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PMAIP1 Gene

protein-coding   GIFtS: 63
GCID: GC18P057568

Phorbol-12-Myristate-13-Acetate-Induced Protein 1

  See PMAIP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phorbol-12-Myristate-13-Acetate-Induced Protein 11 2     PMA-Induced Protein 12 3
Immediate-Early-Response Protein APR2 3     APR2
Protein Noxa2 3     Adult T Cell Leukemia-Derived PMA-Responsive2
NOXA2 3     

External Ids:    HGNC: 91081   Entrez Gene: 53662   Ensembl: ENSG000001416827   OMIM: 6049595   UniProtKB: Q137943   

Export aliases for PMAIP1 gene to outside databases

Previous GC identifers: GC18P057399 GC18P057540 GC18P055716 GC18P055718 GC18P054277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PMAIP1 Gene:
PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1) is a protein-coding gene. Diseases associated with PMAIP1 include adult t-cell leukemia, and t-cell leukemia.

UniProtKB/Swiss-Prot: APR_HUMAN, Q13794
Function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of
apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure.
Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its
binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11
from its binding site on MCL1

Gene Wiki entry for PMAIP1 (Phorbol-12-myristate-13-acetate-induced protein 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the PMAIP1 gene promoter:
         Max1   FOXD3   IRF-1   STAT5A   CUTL1   PPAR-gamma1   HSF2   STAT3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PMAIP1 promoter sequence
   Search Chromatin IP Primers for PMAIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PMAIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.32   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21.32

PMAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMAIP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P057568:  view genomic region     (about GC identifiers)

Start:
57,567,180 bp from pter      End:
57,571,538 bp from pter
Size:
4,359 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APR_HUMAN, Q13794 (See protein sequence)
Recommended Name: Phorbol-12-myristate-13-acetate-induced protein 1  
Size: 54 amino acids; 6030 Da
Subunit: Interacts with MCL1, BCL2A1 and BAX
1 PDB 3D structure from and Proteopedia for PMAIP1:
3MQP (3D)    
Secondary accessions: B2R4T7

Explore the universe of human proteins at neXtProt for PMAIP1: NX_Q13794

Explore proteomics data for PMAIP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys41, Lys48
  • Modification sites at PhosphoSitePlus

  • See PMAIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066950.1  
    ENSEMBL proteins: 
     ENSP00000326119   ENSP00000269518  
    Reactome Protein details: Q13794

    PMAIP1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PMAIP1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024140 Noxa

    Graphical View of Domain Structure for InterPro Entry Q13794

    ProtoNet protein and cluster: Q13794

    UniProtKB/Swiss-Prot: APR_HUMAN, Q13794
    Domain: The BH3 motif is essential for pro-apoptotic activity
    Similarity: Belongs to the PMAIP1 family


    Find genes that share domains with PMAIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APR_HUMAN, Q13794
    Function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of
    apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure.
    Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its
    binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11
    from its binding site on MCL1
    Induction: Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15705586
         
    Find genes that share ontologies with PMAIP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PMAIP1:
     Decreased number of cells in m 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pmaip1):
     cellular  hematopoietic system  immune system  mortality/aging  nervous system 
     tumorigenesis 

    Find genes that share phenotypes with PMAIP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PMAIP1: Pmaip1tm1Ttg Pmaip1tm1Ast

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PMAIP1
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    miRNA
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    miRTarBase miRNAs that target PMAIP1:
    hsa-mir-98-5p (MIRT027675), hsa-mir-331-3p (MIRT043467), hsa-mir-26b-5p (MIRT029656), hsa-mir-186-5p (MIRT021168), hsa-mir-125b-5p (MIRT045943), hsa-mir-200c-3p (MIRT007018), hsa-mir-18a-3p (MIRT040967), hsa-let-7f-2-3p (MIRT038989), hsa-mir-193b-3p (MIRT041571)

    Block miRNA regulation of human, mouse, rat PMAIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PMAIP1 (see all 24):
    hsa-miR-142-3p hsa-miR-429 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-1297 hsa-let-7g hsa-miR-633
    SwitchGear 3'UTR luciferase reporter plasmidPMAIP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PMAIP1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for PMAIP1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMAIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APR_HUMAN, Q13794: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    nucleus5
    extracellular2
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12879012
    GO:0005739mitochondrion IDA14500711
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PMAIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PMAIP1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    2Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members0.00
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    p53 Mediated Apoptosis0.84
    Cellular Apoptosis Pathway0.85
    4Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of NOXA and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68
    5Apoptosis (WikiPathways)
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38


    Find genes that share SuperPaths with PMAIP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PMAIP1
        p53 Mediated Apoptosis
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    Cellular Apoptosis Pathway

    1 GeneGo (Thomson Reuters) Pathway for PMAIP1
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    Selected BioSystems Pathways for PMAIP1 (see all 7)
        Apoptosis
    DNA damage response
    Apoptosis Modulation and Signaling
    DNA damage response (only ATM dependent)
    TP53 network

    2 Reactome Pathways for PMAIP1
        Activation of NOXA and translocation to mitochondria
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members


    2 Kegg Pathways  (Kegg details for PMAIP1):
        p53 signaling pathway
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PMAIP1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Mitochondria in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PMAIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for PMAIP1 (Q137941, 2, 3 ENSP000003261194) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104151, 3, ENSP000003296234EBI-707392,EBI-77694 I2D: score=3 STRING: ENSP00000329623
    ZBTB16Q055162, 3MINT-64159 I2D: score=5 
    PPBPP027752, 3MINT-64158 I2D: score=4 
    GSK3BP498412, 3MINT-8257581 I2D: score=2 
    MCL1Q078201, 2, 3, ENSP000003580224EBI-707392,EBI-1003422 MINT-7543162 I2D: score=4 STRING: ENSP00000358022
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IEA--
    GO:0006974cellular response to DNA damage stimulus ----
    GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage ----

    Find genes that share ontologies with PMAIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PMAIP1 (APR)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PMAIP1 gene: 
    NM_021127.2  

    Unigene Cluster for PMAIP1:

    Phorbol-12-myristate-13-acetate-induced protein 1
    Hs.96  [show with all ESTs]
    Unigene Representative Sequence: NM_021127
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316660(uc002lic.2 uc002lid.2) ENST00000269518 ENST00000590596

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PMAIP1 (see all 24):
    hsa-miR-142-3p hsa-miR-429 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-1297 hsa-let-7g hsa-miR-633
    SwitchGear 3'UTR luciferase reporter plasmidPMAIP1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for PMAIP1 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PMAIP1
      QuantiTect SYBR Green Assays in human, mouse, rat PMAIP1
      QuantiFast Probe-based Assays in human, mouse, rat PMAIP1

    Additional mRNA sequence: 

    AK311943.1 BC013120.1 BC032663.1 D90070.1 

    4 DOTS entries:

    DT.313854  DT.91931984  DT.100785726  DT.91685786 

    Selected AceView cDNA sequences (see all 117):

    BM974198 BX446011 CA428784 AU156466 AA262439 CR591391 CB160144 BM702252 
    CB529063 AA280733 BU165188 CA425957 AI523864 AU138295 BQ438903 AI391568 
    BU193490 CB529873 AU125541 BP353989 CA441516 BU153988 BU164468 BU152998 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PMAIP1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
    SP1:                          -               
    SP2:                                          
    SP3:                    -     -               


    ECgene alternative splicing isoforms for PMAIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PMAIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATTTTGT
    PMAIP1 Expression
    About this image


    PMAIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    PMAIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PMAIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.96

    UniProtKB/Swiss-Prot: APR_HUMAN, Q13794
    Tissue specificity: Highly expressed in adult T-cell leukemia cell line

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PMAIP1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Mitochondria in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMAIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for PMAIP1 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pmaip15 phorbol-12-myristate-13-acetate-induced protein 1   --   18 (39.52 cM) 66458604 


    ENSEMBL Gene Tree for PMAIP1 (if available)
    TreeFam Gene Tree for PMAIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PMAIP1 (see all 140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503983221,2
    --57565241(+) GGATAA/CTAGAT 1 -- us2k10--------
    rs1428483631,2
    --57565569(+) CCTAGC/GTTCCT 1 -- us2k10--------
    rs1916180291,2
    C--57565609(+) AACCTA/GGTTTG 1 -- us2k10--------
    rs724586621,2
    C--57565644(+) TTGTC-/AGAGATT 1 -- us2k10--------
    rs1147836701,2
    F--57565688(+) TTTCAT/CGCAAT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1849308261,2
    --57565694(+) GCAATA/CCCTCA 1 -- us2k10--------
    rs1135862311,2
    C,F--57565909(+) AGTGGC/AGCGAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1899569971,2
    --57565914(+) CGCGAC/TCTCGG 1 -- us2k10--------
    rs1821955681,2
    --57565942(+) CTCCCA/TGGTTC 1 -- us2k10--------
    rs1392630231,2
    --57565966(+) GCCTCA/TGCCGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PMAIP1 (57567180 - 57571538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PMAIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523228CNV Loss19592680

    Human Gene Mutation Database (HGMD): PMAIP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PMAIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for PMAIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604959    OMIM disorders: --

    6 diseases for PMAIP1:    
    About MalaCards
    adult t-cell leukemia    t-cell leukemia    vaccinia    alveolar rhabdomyosarcoma
    mantle cell lymphoma    squamous cell carcinoma of the head and neck


    Find genes that share disorders with PMAIP1           About GenesLikeMe

    Genetic Association Database (GAD): PMAIP1
    Human Genome Epidemiology (HuGE) Navigator: PMAIP1 (1 document)

    Export disorders for PMAIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PMAIP1 gene, integrated from 10 sources (see all 103):
    (articles sorted by number of sources associating them with PMAIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a cDNA for a novel phorbol- 12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line. (PubMed id 2398525)1, 2, 3 Hijikata M.... Shimotohno K. (J. Virol. 1990)
    2. Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection. (PubMed id 15705586)1, 2 Sun Y. and Leaman D.W. (J. Biol. Chem. 2005)
    3. Differential targeting of prosurvival Bcl-2 proteins by their BH3- only ligands allows complementary apoptotic function. (PubMed id 15694340)1, 2 Chen L.... Huang D.C.S. (Mol. Cell 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Noxa in colorectal cancer: a study on DNA, mRNA and protein expression. (PubMed id 12879012)1, 3 Jansson A.K....Sun X.F. (Oncogene 2003)
    6. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. (PubMed id 10807576)1, 2 Oda E.... Tanaka N. (Science 2000)
    7. The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer. (PubMed id 18231856)1, 9 Ishida M....Horii A. (Dig. Dis. Sci. 2008)
    8. The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. (PubMed id 18408751)1, 9 Hassan M....Hengge U.R. (Oncogene 2008)
    9. BOK and NOXA are essential mediators of p53-dependent apoptosis. (PubMed id 15102863)1, 9 Yakovlev A.G....Faden A.I. (J. Biol. Chem. 2004)
    10. pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737. (PubMed id 23429261)1 Bertin-Ciftci J....Braun F. (Cell Death Differ. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5366 HGNC: 9108 AceView: PMAIP1 Ensembl:ENSG00000141682 euGenes: HUgn5366
    ECgene: PMAIP1 Kegg: 5366 H-InvDB: PMAIP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PMAIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PMAIP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PMAIP1 gene:
    Search GeneIP for patents involving PMAIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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