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Aliases for PMF1 Gene

Aliases for PMF1 Gene

  • Polyamine-Modulated Factor 1 2 3 5
  • PMF-1 4

External Ids for PMF1 Gene

Previous GeneCards Identifiers for PMF1 Gene

  • GC01U990242
  • GC01P152960
  • GC01P153400
  • GC01P153401
  • GC01P152996
  • GC01P154450
  • GC01P154451
  • GC01P127544

Summaries for PMF1 Gene

GeneCards Summary for PMF1 Gene

PMF1 (Polyamine-Modulated Factor 1) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases. GO annotations related to this gene include transcription coactivator activity and leucine zipper domain binding. An important paralog of this gene is PMF1-BGLAP.

UniProtKB/Swiss-Prot for PMF1 Gene

  • Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.

Gene Wiki entry for PMF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PMF1 Gene

Genomics for PMF1 Gene

Regulatory Elements for PMF1 Gene

Enhancers for PMF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PMF1 on UCSC Golden Path with GeneCards custom track

Promoters for PMF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PMF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PMF1 Gene

Chromosome:
1
Start:
156,212,988 bp from pter
End:
156,240,077 bp from pter
Size:
27,090 bases
Orientation:
Plus strand

Genomic View for PMF1 Gene

Genes around PMF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PMF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PMF1 Gene

Proteins for PMF1 Gene

  • Protein details for PMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1K2-PMF1_HUMAN
    Recommended name:
    Polyamine-modulated factor 1
    Protein Accession:
    Q6P1K2
    Secondary Accessions:
    • A8K0C5
    • Q5TCJ8
    • Q5TCJ9
    • Q5TCK0
    • Q5TCK1
    • Q5TCK3
    • Q69YZ9
    • Q6PHR4
    • Q6ZVE6
    • Q86VJ6
    • Q8N4T6
    • Q9UBQ3

    Protein attributes for PMF1 Gene

    Size:
    205 amino acids
    Molecular mass:
    23339 Da
    Quaternary structure:
    • Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Interacts with COPS7A. Interacts via its coiled-coil domain with the leucine-zipper domain of NFE2L2. The interaction with NFE2L2 is required for the transcriptional regulation of SSAT.
    SequenceCaution:
    • Sequence=AAD50081.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10730.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10730.1; Type=Frameshift; Positions=75; Evidence={ECO:0000305};

    Alternative splice isoforms for PMF1 Gene

neXtProt entry for PMF1 Gene

Proteomics data for PMF1 Gene at MOPED

Post-translational modifications for PMF1 Gene

  • Ubiquitination at Lys 36 and Lys 154
  • Modification sites at PhosphoSitePlus

Other Protein References for PMF1 Gene

No data available for DME Specific Peptides for PMF1 Gene

Domains & Families for PMF1 Gene

Protein Domains for PMF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PMF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PMF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PMF1 Gene

Function for PMF1 Gene

Molecular function for PMF1 Gene

GENATLAS Biochemistry:
polyamine-modulated factor 1,coregulator of the transcription of the spermidine/spermine N-acetyltransferase gene (SAT),induced by polyamine analog
UniProtKB/Swiss-Prot Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
UniProtKB/Swiss-Prot Induction:
By polyamine analogs in analog-sensitive H157 cells.

Gene Ontology (GO) - Molecular Function for PMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043522 leucine zipper domain binding IPI 11256947
genes like me logo Genes that share ontologies with PMF1: view
genes like me logo Genes that share phenotypes with PMF1: view

miRNA for PMF1 Gene

miRTarBase miRNAs that target PMF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PMF1 Gene

Localization for PMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PMF1 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PMF1 Gene COMPARTMENTS Subcellular localization image for PMF1 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PMF1: view

Pathways & Interactions for PMF1 Gene

genes like me logo Genes that share pathways with PMF1: view

Pathways by source for PMF1 Gene

Interacting Proteins for PMF1 Gene

Gene Ontology (GO) - Biological Process for PMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007059 chromosome segregation IMP 15502821
GO:0007062 sister chromatid cohesion TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with PMF1: view

No data available for SIGNOR curated interactions for PMF1 Gene

Drugs & Compounds for PMF1 Gene

(3) Drugs for PMF1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermine Approved Nutra Full agonist, Agonist 0
putrescine Experimental Pharma Antagonist, Pore Blocker 0
spermidine Experimental Pharma Antagonist, Pore Blocker 0

(2) Additional Compounds for PMF1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
Norspermidine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
56-18-8
genes like me logo Genes that share compounds with PMF1: view

Transcripts for PMF1 Gene

Unigene Clusters for PMF1 Gene

Polyamine-modulated factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PMF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9:
SP10: - - - -

Relevant External Links for PMF1 Gene

GeneLoc Exon Structure for
PMF1
ECgene alternative splicing isoforms for
PMF1

Expression for PMF1 Gene

mRNA expression in normal human tissues for PMF1 Gene

Protein differential expression in normal tissues from HIPED for PMF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Monocytes (7.4), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PMF1 Gene



SOURCE GeneReport for Unigene cluster for PMF1 Gene Hs.530479

mRNA Expression by UniProt/SwissProt for PMF1 Gene

Q6P1K2-PMF1_HUMAN
Tissue specificity: Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver.
genes like me logo Genes that share expression patterns with PMF1: view

Protein tissue co-expression partners for PMF1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PMF1 Gene

Orthologs for PMF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PMF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PMF1 35
  • 85.2 (n)
  • 80 (a)
PMF1 36
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pmf1 35
  • 79.87 (n)
  • 75.25 (a)
Pmf1 36
  • 47 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PMF1 35
  • 99.19 (n)
  • 97.56 (a)
-- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pmf1 35
  • 79.23 (n)
  • 78.53 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pmf1 35
  • 63.24 (n)
  • 54.05 (a)
zebrafish
(Danio rerio)
Actinopterygii im:6898523 35
  • 51.21 (n)
  • 33.77 (a)
PMF1 36
  • 18 (a)
OneToMany
Species with no ortholog for PMF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PMF1 Gene

ENSEMBL:
Gene Tree for PMF1 (if available)
TreeFam:
Gene Tree for PMF1 (if available)

Paralogs for PMF1 Gene

Paralogs for PMF1 Gene

(1) SIMAP similar genes for PMF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PMF1: view

Variants for PMF1 Gene

Sequence variations from dbSNP and Humsavar for PMF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_034147 -
VAR_034148 -

Structural Variations from Database of Genomic Variants (DGV) for PMF1 Gene

Variant ID Type Subtype PubMed ID
esv2677774 CNV Deletion 23128226
nsv509524 CNV Insertion 20534489

Variation tolerance for PMF1 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PMF1 Gene

Disorders for PMF1 Gene

Relevant External Links for PMF1

Genetic Association Database (GAD)
PMF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PMF1

No disorders were found for PMF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PMF1 Gene

Publications for PMF1 Gene

  1. Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene. (PMID: 10419538) Wang Y. … Casero R.A. Jr. (J. Biol. Chem. 1999) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. (PMID: 24656865) Woo D. … Rosand J. (Am. J. Hum. Genet. 2014) 3

Products for PMF1 Gene

Sources for PMF1 Gene

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