Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PMCH Gene

Aliases for PMCH Gene

  • Pro-Melanin-Concentrating Hormone 2 3
  • MCH 3 4
  • Pro-MCH 3

External Ids for PMCH Gene

Previous GeneCards Identifiers for PMCH Gene

  • GC12U990072
  • GC12M102523
  • GC12M101092
  • GC12M102590
  • GC12M099649

Summaries for PMCH Gene

Entrez Gene Summary for PMCH Gene

  • The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary by Nahon et al., 1992 [PubMed 1572663]).[supplied by OMIM, Jan 2011]

GeneCards Summary for PMCH Gene

PMCH (Pro-Melanin-Concentrating Hormone) is a Protein Coding gene. Diseases associated with PMCH include pheochromocytoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include melanin-concentrating hormone activity.

UniProtKB/Swiss-Prot for PMCH Gene

  • MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PMCH Gene

Genomics for PMCH Gene

Regulatory Elements for PMCH Gene

Genomic Location for PMCH Gene

Start:
102,196,459 bp from pter
End:
102,197,845 bp from pter
Size:
1,387 bases
Orientation:
Minus strand

Genomic View for PMCH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PMCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PMCH Gene

Proteins for PMCH Gene

  • Protein details for PMCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20382-MCH_HUMAN
    Recommended name:
    Pro-MCH
    Protein Accession:
    P20382
    Secondary Accessions:
    • Q16044
    • Q8WVG0

    Protein attributes for PMCH Gene

    Size:
    165 amino acids
    Molecular mass:
    18679 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PMCH Gene

Proteomics data for PMCH Gene at MOPED

Post-translational modifications for PMCH Gene

  • Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.

Other Protein References for PMCH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PMCH Gene

Domains for PMCH Gene

Gene Families for PMCH Gene

HGNC:

Protein Domains for PMCH Gene

Suggested Antigen Peptide Sequences for PMCH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20382

UniProtKB/Swiss-Prot:

MCH_HUMAN :
  • P20382
Family:
  • Belongs to the melanin-concentrating hormone family.
genes like me logo Genes that share domains with PMCH: view

Function for PMCH Gene

Molecular function for PMCH Gene

GENATLAS Biochemistry:
pro-melanin concentrating hormone,also encoding glutamic acid-isoleucine (NEI) and glycine-glutamic acids (NGE) neuropeptides,expressed in lateral hypotalamus area (LHA) and neighboring zona incerta (ZI),may be involved in energy balance and in feeding behaviour,ligand of GPR24
UniProtKB/Swiss-Prot Function:
MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation

Gene Ontology (GO) - Molecular Function for PMCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030354 melanin-concentrating hormone activity IEA --
genes like me logo Genes that share ontologies with PMCH: view
genes like me logo Genes that share phenotypes with PMCH: view

Animal Models for PMCH Gene

MGI Knock Outs for PMCH:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PMCH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PMCH Gene

Localization for PMCH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PMCH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PMCH Gene COMPARTMENTS Subcellular localization image for PMCH gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PMCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PMCH: view

Pathways for PMCH Gene

genes like me logo Genes that share pathways with PMCH: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PMCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007268 synaptic transmission IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007631 feeding behavior ISS --
genes like me logo Genes that share ontologies with PMCH: view

Compounds for PMCH Gene

(3) Novoseek inferred chemical compound relationships for PMCH Gene

Compound -log(P) Hits PubMed IDs
acth 46.6 4
dexamethasone 8.76 2
calcium 0 1
genes like me logo Genes that share compounds with PMCH: view

Transcripts for PMCH Gene

mRNA/cDNA for PMCH Gene

(22) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PMCH Gene

Pro-melanin-concentrating hormone:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PMCH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PMCH Gene

No ASD Table

Relevant External Links for PMCH Gene

GeneLoc Exon Structure for
PMCH
ECgene alternative splicing isoforms for
PMCH

Expression for PMCH Gene

mRNA expression in normal human tissues for PMCH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PMCH Gene

This gene is overexpressed in Brain - Hypothalamus (51.6).

SOURCE GeneReport for Unigene cluster for PMCH Gene Hs.707990

mRNA Expression by UniProt/SwissProt for PMCH Gene

P20382-MCH_HUMAN
Tissue specificity: Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly.
genes like me logo Genes that share expressions with PMCH: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for PMCH Gene

Orthologs for PMCH Gene

This gene was present in the common ancestor of chordates.

Orthologs for PMCH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PMCH 35
  • 92.93 (n)
  • 91.52 (a)
PMCH 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PMCH 35
  • 93.54 (n)
  • 93.33 (a)
PMCH 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pmch 35
  • 88.69 (n)
  • 86.67 (a)
Pmch 16
Pmch 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PMCH 35
  • 98.79 (n)
  • 97.58 (a)
PMCH 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pmch 35
  • 85.45 (n)
  • 81.82 (a)
oppossum
(Monodelphis domestica)
Mammalia PMCH 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PMCH 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PMCH 35
  • 73.21 (n)
  • 60.76 (a)
PMCH 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PMCH 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pmch 35
  • 65.24 (n)
  • 55.21 (a)
Species with no ortholog for PMCH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PMCH Gene

ENSEMBL:
Gene Tree for PMCH (if available)
TreeFam:
Gene Tree for PMCH (if available)

Paralogs for PMCH Gene

Selected SIMAP similar genes for PMCH Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PMCH Gene

genes like me logo Genes that share paralogs with PMCH: view

No data available for Paralogs for PMCH Gene

Variants for PMCH Gene

Sequence variations from dbSNP and Humsavar for PMCH Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs34157523 -- 102,199,643(+) TTTCA(-/G)GAATT upstream-variant-2KB
rs35410559 -- 102,198,132(+) TATTG(G/T)TTCCT upstream-variant-2KB
rs75012365 -- 102,198,868(+) AATGC(C/T)TTTTT upstream-variant-2KB
rs76084746 -- 102,198,834(+) TGTTT(C/T)TGAGC upstream-variant-2KB
rs79104317 -- 102,198,881(+) TTTTT(C/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PMCH Gene

Variant ID Type Subtype PubMed ID
nsv899473 CNV Loss 21882294
nsv455702 CNV Loss 19166990

Relevant External Links for PMCH Gene

HapMap Linkage Disequilibrium report
PMCH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PMCH Gene

Disorders for PMCH Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PMCH Gene in MalaCards »

(1) Diseases for PMCH Gene including...

(1) University of Copenhagen DISEASES for PMCH Gene

(3) Novoseek inferred disease relationships for PMCH Gene

Disease -log(P) Hits PubMed IDs
obesity 27.9 3
pheochromocytoma 27 2
inflammation 0 1

Relevant External Links for PMCH

Genetic Association Database (GAD)
PMCH
Human Genome Epidemiology (HuGE) Navigator
PMCH
genes like me logo Genes that share disorders with PMCH: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PMCH Gene

Publications for PMCH Gene

  1. Structure of the human melanin concentrating hormone mRNA. (PMID: 2149166) Presse F. … Vale W. (Mol. Endocrinol. 1990) 2 3 4 23
  2. Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine. (PMID: 17541984) Chagnon Y.C. … Maziade M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48
  3. Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene. (PMID: 8326825) Breton C. … Nahon J.-L. (Brain Res. Mol. Brain Res. 1993) 3 4 23
  4. The melanin-concentrating hormone gene in human: flanking region analysis, fine chromosome mapping, and tissue-specific expression. (PMID: 9191099) Viale A. … Nahon J.-L. (Brain Res. Mol. Brain Res. 1997) 3 4 23
  5. Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. (PMID: 10037747) Viale A. … Nahon J.-L. (J. Biol. Chem. 1999) 3 4

Products for PMCH Gene

Sources for PMCH Gene

Back to Top

Content