Aliases for PM20D2 Gene
Aliases for PM20D2 Gene
External Ids for PM20D2 Gene
- HGNC: 21408
- Entrez Gene: 135293
- Ensembl: ENSG00000146281
- OMIM: 615913
- UniProtKB: Q8IYS1
Previous HGNC Symbols for PM20D2 Gene
- ACY1L2
Previous GeneCards Identifiers for PM20D2 Gene
- GC06P089912
- GC06P087071
Summaries for PM20D2 Gene
GeneCards Summary for PM20D2 Gene
PM20D2 (Peptidase M20 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PM20D2 Gene
Genomics for PM20D2 Gene
Regulatory Elements for PM20D2 Gene
Enhancers for PM20D2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PM20D2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PM20D2 gene promoter:
Regulatory Element Products
Genomic Location for PM20D2 Gene
- Chromosome:
- 6
- Start:
- 89,096,753 bp from pter
- End:
- 89,165,569 bp from pter
- Size:
- 68,817 bases
- Orientation:
- Plus strand
Genomic View for PM20D2 Gene
Genes around PM20D2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q15 by Ensembl
- 6q15 by Entrez Gene
- 6q15 by HGNC
PM20D2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PM20D2 Gene
Proteins for PM20D2 Gene
-
Protein details for PM20D2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYS1-P20D2_HUMAN
- Recommended name:
- Peptidase M20 domain-containing protein 2
- Protein Accession:
- Q8IYS1
- B4DYJ2
- Q5T7J9
- Q6MZV2
- Q86XD9
Protein attributes for PM20D2 Gene
- Size:
- 436 amino acids
- Molecular mass:
- 47776 Da
- Quaternary structure:
- No Data Available
Protein Expression for PM20D2 Gene
Post-translational modifications for PM20D2 Gene
Other Protein References for PM20D2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PM20D2
- Invitrogen Antibodies for PM20D2
- GeneTex PM20D2 antibody for PM20D2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PM20D2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PM20D2
- Origene Custom Protein Services for PM20D2
- Novus Biologicals proteins for PM20D2
- Search GeneTex for Proteins for PM20D2
Assay Products
No data available for DME Specific Peptides for PM20D2 Gene
Domains & Families for PM20D2 Gene
Protein Domains for PM20D2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PM20D2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IYS1- Family:
-
- Belongs to the peptidase M20A family.
No data available for Gene Families for PM20D2 Gene
Function for PM20D2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PM20D2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PM20D2 gene
- Search ViGene Biosciences for PM20D2
CRISPR Products
-
OriGene CRISPR knockouts for PM20D2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PM20D2
- GenScript: Design CRISPR guide RNA sequences for PM20D2
miRNA for PM20D2 Gene
- miRTarBase miRNAs that target PM20D2
-
- hsa-mir-193b-3p (MIRT016356)
- hsa-mir-21-5p (MIRT030804)
- hsa-mir-5096 (MIRT545373)
- hsa-mir-8061 (MIRT545374)
- hsa-mir-629-3p (MIRT545375)
- hsa-mir-4760-5p (MIRT545376)
- hsa-mir-519e-5p (MIRT545377)
- hsa-mir-515-5p (MIRT545378)
- hsa-mir-889-3p (MIRT545379)
- hsa-mir-202-3p (MIRT545380)
- hsa-mir-98-5p (MIRT545381)
- hsa-mir-4458 (MIRT545382)
- hsa-mir-4500 (MIRT545383)
- hsa-let-7i-5p (MIRT545384)
- hsa-let-7g-5p (MIRT545385)
- hsa-let-7f-5p (MIRT545386)
- hsa-let-7e-5p (MIRT545387)
- hsa-let-7d-5p (MIRT545388)
- hsa-let-7c-5p (MIRT545389)
- hsa-let-7b-5p (MIRT545390)
- hsa-let-7a-5p (MIRT545391)
- hsa-mir-4307 (MIRT545392)
- hsa-mir-5583-3p (MIRT545393)
- hsa-mir-4517 (MIRT545394)
- hsa-mir-6792-5p (MIRT564191)
- hsa-mir-1273e (MIRT564192)
- hsa-mir-190b (MIRT564193)
- hsa-mir-5585-5p (MIRT564194)
- hsa-mir-190a-5p (MIRT564195)
- hsa-mir-548ax (MIRT564196)
- hsa-mir-548ao-5p (MIRT564197)
- hsa-mir-380-3p (MIRT564198)
- hsa-mir-411-3p (MIRT564199)
- hsa-mir-4495 (MIRT564200)
- hsa-mir-379-3p (MIRT564201)
- hsa-mir-548s (MIRT685429)
- hsa-mir-4684-5p (MIRT685430)
- hsa-mir-3926 (MIRT685431)
- hsa-mir-4786-5p (MIRT685432)
- hsa-mir-203a-3p (MIRT685433)
- hsa-mir-3190-5p (MIRT685434)
- hsa-mir-6827-3p (MIRT685435)
- hsa-mir-340-3p (MIRT685436)
miRNA Products
- Search ViGene Biosciences for PM20D2
Clone Products
- OriGene clones in human for PM20D2
- OriGene ORF clones in human,mouse,rat for PM20D2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PM20D2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PM20D2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PM20D2 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PM20D2 Gene
Localization for PM20D2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070062 | extracellular exosome | IDA | 23376485 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PM20D2 Gene
Pathways & Interactions for PM20D2 Gene
More details on SuperPathways for PM20D2
No Data Available
Interacting Proteins for PM20D2 Gene
No data available for Pathways by source and SIGNOR curated interactions for PM20D2 Gene
Transcripts for PM20D2 Gene
mRNA/cDNA for PM20D2 Gene
- (7) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (130) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PM20D2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PM20D2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PM20D2
- GenScript: Design CRISPR guide RNA sequences for PM20D2
miRNA Products
- Search ViGene Biosciences for PM20D2
Clone Products
- OriGene clones in human for PM20D2
- OriGene ORF clones in human,mouse,rat for PM20D2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for PM20D2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for PM20D2 Gene
This gene is overexpressed in Muscle - Skeletal (x4.3).
This gene is overexpressed in Ovary (19.5), Pancreas (9.4), and Islet of Langerhans (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PM20D2 Gene
SOURCE GeneReport for Unigene cluster for PM20D2 Gene Hs.356247
Primer Products
-
OriGene qPCR primer pairs for PM20D2
No data available for mRNA Expression by UniProt/SwissProt for PM20D2 Gene
Orthologs for PM20D2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PM20D2 35 |
|
||
| PM20D2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PM20D2 35 |
|
||
| PM20D2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pm20d2 35 |
|
||
| Pm20d2 16 |
|
||||
| Pm20d2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PM20D2 35 |
|
||
| PM20D2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pm20d2 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PM20D2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PM20D2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PM20D2 35 |
|
||
| PM20D2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PM20D2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pm20d2 35 |
|
||
| Str.14998 35 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9866 35 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU08886 35 |
|
- Species with no ortholog for PM20D2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for PM20D2 Gene
No data available for Paralogs for PM20D2 Gene
Variants for PM20D2 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10944433 | - | 89,158,409(+) | GAAGA(A/G)AGCTA | reference, missense, utr-variant-3-prime | |
| rs1045969 | -- | 89,164,388(+) | AGCTA(A/G)GATTA | utr-variant-3-prime | |
| rs1045972 | -- | 89,164,456(+) | GTTCA(C/G)AAGGA | utr-variant-3-prime | |
| rs1045974 | -- | 89,164,469(+) | ATTGT(G/T)GTAAC | utr-variant-3-prime | |
| rs1045975 | -- | 89,164,472(+) | GTTGT(A/G/T)ACAGA | utr-variant-3-prime |
Residual Variation Intolerance Score:
80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.13;
51.35% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PM20D2 Gene
Disorders for PM20D2 Gene
Relevant External Links for PM20D2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- PM20D2
No disorders were found for PM20D2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PM20D2 Gene
Publications for PM20D2 Gene
- Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as I^-alanyl-lysine dipeptidase. (PMID: 24891507) Veiga-da-Cunha M. … Van Schaftingen E. (J. Biol. Chem. 2014) 2 3 67
- Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
- An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
Products for PM20D2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PM20D2
- Origene Custom Protein Services for PM20D2
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for PM20D2
- Browse OriGene Inhibitory RNA Products For PM20D2
- OriGene qPCR primer pairs for PM20D2
- OriGene CRISPR knockouts for PM20D2
- OriGene clones in human for PM20D2
- OriGene ORF clones in human,mouse,rat for PM20D2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for PM20D2
- GenScript Custom Assay Services for PM20D2
- GenScript Custom overexpressing Cell Line Services for PM20D2
- GenScript: Design CRISPR guide RNA sequences for PM20D2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PM20D2
- Novus Biologicals Antibodies for PM20D2
- Novus Biologicals proteins for PM20D2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for PM20D2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PM20D2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PM20D2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PM20D2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PM20D2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PM20D2 gene
- Search ViGene Biosciences for PM20D2
- Search ViGene Biosciences for PM20D2
- Santa Cruz Biotechnology (SCBT) Antibodies for PM20D2
- Search Santa Cruz Biotechnology (SCBT) for PM20D2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PM20D2
Sources for PM20D2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon