External Ids for PLXND1 Gene
Previous GeneCards Identifiers for PLXND1 Gene
GeneCards Summary for PLXND1 Gene
PLXND1 (Plexin D1) is a Protein Coding gene. Diseases associated with PLXND1 include truncus arteriosus and ischemic retinopathy. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNB2.
UniProtKB/Swiss-Prot for PLXND1 Gene
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.