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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PMEPA1 Gene

protein-coding   GIFtS: 52
GCID: GC20M056223

prostate transmembrane protein, androgen induced 1

(Previous names: transmembrane, prostate androgen induced RNA )
(Previous symbol: TMEPAI)
 Explore 9 diseases affiliated with
PMEPA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PMEPA1    

Aliases
for PMEPA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Prostate Transmembrane Protein, Androgen Induced 11 2
TMEPAI1 2 3 5
STAG11 2 3
Transmembrane, Prostate Androgen Induced RNA1 2
Solid Tumor-Associated 1 Protein2 3
Transmembrane Prostate Androgen-Induced Protein2

External Ids:    HGNC: 141071   Entrez Gene: 569372   Ensembl: ENSG000001242257   OMIM: 6065645   UniProtKB: Q969W93   

Export aliases for PMEPA1 gene to outside databases

Previous GC identifers: GC20M055657 GC20M053005


Summaries
for PMEPA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PMEPA1:
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is
induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and
transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene
may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have
been observed for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: PMEPA_HUMAN, Q969W9
Function: Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated
degradation of AR, probably by recruiting NEDD4

Gene Wiki entry for PMEPA1 (TMEPAI)


Genomic Views
for PMEPA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PMEPA1 gene promoter:
         GR   Tal-1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PMEPA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PMEPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PMEPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31-q13.33   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.31-q13.33

PMEPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMEPA1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M056223:  view genomic region     (about GC identifiers)

Start:
 56,223,448 bp from pter      End:
 56,286,592 bp from pter
Size:
 63,145 bases      Orientation:
 minus strand

Proteins
for PMEPA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PMEPA_HUMAN, Q969W9 (See protein sequence)
Recommended Name: Transmembrane prostate androgen-induced protein  
Size: 287 amino acids; 31609 Da
Subunit: Interacts with NEDD4 (via WW domains). Interacts with AR
Subcellular location: Cell membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q5TDR6 Q8NER4 Q96B72 Q9UJD3
Alternative splicing: 3 isoforms:  Q969W9-1   Q969W9-2   Q969W9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PMEPA1: NX_Q969W9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969W9

    • PMEPA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001242905.1  NP_064567.2  NP_954638.1  NP_954639.1  NP_954640.1  

    ENSEMBL proteins: 
     ENSP00000345826   ENSP00000344014   ENSP00000379161   ENSP00000379159   ENSP00000401506  
     ENSP00000379164   ENSP00000265626  
    Reactome Protein details: Q969W9
    Human Recombinant Protein Products: 
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    Novus Biologicals PMEPA1 Protein
    Novus Biologicals PMEPA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PMEPA1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS10873380
    GO:0031901early endosome membrane TAS--


    PMEPA1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PMEPA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q969W9

    UniProtKB/Swiss-Prot: PMEPA_HUMAN, Q969W9
    Domain: The WW-binding motifs mediate interaction with NEDD4 (By similarity)
    Similarity: Belongs to the PMEPA1 family


    Function
    for PMEPA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PMEPA_HUMAN, Q969W9
    Function: Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated
    degradation of AR, probably by recruiting NEDD4
    Induction: By androgen

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    hsa-miR-3678-3p hsa-miR-374a hsa-miR-3653 hsa-miR-877* hsa-miR-3142 hsa-miR-629* hsa-miR-3613-3p hsa-miR-3649
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    Inhib. RNA
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    OriGene shRNA RFP: PMEPA1
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    Gene Editing
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    Clone
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    Cell Line
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    LifeMap BioReagents: cell line associated with PMEPA1: PureStem ES-210, Ecto-ntu Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMEPA1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ----
    GO:0050699WW domain binding IPI12907594


    PMEPA1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PMEPA1:
     Decreased viability of wild-ty  Decreased viability with pacli 


    Pathways & Interactions
    for PMEPA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-beta receptor signaling activates SMADs
    		TGF-beta receptor signaling activates SMADs1.00
    		Downregulation of TGF-beta receptor signaling0.90
    2Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    		Signaling by TGF-beta Receptor Complex0.61
    3Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for PMEPA1
        Signaling by TGF-beta Receptor Complex
    TGF-beta receptor signaling activates SMADs
    Signal Transduction
    Downregulation of TGF-beta receptor signaling



    PMEPA1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PMEPA1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for PMEPA1 (Q969W92, 3 ENSP000003458264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    NEDD4P469343, ENSP000003455304I2D: score=3 STRING: ENSP00000345530
    UBQLN4Q9NRR53, ENSP000003572924I2D: score=2 STRING: ENSP00000357292
    --P310162MINT-8108056
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway TAS--
    GO:0030521androgen receptor signaling pathway NAS10873380


    PMEPA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PMEPA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PMEPA1
    Search CenterWatch for drugs/clinical trials and news about PMEPA1 / PMEPA 

    Transcripts
    for PMEPA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PMEPA1 gene (5 alternative transcripts): 
    NM_001255976.1  NM_020182.4  NM_199169.2  NM_199170.2  NM_199171.2  

    Unigene Cluster for PMEPA1:

    Prostate transmembrane protein, androgen induced 1
    Hs.517155  [show with all ESTs]
    Unigene Representative Sequence: NM_020182
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341744(uc002xyq.3) ENST00000347215(uc002xys.3) ENST00000395816(uc002xyr.3)
    ENST00000395814 ENST00000414037 ENST00000395819 ENST00000472841 ENST00000265626(uc002xyt.3)


    miRNA
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    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate PMEPA1 (see all 88):
    hsa-miR-3678-3p hsa-miR-374a hsa-miR-3653 hsa-miR-877* hsa-miR-3142 hsa-miR-629* hsa-miR-3613-3p hsa-miR-3649
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PMEPA1 (see all 7)
    OriGene shRNA RFP: PMEPA1
    OriGene siRNA: PMEPA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PMEPA1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): PMEPA1 (NM_199170)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PMEPA1
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    Additional cDNA sequence: 

    AF224278.1 AF305616.1 AJ308020.1 AJ308021.1 AK024618.1 AK296199.1 AY128643.1 BC015918.1 
    BC025361.1 BC080635.1 

    11 DOTS entries:

    DT.91901065  DT.117658  DT.91672385  DT.95266738  DT.100037077  DT.101964895  DT.40294287  DT.97797829 
    DT.100037073  DT.120819484  DT.99949886 

    24/428 AceView cDNA sequences (see all 428):

    AX775889 CF144537 AI453180 BQ575679 BC015918 AW135998 AI865867 AA284982 
    BM768155 AI420839 CB214988 BE855409 AW073422 CB044866 AI381991 CB144148 
    AA081064 BM666222 T33325 BQ003820 AI380657 AI936228 AW135709 AK056098 

    GeneLoc Exon Structure


    Expression
    for PMEPA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PMEPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATGTCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PMEPA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11) 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage
    HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)Bone

    See PMEPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PMEPA1

    SOURCE GeneReport for Unigene cluster: Hs.517155

    UniProtKB/Swiss-Prot: PMEPA_HUMAN, Q969W9
    Tissue specificity: Highest expression in prostate. Also expressed in ovary

        SABiosciences Custom PCR Arrays for PMEPA1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMEPA1

    Orthologs
    for PMEPA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PMEPA1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pmepa11 , 5 prostate transmembrane protein, androgen induced 11, 5 87.83(n)1
    91.61(a)1    		   2 (95.85 cM)5
    651121  NM_022995.31  NP_075371.21 
     1732244585 
    chicken
    (Gallus gallus)    		 Aves PMEPA11 prostate transmembrane protein, androgen induced 1 82.69(n)
    84.45(a)    		   428166  NM_001031492.1  NP_001026663.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PMEPA16
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL343217.1(894634-904315)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.131552 Xenopus laevis transcribed sequence with weak similarity more 76.24(n)    48045161 
    zebrafish
    (Danio rerio)    		 Actinopterygii pmepa16
    		 prostate transmembrane protein, androgen induced 1...
    		 65(a)
    		 1 ↔ 1
    		 6(59740415-59768355)


    ENSEMBL Gene Tree for PMEPA1 (if available)
    TreeFam Gene Tree for PMEPA1 (if available) 

    Paralogs
    for PMEPA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PMEPA1 gene
    LDLRAD42  
    2 SIMAP similar genes for PMEPA1 using alignment to 4 protein entries:     PMEPA_HUMAN (see all proteins):
    TMEPAI    LDLRAD4

    PMEPA1 for paralogs           About GeneDecksing



    Genomic Variants
    for PMEPA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1280 NCBI SNPs in PMEPA1 are shown (see all 1280)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1820874931,2
    		--56223000(+) TCCCCC/GTCCTT 5 -- ds50010--------
    rs60997031,2
    		C,F,A,H,--56223061(+) AAAACG/ATCCTA 5 -- ds500116Minor allele frequency- A:0.12NS EA NA WA 2218
    rs134332461,2
    		C,--56223233(+) aacaaC/TgACCA 5 -- ds50012Minor allele frequency- T:0.13WA 120
    rs60256881,2
    		C,F,A,--56223317(+) GAAAGT/GTTGAA 5 -- ds50017Minor allele frequency- G:0.39NA WA CSA 246
    rs283691331,2
    		C,--56223324(+) TGAACG/AAACTG 5 -- ds50012Minor allele frequency- A:0.03WA 120
    rs1848880601,2
    		--56223330(+) AACTGC/TTCAAG 5 -- ds50010--------
    rs1902282771,2
    		--56223394(+) TATTGG/TAGAAA 5 -- ds50010--------
    rs1420475701,2
    		--56223406(+) GGGTGA/GGAAGT 5 -- ds50010--------
    rs60256891,2
    		C,F,A,H,--56223451(+) GCCTCA/GTTCCA 5 -- ut3125Minor allele frequency- G:0.27NS EA NA WA CSA 2762
    rs1456123151,2
    		--56223505(+) ATGTCA/GTCATT 5 -- ut310--------

    HapMap Linkage Disequilibrium report for PMEPA1 (56223448 - 56286592 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for PMEPA1
         3 CNVs: 31042 4104 67718
         3 Indels: 33353 79249 90626

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    Disorders / Diseases
    for PMEPA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PMEPA1 for disorders           About GeneDecksing

    OMIM gene information: 606564    OMIM disorders: --

    9 diseases for PMEPA1:    About MalaCards
    prostatitis    breast-ovarian cancer    renal cell carcinoma    prostate cancer
    prostate cancer, progression of    ovarian cancer    colon cancer    ataxia
    carcinoma

    2 Novoseek disease relationships for PMEPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 43.9 3 12907594 (2), 14639658 (1)
    tumors 8.63 15 12907594 (2), 10873380 (2)


    Export disorders for PMEPA1 gene to outside databases

    Publications
    for PMEPA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PMEPA1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with PMEPA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. (PubMed id 10873380)1, 2, 3, 9 Xu L.L.... Srivastava S. (2000)
    2. PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. (PubMed id 12907594)1, 2, 9 Xu L.L.... Srivastava S. (2003)
    3. A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. (PubMed id 18703514)1, 2 Li H....Srivastava S. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer. (PubMed id 12670906)1, 2 Brunschwig E.B.... Markowitz S. (2003)
    6. Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. (PubMed id 11568975)1, 2 Rae F.K.... Clements J.A. (2001)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer. (PubMed id 14639658)1, 9 Giannini G....Gulino A. (2003)
    9. PMEPA1 promotes androgen receptor-negative prostate c ell proliferation through suppressing the Smad3/4-c-Myc-p21 Cip1 signaling path way. (PubMed id 21341270)1 Liu R....Chen C. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for PMEPA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PMEPA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56937 HGNC: 14107 AceView: TMEPAI Ensembl:ENSG00000124225 euGenes: HUgn56937
    ECgene: PMEPA1 H-InvDB: PMEPA1

    Other Databases showing PMEPA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PMEPA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PMEPA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PMEPA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PMEPA1 gene:
    Search GeneIP for patents involving PMEPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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