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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PMCH Gene

protein-coding   GIFtS: 55
GCID: GC12M102590

pro-melanin-concentrating hormone
 Explore 7 diseases affiliated with
PMCH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PMCH    

Aliases
for PMCH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pro-Melanin-Concentrating Hormone1 2
MCH1 2 3
Pro-MCH1

External Ids:    HGNC: 91091   Entrez Gene: 53672   Ensembl: ENSG000001833957   OMIM: 1767955   UniProtKB: P203823   

Export aliases for PMCH gene to outside databases

Previous GC identifers: GC12U990072 GC12M102523 GC12M101092 GC12M099649


Summaries
for PMCH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PMCH:
The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and
later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona
incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic
distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions
directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other
putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in
many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary
by Nahon et al., 1992 (PubMed 1572663)).(supplied by OMIM, Jan 2011)

UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward
the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in
spermatocyte differentiation




Genomic Views
for PMCH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PMCH gene promoter:
         FOXI1   HFH-3   GR   AML1a   GR-beta   Cart-1   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PMCH promoter sequence
   Search SABiosciences Chromatin IP Primers for PMCH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PMCH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.2

PMCH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMCH gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M102590:  view genomic region     (about GC identifiers)

Start:
 102,590,237 bp from pter      End:
 102,591,623 bp from pter
Size:
 1,387 bases      Orientation:
 minus strand

Proteins
for PMCH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MCH_HUMAN, P20382 (See protein sequence)
Recommended Name: Pro-MCH precursor  
Size: 165 amino acids; 18679 Da
Subcellular location: Secreted
Secondary accessions: Q16044 Q8WVG0

Explore the universe of human proteins at neXtProt for PMCH: NX_P20382

Post-translational modifications:

  • Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third
    • peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI.
    MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and
    PC5/61
  • View neXtProt modification sites for NX_P20382

    • PMCH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002665.2  
    ENSEMBL proteins: 
     ENSP00000332225  
    Reactome Protein details: P20382
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: PMCH
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    Novus Biologicals PMCH Protein
    Novus Biologicals PMCH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PMCH

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ----
    GO:0005634nucleus IEA--


    PMCH for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PMCH

    Protein Domains /
    Families
    for PMCH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PMCH for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005456 Prepro-melanin_conc_hormone

    Graphical View of Domain Structure for InterPro Entry P20382

    ProtoNet protein and cluster: P20382

    1 Blocks protein family: IPB005456 Pre-pro melanin-concentrating hormone signature

    UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
    Similarity: Belongs to the melanin-concentrating hormone family


    Function
    for PMCH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
    Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward
    the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in
    spermatocyte differentiation

         Genatlas biochemistry entry for PMCH:
    pro-melanin concentrating hormone,also encoding glutamic acid-isoleucine (NEI) and glycine-glutamic acids (NGE)
    neuropeptides,expressed in lateral hypotalamus area (LHA) and neighboring zona incerta (ZI),may be involved in energy
    balance and in feeding behaviour,ligand of GPR24

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PMCH
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PMCH:
    hsa-miR-298 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PMCH 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PMCH (see all 7)
    OriGene shRNA RFP: PMCH
    OriGene siRNA: PMCH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PMCH

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PMCH

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMCH 

    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030354melanin-concentrating hormone activity IEA--
    GO:0031777type 1 melanin-concentrating hormone receptor binding ----


    PMCH for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Pmchtm1Emf for PMCH
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pmch):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  liver/biliary system 
     nervous system  reproductive system 

    PMCH for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PMCH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3G alpha (q) signalling events
    		G alpha (q) signalling events1.00
    		Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PMCH
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    5/9        Reactome Pathways for PMCH (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    PMCH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PMCH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/253 Interacting proteins for PMCH (P203823 ENSP000003322254) via UniProtKB, MINT, STRING, and/or I2D (see all 253)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=2 STRING: ENSP00000242152
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    MCHR1Q997053, ENSP000002490164I2D: score=1 STRING: ENSP00000249016
    MCHR2Q969V13, ENSP000002818064I2D: score=1 STRING: ENSP00000281806
    PCSK1P291203, ENSP000003080244I2D: score=1 STRING: ENSP00000308024
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002027regulation of heart rate ----
    GO:0007165signal transduction NAS1572663
    GO:0007204elevation of cytosolic calcium ion concentration ----
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007268synaptic transmission IEA--


    PMCH for ontologies           About GeneDecksing



    Drugs & Compounds
    for PMCH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PMCH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PMCH
    3 Novoseek chemical compound relationships for PMCH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 46.6 4 8326825 (2), 7850873 (2)
    dexamethasone 8.76 2 9495549 (1), 1327720 (1)
    calcium 0 2 10421367 (1)

    Search CenterWatch for drugs/clinical trials and news about PMCH / MCH 

    Transcripts
    for PMCH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PMCH gene: 
    NM_002674.2  

    Unigene Cluster for PMCH:

    Pro-melanin-concentrating hormone
    Hs.707990  [show with all ESTs]
    Unigene Representative Sequence: BG216766
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329406(uc001tjl.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PMCH
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PMCH:
    hsa-miR-298 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PMCH 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PMCH (see all 7)
    OriGene shRNA RFP: PMCH
    OriGene siRNA: PMCH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PMCH
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PMCH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PMCH

    Additional cDNA sequence: 

    BC018048.1 M57703.1 

    3 DOTS entries:

    DT.91741012  DT.95161588  DT.95239731 

    22 AceView cDNA sequences:

    AV708684 BC018048 CB047052 BF196106 BI603807 AV723892 BG706895 BI597555 
    AV727043 AV701768 BG706782 CB047053 NM_002674 M57703 BE244920 AW291615 
    BG216766 AW976791 BX091733 AA482754 AW363659 AV723033 

    GeneLoc Exon Structure


    Expression
    for PMCH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PMCH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTGCCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PMCH expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cardiomyocyte-like cells (Spontaneous differen...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PMCH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PMCH

    SOURCE GeneReport for Unigene cluster: Hs.707990

    UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
    Tissue specificity: Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and
    cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and
    Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In
    peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly

        SABiosciences Expression via Pathway-Focused PCR Array including PMCH: 
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMCH

    Orthologs
    for PMCH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PMCH gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pmch1 , 5 pro-melanin-concentrating hormone1, 5 88.69(n)1
    86.67(a)1    		   10 (43.70 cM)5
    1103121  NM_029971.21  NP_084247.11 
     880910725 
    chicken
    (Gallus gallus)    		 Aves PMCH1 pro-melanin-concentrating hormone 73.21(n)
    60.76(a)    		   418091  NM_001195795.1  NP_001182724.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PMCH6
    		 --
    		 58(a)
    		 1 ↔ 1
    		 5(17558126-17559491)
    zebrafish
    (Danio rerio)    		 Actinopterygii pmch6
    		 pro-melanin concentrating hormone
    		 30(a)
    		 1 ↔ 1
    		 4(16404741-16406937)


    ENSEMBL Gene Tree for PMCH (if available)
    TreeFam Gene Tree for PMCH (if available) 

    Paralogs
    for PMCH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PMCH gene
    2 SIMAP similar genes for PMCH using alignment to 1 protein entry:     MCH_HUMAN:
    PMCHL1    PMCHL2

    PMCH for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PMCH
    PGOHUM00000235529 PGOHUM00000235645


    Genomic Variants
    for PMCH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/52 NCBI SNPs in PMCH are shown (see all 52)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1925756261,2
    		--102590187(+) AGTGTA/GTGTAA 2 -- ut31 ds50010--------
    rs1831022421,2
    		--102590209(+) TAAGCA/GTTGTT 2 -- ut31 ds50010--------
    rs1429335931,2
    		--102590291(+) CAGTTA/GCTGAT 2 -- ut310--------
    rs1995466661,2
    		--102590527(+) TATCAC/TACAAA 2 -- int1 ut310--------
    rs1506104251,2
    		--102590544(+) TAAGAA/GAAAAA 2 -- ut31 int10--------
    rs1876119641,2
    		--102590588(+) CAAAAA/TGATAA 2 -- int1 ut310--------
    rs1928101181,2
    		--102590628(+) TTTTGA/GCAGGT 2 -- int1 ut310--------
    rs1387369991,2
    		C,F,--102590758(+) TCAAAA/GTCTCT 3 D ut31 syn11Minor allele frequency- G:0.00NA 4470
    rs115584371,2
    		C--102590785(+) TTAGCT/GGAGTT 3 /S ut31 syn1 ese32Minor allele frequency- G:0.00NA 4
    rs1503628811,2
    		C,F,--102590800(+) TCATCC/ACCAAT 3 /G ut31 syn11Minor allele frequency- A:0.00NA 4516

    HapMap Linkage Disequilibrium report for PMCH (102590237 - 102591623 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PMCH: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PMCH
    DNA2.0 Custom Variant and Variant Library Synthesis for PMCH

    Disorders / Diseases
    for PMCH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PMCH for disorders           About GeneDecksing

    OMIM gene information: 176795    OMIM disorders: --

    7 diseases for PMCH:    About MalaCards
    byssinosis    neuronitis    pheochromocytoma    vitiligo
    huntington's disease    rhinitis    obesity

    3 diseases from the University of Copenhagen DISEASES database for PMCH:
    Asthma     Rhinitis     Eosinophilia

    3 Novoseek disease relationships for PMCH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 27.9 4 16902961 (1), 17640905 (1), 10421367 (1)
    pheochromocytoma 27 2 9495549 (1), 7617126 (1)
    inflammation 0 1 17640905 (1)

    Human Genome Epidemiology (HuGE) Navigator: PMCH (3 documents)

    Export disorders for PMCH gene to outside databases

    Publications
    for PMCH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PMCH gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with PMCH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human melanin concentrating hormone mRNA. (PubMed id 2149166)1, 2, 3, 9 Presse F.... Vale W. (1990)
    2. The melanin-concentrating hormone gene in human: flanking region analysis, fine chromosome mapping, and tissue-specific expression. (PubMed id 9191099)1, 2, 9 Viale A....Nahon J.-L. (1997)
    3. Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene. (PubMed id 8326825)1, 2, 9 Breton C.... Nahon J.-L. (1993)
    4. Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. (PubMed id 10037747)1, 2 Viale A.... Nahon J.-L. (1999)
    5. Assignment of the human pro-melanin-concentrating hormone gene (PMCH) to chromosome 12q23-q24 and two variant genes (PMCHL1 and PMCHL2) to chromosome 5p14 and 5q12-q13. (PubMed id 8188237)1, 9 Pedeutour F.... Nahon J.-L. (1994)
    6. Human Th2 cells selectively express the orexigenic peptide, pro-melanin-concentrating hormone. (PubMed id 17640905)1, 9 Sandig H....Cousins D.J. (2007)
    7. Pro-melanin-concentrating hormone gene (PMCH) is localized on human chromosome 12q and rat chromosome 7. (PubMed id 1572663)1, 9 Nahon J.L....Szpirer C. (1992)
    8. Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine. (PubMed id 17541984)1, 9 Chagnon Y.C....Maziade M. (2007)
    9. Interleukin-6 receptor a is co-localised with melanin- concentrating hormone in human and mouse hypothalamus. (PubMed id 22295972)1 Schele E....Jansson J.O. (2012)
    10. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1 Kim J.J....Lee J.K. (2010)

    External Searches for PMCH gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing PMCH gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5367 HGNC: 9109 AceView: PMCH Ensembl:ENSG00000183395 euGenes: HUgn5367
    ECgene: PMCH H-InvDB: PMCH

    Other Databases showing PMCH gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PMCH gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PMCH Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PMCH gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PMCH gene:
    Search GeneIP for patents involving PMCH

    Licensable Technologies for PMCH gene:
     Salk Institute: Melanin-Concentrating Hormones
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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