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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLXND1 Gene

protein-coding GIFtS: 65
GCID: GC03M129274

plexin D1

Explore 6 diseases affiliated with
PLXND1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Plexin D1¹ ²
KIAA0620¹ ³
PLEXD1²
Plexin-D1¹

External Ids:	HGNC: 9107¹	Entrez Gene: 23129²	Ensembl: ENSG00000004399⁷	OMIM: 604282⁵	UniProtKB: Q9Y4D7³

Export aliases for PLXND1 gene to outside databases

Previous GC identifers: GC03U990121 GC03M129910 GC03M130555 GC03M130594 GC03M130756 GC03M126657

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PLXD1_HUMAN, Q9Y4D7

Function: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an

important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the

migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the

specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity).

Mediates anti-angiogenic signaling in response to SEMA3E

Gene Wiki entry for PLXND1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLXND1 gene promoter:
Pax-5 Egr-1 HTF E47 PPAR-alpha MZF-1 c-Rel c-Myb Hand1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLXND1 promoter sequence

Search SABiosciences Chromatin IP Primers for PLXND1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLXND1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q21.3

PLXND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXND1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M129274: view genomic region (about GC identifiers)

Start:	129,274,018 bp from pter	End:	129,325,661 bp from pter
Size:	51,644 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLXD1_HUMAN, Q9Y4D7 (See protein sequence)

Recommended Name: Plexin-D1 precursor

Size: 1925 amino acids; 212007 Da

Subunit: Interacts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E (By similarity)

Subcellular location: Cell membrane; Single-pass membrane protein (By similarity)

Sequence caution: Sequence=BAA31595.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

1 PDB 3D structure from and Proteopedia for PLXND1:

3H6N (3D)

Secondary accessions: A7E2C6 C9JPZ6 Q6PJS9 Q8IZJ2 Q9BTQ2

Alternative splicing: 2 isoforms: Q9Y4D7-1 Q9Y4D7-2

Explore the universe of human proteins at neXtProt for PLXND1: NX_Q9Y4D7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y4D7

PLXND1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055918.2

ENSEMBL proteins:

ENSP00000317128 ENSP00000426162 ENSP00000426540 ENSP00000427696 ENSP00000423832

ENSP00000426241 ENSP00000376931

Reactome Protein details: Q9Y4D7
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for PLXND1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PLXND1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	ISS	--
GO:0016021	integral to membrane	--	--

PLXND1 for ontologies About GeneDecksing

PLXND1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PLXND1
	R&D Systems Antibodies for PLXND1 (Plexin D1)
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	GenScript Custom Superior Antibodies Services for PLXND1
	Novus Biologicals PLXND1 Antibodies
	Abcam antibodies for PLXND1
	Uscn Antibodies for PLXND1
	ThermoFisher Antibodies for PLXND1

Assay Products for PLXND1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PLXND1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PLXND1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLXND1 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR014756 Ig_E-set

IPR002165 Plexin_repeat

IPR002909 IPT_TIG_rcpt

IPR008936 Rho_GTPase_activation_prot

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q9Y4D7

ProtoNet protein and cluster: Q9Y4D7

1 Blocks protein family: IPB013548 Plexin cytoplasmic region

UniProtKB/Swiss-Prot: PLXD1_HUMAN, Q9Y4D7

Similarity: Belongs to the plexin family

Similarity: Contains 3 IPT/TIG domains

Similarity: Contains 1 Sema domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLXD1_HUMAN, Q9Y4D7

Function: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an

important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the

migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the

specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity).

Mediates anti-angiogenic signaling in response to SEMA3E

Genatlas biochemistry entry for PLXND1:

plexin D1,calcium-dependent cell adhesion molecule at the neuronal cell surface,receptor for the semaphorin 7A (SEMA7A)

miRNA Products:		miRTarBase miRNAs that target PLXND1: hsa-mir-155 (MIRT001523)

		OriGene 3'-UTR Clone: PLXND1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLXND1
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PLXND1 (see all 38):
		hsa-miR-142-5p hsa-let-7d hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-let-7g hsa-let-7a hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: PLXND1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLXND1 (see all 6) OriGene siRNA: PLXND1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLXND1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PLXND1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLXND1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLXND1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLXND1 (NM_015103)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXND1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXND1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLXND1
		Search LifeMap BioReagents cell lines for PLXND1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXND1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005515	protein binding	--	--
GO:0017154	semaphorin receptor activity	ISS	--

PLXND1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for PLXND1: Plxnd1^tm1Joe Plxnd1^tm1Ddg
     13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Plxnd1):

behavior/neurological	cardiovascular system	cellular	craniofacial	embryogenesis
growth/size	homeostasis/metabolism	limbs/digits/tail	mortality/aging	muscle
nervous system	skeleton	vision/eye

PLXND1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Other semaphorin interactions

Other semaphorin interactions

1.00

Sema4D in semaphorin signaling

Semaphorin interactions

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for PLXND1

	Developmental Biology
	Semaphorin interactions
	Other semaphorin interactions
	Axon guidance

PLXND1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PLXND1

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for PLXND1 (Q9Y4D7^{2, 3} ENSP00000317128⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEMA3E	O15041²^,³, ENSP00000303212⁴	MINT-4507932 MINT-4507966 I2D: score=1 STRING: ENSP00000303212
SEMA4A	Q9H3S1²^,³, ENSP00000347117⁴	MINT-4507879 MINT-4507918 I2D: score=2 STRING: ENSP00000347117
NRP1	ENSP00000265371⁴	STRING: ENSP00000265371
PIP5K1B	ENSP00000265382⁴	STRING: ENSP00000265382
RRAS	ENSP00000246792⁴	STRING: ENSP00000246792

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	ISS	--
GO:0001569	patterning of blood vessels	IEA	--
GO:0007275	multicellular organismal development	--	--
GO:0007411	axon guidance	TAS	--
GO:0007416	synapse assembly	ISS	--

PLXND1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PLXND1
Search CenterWatch for drugs/clinical trials and news about PLXND1 / PLXD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLXND1 gene:

NM_015103.2

Unigene Cluster for PLXND1:

Plexin D1

Hs.301685 [show with all ESTs]

Unigene Representative Sequence: AY116661

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000324093(uc003emx.2) ENST00000501038 ENST00000504689 ENST00000504524(uc003emw.2)

ENST00000512744 ENST00000506979 ENST00000508630 ENST00000512807 ENST00000504979

ENST00000503166 ENST00000514990 ENST00000504767 ENST00000511018 ENST00000515191

ENST00000505505 ENST00000505665 ENST00000505237 ENST00000393239(uc011blb.1)

miRNA Products:		OriGene 3'-UTR Clone: PLXND1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLXND1
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PLXND1 (see all 38):
		hsa-miR-142-5p hsa-let-7d hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-let-7g hsa-let-7a hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: PLXND1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLXND1 (see all 6) OriGene siRNA: PLXND1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLXND1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLXND1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLXND1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLXND1 (NM_015103)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXND1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXND1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLXND1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PLXND1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLXND1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXND1

Additional cDNA sequence:

AB014520.2 AK026388.1 AK299425.1 AL832710.1 AY116661.1 BC003526.1 BC011848.2 BC030110.1

BC044228.1 BC062465.1 BC150280.1

15 DOTS entries:

DT.314549 DT.100700289 DT.100825491 DT.92442433 DT.40213494 DT.95262148 DT.92442435 DT.92442429

DT.99994084 DT.91805780 DT.97843196 DT.100766398 DT.95136034 DT.97818240 DT.100729002

24/280 AceView cDNA sequences (see all 280):

BC044228 BE313727 BI493374 BQ948510 CA435955 BF339693 AA350487 BP432127

AI139124 AI206874 BC062465 AW079275 BM998608 AI804070 BC011848 BQ000625

BI822442 AW471163 BM549021 AA299684 AI870925 T08830 AW341385 AI862799

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for PLXND1 (see all 21) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d	^	13a	·	13b	^	14a	·	14b	·
SP1:
SP2:
SP3:																													-		-		-		-		-		-										-
SP4:																																					-												-
SP5:

ExUns:	14c	^	15a	·	15b	^	16	^	17	^	18a	·	18b	·	18c	^	19a	·	19b	^	20	^	21	^	22a	·	22b	^	23a	·	23b	·	23c	·	23d	^	24	^	25a	·	25b	^	26	^	27	^	28	^	29a	·	29b	^
SP1:																													-																				-
SP2:																																																	-
SP3:
SP4:
SP5:

ExUns:	30	^	31a	·	31b	^	32a	·	32b	^	33	^	34a	·	34b	^	35a	·	35b	·	35c
SP1:					-		-						-
SP2:							-						-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PLXND1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLXND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGCTGGAG

About this image

PLXND1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Endothelium

Arteries

Endothelial tip cells

Endothelium

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLXND1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLXND1

SOURCE GeneReport for Unigene cluster: Hs.301685

UniProtKB/Swiss-Prot: PLXD1_HUMAN, Q9Y4D7

Tissue specificity: Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver.

Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes

SABiosciences Custom PCR Arrays for PLXND1

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLXND1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXND1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXND1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PLXND1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLXND1¹	plexin D1	74.78(n) 75.4(a)		416124 XM_414455.3 XP_414455.3
lizard (Anolis carolinensis)	Reptilia	PLXND1⁶	--	75(a)	1 ↔ 1	GL343273.1(463043-593178)
zebrafish (Danio rerio)	Actinopterygii	CABZ01104251.1⁶ si:dkey-183c2.5⁶ (see all 6)	si:dkey-183c2.5 (see all 6)	90(a) 19(a) (see all 6)	1 ↔ 1 possible ortholog (see all 6)	Zv9_NA979(21-854) 4(13547227-13689873)
fruit fly (Drosophila melanogaster)	Insecta	plexB⁶	plexin B	25(a)	1 → many	4(53104-64404)
worm (Caenorhabditis elegans)	Secernentea	plx-1⁶ plx-2⁶	Plexin-2	25(a) 21(a)	possible ortholog 1 ↔ many	IV(959452-984392) II(14417812-14424815)

ENSEMBL Gene Tree for PLXND1 (if available)
TreeFam Gene Tree for PLXND1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PLXND1 gene

PLXNB2² PLXNA3² PLXNA1² PLXNA2² PLXNB1² PLXNC1² PLXNB3² PLXNA4²

11 SIMAP similar genes for PLXND1 using alignment to 7 protein entries: PLXD1_HUMAN (see all proteins):

DKFZp761P19121 PLXNC1 PLXNB2 PLXNB1 PLXNB3 Nbla00445

MM1 PLXNA3 PLXNA4 PLXNA2 PLXNA1

PLXND1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145241198^1,2	C,	--	129288101(+)	`TAAAC-/ATGTGTG`	1	--	int¹		0	--	--	--	--
rs140808581^1,2	C,	--	129294117(+)	`GAAAC-/TATGCAC`	1	--	int¹		0	--	--	--	--
rs10549024^1,2	C	--	129294118(+)	`AAACT-/ATGCACG`	1	--	int¹		1		NA	2
rs11322894^1,2	C,	--	129309151(+)	`CGGGC-/TGTTCC`	1	--	int¹		2		NA CSA	4
rs201760838^1,2	C	--	129309151(-)	`GGAACA/GGCCCG`	1	--	int¹		0	--	--	--	--
rs57098603^1,2	C	--	129314791(+)	`CACACACACA CAC/-TCTTG`	1	--	int¹		1		NA	2
rs187454241^1,2		--	129325640(+)	`CCGGGC/TCAGCC`	1	--	us2k¹		0	--	--	--	--
rs33919854^1,2	--	--	129309862(+)	`CACAGAA/-GCTCA`	1	--	int¹		1		CSA	2
rs112828037^1,2	--	--	129325456(+)	`AGGGGC/TGCGCC`	2	A	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLXND1 (129274018 - 129325661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PLXND1
1 CNV: 63585
Human Gene Mutation Database (HGMD): PLXND1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PLXND1 for disorders           About GeneDecksing

OMIM gene information: 604282    OMIM disorders: --

6 diseases for PLXND1:    About MalaCards

mobius syndrome endometrioid ovary carcinoma dermatomyositis carcinoma

neuronitis ischemic retinopathy

1 disease from the University of Copenhagen DISEASES database for PLXND1:

Endometrioid ovary carcinoma

1 Novoseek disease relationship for PLXND1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mobius syndrome	81.8	1	15301830 (1)

Human Genome Epidemiology (HuGE) Navigator: PLXND1 (1 document)

Export disorders for PLXND1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PLXND1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with PLXND1)

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PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis. (PubMed id 12412018)^{1, 2, 3, 9} van der Zwaag B.... Van Bokhoven H. (2002)
Semaphorin 3E initiates antiangiogenic signaling thro ugh plexin D1 by regulating Arf6 and R-Ras. (PubMed id 20385769)^{1, 2, 9} Sakurai A....Gutkind J.S. (2010)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (1998)
Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies. (PubMed id 19703316)^{1, 9} Roodink I....Leenders W.P. (2009)
Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression. (PubMed id 18974298)^{1, 9} Roodink I....Leenders W. (2008)
Sequence analysis of the PLEXIN-D1 gene in Mobius syndrome patients. (PubMed id 15301830)^{1, 9} van der Zwaag B....Padberg G.W. (2004)
Plexin D1: new potential biomarker for cervical cancer . (PubMed id 22738647)¹ Shalaby M.A....Hampson I. (2012)
Phosphatidylinositol-4-phosphate 5-kinase and GEP100/ Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 throu gh Arf6 protein. (PubMed id 21795701)¹ Sakurai A....Gutkind J.S. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23129	HGNC: 9107	AceView: PLXND1	Ensembl:ENSG00000004399	euGenes: HUgn23129
ECgene: PLXND1	H-InvDB: PLXND1

(According to HUGE)
About This Section

HUGE: KIAA0620

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PLXND1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PLXND1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLXND1 gene:
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GeneCards and IP:
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