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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PMCH Gene

protein-coding   GIFtS: 57
GCID: GC12M102590

Pro-Melanin-Concentrating Hormone

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pro-Melanin-Concentrating Hormone1 2
MCH2 3
pro-MCH2

External Ids:    HGNC: 91091   Entrez Gene: 53672   Ensembl: ENSG000001833957   OMIM: 1767955   UniProtKB: P203823   

Export aliases for PMCH gene to outside databases

Previous GC identifers: GC12U990072 GC12M102523 GC12M101092 GC12M099649


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PMCH Gene:
The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland
and later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and
zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The
anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal
functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH
and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in
nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating
hormone (PMCH) (summary by Nahon et al., 1992 (PubMed 1572663)).(supplied by OMIM, Jan 2011)

GeneCards Summary for PMCH Gene: 
PMCH (pro-melanin-concentrating hormone) is a protein-coding gene. Diseases associated with PMCH include byssinosis, and pheochromocytoma, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include melanin-concentrating hormone activity.

UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed
toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role
in spermatocyte differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PMCH gene promoter:
         FOXI1   HFH-3   GR   AML1a   GR-beta   Cart-1   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPMCH promoter sequence
   Search SABiosciences Chromatin IP Primers for PMCH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PMCH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.2

PMCH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMCH gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M102590:  view genomic region     (about GC identifiers)

Start:
102,590,237 bp from pter      End:
102,591,623 bp from pter
Size:
1,387 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCH_HUMAN, P20382 (See protein sequence)
Recommended Name: Pro-MCH precursor  
Size: 165 amino acids; 18679 Da
Subcellular location: Secreted
Secondary accessions: Q16044 Q8WVG0

Explore the universe of human proteins at neXtProt for PMCH: NX_P20382

Explore proteomics data for PMCH at MOPED 

Post-translational modifications:

  • UniProtKB: Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third
    peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates
    NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including
    PC1/3, PC2 and PC5/6
  • View neXtProt modification sites for NX_P20382

  • PMCH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PMCH Protein Expression
    REFSEQ proteins: NP_002665.2  
    ENSEMBL proteins: 
     ENSP00000332225  
    Reactome Protein details: P20382
    Human Recombinant Protein Products for PMCH: 
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    OriGene Protein Over-expression Lysate for PMCH
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PMCH
    GenScript Custom Purified and Recombinant Proteins Services for PMCH
    Novus Biologicals PMCH Protein
    Novus Biologicals PMCH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PMCH 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IEA--

    PMCH for ontologies           About GeneDecksing



    PMCH Antibody Products: 
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    Novus Biologicals PMCH Antibodies
    Abcam antibodies for PMCH
    Cloud-Clone Corp. Antibodies for PMCH 
    ThermoFisher Antibody for PMCH
    LSBio Antibodies in human, mouse, rat for PMCH 

    Assay Products for PMCH: 
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    Cloud-Clone Corp. ELISAs for PMCH 
    Cloud-Clone Corp. CLIAs for PMCH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR005456 Prepro-melanin_conc_hormone

    Graphical View of Domain Structure for InterPro Entry P20382

    ProtoNet protein and cluster: P20382

    1 Blocks protein domain: IPB005456 Pre-pro melanin-concentrating hormone signature

    UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
    Similarity: Belongs to the melanin-concentrating hormone family


    PMCH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCH_HUMAN, P20382
    Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed
    toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role
    in spermatocyte differentiation

         Genatlas biochemistry entry for PMCH:
    pro-melanin concentrating hormone,also encoding glutamic acid-isoleucine (NEI) and glycine-glutamic acids (NGE)
    neuropeptides,expressed in lateral hypotalamus area (LHA) and neighboring zona incerta (ZI),may be involved in
    energy balance and in feeding behaviour,ligand of GPR24

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030354melanin-concentrating hormone activity IEA--
         
    PMCH for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pmch):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  liver/biliary system 
     nervous system  reproductive system 

    PMCH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pmchtm1Emf for PMCH

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PMCH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PMCH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PMCH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PMCH 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PMCH
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PMCH:
    hsa-miR-298 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidPMCH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PMCH

    Clone
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    GenScript: all cDNA clones in your preferred vector: PMCH (NM_002674)
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                         Customized lentivirus expression plasmids for stable overexpression of PMCH 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMCH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PMCH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PMCH
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q



    5/9        Reactome Pathways for PMCH (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    PMCH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PMCH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/253 Interacting proteins for PMCH (P203823 ENSP000003322254) via UniProtKB, MINT, STRING, and/or I2D (see all 253)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=2 STRING: ENSP00000242152
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    MCHR1Q997053, ENSP000002490164I2D: score=1 STRING: ENSP00000249016
    MCHR2Q969V13, ENSP000002818064I2D: score=1 STRING: ENSP00000281806
    PCSK1P291203, ENSP000003080244I2D: score=1 STRING: ENSP00000308024
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS1572663
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007268synaptic transmission IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis NAS--

    PMCH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PMCH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PMCH (MCH)

    3 Novoseek inferred chemical compound relationships for PMCH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 46.6 4 8326825 (2), 7850873 (2)
    dexamethasone 8.76 2 9495549 (1), 1327720 (1)
    calcium 0 2 10421367 (1)

    Search CenterWatch for drugs/clinical trials and news about PMCH / MCH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PMCH gene: 
    NM_002674.2  

    Unigene Cluster for PMCH:

    Pro-melanin-concentrating hormone
    Hs.707990  [show with all ESTs]
    Unigene Representative Sequence: BG216766
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329406(uc001tjl.3)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PMCH
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PMCH:
    hsa-miR-298 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidPMCH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PMCH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PMCH
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    OriGene ORF clones in mouse, rat for PMCH
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    GenScript: all cDNA clones in your preferred vector: PMCH (NM_002674)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PMCH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PMCH
    Sirion Biotech Customized lentivirus for stable overexpression of PMCH 
                         Customized lentivirus expression plasmids for stable overexpression of PMCH 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PMCH
    OriGene qSTAR qPCR primer pairs in human, mouse for PMCH
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PMCH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PMCH

    Additional mRNA sequence: 

    BC018048.1 M57703.1 

    3 DOTS entries:

    DT.91741012  DT.95161588  DT.95239731 

    22 AceView cDNA sequences:

    CB047052 BF196106 AV708684 BC018048 AV701768 BG706895 BG706782 AV723892 
    AV727043 BI597555 BI603807 CB047053 BE244920 M57703 NM_002674 BX091733 
    BG216766 AW291615 AW976791 AA482754 AW363659 AV723033 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PMCH expression in normal human tissues (normalized intensities)      PMCH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGCCACT
    PMCH Expression
    About this image


    PMCH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             hypothalamus   
     
     Choroid Plexus (Uncategorized)    fully expand to see all 2 entries
             Human Choroid Plexus Fibroblasts (HCPF)   
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like cells ( Spontaneous differentiation of cardiomyocytes and further...
     
     Fibroblast
             Human Choroid Plexus Fibroblasts (HCPF)   
     
     Epithelium
             Human Choroid Plexus Epithelial Cells (HCPEpiC)   

    See PMCH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PMCH

    SOURCE GeneReport for Unigene cluster: Hs.707990

    UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
    Tissue specificity: Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and
    cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes
    and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are
    present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found
    predominantly

        SABiosciences Expression via Pathway-Focused PCR Array including PMCH: 
              Allergy & Asthma in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PMCH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMCH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PMCH gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pmch1 , 5 pro-melanin-concentrating hormone1, 5 88.69(n)1
    86.67(a)1
      10 (43.70 cM)5
    1103121  NM_029971.21  NP_084247.11 
     880910725 
    chicken
    (Gallus gallus)
    Aves PMCH1 pro-melanin-concentrating hormone 73.21(n)
    60.76(a)
      418091  NM_001195795.1  NP_001182724.1 
    lizard
    (Anolis carolinensis)
    Reptilia PMCH6
    Uncharacterized protein
    58(a)
    1 ↔ 1
    5(17558126-17559491)


    ENSEMBL Gene Tree for PMCH (if available)
    TreeFam Gene Tree for PMCH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PMCH gene
    2 SIMAP similar genes for PMCH using alignment to 1 protein entry:     MCH_HUMAN:
    PMCHL1    PMCHL2

    PMCH for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PMCH
    PGOHUM00000235529 PGOHUM00000235645


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/26 SNPs in PMCH are shown (see all 26)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354105591,2
    C--102591910(+) TATTGT/GTTCCT 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1497906521,2
    --102591986(+) ATAAAA/GTTTTA 1 -- us2k10--------
    rs1457692841,2
    --102592007(+) ATCCTA/GATTAA 1 -- us2k10--------
    rs1396567831,2
    --102592551(+) TCTCAC/TTGTCC 1 -- us2k10--------
    rs791043171,2
    --102592659(+) TTTTTC/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1443969501,2
    --102592802(+) CCCTCA/TGGTGT 1 -- us2k10--------
    rs1466190591,2
    --102592823(+) ACCAAA/GCTGAT 1 -- us2k10--------
    rs1889306581,2
    --102592870(+) TGGCAA/GCTACT 1 -- us2k10--------
    rs1995340911,2
    --102592886(+) TGTGT-/TGTTTTT 1 -- us2k10--------
    rs1424286261,2
    C--102592887(+) GTGTT-/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PMCH (102590237 - 102591623 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PMCH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv455702CNV Loss19166990
    nsv899473CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PMCH
    DNA2.0 Custom Variant and Variant Library Synthesis for PMCH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176795    OMIM disorders: --

    9 diseases for PMCH:    About MalaCards
    byssinosis    pheochromocytoma    vitiligo    eosinophilia
    huntington's disease    obesity    neuronitis    rhinitis
    asthma

    1 disease from the University of Copenhagen DISEASES database for PMCH:
    Keratosis follicularis

    PMCH for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for PMCH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 27.9 4 16902961 (1), 17640905 (1), 10421367 (1)
    pheochromocytoma 27 2 9495549 (1), 7617126 (1)
    inflammation 0 1 17640905 (1)

    Genetic Association Database (GAD): PMCH
    Human Genome Epidemiology (HuGE) Navigator: PMCH (3 documents)

    Export disorders for PMCH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PMCH gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with PMCH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human melanin concentrating hormone mRNA. (PubMed id 2149166)1, 2, 3, 9 Presse F.... Vale W. (1990)
    2. The melanin-concentrating hormone gene in human: flanking region analysis, fine chromosome mapping, and tissue-specific expression. (PubMed id 9191099)1, 2, 9 Viale A....Nahon J.-L. (1997)
    3. Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene. (PubMed id 8326825)1, 2, 9 Breton C.... Nahon J.-L. (1993)
    4. Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine. (PubMed id 17541984)1, 4, 9 Chagnon Y.C....Maziade M. (2007)
    5. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (2010)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    7. Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. (PubMed id 10037747)1, 2 Viale A.... Nahon J.-L. (1999)
    8. Assignment of the human pro-melanin-concentrating hormone gene (PMCH) to chromosome 12q23-q24 and two variant genes (PMCHL1 and PMCHL2) to chromosome 5p14 and 5q12-q13. (PubMed id 8188237)1, 9 Pedeutour F.... Nahon J.-L. (1994)
    9. Human Th2 cells selectively express the orexigenic peptide, pro-melanin-concentrating hormone. (PubMed id 17640905)1, 9 Sandig H....Cousins D.J. (2007)
    10. Pro-melanin-concentrating hormone gene (PMCH) is localized on human chromosome 12q and rat chromosome 7. (PubMed id 1572663)1, 9 Nahon J.L....Szpirer C. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5367 HGNC: 9109 AceView: PMCH Ensembl:ENSG00000183395 euGenes: HUgn5367
    ECgene: PMCH H-InvDB: PMCH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PMCH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PMCH gene:
    Search GeneIP for patents involving PMCH

    Licensable Technologies for PMCH gene:
     Salk Institute: Melanin-Concentrating Hormones
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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