PML Gene
protein-coding GIFtS: 67
GCID: GC15P074287
|
|
promyelocytic leukemia
| |
Aliases
for PML gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Promyelocytic Leukemia1 2 | | RING Finger Protein 712 3 | | MYL1 2 3 5 | | PP86752 | | RNF711 2 3 | | Probable Transcription Factor PML2 | | TRIM191 2 3 | | Promyelocytic Leukemia, Inducer Of2 | | Promyelocytic Leukemia Protein2 3 | | Protein PML2 | | Tripartite Motif-Containing Protein 192 3 | | Tripartite Motif Protein TRIM192 |
Export aliases for PML gene to outside databasesPrevious GC identifers: GC15P070307 GC15P067403 GC15P071862 GC15P072002 GC15P072074 GC15P051118 |
Summaries
for PML gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PML:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoproteinlocalizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression iscell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in thetranslocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensivealternative splicing of this gene results in several variations of the protein's central and C-terminal regions; allvariants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have beenidentified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PML_HUMAN, P29590Function: Key component of PML nuclear bodies that regulate a large number of cellular processes by facilitatingpost-translational modification of target proteins, promoting protein-protein contacts, or by sequestering proteins.Functions as tumor suppressor. Required for normal, caspase-dependent apoptosis in response to DNA damage, FAS, TNF,or interferons. Plays a role in transcription regulation, DNA damage response, DNA repair and chromatin organization.Plays a role in processes regulated by retinoic acid, regulation of cell division, terminal differentiation of myeloidprecursor cells and differentiation of neural progenitor cells. Required for normal immunity to microbial infections.Plays a role in antiviral response. In the cytoplasm, plays a role in TGFB1-dependent processes. Regulates p53/TP53levels by inhibiting its ubiquitination and proteasomal degradation. Regulates activation of p53/TP53 viaphosphorylation at 'Ser-20'. Sequesters MDM2 in the nucleolus after DNA damage, and thereby inhibits ubiquitinationand degradation of p53/TP53. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role inneoangiogenesis and tumor vascularization. Regulates RB1 phosphorylation and activity. Required for normal developmentof the brain cortex during embryogenesis. Can sequester herpes virus and varicella virus proteins inside PML bodies,and thereby inhibit the formation of infectious viral particles. Regulates phosphorylation of ITPR3 and plays a rolein the regulation of calcium homeostasis at the endoplasmic reticulum (By similarity). Regulates transcriptionactivity of ELF4. Inhibits specifically the activity of the tetrameric form of PKM. Together with SATB1, involved inlocal chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Regulates PTEN compartmentalizationthrough the inhibition of USP7-mediated deubiquitination
Gene Wiki entry for PML (Promyelocytic leukemia protein)
|
Genomic Views
for PML gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PML gene promoter:
AML1a STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for PML
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PML |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1PML Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P074287: view genomic region
(about GC identifiers)
Start:
|
74,287,014 bp from pter |
End:
|
74,340,160 bp from pter |
Size:
|
53,147 bases |
Orientation:
|
plus strand |
|
Proteins
for PML gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PML_HUMAN, P29590 (See
protein sequence)Recommended Name: Protein PML Size: 882 amino acids; 97551 Da
Subunit: Key component of PML bodies. PML bodies are formed by the interaction of PML homodimers (via SUMO-bindingmotif) with sumoylated PML, leading to the assembly of higher oligomers. Several types of PML bodies have beenobserved. PML bodies can form hollow spheres that can sequester target proteins inside. Interacts (via SUMO-bindingmotif) with sumoylated proteins. Interacts (via C-terminus) with p53/TP53. Recruits p53/TP53 and CHEK2 into PMLbodies, which promotes p53/TP53 phosphorylation at 'Ser-20' and prevents its proteasomal degradation. Interacts withMDM2, and sequesters MDM2 in the nucleolus, thereby preventing ubiquitination of p53/TP53. Interaction with PML-RARAoncoprotein and certain viral proteins causes disassembly of PML bodies and abolishes the normal PML function.Interacts with HIPK2, TERT, SIRT1, TOPBP1, TRIM27 and TRIM69. Interacts with ELF4 (via C-terminus). Interacts withLassa virus Z protein and rabies virus phosphoprotein. Interacts with ITPR3 (By similarity). Interacts (in thecytoplasm) with TGFBR1, TGFBR2 and PKM. Interacts (via the coiled-coil domain and when sumoylated) with SATB1.Interacts with UBE2I; the interaction is enhanced by arsenic binding. Interacts (PML-RARA oncoprotein, via thecoiled-coil domain) with UBE2I; the interaction is enhanced by arsenic binding and is required for PML-RARAoncoprotein sumoylation and inhibition of RARA transactivational activity. Interacts with RB1, PPP1A, SMAD2, SMAD3,DAXX, RPL11 and MTOR
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Nucleus, PML body. Nucleus, nucleolus. Endoplasmic reticulummembrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Early endosome membrane; Peripheral membraneprotein; Cytoplasmic side. Note=Sumoylated forms localize to the PML nuclear bodies. The B1 box and the RING fingerare also required for this nuclear localization. Isoforms lacking a nuclear localization signal are cytoplasmic.Detected in the nucleolus after DNA damage. Sequestered in the cytoplasm by interaction with rabies virusphosphoprotein
Sequence caution: Sequence=AAA60351.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAA60352.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA60388.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA60390.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=BAB62809.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;Sequence=BAD92648.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for PML:1BOR (3D)
Secondary accessions: P29591 P29592 P29593 Q00755 Q15959 Q59FP9 Q8WUA0 Q96S41 Q9BPW2 Q9BWP7 Q9BZX6Q9BZX7 Q9BZX8 Q9BZX9 Q9BZY0 Q9BZY2 Q9BZY3Alternative splicing: 12 isoforms: P29590-1 P29590-8 P29590-9 P29590-5 P29590-2 P29590-4 P29590-10 P29590-3 P29590-11 P29590-12 P29590-13 P29590-14 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PML: NX_P29590
Post-translational modifications:
Ubiquitinated; mediated by RNF4, SIAH1 or SIAH2 and leading to subsequent proteasomal degradation. 'Lys-6'-, 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 is polysumoylation-dependent. Ubiquitination by UHRF1 leadsto subsequent proteasomal degradation1
Undergoes 'Lys-11'-linked sumoylation. Sumoylation on all three sites is required for nuclear body formation.Sumoylation on Lys-160 is a prerequisite for sumoylation on Lys-65. The PML-RARA fusion protein requires thecoiled-coil domain for sumoylation. Desumoylated by SENP2 and SENP6. Arsenic induces PML and PML-RARA oncogenic fusionproteins polysumoylation and their subsequent RNF4-dependent ubiquitination and proteasomal degradation, and is usedas treatment in acute promyelocytic leukemia (APL)1
Phosphorylated in response to DNA damage, probably by ATR. Stabilized by HIPK2-mediated phosphorylation at Ser-8 andSer-38 in response to DNA damage1
Acetylation may promote sumoylation and enhance induction of apoptosis1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P29590
PML Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (9 alternative transcripts):
NP_002666.1 NP_150241.2 NP_150242.1 NP_150243.2 NP_150247.2 NP_150249.1 NP_150250.2 NP_150252.1 NP_150253.2
ENSEMBL proteins: ENSP00000378567 ENSP00000378564 ENSP00000268059 ENSP00000315434 ENSP00000268058 ENSP00000455838 ENSP00000455612 ENSP00000456486 ENSP00000456277 ENSP00000394642 ENSP00000395576 ENSP00000457023 ENSP00000353004 ENSP00000457032 ENSP00000456989 ENSP00000457669 ENSP00000458061 ENSP00000456329 Reactome Protein details: P29590
Human Recombinant Protein Products for PML:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
PML for ontologies About GeneDecksing
PML Antibody Products:
Assay Products for PML: |
Protein
Domains /
Families
for PML gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PML for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P29590ProtoNet protein and cluster: P29590 2 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger
UniProtKB/Swiss-Prot: PML_HUMAN, P29590Domain: Interacts with PKM via its coiled-coil domainDomain: Binds arsenic via the RING-type zinc fingerSimilarity: Contains 2 B box-type zinc fingersSimilarity: Contains 1 RING-type zinc finger |
Function
for PML gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PML_HUMAN, P29590Function: Key component of PML nuclear bodies that regulate a large number of cellular processes by facilitatingpost-translational modification of target proteins, promoting protein-protein contacts, or by sequestering proteins.Functions as tumor suppressor. Required for normal, caspase-dependent apoptosis in response to DNA damage, FAS, TNF,or interferons. Plays a role in transcription regulation, DNA damage response, DNA repair and chromatin organization.Plays a role in processes regulated by retinoic acid, regulation of cell division, terminal differentiation of myeloidprecursor cells and differentiation of neural progenitor cells. Required for normal immunity to microbial infections.Plays a role in antiviral response. In the cytoplasm, plays a role in TGFB1-dependent processes. Regulates p53/TP53levels by inhibiting its ubiquitination and proteasomal degradation. Regulates activation of p53/TP53 viaphosphorylation at 'Ser-20'. Sequesters MDM2 in the nucleolus after DNA damage, and thereby inhibits ubiquitinationand degradation of p53/TP53. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role inneoangiogenesis and tumor vascularization. Regulates RB1 phosphorylation and activity. Required for normal developmentof the brain cortex during embryogenesis. Can sequester herpes virus and varicella virus proteins inside PML bodies,and thereby inhibit the formation of infectious viral particles. Regulates phosphorylation of ITPR3 and plays a rolein the regulation of calcium homeostasis at the endoplasmic reticulum (By similarity). Regulates transcriptionactivity of ELF4. Inhibits specifically the activity of the tetrameric form of PKM. Together with SATB1, involved inlocal chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Regulates PTEN compartmentalizationthrough the inhibition of USP7-mediated deubiquitination Genatlas biochemistry entry for PML:POD (promyelocytic oncogenic domain),nuclear matrix protein,B box family, colocalizing and interacting withCREBBP,TIF2A and with DAXX in special (PML/SP100) nuclear bodies(NB/POD), to form a retinoic acid (RA) dependentgrowth suppressive RRXA,RARA nuclear complex,involved in development,recombinaison,DNA repair,and in earlyhematopoiesis and late erythropoiesis,recruiting the nuclear corepressor histone deacetylase complex,essential formultiple apoptotic pathways,putative controller of genes devoted to MHC class I antigen presentation.
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
PML for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for PML:
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Pml):
PML for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Pmltm1Ppp for PML
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PML (see all 11)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PML (see all 9)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 9): PML (NM_033244) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PML | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PML |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PML |
|
Pathways & Interactions
for PML gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytokine Signaling in Immune system | | | 2 | Interferon gamma signaling | | | 3 | Proteolysis Putative SUMO-1 pathway | | | 4 | DNA damage Role of SUMO in p53 regulation | | | 5 | Integrated Pancreatic Cancer Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for PML
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PML
3  GeneGo (Thomson Reuters) Pathways for PML
5/8  BioSystems Pathways for PML (see all 8)
5 
Reactome Pathways for PML
5 
Kegg Pathways (Kegg details for PML):
PML for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PML
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/203 Interacting proteins for PML (P295901, 2, 3 ENSP000002680584) via UniProtKB, MINT, STRING, and/or I2D (see all 203)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MDM2 | Q009871, 2, 3, ENSP000004172814 | EBI-870812,EBI-389668 MINT-4793330 MINT-4793420 MINT-4793448 I2D:
score=5 STRING: ENSP00000417281 | | TP53 | P046371, 2, 3, ENSP000002693054 | EBI-870812,EBI-366083 MINT-4793478 MINT-4793489 I2D:
score=5 STRING: ENSP00000269305 | | TOP3A | Q134722, 3, ENSP000003216364 | MINT-6743913 MINT-6743884 MINT-6743926 MINT-6744122 I2D:
score=1 STRING: ENSP00000321636 | | ZBTB16 | Q055161, 3, ENSP000003381574 | EBI-304008,EBI-711925 I2D:
score=4 STRING: ENSP00000338157 | | CSNK2A1 | P684001, 3, ENSP000002172444 | EBI-870812,EBI-347804 I2D:
score=3 STRING: ENSP00000217244 |
About this table
Gene Ontology (GO): 5/47 biological process terms (GO ID links to tree view) (see all 47): About this table
PML for ontologies About GeneDecksing
|
Drugs & Compounds
for PML gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PML for compounds About GeneDecksing
 Browse Tocris compounds for PML
10/18 Novoseek chemical compound relationships for PML gene (see all 18) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoic acid |
87.5 |
151 |
16740359 (5), 8400236 (4), 15529177 (3), 7784078 (3) (see all 99) |
| alpha-retinoic acid |
81.6 |
3 |
8396481 (1), 8207983 (1), 7815831 (1) |
| arsenite |
72 |
10 |
16891316 (3), 12667397 (2), 19380586 (1), 18413806 (1) |
| pic 1 |
68.3 |
3 |
9658103 (2), 10187798 (1) |
| retinoid |
65.1 |
3 |
8916959 (1), 8649787 (1), 8704214 (1) |
| glutamine |
21.4 |
4 |
12430715 (2), 16409557 (1), 15977647 (1) |
| zinc |
17.2 |
9 |
12794076 (2), 12759344 (1), 17988991 (1), 10938104 (1) (see all 8) |
| etoposide |
14.5 |
4 |
9209367 (1) |
| lysine |
13 |
2 |
20205709 (1) |
| bromodeoxyuridine |
11.5 |
1 |
12773567 (1) |
2 PharmGKB related drug/compound annotations for PML gene About this tableSearch CenterWatch for drugs/clinical trials and news about PML
|
Transcripts
for PML gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PML gene (9 alternative transcripts): NM_002675.3 NM_033238.2 NM_033239.2 NM_033240.2 NM_033244.3 NM_033246.2 NM_033247.2 NM_033249.2 NM_033250.2 Unigene Cluster for PML: Promyelocytic leukemia Hs.526464 [show with all ESTs]Unigene Representative Sequence: NM_03323818/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000395135(uc002awq.3 uc002awr.3 uc002aws.3 uc002awt.3)
ENST00000395132(uc002awp.3) ENST00000268059(uc002awk.3 uc002awn.3)
ENST00000354026(uc002awo.3) ENST00000268058 ENST00000565898(uc002awu.3 uc002awv.3 uc010ule.2)
ENST00000569477 ENST00000569965 ENST00000567543 ENST00000436891(uc002awx.3)
ENST00000435786(uc002awm.3 uc002awl.3) ENST00000564428 ENST00000359928
ENST00000563500(uc002awj.1 uc002awy.3) ENST00000564725(uc002aww.1)
ENST00000569161 ENST00000565239 ENST00000567606
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PML (see all 11)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PML (see all 9)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 9): PML (NM_033244) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PML | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PML |
Additional cDNA sequence: AB067754.1 AB208950.1 AB209051.1 AB209411.1 AF230401.1 AF230402.1 AF230403.1 AF230404.1 AF230405.1 AF230406.1 AF230407.1 AF230408.1 AF230409.1 AF230410.1 AF230411.1 AF370432.1 AF388193.1 AF388194.1 AK026871.1 AK300256.1 AK300951.1 BC000080.2 BC020994.2 BC034251.1 BC139795.1 BT009911.1 BX647287.1 M73778.1 M79462.1 M79463.1 M79464.1 M80185.1 S50913.1 X63131.1 24 DOTS entries: DT.97791923 DT.447813 DT.100792863 DT.100792859 DT.91792314 DT.91783610 DT.97787374 DT.210086 DT.317724 DT.102827730 DT.91836290 DT.100792858 DT.92352534 DT.100792875 DT.91722067 DT.100792857 DT.101959716 DT.97772804 DT.100718623 DT.100792873 DT.100792874 DT.92011830 DT.92362935 DT.99993975 24/298 AceView cDNA sequences (see all 298): AI469853 BI757312 NM_033239 BX647287 AI744517 AI160099 AA788922 BI962969 BC034251 BU617120 BI963945 BI793248 AI650742 BM127636 BU543691 BQ670496 NM_002675 BQ642940 BQ933226 AI146508 BQ054226 BQ052031 AA293080 CF272229
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PML (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9a | · | 9b | · | 9c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | |
| ExUns: | 10a | · | 10b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for PML
|
Expression
for PML gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PML expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PML Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PML
SOURCE GeneReport for Unigene cluster: Hs.526464
SABiosciences Expression via Pathway-Focused PCR Arrays including PML:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PML
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PML | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PML | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PML | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PML |
Orthologs
for PML gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PML gene from 1/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008575631 |
protein PML-like |
60.16(n)
43.68(a) |
|
100857563 XM_003641812.1 XP_003641860.1 |
ENSEMBL Gene Tree for PML (if available)
TreeFam Gene Tree for PML (if available) |
Paralogs
for PML gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PML gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PML (74287014 - 74340160 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PML
2 CNVs: 3968 9748
Human Gene Mutation Database (HGMD): PML
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PML |
|
Disorders
/ Diseases
for PML gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PML for disorders About GeneDecksing
OMIM gene information: 102578
OMIM disorders: --
UniProtKB/Swiss-Prot: PML_HUMAN, P29590
Note=A chromosomal aberration involving PML may be a cause of acute promyelocytic leukemia (APL).Translocation t(15;17)(q21;q21) with RARA. The PML breakpoints (type A and type B) lie on either side of analternatively spliced exon
20/73  diseases for PML (see all 73): About MalaCardsleukemia, acute promyelocytic, pml/rara type leukemia acute promyelocytic leukemia langerhans-cell histiocytosis
neuronal intranuclear inclusion disease graft versus host disease nijmegen breakage syndrome soft tissue sarcoma
primary biliary cirrhosis megakaryoblastic leukemia bloom syndrome herpes simplex
histiocytosis acute megakaryoblastic leukemia essential thrombocythemia myeloid leukemia
frontotemporal dementia paget's disease of bone pilocytic astrocytoma esophageal squamous cell carcinoma
1 disease from the University of Copenhagen DISEASES database for PML:Leukemia 10/37 Novoseek disease relationships for PML gene (see all 37) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| promyelocytic leukemia |
96.3 |
303 |
11511788 (3), 16154611 (2), 19380586 (2), 8550548 (2) (see all 99) |
| leukemia promyelocytic acute |
95.6 |
154 |
1310060 (2), 1353379 (2), 9452416 (2), 11068554 (2) (see all 99) |
| leukemogenesis |
72.4 |
8 |
8580793 (1), 18809579 (1), 8609713 (1), 8400236 (1) (see all 7) |
| leukemia |
68.7 |
64 |
19088278 (2), 9591778 (2), 9734655 (2), 18716620 (2) (see all 45) |
| minimal residual disease |
60.9 |
4 |
1310060 (1), 1375840 (1), 8180596 (1), 9260053 (1) |
| bloom syndrome |
58.3 |
2 |
10637504 (1) |
| drpla |
43.3 |
1 |
12901837 (1) |
| biliary cirrhosis primary |
31.8 |
6 |
9362351 (2), 8986606 (1), 9193756 (1), 8749719 (1) |
| tumors |
30.2 |
88 |
14970276 (8), 18566754 (6), 18856066 (3), 19652541 (2) (see all 32) |
| herpes simplex |
29.4 |
11 |
19279115 (2), 10574707 (1), 10233977 (1), 9151854 (1) (see all 9) |
Genatlas disease: PML acute promyelocytic leukemia (APL) with translocation t(15;17)(q22;q12) and with poor prognosis,may be associated witha hemorrhagic diathesis,secundary to an overexpression of annexin II with a secundary itinease of plasmin (see RARA)
Genetic Association Database (GAD): PML
Human Genome Epidemiology (HuGE) Navigator: PML (24 documents)
Tumor Gene Database (TGDB): PML
Export disorders for PML gene to outside databases
|
Publications
for PML gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PML gene, integrated from 9 sources (see all 671):
(articles sorted by number of sources associating them with PML) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PML colocalizes with and stabilizes the DNA damage response protein TopBP1. (PubMed id 12773567)1, 2, 9 Xu Z.-X.... Chang K.-S. (2003)
- Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. (PubMed id 10684855)1, 2, 9 Zhong S....Pandolfi P.P. (2000)
- PML protein isoforms and the RBCC/TRIM motif. (PubMed id 11704850)1, 2, 9 Jensen K....Freemont P.S. (2001)
- The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. (PubMed id 12810724)1, 2, 9 Louria-Hayon I....Haupt Y. (2003)
- Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. (PubMed id 1311253)1, 2, 9 Kastner P.... Chambon P. (1992)
- Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. (PubMed id 9570750)1, 2, 9 Cao T.... Etkin L.D. (1998)
- PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. (PubMed id 15467728)1, 2, 9 Daniels M.J....Venkitaraman A.R. (2004)
- The function of PML in p53-dependent apoptosis. (PubMed id 11025664)1, 2, 9 Guo A....Pandolfi P.P. (2000)
- The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. (PubMed id 18716620)1, 2, 9 Song M.S....Pandolfi P.P. (2008)
- Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. (PubMed id 12006491)1, 2, 9 Langley E.... Kouzarides T. (2002)
|
External Searches for PML gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PML gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PML gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PML gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PML gene:
Search GeneIP for patents involving PML
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PML gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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