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PMCH Gene

protein-coding   GIFtS: 53
GCID: GC12M102590

Pro-Melanin-Concentrating Hormone

  See PMCH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pro-Melanin-Concentrating Hormone1 2
MCH2 3
pro-MCH2

External Ids:    HGNC: 91091   Entrez Gene: 53672   Ensembl: ENSG000001833957   OMIM: 1767955   UniProtKB: P203823   

Export aliases for PMCH gene to outside databases

Previous GC identifers: GC12U990072 GC12M102523 GC12M101092 GC12M099649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PMCH Gene:
The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland
and later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and
zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The
anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal
functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH
and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in
nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating
hormone (PMCH) (summary by Nahon et al., 1992 (PubMed 1572663)).(supplied by OMIM, Jan 2011)

GeneCards Summary for PMCH Gene:
PMCH (pro-melanin-concentrating hormone) is a protein-coding gene. Diseases associated with PMCH include keratosis follicularis, and pheochromocytoma. GO annotations related to this gene include melanin-concentrating hormone activity.

UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed
toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role
in spermatocyte differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PMCH gene promoter:
         FOXI1   HFH-3   GR   AML1a   GR-beta   Cart-1   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPMCH promoter sequence
   Search Chromatin IP Primers for PMCH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PMCH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.2

PMCH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMCH gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M102590:  view genomic region     (about GC identifiers)

Start:
102,590,237 bp from pter      End:
102,591,623 bp from pter
Size:
1,387 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCH_HUMAN, P20382 (See protein sequence)
Recommended Name: Pro-MCH precursor  
Size: 165 amino acids; 18679 Da
Secondary accessions: Q16044 Q8WVG0

Explore the universe of human proteins at neXtProt for PMCH: NX_P20382

Explore proteomics data for PMCH at MOPED

Post-translational modifications: 

  • Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third
    peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates
    NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including
    PC1/3, PC2 and PC5/61
  • Modification sites at neXtProt

  • See PMCH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002665.2  
    ENSEMBL proteins: 
     ENSP00000332225  
    Reactome Protein details: P20382

    PMCH Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for PMCH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR005456 Prepro-melanin_conc_hormone

    Graphical View of Domain Structure for InterPro Entry P20382

    ProtoNet protein and cluster: P20382

    1 Blocks protein domain: IPB005456 Pre-pro melanin-concentrating hormone signature

    UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
    Similarity: Belongs to the melanin-concentrating hormone family


    Find genes that share domains with PMCH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCH_HUMAN, P20382
    Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed
    toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role
    in spermatocyte differentiation

         Genatlas biochemistry entry for PMCH:
    pro-melanin concentrating hormone,also encoding glutamic acid-isoleucine (NEI) and glycine-glutamic acids (NGE)
    neuropeptides,expressed in lateral hypotalamus area (LHA) and neighboring zona incerta (ZI),may be involved in
    energy balance and in feeding behaviour,ligand of GPR24

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030354melanin-concentrating hormone activity IEA--
         
    Find genes that share ontologies with PMCH           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pmch):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  liver/biliary system 
     nervous system  reproductive system 

    Find genes that share phenotypes with PMCH           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pmchtm1Emf for PMCH

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PMCH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PMCH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PMCH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PMCH

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    2 qRT-PCR Assays for microRNAs that regulate PMCH:
    hsa-miR-298 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidPMCH 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PMCH

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCH_HUMAN, P20382: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with PMCH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PMCH About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with PMCH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for PMCH
        Peptide ligand-binding receptors
    G alpha (q) signalling events
    G alpha (i) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Array including PMCH: 
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PMCH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PMCH (P203823 ENSP000003322254) via UniProtKB, MINT, STRING, and/or I2D (see all 253)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=2 STRING: ENSP00000242152
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    MCHR1Q997053, ENSP000002490164I2D: score=1 STRING: ENSP00000249016
    MCHR2Q969V13, ENSP000002818064I2D: score=1 STRING: ENSP00000281806
    PCSK1P291203, ENSP000003080244I2D: score=1 STRING: ENSP00000308024
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007268synaptic transmission IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--

    Find genes that share ontologies with PMCH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PMCH (MCH)

    3 Novoseek inferred chemical compound relationships for PMCH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 46.6 4 8326825 (2), 7850873 (2)
    dexamethasone 8.76 2 9495549 (1), 1327720 (1)
    calcium 0 2 10421367 (1)



    Find genes that share compounds with PMCH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PMCH gene: 
    NM_002674.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329406(uc001tjl.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate PMCH:
    hsa-miR-298 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidPMCH 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PMCH
      QuantiFast Probe-based Assays in human, mouse, rat PMCH

    22 AceView cDNA sequences:

    AV708684 CB047052 BC018048 BF196106 BG706895 BI597555 BI603807 AV701768 
    AV723892 BG706782 AV727043 NM_002674 M57703 CB047053 BE244920 BX091733 
    AW976791 AW291615 BG216766 AA482754 AW363659 AV723033 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PMCH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGCCACT
    PMCH Expression
    About this image


    PMCH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Thalamus
    PMCH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PMCH Protein Expression

    UniProtKB/Swiss-Prot: MCH_HUMAN, P20382
    Tissue specificity: Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and
    cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes
    and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are
    present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found
    predominantly

        Pathway & Disease-focused RT2 Profiler PCR Array including PMCH: 
              Allergy & Asthma in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PMCH gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pmch1 , 5 pro-melanin-concentrating hormone1, 5 88.69(n)1
    86.67(a)1
      10 (43.70 cM)5
    1103121  NM_029971.21  NP_084247.11 
     880910725 
    chicken
    (Gallus gallus)
    Aves PMCH1 pro-melanin-concentrating hormone 73.21(n)
    60.76(a)
      418091  NM_001195795.1  NP_001182724.1 
    lizard
    (Anolis carolinensis)
    Reptilia PMCH6
    pro-melanin-concentrating hormone
    58(a)
    1 ↔ 1
    5(17558126-17559491)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pmch1 pro-melanin-concentrating hormone 65.24(n)
    55.21(a)
      100486479  XM_002936830.1  XP_002936876.1 


    ENSEMBL Gene Tree for PMCH (if available)
    TreeFam Gene Tree for PMCH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PMCH gene
    2 SIMAP similar genes for PMCH using alignment to 1 protein entry:     MCH_HUMAN:
    PMCHL1    PMCHL2

    Find genes that share paralogs with PMCH           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PMCH
    PGOHUM00000235529 PGOHUM00000235645


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PMCH (see all 26)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354105591,2
    C--102591910(+) TATTGT/GTTCCT 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1497906521,2
    --102591986(+) ATAAAA/GTTTTA 1 -- us2k10--------
    rs1457692841,2
    --102592007(+) ATCCTA/GATTAA 1 -- us2k10--------
    rs1396567831,2
    --102592551(+) TCTCAC/TTGTCC 1 -- us2k10--------
    rs791043171,2
    --102592659(+) TTTTTC/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1443969501,2
    --102592802(+) CCCTCA/TGGTGT 1 -- us2k10--------
    rs1466190591,2
    --102592823(+) ACCAAA/GCTGAT 1 -- us2k10--------
    rs1889306581,2
    --102592870(+) TGGCAA/GCTACT 1 -- us2k10--------
    rs1995340911,2
    --102592886(+) TGTGT-/TGTTTTT 1 -- us2k10--------
    rs1424286261,2
    C--102592887(+) GTGTT-/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PMCH (102590237 - 102591623 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PMCH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv455702CNV Loss19166990
    nsv899473CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PMCH
    DNA2.0 Custom Variant and Variant Library Synthesis for PMCH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176795    OMIM disorders: --

    2 diseases for PMCH:    
    About MalaCards
    keratosis follicularis    pheochromocytoma

    1 disease from the University of Copenhagen DISEASES database for PMCH:
    Keratosis follicularis

    Find genes that share disorders with PMCH           About GenesLikeMe

    3 Novoseek inferred disease relationships for PMCH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 27.9 4 16902961 (1), 17640905 (1), 10421367 (1)
    pheochromocytoma 27 2 9495549 (1), 7617126 (1)
    inflammation 0 1 17640905 (1)

    Genetic Association Database (GAD): PMCH
    Human Genome Epidemiology (HuGE) Navigator: PMCH (3 documents)

    Export disorders for PMCH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PMCH gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with PMCH)
        Utopia: connect your pdf to the dynamic
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    1. Structure of the human melanin concentrating hormone mRNA. (PubMed id 2149166)1, 2, 3, 9 Presse F.... Vale W. (Mol. Endocrinol. 1990)
    2. The melanin-concentrating hormone gene in human: flanking region analysis, fine chromosome mapping, and tissue-specific expression. (PubMed id 9191099)1, 2, 9 Viale A....Nahon J.-L. (Brain Res. Mol. Brain Res. 1997)
    3. Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene. (PubMed id 8326825)1, 2, 9 Breton C.... Nahon J.-L. (Brain Res. Mol. Brain Res. 1993)
    4. Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine. (PubMed id 17541984)1, 4, 9 Chagnon Y.C....Maziade M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    5. Identification of 15 loci influencing height in a Korean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (J. Hum. Genet. 2010)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. (PubMed id 10037747)1, 2 Viale A.... Nahon J.-L. (J. Biol. Chem. 1999)
    8. Assignment of the human pro-melanin-concentrating hormone gene (PMCH) to chromosome 12q23-q24 and two variant genes (PMCHL1 and PMCHL2) to chromosome 5p14 and 5q12-q13. (PubMed id 8188237)1, 9 Pedeutour F.... Nahon J.-L. (Genomics 1994)
    9. Human Th2 cells selectively express the orexigenic peptide, pro-melanin-concentrating hormone. (PubMed id 17640905)1, 9 Sandig H....Cousins D.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    10. Pro-melanin-concentrating hormone gene (PMCH) is localized on human chromosome 12q and rat chromosome 7. (PubMed id 1572663)1, 9 Nahon J.L....Szpirer C. (Genomics 1992)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5367 HGNC: 9109 AceView: PMCH Ensembl:ENSG00000183395 euGenes: HUgn5367
    ECgene: PMCH H-InvDB: PMCH

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PMCH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PMCH gene:
    Search GeneIP for patents involving PMCH

    Licensable Technologies for PMCH gene:
     Salk Institute: Melanin-Concentrating Hormones
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