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PML Gene

protein-coding GIFtS: 69

GC15P072074

promyelocytic leukemia
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MYL ^¹, ², ³, ⁵
PP8675 ^²
RNF71 ^¹, ², ³
TRIM19 ^¹, ², ³

Descriptions
RING finger protein 71 ^³
Tripartite motif-containing protein 19 ^³
promyelocytic leukemia ^²
promyelocytic leukemia protein ^²
promyelocytic leukemia, inducer of ^²
tripartite motif protein TRIM19 ^²

External Ids
HGNC: 9113¹
Entrez Gene: 5371²
UniProtKB: P29590³
Ensembl: ENSG00000140464⁷

Search outside databases for aliases for PML gene

Previous GC identifers: GC15P070307 GC15P067403 GC15P071862 GC15P072002

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PML:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif

includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil

region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription

factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53

response to oncogenic signals. The gene is often involved in the translocation with the retinoic

acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative

splicing of this gene results in several variations of the protein's central and C-terminal

regions; all variants encode the same N-terminus. Alternatively spliced transcript variants

encoding different isoforms have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: PML_HUMAN, P29590

Function: Probable transcription factor. May play an important role in recruitment of ELF4 into PML

nuclear bodies

Gene Wiki entry for PML (Promyelocytic_leukemia_protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PML gene

Entrez Gene cytogenetic band: 15q22 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q22

PML Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P072074: (about GC identifiers)

Start:	72,074,067 bp from pter
End:	72,127,213 bp from pter
Size:	53,147 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PML_HUMAN, P29590 (See protein sequence)

Recommended Name: Probable transcription factor PML

Size: 882 amino acids; 97551 Da

Subunit: Interacts with SIRT1, TOPBP1, TRIM27 and TRIM69. Interacts with the C-terminus of ELF4.

Interacts with Lassa virus Z protein and rabies virus phosphoprotein (By similarity)

Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Sumoylated forms localize to the PML

nuclear bodies. The B1 box and the RING finger are also required for this nuclear localization.

Isoforms lacking a nuclear localization signal are cytoplasmic

PDB structures from and Proteopedia :

1BOR (3D)

Secondary accessions: P29591 P29592 P29593 Q00755 Q96S41

Alternative splicing: 7 isoforms: P29590-1 P29590-2 P29590-3 P29590-4 P29590-5 P29590-6 P29590-7 (Additional isoforms seem to exist)

Post-translational modifications:

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation¹

Sumoylated on all three sites is required for nuclear body formation. Sumoylation on Lys-160 is a

prerequisite for sumoylation on Lys-65. The PML-RARA fusion protein is not sumoylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (9 alternative transcripts):

NP_002666.1 NP_150241.2 NP_150242.1 NP_150243.2 NP_150247.2 NP_150249.1 NP_150250.2 NP_150252.1

NP_150253.2

ENSEMBL proteins:

ENSP00000353004 ENSP00000268059 ENSP00000315434 ENSP00000378564 ENSP00000378567 ENSP00000268058

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PML+RARA Fusion, PML Protein)
	Human Recombinant Proteins from Abnova (PML)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005626	insoluble fraction	IDA	12915590
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	IDA	12915590
GO:0005730	nucleolus	IDA	15195100

About this table

Antibodies for PML:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PML
	Sigma-Aldrich Antibody Arrays and Antibodies for PML
	R&D Systems Antibodies for PML
	Antibodies from Abcam (PML+RARA Fusion, PML Protein), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PML)
	Novus Biologicals Antibodies for PML

Assays for PML:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P29590

ProtoNet protein and cluster: P29590

2 Blocks protein families:

IPB000315 B-box zinc finger signature

IPB001841 Zn-finger

UniProtKB/Swiss-Prot: PML_HUMAN, P29590

Similarity: Contains 2 B box-type zinc fingers

Similarity: Contains 1 RING-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PML)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PML)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 11): NM_033238

Applied Biosystems Silencer® siRNAs for PML

Sigma-Aldrich siRNA and siRNA Panels for PML

Sigma-Aldrich shRNA Panels and shRNA for PML

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 9): NM_002675
Myc/DDK tagged cDNA clones in CMV expression vector (see all 9): NM_002675
untagged cDNA clones in CMV expression vector (see all 9): NM_002675

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_033238

UniProtKB/Swiss-Prot: PML_HUMAN, P29590

Function: Probable transcription factor. May play an important role in recruitment of ELF4 into PML

nuclear bodies

Genatlas biochemistry entry for PML:

POD (promyelocytic oncogenic domain),nuclear matrix protein,B box family, colocalizing and

interacting with CREBBP,TIF2A and with DAXX in special (PML/SP100) nuclear bodies(NB/POD), to form

a retinoic acid (RA) dependent growth suppressive RRXA,RARA nuclear complex,involved in

development,recombinaison,DNA repair,and in early hematopoiesis and late erythropoiesis,recruiting

the nuclear corepressor histone deacetylase complex,essential for multiple apoptotic

pathways,putative controller of genes devoted to MHC class I antigen presentation.

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pml):

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0030528	transcription regulator activity	IEA	--
GO:0032184	SUMO polymer binding	IPI	9412458
GO:0042803	protein homodimerization activity	IPI	9230084

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for PML (Your Favorite Gene powered by Ingenuity)

Acute Myeloid Leukemia Signaling
RAR Activation

GeneDecks PML for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PML

5/72 Interacting proteins for PML (ENSP00000268058³ P29590^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 72 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DAXX	Q9UER7¹	STRING (score=.998) EBI-295890, EBI-77321
ZBTB16	Q05516¹	STRING (score=.994) EBI-304008, EBI-711925
TERF2	Q15554²	STRING (score=.743) MINT-6744122
ZFYVE9	O95405²	STRING (score=.994) MINT-6799194
MDM2	Q00987¹^,²	STRING (score=.993) EBI-295890, EBI-389668 MINT-4793330 MINT-4793420 MINT-4793448 EBI-295890, EBI-389668 MINT-4793330 MINT-4793420 MINT-4793448

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5/24 Gene Ontology (GO) biological process terms (links to tree view) (see all 24 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	16915281
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006461	protein complex assembly	IDA	12915590
GO:0006917	induction of apoptosis	IEA	--
GO:0006919	activation of caspase activity	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PML
7 Novoseek chemical compound relationships for PML gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha-retinoic acid	81.79	3	8396481 (1), 8207983 (1), 7815831 (1)
pic 1	68.64	3	9658103 (2), 10187798 (1)
zinc	18.80	9	12794076 (2), 12759344 (1), 17988991 (1), 10938104 (1) (see all 8)
bromodeoxyuridine	12.84	1	12773567 (1)
cadmium	0.00	3	12167712 (3)
leucine	0.00	1	11485412 (1)
proline	0.00	1	10597310 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PML)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PML)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 11): NM_033238

Sigma-Aldrich siRNA and siRNA Panels for PML

Sigma-Aldrich shRNA Panels and shRNA for PML

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002675 NM_033238 NM_033239 NM_033240 NM_033244 NM_033246 NM_033247 NM_033249

NM_033250

REFSEQ mRNAs for PML gene (9 alternative transcripts):

NM_002675.3 NM_033238.2 NM_033239.2 NM_033240.2 NM_033244.3 NM_033246.2 NM_033247.2 NM_033249.2

NM_033250.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002675 NM_033238 NM_033239 NM_033240 NM_033244 NM_033246 NM_033247 NM_033249

NM_033250

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 9): NM_002675
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 9): NM_002675
                                 untagged cDNA clones in CMV expression vector (see all 9): NM_002675

Additional cDNA sequence:

AB067754.1 AB208950.1 AB209051.1 AB209411.1 AF230401.1 AF230402.1 AF230403.1 AF230404.1

AF230405.1 AF230406.1 AF230407.1 AF230408.1 AF230409.1 AF230410.1 AF230411.1 AF370432.1

AF388193.1 AF388194.1 AK026871.1 AK300256.1 AK300951.1 BC000080.2 BC020994.2 BC034251.1

BC139795.1 BT009911.1 BX647287.1 CR602508.1 M73778.1 M79462.1 M79463.1 M79464.1

M80185.1 S50913.1 X63131.1

24 DOTS entries:

DT.447813 DT.97791923 DT.100792863 DT.100792859 DT.91792314 DT.91783610 DT.97787374 DT.210086

DT.317724 DT.102827730 DT.91836290 DT.100792858 DT.92352534 DT.100792875 DT.91722067 DT.97772804

DT.100792857 DT.100718623 DT.101959716 DT.100792873 DT.100792874 DT.92011830 DT.92362935 DT.99993975

24/298 AceView cDNA sequences (see all 298 ):

BQ933226 NM_002675 BM469516 BM127636 BU902386 AI650742 BQ438276 BI793248

NM_033240 BQ059293 CA487430 AI659853 AA788922 NM_033246 BU753248 BU543691

CR602508 BQ430284 BE336744 BU617120 BQ052031 BQ642937 BI757312 AI635829

highest scoring ESTs for PML:

M79462 AA232665 AA234052 AA243463 AA250795 AA251040 AA279838 AA280067 AA417793 AA417794

Unigene Cluster for PML:

Promyelocytic leukemia

Hs.526464 [show with all ESTs]

Unigene Representative Sequence: NM_033238

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PML (see all 16 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	^	9a	·	9b	·	9c	^
SP1:																													-				-		-		-		-		-		-		-				-		-
SP2:																													-				-		-		-		-		-		-		-
SP3:																									-				-				-		-		-		-		-		-		-				-		-
SP4:																													-				-
SP5:																																	-		-		-		-		-		-		-

ExUns:	10a	·	10b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PML

6 Ensembl transcripts including schematic representations:

ENST00000359928 ENST00000268059 ENST00000354026 ENST00000395132 ENST00000395135 ENST00000268058

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PML expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PML

¹ / ² / ³

25 probe-sets matching PML gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
566_at²^{, 3}	U95-A	1	1.00	1.00	0.76	0.99	M79462	1.00	1.00	1.00	1
38787_at²^{, 3}	U95-A	1	1.00	1.00	0.04	0.72	X63131	0.80	1.00	0.91	1
48964_at²^{, 3}	U95-B	1	1.00	1.00	0.80	0.91	AI629027	0.60	1.00	0.82	1
567_s_at²^{, 3}	U95-A	2	1.00	0.50	0.89	1.37	M79463	0.80	0.88	0.84	1
38788_at²^{, 3}	U95-A	2	0.75	0.50	0.95	1.02	M82827	0.20	0.50	0.38	1
210362_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF230409	0.60	1.00	0.82	1
239582_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW514654	0.60	1.00	0.82	1
211588_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF230401	0.80	1.00	0.91	1
235508_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW291023	0.40	1.00	0.76	1
211589_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF230401	0.80	1.00	0.91	1
209640_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M79462	1.00	1.00	1.00	1
211013_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AF230411	0.60	1.00	0.82	1
206503_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_002675	0.60	1.00	0.82	1
211014_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	AF230410	0.60	1.00	0.82	1
211012_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	BC000080	0.60	1.00	0.82	1
210362_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
239582_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211588_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235508_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211589_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209640_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211013_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
206503_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
211014_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
211012_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks PML for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.526464
Expression variation in blood from EXPOLDB for PML

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PML gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	PML¹	--	promyelocytic leukemia	99.62(n) 99.89(a)	453736 NM_001042435.1 NP_001035900.1
rat (Rattus norvegicus)	Pml¹	--	promyelocytic leukemia	77.88(n) 71.23(a)	315713 XM_236296.4 XP_236296.4
mouse (Mus musculus)	Pml^{1, 5}	9 (32.00 cM)⁵	promyelocytic leukemia^{1, 5}	77.18(n)¹ 70.93(a)¹	18854¹ NM_178087.3¹ NP_835188.1¹ AA821782⁵ AI661194⁵ (see all 28)
chicken (Gallus gallus)	PML¹	--	promyelocytic leukemia	56.14(n) 40.94(a)	415302 XM_413690.2 XP_413690.2

About this table Species with no ortholog for PML

ENSEMBL Gene Tree for PML

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/221 NCBI SNPs in PML are shown (see all 221 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 101)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1036673^1,2	A,C,F,H,O	72125515(+)	`CTCCAT/CGGTCA`	1	--	ut3¹ ese³		16	EA NA MN EU WA	1314
	rs6772^1,2	A,C,F,H	72125992(+)	`TAAAAC/TAGGCG`	1	--	ut3¹ ese³		10	MN EU EA WA NA	998
--	rs9479^1,2	A,C,F,H	72115629(+)	`CCTGTG/ATTCTG`	9	--	ut3¹ int¹		8	MN EA EU WA	2368
	rs5742915^1,2	C,F,H	72123686(+)	`AAGCCT/CTCTTC`	1	L/F	mis¹		5	EU EA WA	511
	rs743580^1,2	A,C,F	72115169(+)	`GGGAAG/AGCAGA`	9	G/S	mis¹ int¹ ut3¹		8	NA EA MN	917
	rs752004^1,2	A,C,F	72116074(-)	`CCTCAG/ATGAGG`	9	--	ng3¹ int¹		4	NA EA MN	1674
	rs5742914^1,2	C,F,H	72073982(+)	`CTCTAC/TCTCCT`	9	--	ng5¹ trp³		9	EU EA WA	933
	rs743582^1,2	C,F,H	72115259(+)	`TGGAAG/CCCTCT`	9	P/A	mis¹ int¹ ut3¹		13	MN EU EA WA NA	1236
--	rs743581^1,2	A,C,F	72115194(+)	`AGCAGG/TTGTTC`	9	G/V	mis¹ int¹ ut3¹ ese³		1	MN	184
	rs2301273^1,2	C,F,H	72073935(+)	`CCTCTC/TCCGCT`	9	--	ng5¹		5	EU EA WA	513

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HapMap Linkage Disequilibrium images for PML (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 102578

UniProtKB/Swiss-Prot: PML_HUMAN, P29590

A chromosomal aberration involving PML may be a cause of acute promyelocytic leukemia

(APL). Translocation t(15;17)(q21;q21) with RARA. The PML breakpoints (type A and type B) lie on

either side of an alternatively spliced exon

10/37 Novoseek disease relationships for PML gene (see all 37 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
promyelocytic leukemia	96.06	269	11511788 (3), 16154611 (2), 8550548 (2), 10684855 (2) (see all 99)
leukemia promyelocytic acute	95.68	147	1310060 (2), 1353379 (2), 9452416 (2), 11068554 (2) (see all 99)
leukemogenesis	73.25	8	8580793 (1), 18809579 (1), 8609713 (1), 8400236 (1) (see all 7)
leukemia	69.11	60	19088278 (2), 9591778 (2), 9734655 (2), 18716620 (2) (see all 43)
minimal residual disease	62.05	4	1310060 (1), 1375840 (1), 8180596 (1), 9260053 (1)
bloom syndrome	59.56	2	10637504 (1)
drpla	44.27	1	12901837 (1)
biliary cirrhosis primary	32.84	6	9362351 (2), 8986606 (1), 9193756 (1), 8749719 (1)
herpes simplex	30.53	11	19279115 (2), 10574707 (1), 10233977 (1), 9151854 (1) (see all 9)
tumors	28.33	67	14970276 (8), 18566754 (6), 18856066 (3), 10684855 (2) (see all 28)

About this table

Genatlas disease: PML

acute promyelocytic leukemia (APL) with translocation t(15;17)(q22;q12) and with poor

prognosis,may be associated with a hemorrhagic diathesis,secundary to an overexpression of annexin

II with a secundary itinease of plasmin (see RARA)

Genetic Association Database: PML
Human Genome Epidemiology Navigator: PML (14 documents)
Tumor Gene Database: PML

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/482 PubMed articles for PML gene (see all 482 ):

PML colocalizes with and stabilizes the DNA damage response protein TopBP1. (PubMed id 12773567)^{1, 3, 4} Xu Z.-X.... Chang K.-S. (2003)
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. (PubMed id 1311253)^{1, 3, 4} Kastner P.... Chambon P. (1992)
Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. (PubMed id 9570750)^{1, 3, 4} Cao T.... Etkin L.D. (1998)
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. (PubMed id 12006491)^{1, 3, 4} Langley E.... Kouzarides T. (2002)
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. (PubMed id 1652368)^{1, 3, 4} Kakizuka A.... Evans R.M. (1991)
Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein. (PubMed id 14976184)^{1, 3, 4} Suico M.A.... Kai H. (2004)
Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants. (PubMed id 1312695)^{1, 3, 4} Tong J.H.... Berger R. (1992)
Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. (PubMed id 1720570)^{1, 3, 4} Goddard A.D.... Solomon E. (1991)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
[Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia] (PubMed id 15968309)^{3, 6} Zhu Y.L....Liu J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5371	HGNC: 9113	AceView: PML	Ensembl:ENSG00000140464	euGenes: HUgn5371
ECgene: PML	H-InvDB: PML

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PML	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PML
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PML:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PML-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PML		Antibodies for PML
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PML		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PML)
	Antibodies (PML)
	Chimera RNAi (PML)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PML+RARA Fusion, PML Protein)
	Antibodies (PML+RARA Fusion, PML Protein)

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Antibodies for PML

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PML Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for PML

Summaries
for PML

Genomic Location
for PML

Proteins
for PML

Protein Domains/
Families
for PML

Gene Function
for PML

Pathways & Interactions
for PML

Drugs & Compounds
for PML

Transcripts
for PML

Expression
for PML

Orthologs
for PML

Paralogs
for PML

SNPs/Variants
for PML

Disorders & Mutations
for PML

Medical News
for PML

Publications
for PML

Search for PML

Genome Databases showing PML

Other Databases showing PML

Specialized Databases showing PML

Licensable Technologies
for PML

Services
for PML

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PML Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor PML

Summariesfor PML

Genomic Locationfor PML

Proteinsfor PML

Protein Domains/Familiesfor PML

Gene Functionfor PML

Pathways & Interactionsfor PML

Drugs & Compoundsfor PML

Transcriptsfor PML

Expression for PML

Orthologsfor PML

Paralogsfor PML

SNPs/Variantsfor PML

Disorders & Mutationsfor PML

Medical Newsfor PML

Publicationsfor PML

Search for PML

Genome Databases showing PML

Other Databases showing PML

Specialized Databases showing PML

Licensable Technologiesfor PML

Servicesfor PML

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PML

Summaries
for PML

Genomic Location
for PML

Proteins
for PML

Protein Domains/
Families
for PML

Gene Function
for PML

Pathways & Interactions
for PML

Drugs & Compounds
for PML

Transcripts
for PML

Expression
for PML

Orthologs
for PML

Paralogs
for PML

SNPs/Variants
for PML

Disorders & Mutations
for PML

Medical News
for PML

Publications
for PML

Licensable Technologies
for PML

Services
for PML