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Aliases for PLXND1 Gene

Aliases for PLXND1 Gene

  • Plexin D1 2 3
  • Plexin-D1 3
  • KIAA0620 4
  • PLEXD1 3

External Ids for PLXND1 Gene

Previous GeneCards Identifiers for PLXND1 Gene

  • GC03U990121
  • GC03M129910
  • GC03M130555
  • GC03M130594
  • GC03M130756
  • GC03M129274
  • GC03M126657

Summaries for PLXND1 Gene

GeneCards Summary for PLXND1 Gene

PLXND1 (Plexin D1) is a Protein Coding gene. Diseases associated with PLXND1 include truncus arteriosus and ischemic retinopathy. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXND1 Gene

  • Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.

Gene Wiki entry for PLXND1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXND1 Gene

Genomics for PLXND1 Gene

Regulatory Elements for PLXND1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLXND1 Gene

Start:
129,555,175 bp from pter
End:
129,606,818 bp from pter
Size:
51,644 bases
Orientation:
Minus strand

Genomic View for PLXND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLXND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXND1 Gene

Proteins for PLXND1 Gene

  • Protein details for PLXND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4D7-PLXD1_HUMAN
    Recommended name:
    Plexin-D1
    Protein Accession:
    Q9Y4D7
    Secondary Accessions:
    • A7E2C6
    • C9JPZ6
    • Q6PJS9
    • Q8IZJ2
    • Q9BTQ2

    Protein attributes for PLXND1 Gene

    Size:
    1925 amino acids
    Molecular mass:
    212007 Da
    Quaternary structure:
    • Interacts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E.
    SequenceCaution:
    • Sequence=BAA31595.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLXND1 Gene

    Alternative splice isoforms for PLXND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLXND1 Gene

Proteomics data for PLXND1 Gene at MOPED

Post-translational modifications for PLXND1 Gene

  • Glycosylation at Asn86, Asn155, Asn188, Asn224, Asn481, Asn500, Asn583, Asn696, Asn736, Asn802, Asn965, Asn1017, Asn1060, Asn1099, Asn1118, Asn1132, Asn1237, and Asn1257
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXND1 Gene

Antibody Products

No data available for DME Specific Peptides for PLXND1 Gene

Domains for PLXND1 Gene

Gene Families for PLXND1 Gene

HGNC:

Suggested Antigen Peptide Sequences for PLXND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4D7

UniProtKB/Swiss-Prot:

PLXD1_HUMAN :
  • Q9Y4D7
Domain:
  • Contains 3 IPT/TIG domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXND1: view

Function for PLXND1 Gene

Molecular function for PLXND1 Gene

GENATLAS Biochemistry:
plexin D1,calcium-dependent cell adhesion molecule at the neuronal cell surface,receptor for the semaphorin 7A (SEMA7A)
UniProtKB/Swiss-Prot Function:
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.

Gene Ontology (GO) - Molecular Function for PLXND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity --
GO:0005515 protein binding IPI 17318185
GO:0017154 semaphorin receptor activity ISS --
GO:0019904 protein domain specific binding IPI 24841563
genes like me logo Genes that share ontologies with PLXND1: view
genes like me logo Genes that share phenotypes with PLXND1: view

Animal Models for PLXND1 Gene

MGI Knock Outs for PLXND1:

Animal Model Products

miRNA for PLXND1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLXND1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLXND1 Gene

Localization for PLXND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXND1 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXND1 Gene COMPARTMENTS Subcellular localization image for PLXND1 gene
Compartment Confidence
plasma membrane 5
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane --
GO:0030027 lamellipodium IDA 24841563
genes like me logo Genes that share ontologies with PLXND1: view

Pathways for PLXND1 Gene

genes like me logo Genes that share pathways with PLXND1: view

Pathways by source for PLXND1 Gene

Gene Ontology (GO) - Biological Process for PLXND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001569 patterning of blood vessels IEA --
GO:0003151 outflow tract morphogenesis IEA --
GO:0007165 signal transduction --
GO:0007275 multicellular organismal development --
genes like me logo Genes that share ontologies with PLXND1: view

Transcripts for PLXND1 Gene

Unigene Clusters for PLXND1 Gene

Plexin D1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLXND1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXND1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ·
SP1:
SP2:
SP3: - - - - - - -
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:

ExUns: 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c · 23d ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:

Relevant External Links for PLXND1 Gene

GeneLoc Exon Structure for
PLXND1
ECgene alternative splicing isoforms for
PLXND1

Expression for PLXND1 Gene

mRNA expression in normal human tissues for PLXND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PLXND1 Gene

This gene is overexpressed in Serum (23.4), Breast (13.4), Stomach (12.8), and Heart (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLXND1 Gene

SOURCE GeneReport for Unigene cluster for PLXND1 Gene Hs.301685

mRNA Expression by UniProt/SwissProt for PLXND1 Gene

Q9Y4D7-PLXD1_HUMAN
Tissue specificity: Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.
genes like me logo Genes that share expressions with PLXND1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for PLXND1 Gene

Orthologs for PLXND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXND1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLXND1 35
  • 90.23 (n)
  • 93.32 (a)
PLXND1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXND1 35
  • 90.99 (n)
  • 94.29 (a)
PLXND1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxnd1 35
  • 87.19 (n)
  • 92.16 (a)
Plxnd1 16
Plxnd1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxnd1 35
  • 86.48 (n)
  • 91.84 (a)
oppossum
(Monodelphis domestica)
Mammalia PLXND1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PLXND1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLXND1 35
  • 74.86 (n)
  • 75.81 (a)
PLXND1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXND1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxnd1 35
  • 65.47 (n)
  • 65.27 (a)
zebrafish
(Danio rerio)
Actinopterygii plxnd1 35
  • 66.23 (n)
  • 60.81 (a)
PLXND1 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta plexB 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea plx-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for PLXND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXND1 Gene

ENSEMBL:
Gene Tree for PLXND1 (if available)
TreeFam:
Gene Tree for PLXND1 (if available)

Paralogs for PLXND1 Gene

Paralogs for PLXND1 Gene

genes like me logo Genes that share paralogs with PLXND1: view

Variants for PLXND1 Gene

Sequence variations from dbSNP and Humsavar for PLXND1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2824 -- 129,555,613(-) GCACC(A/G)AGGCT utr-variant-3-prime
rs746210 -- 129,575,725(+) TTAAC(A/G)CAGGC intron-variant
rs1010885 -- 129,579,263(-) AGCCC(A/T)GTCCT intron-variant
rs1052883 -- 129,555,812(-) CACCC(A/G)TAGAG utr-variant-3-prime
rs1052910 -- 129,555,520(-) CGTAT(C/T)ATGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PLXND1 Gene

Variant ID Type Subtype PubMed ID
dgv5254n71 CNV Loss 21882294
dgv5255n71 CNV Loss 21882294
nsv522149 CNV Loss 19592680
nsv508953 CNV Insertion 20534489
nsv520828 CNV Loss 19592680
nsv877482 CNV Gain 21882294
nsv519392 CNV Gain 19592680
esv27314 CNV Loss 19812545

Relevant External Links for PLXND1 Gene

HapMap Linkage Disequilibrium report
PLXND1
Human Gene Mutation Database (HGMD)
PLXND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXND1 Gene

Disorders for PLXND1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PLXND1 Gene in MalaCards »

(2) Diseases for PLXND1 Gene including...

(1) University of Copenhagen DISEASES for PLXND1 Gene

(1) Novoseek inferred disease relationships for PLXND1 Gene

Disease -log(P) Hits PubMed IDs
mobius syndrome 81.8 1

Relevant External Links for PLXND1

Human Genome Epidemiology (HuGE) Navigator
PLXND1
genes like me logo Genes that share disorders with PLXND1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PLXND1 Gene

Publications for PLXND1 Gene

  1. PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis. (PMID: 12412018) van der Zwaag B. … Van Bokhoven H. (Dev. Dyn. 2002) 2 3 4 23
  2. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. (PMID: 20385769) Sakurai A. … Gutkind J.S. (Mol. Cell. Biol. 2010) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Sequence analysis of the PLEXIN-D1 gene in MAPbius syndrome patients. (PMID: 15301830) van der Zwaag B. … Padberg G.W. (Pediatr. Neurol. 2004) 3 23

Products for PLXND1 Gene

Sources for PLXND1 Gene

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