H. (J. Biol. Chem. 2005)
    105. PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription. (PubMed id 12384561)1, 9 Shtutman M....Ben-Ze'ev A. (Cancer Res. 2002)
    106. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein. (PubMed id 10938104)1, 9 Tsuzuki S....Enver T. (Mol. Cell. Biol. 2000)
    107. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. (PubMed id 10910364)1, 9 Pearson M....Pelicci P.G. (Nature 2000)
    108. The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. (PubMed id 10597310)1, 9 Topcu Z....Borden K.L. (Oncogene 1999)
    109. PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. (PubMed id 15735755)1, 9 Cairo S....Meroni G. (Oncogene 2005)
    110. The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63. (PubMed id 16007146)1, 9 Bernassola F....Pandolfi P.P. (Oncogene 2005)
    111. Gamma interferon and cadmium treatments modulate eukaryotic initiation factor 4E-dependent mRNA transport of cyclin D1 in a PML-dependent manner. (PubMed id 12167712)1, 9 Topisirovic I....Borden K.L. (Mol. Cell. Biol. 2002)
    112. In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML. (PubMed id 8643677)1, 9 Borden K.L....Freemont P.S. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    113. [Increase of BIRC5 gene expression in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with expression of genes SMAC/DIABLO and PML encoding its inhibitors]. (PubMed id 18856066)1, 9 VaA-shlia N.A....Sverdlov E.D. (Mol. Biol. (Mosk.) 2008)
    114. Acute promyelocytic leukemia with insertion of PML exon 7a and partial deletion of exon 3 of RARA: a novel variant transcript related to aggressive course and not detected with real-time polymerase chain reaction analysis. (PubMed id 19100514)1, 9 Park T.S....Choi J.R. (Cancer Genet. Cytogenet. 2009)
    115. PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers. (PubMed id 19597475)1, 9 Klanrit P....Tavassoli M. (Oncogene 2009)
    116. Regulation of p53 activity in nuclear bodies by a specific PML isoform. (PubMed id 11080164)1, 9 Fogal V....Del Sal G. (EMBO J. 2000)
    117. Dysregulation of promyelocytic leukemia (PML) protein expression in preeclamptic placentae. (PubMed id 20228380)1, 9 Leavenworth J.D....Torry D.S. (Reprod Sci 2010)
    118. Pro-apoptotic function of checkpoint kinase-2 in syncytia elicited by the HIV-1 envelope. (PubMed id 19177012)1, 9 SAcror C....Kroemer G. (Cell Cycle 2009)
    119. Promyelocytic leukemia protein is required for gain of function by mutant p53. (PubMed id 19487292)1, 9 Haupt S....Haupt Y. (Cancer Res. 2009)
    120. Nuclear phospholipase C gamma: punctate distribution and association with the promyelocytic leukemia protein. (PubMed id 17419608)1, 9 Ferguson B.J....Rich T. (J. Proteome Res. 2007)
    121. Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein. (PubMed id 17062732)1, 9 VlasA!kovA! J....Hodny Z. (Blood 2007)
    122. A cytoplasmic PML mutant inhibits p53 function. (PubMed id 17172828)1, 9 Bellodi C....Salomoni P. (Cell Cycle 2006)
    123. Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukemia protein isoform II is required for ND10 disruption. (PubMed id 16501113)1, 9 Hoppe A....Leppard K.N. (J. Virol. 2006)
    124. PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins. (PubMed id 16818720)1, 9 Janer A....Sittler A. (J. Cell Biol. 2006)
    125. Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins. (PubMed id 15833741)1, 9 Tatematsu K....Kuroda S. (J. Biol. Chem. 2005)
    126. E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies. (PubMed id 15017387)1, 9 Fukuyo Y....Nakajima T. (Cell Death Differ. 2004)
    127. Recruitment of herpes simplex virus type 1 transcriptional regulatory protein ICP4 into foci juxtaposed to ND10 in live, infected cells. (PubMed id 12610143)1, 9 Everett R.D....Orr A. (J. Virol. 2003)
    128. Control of biochemical reactions through supramolecular RING domain self-assembly. (PubMed id 12438698)1, 9 Kentsis A....Borden K.L. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    129. The role of PML in tumor suppression. (PubMed id 11832207)1, 9 Salomoni P. and Pandolfi P.P. (Cell 2002)
    130. The promyelocytic leukemia protein represses A20-mediated transcription. (PubMed id 12080044)1, 9 Wu W.S....Chang K.S. (J. Biol. Chem. 2002)
    131. Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF. (PubMed id 11175338)1, 9 Dhordain P....Koken M.H. (Oncogene 2000)
    132. Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. (PubMed id 9294197)1, 9 Koken M.H....Zelent A. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    133. Molecular study on the chromosome 15 breakpoints in the translocation t(15; 17) in acute promyelocytic leukemia (APL). (PubMed id 8274203)1, 9 Dong S.... Qi Z.W. (Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 1993)
    134. The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPI+ during granulocytic differentiation but repressed by PML-RARI+ in APL. (PubMed id 24038216)1 Humbert M....Tschan M.P. (J. Leukoc. Biol. 2014)
    135. PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation. (PubMed id 24190887)1 Hands K.J....Hay R.T. (J. Cell. Sci. 2014)
    136. Cytoplasmic localization of PML particles in laminopathies. (PubMed id 22918509)1 Houben F....Broers J.L. (Histochem. Cell Biol. 2013)
    137. Sequence-specific electrochemical detection of double-strand PCR amplicons of PML/RARI+ fusion gene in acute promyelocytic leukemia. (PubMed id 23064710)1 Lei Y....Lin X.H. (Anal Bioanal Chem 2013)
    138. Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation. (PubMed id 23530056)1 Erker Y....Levy L. (Mol. Cell. Biol. 2013)
    139. Promyelocytic leukaemia protein links DNA damage response and repair to hepatitis B virus-related hepatocarcinogenesis. (PubMed id 23620081)1 Chung Y.L. and Wu M.L. (J. Pathol. 2013)
    140. Activation of protein kinase CK2 attenuates FOXO3a functioning in a PML-dependent manner: implications in human prostate cancer. (PubMed id 23492774)1 Chatterjee A....Ghosh M.K. (amp 2013)
    141. Components of promyelocytic leukemia nuclear bodies (ND10) act cooperatively to repress herpesvirus infection. (PubMed id 23221561)1 Glass M. and Everett R.D. (J. Virol. 2013)
    142. Two overlapping regions within the N-terminal half of the herpes simplex virus 1 E3 ubiquitin ligase ICP0 facilitate the degradation and dissociation of PML and dissociation of Sp100 from ND10. (PubMed id 24089549)1 Perusina Lanfranca M....Davido D.J. (J. Virol. 2013)
    143. Downregulation of tumor suppressor gene PML in uterine cervical carcinogenesis: impact of human papillomavirus infection (HPV). (PubMed id 23220564)1 Singh N....Hussain S. (Gynecol. Oncol. 2013)
    144. Trafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: implications for degradation of NRF2 in the nucleus. (PubMed id 23543742)1 Malloy M.T....Arinze I.J. (J. Biol. Chem. 2013)
    145. The PML isoform IV is a negative regulator of nuclear EGFR's transcriptional activity in lung cancer. (PubMed id 23563092)1 Kuo H.Y....Wu C.W. (Carcinogenesis 2013)
    146. Analysis of SUMOylated proteins using SUMO-traps. (PubMed id 23604351)1 Da Silva-Ferrada E....RodrA-guez M.S. (Sci Rep 2013)
    147. The limited contribution of DNA methylation to PML-RARI+ induced leukemia. (PubMed id 23448850)1 Rohde C....MA1ller-Tidow C. (Oncotarget 2013)
    148. Proximity to PML nuclear bodies regulates HIV-1 latency in CD4+ T cells. (PubMed id 23768491)1 Lusic M....Giacca M. (amp 2013)
    149. Dual roles for lysine 490 of promyelocytic leukemia protein in the transactivation of glucocorticoid receptor-interacting protein 1. (PubMed id 23542129)1 Liu S.T....Huang S.M. (Biochim. Biophys. Acta 2013)
    150. Death-domain associated protein-6 (DAXX) mediated apoptosis in hantavirus infection is counter-balanced by activation of interferon-stimulated nuclear transcription factors. (PubMed id 23830076)1 Khaiboullina S.F....Rizvanov A.A. (Virology 2013)
    151. PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. (PubMed id 23440206)1 Iwanami A....Mischel P.S. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    152. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    153. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. (PubMed id 23431171)2 Rokudai S....Prives C. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    154. A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population. (PubMed id 23049088)1 Meng W....Malecaze F. (amp 2012)
    155. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    156. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    157. Differential regulation of PML-RARI+ stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1. (PubMed id 22037423)1 Pietschmann K....KrAomer O.H. (amp 2012)
    158. Microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (PML) and tumor necrosis factor alpha (TNFI+) signaling in endothelial cells. (PubMed id 22947142)1 Cheng X. and Kao H.Y. (BMC Genomics 2012)
    159. Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy. (PubMed id 23092969)1 Katome T....Mitamura Y. (Diabetes Res. Clin. Pract. 2012)
    160. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    161. Association of promyelocytic leukemia protein with expression of IL-6 and resistance to treatment in multiple myeloma. (PubMed id 22906876)1 Ohgiya D....Ando K. (Acta Haematol. 2012)
    162. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)
    163. The role of PML ubiquitination in human malignancies. (PubMed id 22935031)2 Chen R.H.... Yuan W.C. (J. Biomed. Sci. 2012)
    164. An acetylation switch regulates SUMO-dependent protein interaction networks. (PubMed id 22578841)1 Ullmann R....Muller S. (Mol. Cell 2012)
    165. PML expression in soft tissue sarcoma: prognostic and predictive value in alkylating agents/antracycline-based first line therapy. (PubMed id 21678421)1 Vincenzi B....Tonini G. (J. Cell. Physiol. 2012)
    166. PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells. (PubMed id 22498738)1 Federzoni E.A....Tschan M.P. (Blood 2012)
    167. Microarray, gene sequencing, and reverse transcriptase-polymerase chain reaction analyses of a cryptic PML-RARA translocation. (PubMed id 22982005)1 Koshy J....Papenhausen P. (Cancer Genet 2012)
    168. Post-translational modifications of PML: consequences and implications. (PubMed id 23316480)2 Cheng X. and Kao H.Y. (Front. Oncol. 2012)
    169. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    170. Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodies. (PubMed id 22573317)1 Patsalo V....Hearing P. (J. Biol. Chem. 2012)
    171. BMK1 is involved in the regulation of p53 through disrupting the PML- MDM2 interaction. (PubMed id 22869143)2 Yang Q....Lee J.D. (Oncogene 2012)
    172. Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. (PubMed id 22002537)2 Martin N.... Bischof O. (EMBO J. 2012)
    173. PML regulates PER2 nuclear localization and circadian function. (PubMed id 22274616)2 Miki T.... Chang K.S. (EMBO J. 2012)
    174. MPL immunohistochemical expression as a novel marker for essential thrombocythemia and primary myelofibrosis differential diagnosis. (PubMed id 21752469)1 Ponce C.C....Silva M.R. (Leuk. Res. 2012)
    175. Moloney murine leukemia virus integrase and reverse transcriptase interact with PML proteins. (PubMed id 22685230)2 Okino Y.... Iijima S. (J. Biochem. 2012)
    176. Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells. (PubMed id 22711534)1 Hubackova S....Hodny Z. (J. Biol. Chem. 2012)
    177. A novel hierarchical prognostic model of AML solely based on molecular mutations. (PubMed id 22915647)1 Grossmann V....Haferlach C. (Blood 2012)
    178. A 15q24 microdeletion in transient myeloproliferative disease (TMD) and acute megakaryoblastic leukaemia (AMKL) implicates PML and SUMO3 in the leukaemogenesis of TMD/AMKL. (PubMed id 22296450)1 Haemmerling S....Kulozik A.E. (Br. J. Haematol. 2012)
    179. A novel PML-ADAMTS17-RARA gene rearrangement in a patient with pregnancy-related acute promyelocytic leukemia. (PubMed id 21529941)1 Lim G....Park T.S. (Leuk. Res. 2011)
    180. AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. (PubMed id 21057547)1 Li Q....Lin S.C. (Oncogene 2011)
    181. The nuclear bodies inside out: PML conquers the cytoplasm. (PubMed id 21501958)2 Carracedo A.... Pandolfi P.P. (Curr. Opin. Cell Biol. 2011)
    182. De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation. (PubMed id 22045732)1 Chung I....Rippe K. (J. Cell. Sci. 2011)
    183. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (Nat. Genet. 2011)
    184. Functional connection between Rad51 and PML in homology-directed repair. (PubMed id 21998700)1 Boichuk S....Gjoerup O.V. (PLoS ONE 2011)
    185. A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. (PubMed id 21840486)1 Yuan W.C....Chen R.H. (Cancer Cell 2011)
    186. SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes. (PubMed id 21779164)1 Cuchet-LourenAso D....Everett R.D. (PLoS Pathog. 2011)
    187. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    188. Dual functions of histone-lysine N-methyltransferase Setdb1 protein at promyelocytic leukemia-nuclear body (PML-NB): maintaining PML-NB structure and regulating the expression of its associated genes. (PubMed id 21921037)1 Cho S....Kang Y.K. (J. Biol. Chem. 2011)
    189. Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53. (PubMed id 21192925)1 Sung K.S.... Choi C.Y. (Exp. Cell Res. 2011)
    190. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    191. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    192. PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery. (PubMed id 21240990)1 Yen C.C....Hsu W.H. (J Surg Oncol 2011)
    193. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. (PubMed id 21364283)1 Welch J.S....Ley T.J. (J. Clin. Invest. 2011)
    194. Functional reorganization of promyelocytic leukemia nuclear bodies during BK virus infection. (PubMed id 21304169)1 Jiang M....Imperiale M.J. (MBio 2011)
    195. Regulation of E2Fs and senescence by PML nuclear bodies. (PubMed id 21205865)1 Vernier M....Ferbeyre G. (amp 2011)
    196. Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins. (PubMed id 21900687)1 Lokireddy S....McFarlane C. (Am. J. Physiol., Cell Physiol. 2011)
    197. Curcumin enhances the efficacy of chemotherapy by tailoring p65NFI_B-p300 cross-talk in favor of p53-p300 in breast cancer. (PubMed id 22013068)1 Sen G.S....Sa G. (J. Biol. Chem. 2011)
    198. Regulation of S100A10 by the PML-RAR-I+ oncoprotein. (PubMed id 21310922)1 O'Connell P.A....Waisman D.M. (Blood 2011)
    199. Daxx-beta and Daxx-gamma, two novel splice variants of the transcriptional co-repressor Daxx. (PubMed id 21482821)1 Wethkamp N....Mahotka C. (J. Biol. Chem. 2011)
    200. PMLRARI+ binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo. (PubMed id 21803845)1 Tao R.H....Samaniego F. (Blood 2011)
    201. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    202. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation. (PubMed id 21474068)1 Chang C.C....Shih H.M. (Mol. Cell 2011)
    203. A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. (PubMed id 21098080)1 Galisson F....Thibault P. (amp 2011)
    204. General blockade of human cytomegalovirus immediate-early mRNA expression in the S/G2 phase by a nuclear, Daxx- and PML-independent mechanism. (PubMed id 21832009)1 Zydek M....Wiebusch L. (J. Gen. Virol. 2011)
    205. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    206. Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment. (PubMed id 21613260)1 Goto E....Naoe T. (Blood 2011)
    207. PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML. (PubMed id 21217775)1 Kurahashi S....Naoe T. (Oncogene 2011)
    208. The reduced and altered activities of PAX5 are linked to the protein-protein interaction motif (coiled-coil domain) of the PAX5-PML fusion protein in t(9;15)-associated acute lymphocytic leukemia. (PubMed id 20972455)1 Qiu J.J....Dong S. (Oncogene 2011)
    209. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    210. The PML gene of the PML-RARI+ V-form fusion transcript breaks within exon 6. (PubMed id 21934296)1 Qi X....Wang H. (Acta Haematol. 2011)
    211. Nuclear body formation and PML body remodeling by the human cytomegalovirus protein UL35. (PubMed id 21489587)1 Salsman J....Frappier L. (Virology 2011)
    212. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    213. Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access. (PubMed id 21704408)1 Dittmann K....Rodemann H.P. (Radiother Oncol 2011)
    214. SUMO E3 ligase activity of TRIM proteins. (PubMed id 20972456)1 Chu Y. and Yang X. (Oncogene 2011)
    215. The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies. (PubMed id 21305000)1 Sarkari F....Frappier L. (PLoS ONE 2011)
    216. The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites. (PubMed id 21475307)2 Pinton P.... Pandolfi P.P. (Cell Death Differ. 2011)
    217. Genome-wide functions of PML-RARI+ in acute promyelocytic leukaemia. (PubMed id 21245861)1 Saeed S....Martens J.H. (Br. J. Cancer 2011)
    218. Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter. (PubMed id 21360626)1 Chuang Y.S....Wei L.N. (Stem Cells 2011)
    219. Control of nuclear HIPK2 localization and function by a SUMO interaction motif. (PubMed id 21145359)1 de la Vega L....Schmitz M.L. (Biochim. Biophys. Acta 2011)
    220. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (EMBO Rep. 2011)
    221. Loss of the promyelocytic leukemia protein in gastric cancer: implications for IP-10 expression and tumor-infiltrating lymphocytes. (PubMed id 22022583)1 Kim H.J....Choi Y.H. (PLoS ONE 2011)
    222. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    223. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    224. Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARI+ oncoprotein. (PubMed id 21187718)1 Wang Z....Tang D. (Autophagy 2011)
    225. PML positively regulates interferon gamma signaling. (PubMed id 21115099)1 El Bougrini J....Chelbi-Alix M.K. (Biochimie 2011)
    226. The alphaherpesvirus serine/threonine kinase us3 disrupts promyelocytic leukemia protein nuclear bodies. (PubMed id 21430051)1 Jung M....Banfield B.W. (J. Virol. 2011)
    227. Telomerase suppression initiates PML-dependent p53 activation to inhibit bladder cancer cell growth. (PubMed id 21042751)1 Xue Y....He D. (Oncol. Rep. 2010)
    228. Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies. (PubMed id 20123968)1 Gialitakis M....Papamatheakis J. (Mol. Cell. Biol. 2010)
    229. Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies. (PubMed id 20719947)1 Sivachandran N....Frappier L. (J. Virol. 2010)
    230. Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein. (PubMed id 21092142)1 Jul-Larsen A....e S.O. (BMC Mol. Biol. 2010)
    231. PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia. (PubMed id 20159609)1 Martens J.H....Stunnenberg H.G. (Cancer Cell 2010)
    232. PML-RARalpha ligand-binding domain deletion mutations associated with reduced disease control and outcome after first relapse of APL. (PubMed id 19865110)1 Schachter-Tokarz E....Gallagher R. (Leukemia 2010)
    233. Resistance to rabies virus infection conferred by the PMLIV isoform. (PubMed id 20702643)2 Blondel D.... Chelbi-Alix M.K. (J. Virol. 2010)
    234. Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling. (PubMed id 20699642)1 Hubackova S....Hodny Z. (Cell Cycle 2010)
    235. Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. (PubMed id 19861416)1 Warren D.T....Shanahan C.M. (J. Biol. Chem. 2010)
    236. SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. (PubMed id 20188669)1 Renner F.... Schmitz M.L. (Mol. Cell 2010)
    237. Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. (PubMed id 20797634)1 Matic I....Vertegaal A.C. (Mol. Cell 2010)
    238. Two-step colocalization of MORC3 with PML nuclear bodies. (PubMed id 20501696)1 Mimura Y....Inoue N. (J. Cell. Sci. 2010)
    239. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. (PubMed id 20378816)2 Zhang X.W.... Chen Z. (Science 2010)
    240. SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML. (PubMed id 20639899)1 Wimmer P....Dobner T. (Oncogene 2010)
    241. Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. (PubMed id 20075864)1 Sinha S....Chattopadhyay S. (EMBO J. 2010)
    242. The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. (PubMed id 20389280)1 Lee Y.R.... Chen R.H. (EMBO J. 2010)
    243. PML down-regulation in soft tissue sarcomas. (PubMed id 20578240)1 Vincenzi B....Tonini G. (J. Cell. Physiol. 2010)
    244. Atypical mRNA fusions in PML-RARA positive, RARA-PML negative acute promyelocytic leukemia. (PubMed id 20155840)1 Walz C....Reiter A. (amp 2010)
    245. Expression patterns of specific promyelocytic/retinoic acid receptor-alpha transcripts in patients with acute promyelocytic leukemia. (PubMed id 19863682)1 Lin J....Sheng X.J. (Int J Lab Hematol 2010)
    246. Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres. (PubMed id 21037079)1 Slatter T....Hung N. (Am. J. Pathol. 2010)
    247. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. (PubMed id 20832753)1 Yang Q....Lee J.D. (Cancer Cell 2010)
    248. Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci. (PubMed id 20544846)1 Hasan S.K....Lo-Coco F. (amp 2010)
    249. Long FLT3 internal tandem duplications and reduced PML-RARI+ expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patients. (PubMed id 20133893)1 ChillA^n M.C....GonzA!lez M. (Haematologica 2010)
    250. PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. (PubMed id 20159610)1 Wang K....Zhang J. (Cancer Cell 2010)
    251. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    252. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    253. Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. (PubMed id 20943951)2 Geoffroy M.C.... Hay R.T. (Mol. Biol. Cell 2010)
    254. PML/RARalpha fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association. (PubMed id 20133705)1 Yan J....Xi X. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    255. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. (PubMed id 20181954)1 Han Y....Yi J. (J. Biol. Chem. 2010)
    256. Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. (PubMed id 20574048)1 Isakson P....Simonsen A. (Blood 2010)
    257. SUMOylation promotes PML degradation during encephalomyocarditis virus infection. (PubMed id 20826694)1 El McHichi B....Chelbi-Alix M.K. (J. Virol. 2010)
    258. Promyelocytic leukemia nuclear bodies link the DNA damage repair pathway with hepatitis B virus replication: implications for hepatitis B virus exacerbation during chemotherapy and radiotherapy. (PubMed id 19808906)1 Chung Y.L. and Tsai T.Y. (Mol. Cancer Res. 2009)
    259. HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. (PubMed id 19204783)1 Gupta P....Wei L.N. (PLoS ONE 2009)
    260. Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene. (PubMed id 19553342)1 Marcos-Villar L....Rivas C. (J. Virol. 2009)
    261. Maturation of the HIV reverse transcription complex: putting the jigsaw together. (PubMed id 19750561)1 Warrilow D....Harrich D. (Rev. Med. Virol. 2009)
    262. Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma. (PubMed id 18812519)1 Kuwayama K....Nagahiro S. (Neuro-oncology 2009)
    263. SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4. (PubMed id 19553542)1 Leavenworth J.W....Pauza M.E. (J. Immunol. 2009)
    264. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)
    265. PML3 Orchestrates the Nuclear Dynamics and Function of TIP60. (PubMed id 19150978)1 Wu Q....Yao X. (J. Biol. Chem. 2009)
    266. Promyelocytic leukemia (PML) gene expression is a prognostic factor in ampullary cancer patients. (PubMed id 18689862)1 Vincenzi B....Tonini G. (Ann. Oncol. 2009)
    267. Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling. (PubMed id 19217413)1 Stehmeier P. and Muller S. (Mol. Cell 2009)
    268. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    269. Germline variants of the promyelocytic leukemia tumor suppressor gene in patients with familial cancer. (PubMed id 19728758)1 Plevova P....Silhanova E. (Neoplasma 2009)
    270. The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem. (PubMed id 18945770)1 Gu H. and Roizman B. (J. Virol. 2009)
    271. Do checkpoint kinases contribute to HIV-1-mediated apoptosis? (PubMed id 19164952)1 Vakifahmetoglu H. and Zhivotovsky B. (Cell Cycle 2009)
    272. E6AP promotes the degradation of the PML tumor suppressor. (PubMed id 19325566)1 Louria-Hayon I.... Haupt Y. (Cell Death Differ. 2009)
    273. The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope. (PubMed id 19023333)1 Perfettini J.L....Kroemer G. (Cell Death Differ. 2009)
    274. Identification of PML/RARalpha fusion gene transcripts that showed no t(15;17) with conventional karyotyping and fluorescent in situ hybridization. (PubMed id 19224461)1 Choughule A....Parikh P.M. (Genet. Mol. Res. 2009)
    275. PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors. (PubMed id 19322209)1 Wojiski S....Gilliland D.G. (Leukemia 2009)
    276. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    277. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    278. PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. (PubMed id 18636556)1 Li L....Yi J. (J. Cell. Physiol. 2008)
    279. Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. (PubMed id 19029980)1 Nasr R....de ThAc H. (Nat. Med. 2008)
    280. The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction. (PubMed id 18474224)1 Ohbayashi N....Matsuda T. (Biochem. Biophys. Res. Commun. 2008)
    281. Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha. (PubMed id 18073335)1 KrAomer O.H....Heinzel T. (FASEB J. 2008)
    282. SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage. (PubMed id 18408014)1 Tan J.-A.T.... Durrin L.K. (J. Biol. Chem. 2008)
    283. Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies. (PubMed id 18833293)1 Sivachandran N....Frappier L. (PLoS Pathog. 2008)
    284. Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance. (PubMed id 18212063)1 McNamara S....Miller W.H. (Mol. Cell. Biol. 2008)
    285. Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARalpha, resulting in sequestration and decreased mobility of SMRT. (PubMed id 17991421)1 Huang Y....Dong S. (Biochem. Biophys. Res. Commun. 2008)
    286. Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein. (PubMed id 18480450)1 Ullman A.J. and Hearing P. (J. Virol. 2008)
    287. Dynamics of component exchange at PML nuclear bodies. (PubMed id 18664490)1 Weidtkamp-Peters S....Hemmerich P. (J. Cell. Sci. 2008)
    288. Arsenic trioxide stimulates SUMO-2/3 modification leading to RNF4-dependent proteolytic targeting of PML. (PubMed id 18708055)1 Weisshaar S.R....Praefcke G.J. (FEBS Lett. 2008)
    289. Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling. (PubMed id 18511908)1 Faresse N....Atfi A. (EMBO J. 2008)
    290. MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks. (PubMed id 18644863)1 Morey L....Di Croce L. (Mol. Cell. Biol. 2008)
    291. Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip. (PubMed id 18024792)1 Hoemme C....MA1ller-Tidow C. (Blood 2008)
    292. Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body. (PubMed id 18160400)1 Eun B....Kim H. (J. Biol. Chem. 2008)
    293. The genetic characterization of acute promyelocytic leukemia with cryptic t(15;17) including a new recurrent additional cytogenetic abnormality i(17)(q10). (PubMed id 17943164)1 Kim M....Min W.S. (Leukemia 2008)
    294. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    295. The presence of a single PML-RARA isoform lacking exon 5 in FISH-negative APL samples. (PubMed id 17960172)1 Ashur-Fabian O....Amariglio N. (Leukemia 2008)
    296. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. (PubMed id 18248090)1 Uchil P.D.... Mothes W. (PLoS Pathog. 2008)
    297. Activating mutations in human acute megakaryoblastic leukemia. (PubMed id 18755984)1 Malinge S....Bernard O.A. (Blood 2008)
    298. Ubc9 sumoylation regulates SUMO target discrimination. (PubMed id 18691969)1 Knipscheer P....Pichler A. (Mol. Cell 2008)
    299. Selective activation of NFAT by promyelocytic leukemia protein. (PubMed id 18246125)1 Lo Y.H....Lai M.Z. (Oncogene 2008)
    300. PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop. (PubMed id 19111660)1 Lapi E....Blandino G. (Mol. Cell 2008)
    301. A role for cytoplasmic PML in cellular resistance to viral infection. (PubMed id 18509536)2 McNally B.A.... Zheng P. (PLoS ONE 2008)
    302. Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. (PubMed id 18158568)1 Chang H.J....Kim W.H. (Pathol. Oncol. Res. 2007)
    303. Identification of PML-RARA rearrangement by RT-PCR and sequencing in an acute promyelocytic leukemia without t(15;17) on G-banding and FISH. (PubMed id 16797070)1 Han J.Y....Kim J.S. (Leuk. Res. 2007)
    304. The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. (PubMed id 17344210)1 Saether T....Gabrielsen O.S. (J. Biol. Chem. 2007)
    305. A nucleolar targeting signal in PML-I addresses PML to nucleolar caps in stressed or senescent cells. (PubMed id 17878236)1 Condemine W....de ThAc H. (J. Cell. Sci. 2007)
    306. Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA. (PubMed id 18056407)1 Stagno D'Alcontres M....Salomoni P. (J. Cell Biol. 2007)
    307. SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment. (PubMed id 17060459)1 Mohan R.D....Tini M. (Mol. Cell. Biol. 2007)
    308. Induction of promyelocytic leukemia (PML) oncogenic domains (PODs) by papillomavirus. (PubMed id 17543368)1 Nakahara T. and Lambert P.F. (Virology 2007)
    309. PRIMA-1(MET) induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins. (PubMed id 16909106)1 RAPkaeus N....Mattsson K. (Oncogene 2007)
    310. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. (PubMed id 17332504)1 Takahashi K....Inoue N. (Mol. Biol. Cell 2007)
    311. Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression. (PubMed id 17475621)1 Reineke E.L....Kao H.Y. (J. Biol. Chem. 2007)
    312. PML4 induces differentiation by Myc destabilization. (PubMed id 17146439)1 Buschbeck M....Di Croce L. (Oncogene 2007)
    313. PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation. (PubMed id 17562868)1 Yoshida H....Kitabayashi I. (Mol. Cell. Biol. 2007)
    314. Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML. (PubMed id 17996922)1 Vaitiekunaite R....Rusin M. (Mech. Ageing Dev. 2007)
    315. [Expression of PML in carcinogenesis of laryngocarcinoma and nasopharyngeal carcinoma]. (PubMed id 17441430)1 Chen W....Tao Z. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007)
    316. PML protein expression in hereditary and sporadic breast cancer. (PubMed id 17822314)1 PlevovA! P....KolA!r Z. (Neoplasma 2007)
    317. Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. (PubMed id 17360386)1 Meinecke I....Pap T. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    318. Concordant expression of proto-oncogene promyelocytic leukemia and major histocompatibility antigen HLA class I in human hepatocellular carcinoma. (PubMed id 17767548)1 Xia M....Xie W. (Tissue Antigens 2007)
    319. Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. (PubMed id 17560333)1 Villa R....Di Croce L. (Cancer Cell 2007)
    320. Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. (PubMed id 16924230)1 Janssen K....Fischer U. (Oncogene 2007)
    321. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. (PubMed id 17823119)1 Gibb S.L....Trotti D. (J. Biol. Chem. 2007)
    322. Cytoplasmic function of mutant promyelocytic leukemia (PML) and PML-retinoic acid receptor-alpha. (PubMed id 16540467)1 Bellodi C....Salomoni P. (J. Biol. Chem. 2006)
    323. Functional interactions between the Epstein-Barr virus BZLF1 protein and the promyelocytic leukemia protein. (PubMed id 16307818)1 Bowling B.L. and Adamson A.L. (Virus Res. 2006)
    324. An extended consensus motif enhances the specificity of substrate modification by SUMO. (PubMed id 17036045)1 Yang S.H....Sharrocks A.D. (EMBO J. 2006)
    325. Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein. (PubMed id 16449642)1 Carbone R.... Minucci S. (Mol. Cell. Biol. 2006)
    326. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. (PubMed id 17081986)1 Lin D.Y.... Shih H.M. (Mol. Cell 2006)
    327. PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. (PubMed id 16873256)1 Everett R.D....Orr A. (J. Virol. 2006)
    328. Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections. (PubMed id 16873257)1 Tavalai N....Stamminger T. (J. Virol. 2006)
    329. Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling. (PubMed id 16916642)1 Seo S.R....Atfi A. (Mol. Cell 2006)
    330. ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML. (PubMed id 17027752)1 Kunapuli P....Cowell J.K. (Exp. Cell Res. 2006)
    331. The methyl-CpG binding protein MBD1 is required for PML-RARalpha function. (PubMed id 16432238)1 Villa R....Di Croce L. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    332. PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies. (PubMed id 16412420)1 Fleischer S....Hofmann T.G. (Exp. Cell Res. 2006)
    333. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. (PubMed id 16449650)1 Shiio Y.... Eisenman R.N. (Mol. Cell. Biol. 2006)
    334. The promyelocytic leukemia protein stimulates SUMO conjugation in yeast. (PubMed id 16501610)1 Quimby B.B....Dasso M. (Oncogene 2006)
    335. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. (PubMed id 17000875)1 Mukhopadhyay D.... Dasso M. (J. Cell Biol. 2006)
    336. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    337. A CK2-dependent mechanism for degradation of the PML tumor suppressor. (PubMed id 16873060)1 Scaglioni P.P....Pandolfi P.P. (Cell 2006)
    338. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. (PubMed id 16915281)1 Bernardi R....Pandolfi P.P. (Nature 2006)
    339. PML-RARalpha fusion gene transcripts and biological features in acute promyelocytic leukemia patients. (PubMed id 16630218)1 Melo R.A....Souto F.R. (Clin Lab Haematol 2006)
    340. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PubMed id 17000644)1 Vertegaal A.C....Lamond A.I. (amp 2006)
    341. Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha. (PubMed id 16935935)1 Wang J.G....Wu L. (FASEB J. 2006)
    342. Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells. (PubMed id 15601827)1 Lane A.A. and Ley T.J. (Mol. Cell. Biol. 2005)
    343. PML mediates IFN-alpha-induced apoptosis in myeloma by regulating TRAIL induction. (PubMed id 15459016)1 Crowder C....Rudikoff S. (Blood 2005)
    344. Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells. (PubMed id 15746941)1 Ikeda T....Kufe D. (Cell Death Differ. 2005)
    345. A role for PML3 in centrosome duplication and genome stability. (PubMed id 15749021)1 Xu Z.X....Chang K.S. (Mol. Cell 2005)
    346. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (amp 2005)
    347. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    348. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. (PubMed id 15569683)1 Takahashi H....Nakayama K.I. (J. Biol. Chem. 2005)
    349. Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha. (PubMed id 16113082)1 Walter M.J....Ley T.J. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    350. The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage. (PubMed id 15626733)1 Salomoni P....Pandolfi P.P. (Blood 2005)
    351. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. (PubMed id 16154098)1 Kitamura Y.I....Accili D. (Cell Metab. 2005)
    352. SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies. (PubMed id 15707587)1 Haekli M.... Palvimo J.J. (Exp. Cell Res. 2005)
    353. Physical and functional link of the leukemia-associated factors AML1 and PML. (PubMed id 15331439)1 Nguyen L.A....Kitabayashi I. (Blood 2005)
    354. PML is a direct p53 target that modulates p53 effector functions. (PubMed id 14992722)1 de Stanchina E....Lowe S.W. (Mol. Cell 2004)
    355. PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation. (PubMed id 15096541)1 Kamashev D....De ThAc H. (J. Exp. Med. 2004)
    356. More on geographic hematology: the breakpoint cluster regions of the PML/RARalpha fusion gene in Mexican Mestizo patients with promyelocytic leukemia are different from those in Caucasians. (PubMed id 15359634)1 Ruiz-ArgA1elles G.J....Ruiz-Delgado G.J. (amp 2004)
    357. Nuclear partners of Bcl-2: Bax and PML. (PubMed id 15231068)1 Hoetelmans R.W. (DNA Cell Biol. 2004)
    358. Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions. (PubMed id 14970191)1 Wang J....Sheer D. (J. Cell Biol. 2004)
    359. c-Myb associates with PML in nuclear bodies in hematopoietic cells. (PubMed id 15194430)1 Dahle A.9....Gabrielsen O.S. (Exp. Cell Res. 2004)
    360. Androgen suppresses PML protein expression in prostate cancer CWR22R cells. (PubMed id 14715247)1 Yang L....Chang C. (Biochem. Biophys. Res. Commun. 2004)
    361. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    362. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    363. Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. (PubMed id 14976551)1 Insinga A....Minucci S. (EMBO J. 2004)
    364. Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2. (PubMed id 15060166)1 Tashiro S....Igarashi K. (Mol. Cell. Biol. 2004)
    365. Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells. (PubMed id 15163746)1 Lee H.R....Ahn J.H. (J. Virol. 2004)
    366. Ubiquitin-dependent degradation of p73 is inhibited by PML. (PubMed id 15184504)1 Bernassola F....Pandolfi P.P. (J. Exp. Med. 2004)
    367. Cloning and functional characterization of a rat Daxx that functions as a corepressor for the androgen receptor. (PubMed id 15350595)1 Mizuta H. and Kuroda Y. (Cell Biol. Int. 2004)
    368. Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration. (PubMed id 15589835)1 Boese A....Nehrbass U. (FEBS Lett. 2004)
    369. Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia. (PubMed id 14630830)1 Gurrieri C....Pandolfi P.P. (Blood 2004)
    370. Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression. (PubMed id 14597622)1 Xu Z.X....Chang K.S. (J. Biol. Chem. 2004)
    371. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. (PubMed id 14522971)1 Fukuda N.... Takahashi M. (J. Biol. Chem. 2003)
    372. MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53. (PubMed id 14507915)1 Zhu H....Maki C.G. (J. Biol. Chem. 2003)
    373. PML-nuclear bodies are involved in cellular serum response. (PubMed id 12622724)1 Matsuzaki K....Nakao M. (amp 2003)
    374. PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells. (PubMed id 14597990)1 Tenno T....Siegbahn A. (Thromb. Haemost. 2003)
    375. Promyelocytic leukaemia (PML) protein expression in human placenta and choriocarcinoma. (PubMed id 12950020)1 Kim C.J....Yu E.S. (J. Pathol. 2003)
    376. Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway. (PubMed id 12540841)1 Wu W.S....Chang K.S. (J. Biol. Chem. 2003)
    377. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. (PubMed id 12915590)1 Kurki S....Laiho M. (J. Cell. Sci. 2003)
    378. Adenovirus protein IX sequesters host-cell promyelocytic leukaemia protein and contributes to efficient viral proliferation. (PubMed id 14528266)1 Rosa-Calatrava M....Kedinger C. (EMBO Rep. 2003)
    379. Forced expression of RNF36 induces cell apoptosis. (PubMed id 12837286)1 Shyu H.W....Li H. (Exp. Cell Res. 2003)
    380. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. (PubMed id 12917339)1 Kawai T.... Reed J.C. (Mol. Cell. Biol. 2003)
    381. Role of PML and the PML-nuclear body in the control of programmed cell death. (PubMed id 14663483)1 Bernardi R. and Pandolfi P.P. (Oncogene 2003)
    382. Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. (PubMed id 12727882)1 Marcello A....Giacca M. (EMBO J. 2003)
    383. Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis. (PubMed id 14534537)1 Puccetti E....Ruthardt M. (Oncogene 2003)
    384. PML is required for homeodomain-interacting protein kinase 2 (HIPK2)- mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. (PubMed id 12907596)1 Moeller A.... Schmitz M.L. (Cancer Res. 2003)
    385. THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis- response-4 (Par-4) to PML nuclear bodies. (PubMed id 12717420)1 Roussigne M.... Girard J.-P. (Oncogene 2003)
    386. Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential. (PubMed id 12595526)1 Lin D.Y....Shih H.M. (J. Biol. Chem. 2003)
    387. High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML. (PubMed id 14526201)1 Favre M.... Telenti A. (J. Acquir. Immune Defic. Syndr. 2003)
    388. New highly sensitive fluorescence in situ hybridization method to detect PML/RARA fusion in acute promyelocytic leukemia. (PubMed id 12935927)1 Brockman S.R....Dewald G.W. (Cancer Genet. Cytogenet. 2003)
    389. Expression of promyelocytic leukemia protein increases during the differentiation of human neuroblastoma cells. (PubMed id 12647219)1 Yu E....Kim C.J. (Virchows Arch. 2003)
    390. Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex. (PubMed id 12641448)1 Tatham M.H.... Hay R.T. (Biochemistry 2003)
    391. Effects of promyelocytic leukemia protein on virus-host balance. (PubMed id 11907221)1 Bonilla W.V....Hengartner H. (J. Virol. 2002)
    392. Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. (PubMed id 12032831)1 Wu W.S....Chang K.S. (Oncogene 2002)
    393. Modification of Daxx by small ubiquitin-related modifier-1. (PubMed id 12150977)1 Jang M.-S.... Kim E. (Biochem. Biophys. Res. Commun. 2002)
    394. Deconstructing PML-induced premature senescence. (PubMed id 12093737)1 Bischof O....Dejean A. (EMBO J. 2002)
    395. The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. (PubMed id 11940591)1 Hoffmeister A....Iovanna J.L. (J. Biol. Chem. 2002)
    396. Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy. (PubMed id 12032336)1 Gu B.W....Chen S.J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    397. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    398. The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system. (PubMed id 12354770)1 Tojo M....Nakao M. (J. Biol. Chem. 2002)
    399. An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). (PubMed id 12234245)1 Combes R....Stewart J. (Altern Lab Anim 2002)
    400. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. (PubMed id 12060771)1 Kelly L.M....Gilliland D.G. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    401. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. (PubMed id 11948183)1 Lin D.-Y. and Shih H.-M. (J. Biol. Chem. 2002)
    402. Differential expression of the suppressor PML and Ki-67 identifies three subtypes of human nasopharyngeal carcinoma. (PubMed id 12142048)1 Chan J.Y....Johnson P.J. (Eur. J. Cancer 2002)
    403. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. (PubMed id 11891284)1 Kitareewan S....Dmitrovsky E. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    404. Cryptic translocation of PML/RARA on 17q. A rare event in acute promyelocytic leukemia. (PubMed id 12505266)1 Zaccaria A....Martinelli G. (Cancer Genet. Cytogenet. 2002)
    405. Rabies virus P and small P products interact directly with PML and reorganize PML nuclear bodies. (PubMed id 12439746)2 Blondel D.... Chelbi-Alix M.K. (Oncogene 2002)
    406. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. (PubMed id 11430827)1 Turelli P....Trono D. (Mol. Cell 2001)
    407. Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies. (PubMed id 11160742)1 Adamson A.L. and Kenney S. (J. Virol. 2001)
    408. The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease. (PubMed id 11572863)1 Chai Y....Paulson H.L. (J. Biol. Chem. 2001)
    409. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. (PubMed id 11430826)1 Khan M.M....Ishii S. (Mol. Cell 2001)
    410. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. (PubMed id 11244500)1 Lehembre F....Dejean A. (Oncogene 2001)
    411. PML interaction with p53 and its role in apoptosis and replicative senescence. (PubMed id 11704853)1 Pearson M. and Pelicci P.G. (Oncogene 2001)
    412. Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation. (PubMed id 11158586)1 Mattsson K....Szekely L. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    413. Evidence for separate ND10-binding and homo-oligomerization domains of Sp100. (PubMed id 11112690)1 Negorev D....Maul G.G. (J. Cell. Sci. 2001)
    414. Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia. (PubMed id 11585900)1 Hong S.H....Privalsky M.L. (Mol. Cell. Biol. 2001)
    415. PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. (PubMed id 11500381)1 Cohen N....Borden K.L. (EMBO J. 2001)
    416. Altered ligand binding and transcriptional regulation by mutations in the PML/RARalpha ligand-binding domain arising in retinoic acid-resistant patients with acute promyelocytic leukemia. (PubMed id 11050004)1 CA'tAc S....Miller W.H. (Blood 2000)
    417. The transcriptional role of PML and the nuclear body. (PubMed id 10806494)1 Zhong S....Pandolfi P.P. (Nat. Cell Biol. 2000)
    418. Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies. (PubMed id 10629064)1 Lehembre F....Dejean A. (Mol. Cell. Biol. 2000)
    419. Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. (PubMed id 10882117)1 Minucci S....Pelicci P.G. (Mol. Cell 2000)
    420. Role of SUMO-1-modified PML in nuclear body formation. (PubMed id 10779416)1 Zhong S....Pandolfi P.P. (Blood 2000)
    421. Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies. (PubMed id 10620019)1 Yasuda S....Kakizuka A. (amp 1999)
    422. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. (PubMed id 10077561)1 Doucas V.... Evans R.M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    423. SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. (PubMed id 9885291)1 Duprez E....Freemont P.S. (J. Cell. Sci. 1999)
    424. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. (PubMed id 9448006)1 Alcalay M....Pelicci P.G. (Mol. Cell. Biol. 1998)
    425. Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML. (PubMed id 9671498)1 Ahn J.H....Hayward G.S. (Mol. Cell. Biol. 1998)
    426. Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein. (PubMed id 9671405)1 Vallian S....Farzaneh F. (Oncogene 1998)
    427. The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter. (PubMed id 9819401)1 Vallian S....Chang K.S. (Mol. Cell. Biol. 1998)
    428. Cellular localization, expression, and structure of the nuclear dot protein 52. (PubMed id 9230084)1 Sternsdorf T.... Will H. (J. Cell Biol. 1997)
    429. Stable overexpression of PML alters regulation of cell cycle progression in HeLa cells. (PubMed id 9395203)1 Mu Z.M....Chang K.S. (Carcinogenesis 1997)
    430. Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1. (PubMed id 9412458)1 Sternsdorf T.... Will H. (J. Cell Biol. 1997)
    431. PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. (PubMed id 8806687)1 Boddy M.N.... Freemont P.S. (Oncogene 1996)
    432. The PML gene encodes a phosphoprotein associated with the nuclear matrix. (PubMed id 7780148)1 Chang K.S....Mu Z.M. (Blood 1995)
    433. PML, a growth suppressor disrupted in acute promyelocytic leukemia. (PubMed id 7935403)1 Mu Z.M....Chang K.S. (Mol. Cell. Biol. 1994)
    434. The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. (PubMed id 8394219)1 Grignani F....Nicoletti I. (Cell 1993)
    435. Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients. (PubMed id 8380300)1 Geng J.P.... Larsen C.J. (Leukemia 1993)
    436. [The laboratory in programs for enteric infection control]. (PubMed id 123456)1 Grados O.B. (Bol Oficina Sanit Panam 1975)
    437. Cooperation between the RING + B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival. (PubMed id 9671411)9 Fagioli M....Pelicci P.G. (Oncogene 1998)
    438. Inhibition of SUMO-independent PML oligomerization by the human cytomegalovirus IE1 protein. (PubMed id 16847114)9 Kang H....Ahn J.H. (J. Gen. Virol. 2006)
    439. Finding a role for PML in APL pathogenesis: a critical assessment of potential PML activities. (PubMed id 12357342)9 Strudwick S. and Borden K.L. (Leukemia 2002)
    440. Human-herpesvirus-8-encoded K8 protein colocalizes with the promyelocytic leukemia protein (PML) bodies and recruits p53 to the PML bodies. (PubMed id 11485412)9 Katano H....Sata T. (Virology 2001)
    441. Overexpression of promyelocytic leukemia protein and alteration of PML nuclear bodies in early stage of hepatocarcinogenesis. (PubMed id 11511788)9 Yoon G.S. and Yu E. (J. Korean Med. Sci. 2001)
    442. PML-containing nuclear bodies: their spatial distribution in relation to other nuclear components. (PubMed id 8913879)9 Grande M.A....van Driel R. (J. Cell. Biochem. 1996)
    443. Promyelocytic leukemia protein-induced growth suppression and cell death in liver cancer cells. (PubMed id 15529177)9 Son S.H....Choi J. (Cancer Gene Ther. 2005)
    444. Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia. (PubMed id 7535592)9 Flenghi L....Martelli M.F. (Blood 1995)
    445. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. (PubMed id 7784078)9 Ahn M.J....Dmitrovsky E. (Oncogene 1995)
    446. Perspectives in PML: a unifying framework for PML function. (PubMed id 19273081)9 Borden K.L. and Culjkovic B. (Front Biosci (Landmark Ed) 2009)
    447. Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon? (PubMed id 18616965)9 Borden K.L. (Biochim. Biophys. Acta 2008)
    448. Overexpression of PML induced apoptosis in bladder cancer cell by caspase dependent pathway. (PubMed id 16216409)9 Li L....Nan X. (Cancer Lett. 2006)
    449. UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML. (PubMed id 12642865)9 Seker H....Harris C.C. (Oncogene 2003)
    450. The puzzling multiple lives of PML and its role in the genesis of cancer. (PubMed id 10944585)9 Ruggero D....Pandolfi P.P. (Bioessays 2000)
    451. Expression of promyelocytic leukaemia protein in thyroid neoplasms. (PubMed id 11012736)9 Yu E....Lee H.J. (Histopathology 2000)
    452. PML protein expression in hematopoietic and acute promyelocytic leukemia cells. (PubMed id 8400236)9 Daniel M.T....de ThAc H. (Blood 1993)
    453. SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome. (PubMed id 18413806)9 Cao X....Ann D.K. (Mol. Cancer Ther. 2008)
    454. Cell cycle regulation of PML modification and ND10 composition. (PubMed id 10574707)9 Everett R.D.... Orr A. (J. Cell Sci. 1999)
    455. The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells. (PubMed id 9151854)9 Ahn J.H. and Hayward G.S. (J. Virol. 1997)
    456. Assembly dynamics of PML nuclear bodies in living cells. (PubMed id 20205709)9 Brand P....Hemmerich P. (PMC Biophys 2010)
    457. Nuclear matrix associated protein PML: an arsenic trioxide apoptosis therapeutic target protein in HepG2 cells. (PubMed id 12667397)9 Yu D....Chew E.C. (Chin. Med. J. 2003)
    458. Proteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression. (PubMed id 11602710)9 Xu Y....Hayward G.S. (J. Virol. 2001)
    459. PML is expressed in chronic graft-versus-host disease lesions. (PubMed id 9193756)9 Aractingi S....Carosela E.D. (Bone Marrow Transplant. 1997)
    460. PML nuclear bodies are general targets for inflammation and cell proliferation. (PubMed id 7882370)9 Terris B....Dejean A. (Cancer Res. 1995)
    461. Stemming out of a new PML era? (PubMed id 19521423)9 Salomoni P. (Cell Death Differ. 2009)
    462. Retinoic acid attenuates promyelocytic leukemia protein-induced cell death in breast cancer cells by activation of the ubiquitin-proteasome pathway. (PubMed id 16740359)9 Son S.H....Choi J. (Cancer Lett. 2007)
    463. The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML. (PubMed id 16504291)9 Rush E.A....Redner R.L. (Leuk. Res. 2006)
    464. The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies. (PubMed id 9591778)9 Ruthardt M....Pelicci P.G. (Oncogene 1998)
    465. Transcriptional repression by the promyelocytic leukemia protein, PML. (PubMed id 9434633)9 Vallian S....Farzaneh F. (Exp. Cell Res. 1997)
    466. Altered distribution of the promyelocytic leukemia-associated protein is associated with cellular senescence. (PubMed id 9213441)9 Jiang W.Q. and Ringertz N. (amp 1997)
    467. The PML and PML/RARalpha domains: from autoimmunity to molecular oncology and from retinoic acid to arsenic. (PubMed id 8986606)9 Andre C....de The H. (Exp. Cell Res. 1996)
    468. Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, PML. (PubMed id 8550548)9 Le X.F....Chang K.S. (J. Biol. Chem. 1996)
    469. LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. (PubMed id 8695863)9 Dent A.L....Staudt L.M. (Blood 1996)
    470. Induction of the PML protein by interferons in normal and APL cells. (PubMed id 8609713)9 Chelbi-Alix M.K....de ThAc H. (Leukemia 1995)
    471. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. (PubMed id 1314166)9 Pandolfi P.P....Grignani F. (EMBO J. 1992)
    472. Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. (PubMed id 19884644)9 Mays A.N....Grimwade D. (Blood 2010)
    473. A bcr3/short form PML-RARalpha transcript in an acute promyelocytic leukemia resulted from a derivative chromosome 17 due to submicroscopic insertion of the PML gene into the RARalpha locus. (PubMed id 19095567)9 Wang H.Y....Wilson K.S. (Am. J. Clin. Pathol. 2009)
    474. [The molecular mechanism of PML in inducing apoptosis of bladder cancer cell line]. (PubMed id 16253165)9 Li L....Nan X.Y. (Zhonghua Yi Xue Za Zhi 2005)
    475. Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones. (PubMed id 12353268)9 Mozziconacci M.J....Lafage-Pochitaloff M. (amp 2002)
    476. Nuclear IE2 structures are related to viral DNA replication sites during baculovirus infection. (PubMed id 11967334)9 Mainz D....Knebel-MAPrsdorf D. (J. Virol. 2002)
    477. A role for PML and the nuclear body in genomic stability. (PubMed id 10637504)9 Zhong S....Pandolfi P.P. (Oncogene 1999)
    478. Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cells. (PubMed id 9157977)9 He D....Chang K.S. (Cancer Res. 1997)
    479. Characterisation of the PML/RAR alpha rearrangement associated with t(15;17) acute promyelocytic leukaemia. (PubMed id 9103677)9 Grimwade D. and Solomon E. (Curr. Top. Microbiol. Immunol. 1997)
    480. Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. (PubMed id 9108090)9 Zhu J....de ThAc H. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    481. Cloning of the murine homolog of the leukemia-associated PML gene. (PubMed id 8563172)9 Goddard A.D....Solomon E. (Mamm. Genome 1995)
    482. Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. (PubMed id 8545113)9 Stadler M....Schindler C. (Oncogene 1995)
    483. Differential functions of interferon-upregulated Sp100 isoforms: herpes simplex virus type 1 promoter-based immediate-early gene suppression and PML protection from ICP0-mediated degradation. (PubMed id 19279115)9 Negorev D.G....Maul G.G. (J. Virol. 2009)
    484. PML: a tumor suppressor that regulates cell fate in mammary gland. (PubMed id 19652541)9 Li W....Watson C.J. (Cell Cycle 2009)
    485. New insights into the role of PML in tumour suppression. (PubMed id 18504460)9 Salomoni P....Rich T. (Cell Res. 2008)
    486. Human papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways. (PubMed id 15657429)9 Bischof O....Dejean A. (Mol. Cell. Biol. 2005)
    487. PML and the oncogenic nuclear domains in regulating transcriptional repression. (PubMed id 10978902)9 Li H. and Chen J.D. (Curr. Opin. Cell Biol. 2000)
    488. Rapid diagnosis of acute promyelocytic leukemia by analyzing the immunocytochemical pattern of the PML protein with the monoclonal antibody PG-M3. (PubMed id 11068554)9 Villamor N....Colomer D. (Am. J. Clin. Pathol. 2000)
    489. [Progress in researches on the function of PML gene]. (PubMed id 10751540)9 Zhou L....Shen Z. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000)
    490. Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption. (PubMed id 10233977)9 MA1ller S. and Dejean A. (J. Virol. 1999)
    491. Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 9794812)9 Carlile G.W....Borden K.L. (Biochem. J. 1998)
    492. The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoforms. (PubMed id 9658103)9 Everett R.D....Parkinson J. (J. Virol. 1998)
    493. Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. (PubMed id 8916959)9 Nason-Burchenal K....Pandolfi P.P. (Blood 1996)
    494. Molecular heterogeneity of the PML gene rearrangement in acute promyelocytic leukemia: prevalence and clinical significance. (PubMed id 8387477)9 Fukutani H....Ohno R. (Jpn. J. Cancer Res. 1993)
    495. The t(15;17) breakpoint in acute promyelocytic leukemia cluster within two different sites of the myl gene: targets for the detection of minimal residual disease by the polymerase chain reaction. (PubMed id 1310060)9 Chang K.S....Stass S.A. (Blood 1992)
    496. ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. (PubMed id 16891316)9 Joe Y....Kim M.K. (J. Biol. Chem. 2006)
    497. Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells. (PubMed id 15111320)9 Saegusa M....Okayasu I. (Am. J. Pathol. 2004)
    498. Acute myeloblastic leukaemias of FAB types M6 and M4, with cryptic PML/RARalpha fusion gene formation, relapsing as acute promyelocytic leukaemia M3. (PubMed id 11552979)9 Virchis A....Mehta A. (Br. J. Haematol. 2001)
    499. Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells. (PubMed id 9834237)9 MA1ller S....Dejean A. (Blood 1998)
    500. Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains. (PubMed id 8890168)9 Grignani F....Pelicci P.G. (EMBO J. 1996)
    501. Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2. (PubMed id 19095951)9 Lin Z....Roden R.B. (Am. J. Pathol. 2009)
    502. Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis. (PubMed id 19088278)9 Leppard K.N....Rich T. (J. Gen. Virol. 2009)
    503. Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. (PubMed id 18650449)9 Hasan S.K....Lo-Coco F. (Blood 2008)
    504. Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. (PubMed id 16199871)9 Rao V.A....Pommier Y. (Mol. Cell. Biol. 2005)
    505. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. (PubMed id 15829534)9 Mistry A.R....Grimwade D. (N. Engl. J. Med. 2005)
    506. Retinoids in cancer chemoprevention. (PubMed id 15134535)9 Okuno M....Moriwaki H. (Curr Cancer Drug Targets 2004)
    507. Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence. (PubMed id 14712214)9 Mallette F.A....Ferbeyre G. (Oncogene 2004)
    508. The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia protein. (PubMed id 15286431)9 Suico M.A....Kai H. (J. Pharmacol. Sci. 2004)
    509. Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus. (PubMed id 14990737)9 Asper M....GA1nther S. (J. Virol. 2004)
    510. Fusion protein of retinoic acid receptor alpha with promyelocytic leukemia protein or promyelocytic leukemia zinc finger protein recruits N-CoR-TBLR1 corepressor complex to repress transcription in vivo. (PubMed id 12794076)9 Tomita A....Shi Y.B. (J. Biol. Chem. 2003)
    511. ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. (PubMed id 12814551)9 Barr S.M.... Cimprich K.A. (Curr. Biol. 2003)
    512. Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein. (PubMed id 12470659)9 Naka K.... Motoyama N. (Biochem. Biophys. Res. Commun. 2002)
    513. Promyelocytic leukemia protein is redistributed during the formation of intranuclear inclusions independent of polyglutamine expansion: an immunohistochemical study on Marinesco bodies. (PubMed id 12430715)9 Kumada S....Oda M. (J. Neuropathol. Exp. Neurol. 2002)
    514. PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage. (PubMed id 11896594)9 Carbone R....Pelicci P.G. (Oncogene 2002)
    515. Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. (PubMed id 11313457)9 Seeler J.-S.... Dejean A. (Mol. Cell. Biol. 2001)
    516. Dynamic nuclear localization of the baculovirus proteins IE2 and PE38 during the infection cycle: the promyelocytic leukemia protein colocalizes with IE2. (PubMed id 11262179)9 Murges D....Knebel-MAPrsdorf D. (Exp. Cell Res. 2001)
    517. PML-RARA fusion transcripts in irradiated and normal hematopoietic cells. (PubMed id 10992301)9 Quina A.S....Parreira L. (amp 2000)
    518. Atypical response to all-trans retinoic acid in a der(5)t(5;17) acute promyelocytic leukemia. (PubMed id 10360373)9 Mozziconacci M.J....Lafage-Pochitaloff M. (Leukemia 1999)
    519. Prevalence, kinetics, and therapeutic modulation of autoantibodies against Sp100 and promyelocytic leukemia protein in a large cohort of patients with primary biliary cirrhosis. (PubMed id 9362351)9 ZA1chner D....Will H. (Hepatology 1997)
    520. Interferon-modulated expression of genes encoding the nuclear-dot-associated proteins Sp100 and promyelocytic leukemia protein (PML). (PubMed id 8681971)9 GrAPtzinger T....Will H. (Eur. J. Biochem. 1996)
    521. Acute promyelocytic leukemia with t(15;16;17;19) and unusual fluorescence in situ hybridization pattern with PML and RARA probes. (PubMed id 8956873)9 Kamal N.R....Dewald G.W. (Cancer Genet. Cytogenet. 1996)
    522. [A study on the relationship between morphology and gene heterogeneity in acute promyelocytic leukemia]. (PubMed id 7648936)9 Xiong S....Huang W. (Zhonghua Nei Ke Za Zhi 1995)
    523. CD2 expression in acute promyelocytic leukemia is associated with microgranular morphology (FAB M3v) but not with any PML gene breakpoint. (PubMed id 7658712)9 Biondi A....Masera G. (Leukemia 1995)
    524. Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells. (PubMed id 7529139)9 Grignani F....Pelicci P.G. (Cancer Res. 1995)
    525. The t(15;17) translocation in acute promyelocytic leukemia. (PubMed id 7934155)9 Lavau C. and Dejean A. (Leukemia 1994)
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    527. Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia. (PubMed id 1323928)9 Yamamoto K....Aoki N. (Am. J. Hematol. 1992)
    528. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. (PubMed id 2170850)9 de ThAc H....Dejean A. (Nature 1990)
    529. PML nuclear bodies and their spatial relationships in the mammalian cell nucleus. (PubMed id 19273124)9 Batty E....Freemont P. (Front Biosci (Landmark Ed) 2009)
    530. PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders? (PubMed id 19273155)9 Brown N.J....Grimwade D. (Front Biosci (Landmark Ed) 2009)
    531. The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis. (PubMed id 19058256)9 Virador V.M....Yuspa S.H. (Mol. Carcinog. 2009)
    532. Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. (PubMed id 19390558)9 Laane E....GrandAcr D. (Cell Death Differ. 2009)
    533. Differential expression patterns of SUMO proteins in HL-60 cancer cell lines support a role for sumoylation in the development of drug resistance. (PubMed id 19326147)9 Vigodner M....Skop N. (Cell Tissue Res. 2009)
    534. Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies. (PubMed id 19471587)9 Reineke E.L. and Kao H.Y. (Int. J. Biol. Sci. 2009)
    535. IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53. (PubMed id 19141642)9 Herzer K....Galle P.R. (Cancer Res. 2009)
    536. Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta. (PubMed id 19690170)9 Wethkamp N. and Klempnauer K.H. (J. Biol. Chem. 2009)
    537. Pml and TAp73 interacting at nuclear body mediate imatinib-induced p53-independent apoptosis of chronic myeloid leukemia cells. (PubMed id 19291793)9 Liu J.H....Tzeng C.H. (Int. J. Cancer 2009)
    538. Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence. (PubMed id 18852884)9 Ghosh A.K....Ray R.B. (PLoS ONE 2008)
    539. The expanding role of arsenic in acute promyelocytic leukemia. (PubMed id 18760708)9 Tallman M.S. (Semin. Hematol. 2008)
    540. Human herpesvirus 6B U19 protein is a PML-regulated transcriptional activator that localizes to nuclear foci in a PML-independent manner. (PubMed id 18089734)9 Kofod-Olsen E....HAPllsberg P. (J. Gen. Virol. 2008)
    541. A new complex translocation t(5;17;15)(q11;q21;q22) in acute promyelocytic leukemia. (PubMed id 18558288)9 Abe S....Sugawara T. (Cancer Genet. Cytogenet. 2008)
    542. [Therapy of acute promyelocytic leukemia in Czechia: results and analysis of prognostic factors]. (PubMed id 18780575)9 Schwarz J....CetkovskA1 P. (Vnitr Lek 2008)
    543. Kinetics of repression by modified p53 on the PDGF beta-receptor promoter. (PubMed id 18697203)9 Yang W....Funa K. (Int. J. Cancer 2008)
    544. Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters. (PubMed id 18504436)9 Petrie K....Zelent A. (Oncogene 2008)
    545. The eIF4E RNA regulon promotes the Akt signaling pathway. (PubMed id 18391071)9 Culjkovic B....Borden K.L. (J. Cell Biol. 2008)
    546. Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein. (PubMed id 18609705)9 Sieben M....Moehler M. (World J. Gastroenterol. 2008)
    547. Split mCherry as a new red bimolecular fluorescence complementation system for visualizing protein-protein interactions in living cells. (PubMed id 18158915)9 Fan J.Y....Zhang X.E. (Biochem. Biophys. Res. Commun. 2008)
    548. Loss of promyelocytic leukemia protein in human gastric cancers. (PubMed id 16713073)9 Lee H.E....Kim W.H. (Cancer Lett. 2007)
    549. Successful all-trans retinoic acid treatment of acute promyelocytic leukemia in a patient with NPM/RAR fusion. (PubMed id 17988991)9 Okazuka K....Aizawa Y. (Int. J. Hematol. 2007)
    550. The theory of APL revisited. (PubMed id 17217040)9 Scaglioni P.P. and Pandolfi P.P. (Curr. Top. Microbiol. Immunol. 2007)
    551. Diagnosis and treatment of acute promyelocytic leukemia. (PubMed id 17706161)9 Jurcic J.G....Maslak A.P. (Curr Oncol Rep 2007)
    552. Recruitment of human cytomegalovirus immediate-early 2 protein onto parental viral genomes in association with ND10 in live-infected cells. (PubMed id 17626080)9 Sourvinos G....Stamminger T. (J. Virol. 2007)
    553. PML and TRF2 protein expression in hereditary and sporadic colon cancer. (PubMed id 17822315)9 PlevovA! P....KolA!r Z. (Neoplasma 2007)
    554. Lysosomes and trivalent arsenic treatment in acute promyelocytic leukemia. (PubMed id 17202112)9 Kitareewan S....Dmitrovsky E. (J. Natl. Cancer Inst. 2007)
    555. The adenovirus E4 ORF3 protein binds and reorganizes the TRIM family member transcriptional intermediary factor 1 alpha. (PubMed id 17287283)9 Yondola M.A. and Hearing P. (J. Virol. 2007)
    556. Evidence for the receipt of DNA damage stimuli by PML nuclear domains. (PubMed id 17206596)9 Varadaraj A....Rich T. (J. Pathol. 2007)
    557. Therapeutic targeting of nuclear receptor corepressor misfolding in acute promyelocytic leukemia cells with genistein. (PubMed id 17699721)9 Ng A.P....Khan M. (Mol. Cancer Ther. 2007)
    558. A novel GTPase, CRAG, mediates promyelocytic leukemia protein- associated nuclear body formation and degradation of expanded polyglutamine protein. (PubMed id 16461359)9 Qin Q.... Yanagi S. (J. Cell Biol. 2006)
    559. CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus. (PubMed id 16679534)9 Lemos T.A. and Kobarg J. (Cell Biochem. Biophys. 2006)
    560. Interactions between DNA viruses, ND10 and the DNA damage response. (PubMed id 16469050)9 Everett R.D. (Cell. Microbiol. 2006)
    561. SUMOylation substrates in neuronal intranuclear inclusion disease. (PubMed id 16409557)9 Takahashi-Fujigasaki J....Fujigasaki H. (Neuropathol. Appl. Neurobiol. 2006)
    562. The estrogen-responsive B box protein is a novel regulator of the retinoid signal. (PubMed id 16636064)9 Cheung B.B....Marshall G.M. (J. Biol. Chem. 2006)
    563. Chromatin structural elements and chromosomal translocations in leukemia. (PubMed id 16893685)9 Zhang Y. and Rowley J.D. (DNA Repair (Amst.) 2006)
    564. Repression of SOX6 transcriptional activity by SUMO modification. (PubMed id 16442531)9 Fernandez-Lloris R.... Ventura F. (FEBS Lett. 2006)
    565. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. (PubMed id 16331271)9 Rego E.M....Pandolfi P.P. (Oncogene 2006)
    566. Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNA. (PubMed id 16868026)9 BA...nning P.E. (J. Cell. Sci. 2006)
    567. Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA. (PubMed id 16537904)9 Bishop C.L....Krauzewicz N. (Mol. Cell. Biol. 2006)
    568. A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. (PubMed id 16401619)9 Mackenzie I.R....Pickering-Brown S.M. (Brain 2006)
    569. Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation. (PubMed id 16835227)9 Yang S....Kim M.K. (J. Biol. Chem. 2006)
    570. Development of a novel GFP-based ratiometric excitation and emission pH indicator for intracellular studies. (PubMed id 16603505)9 Bizzarri R....Beltram F. (Biophys. J. 2006)
    571. PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase. (PubMed id 16735446)9 Luciani J.J....Mattei M.G. (J. Cell. Sci. 2006)
    572. Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication. (PubMed id 15858005)9 Evans J.D. and Hearing P. (J. Virol. 2005)
    573. Cellular UV damage responses--functions of tumor suppressor p53. (PubMed id 15921859)9 Latonen L. and Laiho M. (Biochim. Biophys. Acta 2005)
    574. Upregulation of Daxx mediates apoptosis in response to oxidative stress. (PubMed id 16088932)9 Kim K.S....Kwon K.S. (J. Cell. Biochem. 2005)
    575. Regulation of the p73 protein stability and degradation. (PubMed id 15865926)9 Oberst A....Bernassola F. (Biochem. Biophys. Res. Commun. 2005)
    576. Antinuclear antibodies in primary biliary cirrhosis. (PubMed id 16143945)9 Invernizzi P....Wesierska-Gadek J. (Semin. Liver Dis. 2005)
    577. Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. (PubMed id 15782138)9 Ma H....Kahn M. (Oncogene 2005)
    578. SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy- dependent activation of Tcf-4. (PubMed id 15831457)9 Ihara M.... Kikuchi A. (Mol. Cell. Biol. 2005)
    579. SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin. (PubMed id 15923626)9 Chalkiadaki A. and Talianidis I. (Mol. Cell. Biol. 2005)
    580. Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus. (PubMed id 16287851)9 Shyu Y.-C.... Shen C.-K.J. (Mol. Cell. Biol. 2005)
    581. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage. (PubMed id 15893728)9 Strano S....Blandino G. (Mol. Cell 2005)
    582. Neuronal intranuclear inclusion disease without polyglutamine inclusions in a child. (PubMed id 15977647)9 McFadden K....Wiley C.A. (J. Neuropathol. Exp. Neurol. 2005)
    583. Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein. (PubMed id 15964198)9 Fu L....Sztul E. (Neurobiol. Dis. 2005)
    584. Characterization of human herpesvirus 6 variant B immediate-early 1 protein modifications by small ubiquitin-related modifiers. (PubMed id 15105549)9 Gravel A....Flamand L. (J. Gen. Virol. 2004)
    585. A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. (PubMed id 14990586)9 Tang J....Yang X. (J. Biol. Chem. 2004)
    586. Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PubMed id 15161980)9 Li T.... Chock P.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    587. In situ imaging and isolation of proteins using dsDNA oligonucleotides. (PubMed id 15562000)9 Dellaire G....Bazett-Jones D.P. (Nucleic Acids Res. 2004)
    588. Leukemia: beneficial actions of retinoids and rexinoids. (PubMed id 14643883)9 Altucci L....Gronemeyer H. (amp 2004)
    589. 5-lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking. (PubMed id 15375079)9 Catalano A....Romano M. (FASEB J. 2004)
    590. Intranuclear rodlets in the substantia nigra: interactions with marinesco bodies, ubiquitin, and promyelocytic leukemia protein. (PubMed id 15581187)9 Woulfe J....Chretien M. (J. Neuropathol. Exp. Neurol. 2004)
    591. Signalling pathways activated by all-trans-retinoic acid in acute promyelocytic leukemia cells. (PubMed id 15512805)9 Kambhampati S....Platanias L.C. (amp 2004)
    592. Mx1 GTPase accumulates in distinct nuclear domains and inhibits influenza A virus in cells that lack promyelocytic leukaemia protein nuclear bodies. (PubMed id 15269373)9 Engelhardt O.G....Haller O. (J. Gen. Virol. 2004)
    593. [Detection of PML/RARalpha gene rearrangement in suspected acute promyelocytic leukemia patients using dual-color fluorescence in situ hybridization on bone marrow smears]. (PubMed id 15631655)9 Zhu Y.L....Xue Y.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004)
    594. The Nijmegen breakage syndrome gene and its role in genome stability. (PubMed id 15258809)9 Iijima K....Tauchi H. (Chromosoma 2004)
    595. Monitoring PML-RARalpha in acute promyelocytic leukemia. (PubMed id 12895391)9 Jurcic J.G. (Curr Oncol Rep 2003)
    596. Use of arsenic trioxide (As2O3) in the treatment of patients with acute promyelocytic leukemia: the M. D. Anderson experience. (PubMed id 12712474)9 Lazo G....Cortes J. (Cancer 2003)
    597. Serum response factor is modulated by the SUMO-1 conjugation system. (PubMed id 12788062)9 Matsuzaki K....Nakao M. (Biochem. Biophys. Res. Commun. 2003)
    598. Molecular diagnostics of promyelocytic leukaemia. (PubMed id 14617837)9 Kocki J....Wojcierowski J. (J. Appl. Genet. 2003)
    599. Molecular pathogenesis of acute promyelocytic leukaemia and APL variants. (PubMed id 12935958)9 Sirulnik A....Licht J.D. (amp 2003)
    600. The ND10 component promyelocytic leukemia protein relocates to human papillomavirus type 1 E4 intranuclear inclusion bodies in cultured keratinocytes and in warts. (PubMed id 12477870)9 Roberts S....Gallimore P.H. (J. Virol. 2003)
    601. PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases. (PubMed id 12901837)9 Takahashi J....Brice A. (Neurobiol. Dis. 2003)
    602. Acute promyelocytic leukaemia in patients originating in Latin America is associated with an increased frequency of the bcr1 subtype of the PML/RARalpha fusion gene. (PubMed id 12899711)9 Douer D....Vallejos C. (Br. J. Haematol. 2003)
    603. Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571. (PubMed id 12829585)9 Beissert T....Ruthardt M. (Blood 2003)
    604. Concordant down-regulation of proto-oncogene PML and major histocompatibility antigen HLA class I expression in high-grade prostate cancer. (PubMed id 12747744)9 Zhang H....Zheng P. (Cancer Immun. 2003)
    605. Acute promyelocytic leukemia M3: cytomorphologic, immunophenotypic, cytogenetic, and molecular variants. (PubMed id 12590709)9 SuciA8 M....StavljeniA8-Rukavina A. (amp 2002)
    606. Receptor selective synthetic retinoids as potential cancer chemotherapy agents. (PubMed id 12188922)9 Crowe D.L. (Curr Cancer Drug Targets 2002)
    607. Mutations in the S4-H2 loop of eIF4E which increase the affinity for m7GTP. (PubMed id 11959093)9 Spivak-Kroizman T....Hagedorn C.H. (FEBS Lett. 2002)
    608. The emerging roles of translation factor eIF4E in the nucleus. (PubMed id 11963652)9 Strudwick S. and Borden K.L. ( research in biological diversity 2002)
    609. Functional interaction between the pp71 protein of human cytomegalovirus and the PML-interacting protein human Daxx. (PubMed id 11992005)9 Hofmann H....Stamminger T. (J. Virol. 2002)
    610. PML and COP1--two proteins with much in common. (PubMed id 11165511)9 Reyes J.C. (Trends Biochem. Sci. 2001)
    611. DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia. (PubMed id 11243468)9 HauksdA^ttir H. and Privalsky M.L. (amp 2001)
    612. Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis. (PubMed id 11331249)9 Waerner T.... Kraut N. (Cell Growth Differ. 2001)
    613. Expression of human herpesvirus 8 (HHV-8)-encoded immediate early protein, open reading frame 50, in HHV-8-associated diseases. (PubMed id 11437319)9 Katano H....Sata T. (J. Hum. Virol. 2001)
    614. Modeling acute promyelocytic leukemia in the mouse: new insights in the pathogenesis of human leukemias. (PubMed id 11358384)9 Merghoub T....Pandolfi P.P. (amp 2001)
    615. Histone deacetylases and transcriptional therapy with their inhibitors. (PubMed id 11587360)9 Pandolfi P.P. (Cancer Chemother. Pharmacol. 2001)
    616. In vivo analysis of the molecular genetics of acute promyelocytic leukemia. (PubMed id 11607822)9 Pandolfi P.P. (Oncogene 2001)
    617. Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability. (PubMed id 11406610)9 Hu P....Ellis N.A. (Hum. Mol. Genet. 2001)
    618. Analysis of the molecular genetics of acute promyelocytic leukemia in mouse models. (PubMed id 11172540)9 Rego E.M. and Pandolfi P.P. (Semin. Hematol. 2001)
    619. Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid. (PubMed id 11454693)9 Mologni L....Gambacorti-Passerini C. (Cancer Res. 2001)
    620. [Monoclonal antibodies against protein Daxx and its localization in nuclear domains 10]. (PubMed id 11881150)9 Sotnikov A.G....Maul G.G. (Tsitologiia 2001)
    621. Regulation and localization of the Bloom syndrome protein in response to DNA damage. (PubMed id 11309417)9 Bischof O....Campisi J. (J. Cell Biol. 2001)
    622. Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. (PubMed id 11696577)9 He L.Z....Pandolfi P.P. (J. Clin. Invest. 2001)
    623. Molecular analysis and clinical outcome of adult APL patients with the type V PML-RARalpha isoform: results from intergroup protocol 0129. (PubMed id 10627441)9 Slack J.L....Gallagher R.E. (Blood 2000)
    624. Acute promyelocytic leukemia. From morphology to molecular lesions. (PubMed id 10702898)9 Mattson J.C. (Clin. Lab. Med. 2000)
    625. HLA class I in acute promyelocytic leukemia (APL): possible correlation with clinical outcome. (PubMed id 10720132)9 Bolognesi E....Momigliano-Richiardi P. (Leukemia 2000)
    626. ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle. (PubMed id 11082050)9 Grobelny J.V....Broccoli D. (J. Cell. Sci. 2000)
    627. The effects of arsenic trioxide (As2O3) on human megakaryocytic leukemia cell lines. With a comparison of its effects on other cell lineages. (PubMed id 10811458)9 Alemany M. and Levin J. (amp 2000)
    628. Modified intranuclear organization of regulatory factors in human acute leukemias: reversal after treatment. (PubMed id 10679814)9 Gordon J.A....Stein G.S. (J. Cell. Biochem. 2000)
    629. Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8). (PubMed id 10951564)9 Odaka Y....Meyers S. (Oncogene 2000)
    630. Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b. (PubMed id 10684265)9 Hofmann H....Stamminger T. (J. Virol. 2000)
    631. Acute myeloid leukemia with hypergranular cytoplasm: a differential diagnosis of acute promyelocytic leukemia. (PubMed id 11086183)9 Girodon F....MaynadiAc M. (Leuk. Res. 2000)
    632. The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis. (PubMed id 10187798)9 Liou M.L. and Liou H.C. (J. Biol. Chem. 1999)
    633. Identification of the t(15;17) in AML FAB types other than M3: evaluation of the role of molecular screening for the PML/RARalpha rearrangement in newly diagnosed AML. The Medical Research Council (MRC) Adult Leukaemia Working Party. (PubMed id 10233384)9 Allford S....Linch D. (Br. J. Haematol. 1999)
    634. A novel, non-nested reverse-transcriptase polymerase chain reaction (RT-PCR) test for the detection of the t(15;17) translocation: a comparative study of RT-PCR cytogenetics, and fluorescence In situ hybridization. (PubMed id 10553020)9 Rennert H....Leonard D.G. (Mol. Diagn. 1999)
    635. The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10). (PubMed id 10559364)9 Ahn J.H....Hayward G.S. (J. Virol. 1999)
    636. Terminal deletion of the long arm of chromosome 9 in acute promyelocytic leukemia with a cryptic PML/RAR alpha rearrangement. (PubMed id 10484977)9 Yamamoto K....Nagata K. (Cancer Genet. Cytogenet. 1999)
    637. In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies. (PubMed id 10374879)9 GiannA- M. and de ThAc H. (Leukemia 1999)
    638. In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications. (PubMed id 10498880)9 He L.Z....Pandolfi P.P. (Oncogene 1999)
    639. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (PubMed id 10328107)9 Zhu X.H....Chen G.Q. (J. Natl. Cancer Inst. 1999)
    640. Human papillomavirus DNA replication compartments in a transient DNA replication system. (PubMed id 9882301)9 Swindle C.S....Chow L.T. (J. Virol. 1999)
    641. PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. (PubMed id 10373566)9 Sternsdorf T....Ruthardt M. (Mol. Cell. Biol. 1999)
    642. Etoposide-related acute promyelocytic leukemia. (PubMed id 9697869)9 Kudo K....Naoe T. (Leukemia 1998)
    643. Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. (PubMed id 9636146)9 Seeler J.-S.... Dejean A. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    644. Immunophenotype of adult and childhood acute promyelocytic leukaemia: correlation with morphology, type of PML gene breakpoint and clinical outcome. A cooperative Italian study on 196 cases. (PubMed id 9734655)9 Guglielmi C....Lo Coco F. (Br. J. Haematol. 1998)
    645. [Acute promyelocytic leukemia, histone deacetylase, and response to retinoids]. (PubMed id 9752292)9 Jeanteur P. (Bull Cancer 1998)
    646. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. (PubMed id 9462740)9 He L.Z....Pandolfi P.P. (Nat. Genet. 1998)
    647. Leukemic cellular retinoic acid resistance and missense mutations in the PML-RARalpha fusion gene after relapse of acute promyelocytic leukemia from treatment with all-trans retinoic acid and intensive chemotherapy. (PubMed id 9694705)9 Ding W....Gallagher R.E. (Blood 1998)
    648. A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation. (PubMed id 9192750)9 Shao W....Miller W.H. (Blood 1997)
    649. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. (PubMed id 9002938)9 Grisolano J.L....Ley T.J. (Blood 1997)
    650. Association of nuclear matrix proteins with granular and threaded nuclear bodies in cell lines undergoing apoptosis. (PubMed id 9024791)9 Zweyer M....Martelli A.M. (Exp. Cell Res. 1997)
    651. Secondary cytogenetic changes in acute promyelocytic leukemia--prognostic importance in patients treated with chemotherapy alone and association with the intron 3 breakpoint of the PML gene: a Cancer and Leukemia Group B study. (PubMed id 9164186)9 Slack J.L....Bloomfield C.D. (J. Clin. Oncol. 1997)
    652. Identification of classic and complex t(15;17) and/or RAR alpha/PML gene fusion in APL by cytogenetic and dual color-FISH techniques. (PubMed id 9276968)9 Acar H....Stewart J. (Proc. Natl. Sci. Counc. Repub. China B 1997)
    653. Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells. (PubMed id 9242550)9 Benedetti L....Nervi C. (Blood 1997)
    654. Nuclear proteins binding to the recombination hotspot region of the retinoic acid receptor alpha gene. (PubMed id 9209366)9 Tashiro S....Kamada N. (Leukemia 1997)
    655. Association of PML-RAR alpha fusion mRNA type with pretreatment hematologic characteristics but not treatment outcome in acute promyelocytic leukemia: an intergroup molecular study. (PubMed id 9269786)9 Gallagher R.E....Wiernik P.H. (Blood 1997)
    656. A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. (PubMed id 9122233)9 Brown D....Bishop J.M. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    657. The rapid diagnosis of acute promyelocytic leukaemia using PML (5E10) monoclonal antibody. (PubMed id 9401072)9 O'Connor S.J....Morgan G.J. (Br. J. Haematol. 1997)
    658. Recent advances in the treatment of acute leukemia. (PubMed id 9260053)9 Berman E. (Curr. Opin. Hematol. 1997)
    659. New strategies for the treatment of acute promyelocytic leukaemia. (PubMed id 9350178)9 Mandelli F. (J Intern Med Suppl 1997)
    660. Molecular analysis of the t(15;17) translocation in de novo and secondary acute promyelocytic leukemia. (PubMed id 9209367)9 Naoe T....Ohno R. (Leukemia 1997)
    661. Nuclear dots: actors on many stages. (PubMed id 9442402)9 Sternsdorf T....Will H. (Immunobiology 1997)
    662. [A preliminary study of the relation between topoisomerase I and translocation (15;17)]. (PubMed id 9206036)9 Dong S....Chen S. (Zhonghua Zhong Liu Za Zhi 1996)
    663. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. (PubMed id 8704214)9 Chen G.Q....Chen Z. (Blood 1996)
    664. PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia. (PubMed id 8952164)9 Pandolfi P.P. (Haematologica 1996)
    665. The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1. (PubMed id 8940259)9 Korioth F....Frey J. (Exp. Cell Res. 1996)
    666. cAMP signalling is decisive for recovery of nuclear bodies (PODs) during maturation of RA-resistant t(15;17) promyelocytic leukemia NB4 cells expressing PML-RAR alpha. (PubMed id 8649787)9 Duprez E....Lanotte M. (Oncogene 1996)
    667. Two distinct actions of retinoid-receptor ligands. (PubMed id 8752277)9 Chen J.Y....Gronemeyer H. (Nature 1996)
    668. Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia. (PubMed id 8570209)9 Licht J.D....Waxman S. (Oncogene 1996)
    669. Mouse ret finger protein (rfp) proto-oncogene is expressed at specific stages of mouse spermatogenesis. (PubMed id 9023983)9 Cao T....Etkin L.D. (Dev. Genet. 1996)
    670. Characterization of acute promyelocytic leukemia cases with PML-RAR alpha break/fusion sites in PML exon 6: identification of a subgroup with decreased in vitro responsiveness to all-trans retinoic acid. (PubMed id 7632962)9 Gallagher R.E....Wiernik P.H. (Blood 1995)
    671. Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress. (PubMed id 8749719)9 Maul G.G....Epstein A.L. (J. Cell. Biochem. 1995)

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    Entrez Gene: 5371 HGNC: 9113 AceView: PML Ensembl:ENSG00000140464 euGenes: HUgn5371
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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