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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PMAIP1 Gene

protein-coding   GIFtS: 63
GCID: GC18P057540

phorbol-12-myristate-13-acetate-induced protein 1
 Explore 24 diseases affiliated with
PMAIP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PMAIP1    

Aliases
for PMAIP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Phorbol-12-Myristate-13-Acetate-Induced Protein 11 2     Protein Noxa2 3
NOXA1 2 3     PMA-Induced Protein 12 3
APR1 2     Adult T Cell Leukemia-Derived PMA-Responsive2
Immediate-Early-Response Protein APR2 3     

External Ids:    HGNC: 91081   Entrez Gene: 53662   Ensembl: ENSG000001416827   OMIM: 6049595   UniProtKB: Q137943   
ORGUL members:         
NONCODE:n342580    

Export aliases for PMAIP1 gene to outside databases

Previous GC identifers: GC18P057399 GC18P055716 GC18P055718 GC18P054277


Summaries
for PMAIP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: APR_HUMAN, Q13794
Function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of
apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure.
Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its
binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from
its binding site on MCL1

Gene Wiki entry for PMAIP1 (Phorbol-12-myristate-13-acetate-induced protein 1)


Genomic Views
for PMAIP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PMAIP1 gene promoter:
         Max1   FOXD3   IRF-1   STAT5A   CUTL1   PPAR-gamma1   HSF2   STAT3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PMAIP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PMAIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PMAIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.32   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21.32

PMAIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PMAIP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P057540:  view genomic region     (about GC identifiers)

Start:
 57,567,180 bp from pter      End:
 57,571,538 bp from pter
Size:
 4,359 bases      Orientation:
 plus strand

Proteins
for PMAIP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: APR_HUMAN, Q13794 (See protein sequence)
Recommended Name: Phorbol-12-myristate-13-acetate-induced protein 1  
Size: 54 amino acids; 6030 Da
Subunit: Interacts with MCL1, BCL2A1 and BAX
Subcellular location: Mitochondrion
1 PDB 3D structure from and Proteopedia for PMAIP1:
3MQP (3D)    
Secondary accessions: B2R4T7

Explore the universe of human proteins at neXtProt for PMAIP1: NX_Q13794

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13794

    • PMAIP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066950.1  
    ENSEMBL proteins: 
     ENSP00000326119   ENSP00000269518  
    Reactome Protein details: Q13794
    Human Recombinant Protein Products: 
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    Novus Biologicals PMAIP1 Proteins
    Novus Biologicals PMAIP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PMAIP1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12879012
    GO:0005739mitochondrion IDA15705586
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005829cytosol TAS--


    PMAIP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PMAIP1

    Protein Domains /
    Families
    for PMAIP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PMAIP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024140 PMA-induced_Noxa

    Graphical View of Domain Structure for InterPro Entry Q13794

    ProtoNet protein and cluster: Q13794

    UniProtKB/Swiss-Prot: APR_HUMAN, Q13794
    Domain: The BH3 motif is essential for pro-apoptotic activity
    Similarity: Belongs to the PMAIP1 family


    Function
    for PMAIP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: APR_HUMAN, Q13794
    Function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of
    apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure.
    Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its
    binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from
    its binding site on MCL1
    Induction: Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PMAIP1
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate PMAIP1 (see all 24):
    hsa-miR-142-3p hsa-miR-429 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-1297 hsa-let-7g hsa-miR-633
    SwitchGear 3'UTR luciferase reporter plasmid: PMAIP1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for PMAIP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PMAIP1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    PMAIP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PMAIP1:
     Decreased number of cells in m 

    Animal Models:
         Mouse knock-outs for PMAIP1: Pmaip1tm1Ttg Pmaip1tm1Ast
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pmaip1):
     cellular  hematopoietic system  immune system  mortality/aging  nervous system 
     tumorigenesis 

    PMAIP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PMAIP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members1.00
    		Intrinsic Pathway for Apoptosis0.23
    		Activation of BH3-only proteins0.30
    		Transactivation of NOXA by p530.12
    		Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins0.24
    		Transactivation of NOXA by E2F10.12
    		Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins0.24
    		Activation of NOXA and translocation to mitochondria0.12
    2Apoptotic Pathways in Synovial Fibroblasts
    		p53 Mediated Apoptosis0.84
    		Cellular Apoptosis Pathway0.65
    		Mitochondrial Apoptosis0.73
    3Apoptosis Modulation and Signaling
    		Apoptosis Modulation and Signaling1.00
    		Apoptosis0.38
    4p53 signaling pathway
    		p53 signaling pathway1.00
    		DNA damage response0.40
    5TP53 network
    		TP53 network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PMAIP1
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PMAIP1
        p53 Mediated Apoptosis
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    Cellular Apoptosis Pathway

    1 GeneGo (Thomson Reuters) Pathway for PMAIP1
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    5/7 BioSystems Pathways for PMAIP1 (see all 7) 
        Apoptosis Modulation and Signaling
    DNA damage response (only ATM dependent)
    DNA damage response
    Apoptosis
    TP53 network

    5/7        Reactome Pathways for PMAIP1 (see all 7)
        Activation of BH3-only proteins
    Intrinsic Pathway for Apoptosis
    Activation of NOXA and translocation to mitochondria
    Transactivation of NOXA by p53
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members


    1         Kegg Pathway  (Kegg details for PMAIP1):
        p53 signaling pathway


    PMAIP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PMAIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/25 Interacting proteins for PMAIP1 (Q137941, 2, 3 ENSP000003261194) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104151, 3, ENSP000003296234EBI-707392,EBI-77694 I2D: score=3 STRING: ENSP00000329623
    ZBTB16Q055162, 3MINT-64159 I2D: score=5 
    PPBPP027752, 3MINT-64158 I2D: score=4 
    GSK3BP498412, 3MINT-8257581 I2D: score=2 
    MCL1Q078201, 2, 3, ENSP000003580224EBI-707392,EBI-1003422 MINT-7543162 I2D: score=4 STRING: ENSP00000358022
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0001844protein insertion into mitochondrial membrane involved in apoptotic signaling pathway ----
    GO:0006915apoptotic process TAS--
    GO:0006917induction of apoptosis IDA15705586
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA15705586


    PMAIP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PMAIP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PMAIP1
    Search CenterWatch for drugs/clinical trials and news about PMAIP1 / APR 

    Transcripts
    for PMAIP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PMAIP1 gene: 
    NM_021127.2  

    Unigene Cluster for PMAIP1:

    Phorbol-12-myristate-13-acetate-induced protein 1
    Hs.96  [show with all ESTs]
    Unigene Representative Sequence: NM_021127
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316660(uc002lic.2 uc002lid.2) ENST00000269518 ENST00000590596


    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate PMAIP1 (see all 24):
    hsa-miR-142-3p hsa-miR-429 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-1297 hsa-let-7g hsa-miR-633
    SwitchGear 3'UTR luciferase reporter plasmid: PMAIP1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: PMAIP1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK311943.1 BC013120.1 BC032663.1 D90070.1 

    4 DOTS entries:

    DT.313854  DT.91931984  DT.100785726  DT.91685786 

    24/117 AceView cDNA sequences (see all 117):

    BX115773 AI080512 BX446011 AU138295 BM702252 BQ921701 BU193490 AA262439 
    CB529873 BM068801 CB053430 CB529063 CA428784 BU165188 AU156466 CR591391 
    BM999509 AA280733 BU164468 BP353989 BU153988 AU125541 AA580892 AI523864 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PMAIP1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
    SP1:                          -               
    SP2:                                          
    SP3:                    -     -               


    ECgene alternative splicing isoforms for PMAIP1

    Expression
    for PMAIP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PMAIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGATTTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PMAIP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMaxillary ProcessBone
    BoneZeugopod PeriosteumBone
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    KidneyRenal Collecting Duct SystemKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Matrigel embedded cells (Derivation of cardio...)
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See PMAIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PMAIP1

    SOURCE GeneReport for Unigene cluster: Hs.96

    UniProtKB/Swiss-Prot: APR_HUMAN, Q13794
    Tissue specificity: Highly expressed in adult T-cell leukemia cell line

        SABiosciences Expression via Pathway-Focused PCR Arrays including PMAIP1: 
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              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for PMAIP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for PMAIP1 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pmaip15 phorbol-12-myristate-13-acetate-induced protein 1   --   18 (39.52 cM) 66458604 


    ENSEMBL Gene Tree for PMAIP1 (if available)
    TreeFam Gene Tree for PMAIP1 (if available) 

    Paralogs
    for PMAIP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PMAIP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/125 NCBI SNPs in PMAIP1 are shown (see all 125)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1503983221,2
    		--57565241(+) GGATAA/CTAGAT 1 -- us2k10--------
    rs1428483631,2
    		--57565569(+) CCTAGC/GTTCCT 1 -- us2k10--------
    rs1916180291,2
    		--57565609(+) AACCTA/GGTTTG 1 -- us2k10--------
    rs724586621,2
    		C,--57565644(+) TTGTC-/AGAGATT 1 -- us2k10--------
    rs1147836701,2
    		F,--57565688(+) TTTCAT/CGCAAT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1849308261,2
    		--57565694(+) GCAATA/CCCTCA 1 -- us2k10--------
    rs1416620001,2
    		C,--57565844(+) CACGC-/TTTTTT 1 -- us2k10--------
    rs711770731,2
    		C--57565845(+) TTTTTT/-CTTTT 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1135862311,2
    		C,--57565909(+) AGTGGC/AGCGAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1899569971,2
    		--57565914(+) CGCGAC/TCTCGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PMAIP1 (57567180 - 57571538 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PMAIP1: --
    Human Gene Mutation Database (HGMD): PMAIP1

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    Disorders / Diseases
    for PMAIP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PMAIP1 for disorders           About GeneDecksing

    OMIM gene information: 604959    OMIM disorders: --

    20/24 diseases for PMAIP1 (see all 24):    About MalaCards
    adult t-cell leukemia    t-cell leukemia    leukemia    mantle cell lymphoma
    chronic lymphocytic leukemia    chronic myeloid leukemia    lymphocytic leukemia    myeloid leukemia
    squamous cell carcinoma    cholera    rhabdomyosarcoma    pancreatic cancer
    colorectal cancer    lung cancer    prostate cancer    breast cancer
    pancreatitis    myeloma    hypoxia    neuroblastoma

    Human Genome Epidemiology (HuGE) Navigator: PMAIP1 (1 document)

    Export disorders for PMAIP1 gene to outside databases

    Publications
    for PMAIP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PMAIP1 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with PMAIP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a cDNA for a novel phorbol- 12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line. (PubMed id 2398525)1, 2, 3 Hijikata M.... Shimotohno K. (1990)
    2. Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection. (PubMed id 15705586)1, 2 Sun Y. and Leaman D.W. (2005)
    3. Differential targeting of prosurvival Bcl-2 proteins by their BH3- only ligands allows complementary apoptotic function. (PubMed id 15694340)1, 2 Chen L.... Huang D.C.S. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Noxa in colorectal cancer: a study on DNA, mRNA and p rotein expression. (PubMed id 12879012)1, 3 Jansson A.K....Sun X.F. (2003)
    6. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. (PubMed id 10807576)1, 2 Oda E....Tanaka N. (2000)
    7. The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer. (PubMed id 18231856)1, 9 Ishida M....Horii A. (2008)
    8. The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. (PubMed id 18408751)1, 9 Hassan M....Hengge U.R. (2008)
    9. BOK and NOXA are essential mediators of p53-dependent apoptosis. (PubMed id 15102863)1, 9 Yakovlev A.G....Faden A.I. (2004)
    10. MiR-200c regulates Noxa expression and sensitivity to proteasomal inhibitors. (PubMed id 22615771)1 Lerner M....Grander D. (2012)

    External Searches for PMAIP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing PMAIP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5366 HGNC: 9108 AceView: PMAIP1 Ensembl:ENSG00000141682 euGenes: HUgn5366
    ECgene: PMAIP1 Kegg: 5366 H-InvDB: PMAIP1

    Other Databases showing PMAIP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PMAIP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PMAIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PMAIP1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PMAIP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PMAIP1 gene:
    Search GeneIP for patents involving PMAIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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