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Aliases for PMF1 Gene

Aliases for PMF1 Gene

  • Polyamine Modulated Factor 1 2 3 5
  • PMF-1 4

External Ids for PMF1 Gene

Previous GeneCards Identifiers for PMF1 Gene

  • GC01U990242
  • GC01P152960
  • GC01P153400
  • GC01P153401
  • GC01P152996
  • GC01P154450
  • GC01P154451
  • GC01P127544

Summaries for PMF1 Gene

GeneCards Summary for PMF1 Gene

PMF1 (Polyamine Modulated Factor 1) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and leucine zipper domain binding. An important paralog of this gene is PMF1-BGLAP.

UniProtKB/Swiss-Prot for PMF1 Gene

  • Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.

Gene Wiki entry for PMF1 Gene

Additional gene information for PMF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PMF1 Gene

Genomics for PMF1 Gene

GeneHancer (GH) Regulatory Elements for PMF1 Gene

Promoters and enhancers for PMF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I156212 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.6 568 2.8 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 PMF1 PMF1-BGLAP ISG20L2 YY1AP1 CCT3 GON4L MSTO2P MSTO1 RRNAD1 SLC25A44
GH01I155242 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 19.1 -968.7 -968746 2.9 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GBA KHDC4 GON4L CLK2 ENSG00000271267 MSTO1 MSTO2P RUSC1-AS1 THBS3 SHC1
GH01I155561 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 -649.8 -649787 4.4 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ASH1L-AS1 ASH1L CLK2 GON4L KHDC4 THBS3 SSR2 ENSG00000271267 GLMP RUSC1-AS1
GH01I155965 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -237.6 -237611 19 MLX ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 ZNF416 ZNF143 ZNF263 ARHGEF2 RIT1 KHDC4 GON4L CLK2 PAQR6 PRCC RRNAD1 YY1AP1 ENSG00000271267
GH01I156336 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +125.1 125064 2.9 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 CCT3 PIR53317 TSACC GLMP GON4L RRNAD1 KHDC4 MSTO2P ISG20L2 ENSG00000271267
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PMF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PMF1 gene promoter:

Genomic Locations for PMF1 Gene

Genomic Locations for PMF1 Gene
chr1:156,212,988-156,240,077
(GRCh38/hg38)
Size:
27,090 bases
Orientation:
Plus strand
chr1:156,182,779-156,212,874
(GRCh37/hg19)

Genomic View for PMF1 Gene

Genes around PMF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PMF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PMF1 Gene

Proteins for PMF1 Gene

  • Protein details for PMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1K2-PMF1_HUMAN
    Recommended name:
    Polyamine-modulated factor 1
    Protein Accession:
    Q6P1K2
    Secondary Accessions:
    • A8K0C5
    • Q5TCJ8
    • Q5TCJ9
    • Q5TCK0
    • Q5TCK1
    • Q5TCK3
    • Q69YZ9
    • Q6PHR4
    • Q6ZVE6
    • Q86VJ6
    • Q8N4T6
    • Q9UBQ3

    Protein attributes for PMF1 Gene

    Size:
    205 amino acids
    Molecular mass:
    23339 Da
    Quaternary structure:
    • Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Interacts with COPS7A. Interacts via its coiled-coil domain with the leucine-zipper domain of NFE2L2. The interaction with NFE2L2 is required for the transcriptional regulation of SSAT.
    SequenceCaution:
    • Sequence=AAD50081.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10730.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10730.1; Type=Frameshift; Positions=75; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PMF1 Gene

    Alternative splice isoforms for PMF1 Gene

neXtProt entry for PMF1 Gene

Post-translational modifications for PMF1 Gene

  • Ubiquitination at Lys36 and isoforms=2, 4154

Other Protein References for PMF1 Gene

No data available for DME Specific Peptides for PMF1 Gene

Domains & Families for PMF1 Gene

Gene Families for PMF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PMF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PMF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PMF1: view

No data available for UniProtKB/Swiss-Prot for PMF1 Gene

Function for PMF1 Gene

Molecular function for PMF1 Gene

GENATLAS Biochemistry:
polyamine-modulated factor 1,coregulator of the transcription of the spermidine/spermine N-acetyltransferase gene (SAT),induced by polyamine analog
UniProtKB/Swiss-Prot Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
UniProtKB/Swiss-Prot Induction:
By polyamine analogs in analog-sensitive H157 cells.

Phenotypes From GWAS Catalog for PMF1 Gene

Gene Ontology (GO) - Molecular Function for PMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IMP,TAS 11256947
GO:0005515 protein binding IPI 15371340
GO:0043522 leucine zipper domain binding IPI 11256947
genes like me logo Genes that share ontologies with PMF1: view
genes like me logo Genes that share phenotypes with PMF1: view

miRNA for PMF1 Gene

miRTarBase miRNAs that target PMF1

Clone Products

  • Addgene plasmids for PMF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PMF1 Gene

Localization for PMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PMF1 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PMF1 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000444 MIS12/MIND type complex IDA 16585270
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IDA 15371340
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PMF1: view

Pathways & Interactions for PMF1 Gene

genes like me logo Genes that share pathways with PMF1: view

Pathways by source for PMF1 Gene

Gene Ontology (GO) - Biological Process for PMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 10419538
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IMP 15502821
genes like me logo Genes that share ontologies with PMF1: view

No data available for SIGNOR curated interactions for PMF1 Gene

Drugs & Compounds for PMF1 Gene

(3) Drugs for PMF1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermine Approved Nutra Full agonist, Agonist 0
putrescine Experimental Pharma Antagonist, Pore Blocker 0
spermidine Experimental Pharma Antagonist, Pore Blocker 0

(2) Additional Compounds for PMF1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
Norspermidine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
56-18-8
genes like me logo Genes that share compounds with PMF1: view

Transcripts for PMF1 Gene

Unigene Clusters for PMF1 Gene

Polyamine-modulated factor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for PMF1

Alternative Splicing Database (ASD) splice patterns (SP) for PMF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9:
SP10: - - - -

Relevant External Links for PMF1 Gene

GeneLoc Exon Structure for
PMF1
ECgene alternative splicing isoforms for
PMF1

Expression for PMF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PMF1 Gene

Protein differential expression in normal tissues from HIPED for PMF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Monocytes (7.4), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PMF1 Gene



Protein tissue co-expression partners for PMF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PMF1 Gene:

PMF1

SOURCE GeneReport for Unigene cluster for PMF1 Gene:

Hs.530479

mRNA Expression by UniProt/SwissProt for PMF1 Gene:

Q6P1K2-PMF1_HUMAN
Tissue specificity: Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver.

Evidence on tissue expression from TISSUES for PMF1 Gene

  • Nervous system(4.6)
  • Intestine(4.1)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with PMF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PMF1 Gene

Orthologs for PMF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PMF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PMF1 33
  • 99.19 (n)
-- 34
  • 47 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PMF1 33 34
  • 85.2 (n)
mouse
(Mus musculus)
Mammalia Pmf1 34 33
  • 79.87 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pmf1 33
  • 79.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 43 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pmf1 33
  • 63.24 (n)
zebrafish
(Danio rerio)
Actinopterygii im:6898523 33
  • 51.21 (n)
PMF1 34
  • 18 (a)
OneToMany
Species where no ortholog for PMF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PMF1 Gene

ENSEMBL:
Gene Tree for PMF1 (if available)
TreeFam:
Gene Tree for PMF1 (if available)

Paralogs for PMF1 Gene

Paralogs for PMF1 Gene

(1) SIMAP similar genes for PMF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PMF1: view

Variants for PMF1 Gene

Sequence variations from dbSNP and Humsavar for PMF1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000095661 -- 156,220,216(+) G/A intron_variant
rs1000125308 -- 156,238,150(+) A/G intron_variant
rs1000184287 -- 156,212,364(+) T/G upstream_transcript_variant
rs1000233679 -- 156,225,358(+) G/A/C intron_variant
rs1000295157 -- 156,219,022(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PMF1 Gene

Variant ID Type Subtype PubMed ID
esv2677774 CNV deletion 23128226
esv6098 CNV gain 19470904
nsv509524 CNV insertion 20534489

Variation tolerance for PMF1 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PMF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PMF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PMF1 Gene

Disorders for PMF1 Gene

Additional Disease Information for PMF1

No disorders were found for PMF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PMF1 Gene

Publications for PMF1 Gene

  1. Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene. (PMID: 10419538) Wang Y … Casero RA (The Journal of biological chemistry 1999) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. (PMID: 16585270) Kline SL … Desai A (The Journal of cell biology 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PMF1 Gene

  • Addgene plasmids for PMF1

Sources for PMF1 Gene

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