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Aliases for PLXNC1 Gene

Aliases for PLXNC1 Gene

  • Plexin C1 2 3 5
  • Virus-Encoded Semaphorin Protein Receptor 3 4
  • VESPR 3 4
  • Receptor For Virally-Encoded Semaphorin 3
  • Receptor For Viral Semaphorin Protein 3
  • Plexin (Semaphorin Receptor) 3
  • CD232 Antigen 4
  • PLXN-C1 3
  • CD232 3

External Ids for PLXNC1 Gene

Previous GeneCards Identifiers for PLXNC1 Gene

  • GC12P094074
  • GC12P095063
  • GC12P094475
  • GC12P093044
  • GC12P093066
  • GC12P094542
  • GC12P091610

Summaries for PLXNC1 Gene

Entrez Gene Summary for PLXNC1 Gene

  • This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLXNC1 Gene

PLXNC1 (Plexin C1) is a Protein Coding gene. Diseases associated with PLXNC1 include polycystic kidney and hepatic disease. Among its related pathways are Developmental Biology and Axon guidance. GO annotations related to this gene include receptor binding and receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNC1 Gene

  • Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNC1 Gene

Genomics for PLXNC1 Gene

Regulatory Elements for PLXNC1 Gene

Promoters for PLXNC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLXNC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLXNC1 Gene

Chromosome:
12
Start:
94,148,723 bp from pter
End:
94,307,675 bp from pter
Size:
158,953 bases
Orientation:
Plus strand

Genomic View for PLXNC1 Gene

Genes around PLXNC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNC1 Gene

Proteins for PLXNC1 Gene

  • Protein details for PLXNC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60486-PLXC1_HUMAN
    Recommended name:
    Plexin-C1
    Protein Accession:
    O60486
    Secondary Accessions:
    • Q59H25

    Protein attributes for PLXNC1 Gene

    Size:
    1568 amino acids
    Molecular mass:
    175742 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with SEMA7A.

    Three dimensional structures from OCA and Proteopedia for PLXNC1 Gene

neXtProt entry for PLXNC1 Gene

Proteomics data for PLXNC1 Gene at MOPED

Post-translational modifications for PLXNC1 Gene

  • N-glycosylated.
  • Glycosylation at Asn 86, Asn 141, Asn 149, Asn 241, Asn 252, Asn 386, Asn 407, Asn 548, Asn 582, Asn 653, Asn 686, Asn 692, Asn 771, Asn 796, Asn 821, Asn 871, and Asn 890
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNC1 Gene

Antibody Products

No data available for DME Specific Peptides for PLXNC1 Gene

Domains & Families for PLXNC1 Gene

Gene Families for PLXNC1 Gene

Suggested Antigen Peptide Sequences for PLXNC1 Gene

Graphical View of Domain Structure for InterPro Entry

O60486

UniProtKB/Swiss-Prot:

PLXC1_HUMAN :
  • Contains 1 Sema domain.
  • Belongs to the plexin family.
Domain:
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNC1: view

Function for PLXNC1 Gene

Molecular function for PLXNC1 Gene

GENATLAS Biochemistry:
plexin C1,calcium-dependent cell adhesion molecule at the neuronal cell surface,receptor for the semaphorin 7A (SEMA7A)
UniProtKB/Swiss-Prot Function:
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).

Gene Ontology (GO) - Molecular Function for PLXNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9586637
genes like me logo Genes that share ontologies with PLXNC1: view
genes like me logo Genes that share phenotypes with PLXNC1: view

Animal Models for PLXNC1 Gene

MGI Knock Outs for PLXNC1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNC1 Gene

Localization for PLXNC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNC1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNC1 Gene COMPARTMENTS Subcellular localization image for PLXNC1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with PLXNC1: view

Pathways & Interactions for PLXNC1 Gene

genes like me logo Genes that share pathways with PLXNC1: view

Pathways by source for PLXNC1 Gene

1 KEGG pathway for PLXNC1 Gene

Interacting Proteins for PLXNC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258526%0d%0a9606.ENSP00000261918%0d%0a
Selected Interacting proteins: O60486-PLXC1_HUMAN ENSP00000258526 for PLXNC1 Gene via UniProtKB STRING I2D

SIGNOR curated interactions for PLXNC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLXNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007411 axon guidance TAS --
GO:0048841 regulation of axon extension involved in axon guidance IBA --
genes like me logo Genes that share ontologies with PLXNC1: view

Drugs & Compounds for PLXNC1 Gene

(4) Drugs for PLXNC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PLXNC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLXNC1: view

Transcripts for PLXNC1 Gene

Unigene Clusters for PLXNC1 Gene

Plexin C1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNC1 Gene

No ASD Table

Relevant External Links for PLXNC1 Gene

GeneLoc Exon Structure for
PLXNC1
ECgene alternative splicing isoforms for
PLXNC1

Expression for PLXNC1 Gene

mRNA expression in normal human tissues for PLXNC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLXNC1 Gene

This gene is overexpressed in Whole Blood (x17.8).

Protein differential expression in normal tissues from HIPED for PLXNC1 Gene

This gene is overexpressed in Fetal Brain (20.6) and Neutrophil (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PLXNC1 Gene



SOURCE GeneReport for Unigene cluster for PLXNC1 Gene Hs.584845

mRNA Expression by UniProt/SwissProt for PLXNC1 Gene

O60486-PLXC1_HUMAN
Tissue specificity: Detected in heart, brain, lung, spleen and placenta.
genes like me logo Genes that share expression patterns with PLXNC1: view

Protein tissue co-expression partners for PLXNC1 Gene

Primer Products

In Situ Assay Products

Orthologs for PLXNC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLXNC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLXNC1 35
  • 90.11 (n)
  • 88.77 (a)
PLXNC1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNC1 35
  • 91.23 (n)
  • 91.21 (a)
PLXNC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxnc1 35
  • 87.73 (n)
  • 90.68 (a)
Plxnc1 16
Plxnc1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLXNC1 35
  • 99.66 (n)
  • 99.81 (a)
PLXNC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxnc1 35
  • 86.64 (n)
  • 89.22 (a)
oppossum
(Monodelphis domestica)
Mammalia PLXNC1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLXNC1 35
  • 66.81 (n)
  • 60.99 (a)
PLXNC1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNC1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxnc1 35
  • 53.75 (n)
  • 45.88 (a)
Str.17344 35
zebrafish
(Danio rerio)
Actinopterygii plxnc1 35
  • 52.29 (n)
  • 43.55 (a)
plxnc1 36
  • 40 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9975 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10318 35
Species with no ortholog for PLXNC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLXNC1 Gene

ENSEMBL:
Gene Tree for PLXNC1 (if available)
TreeFam:
Gene Tree for PLXNC1 (if available)

Paralogs for PLXNC1 Gene

Paralogs for PLXNC1 Gene

genes like me logo Genes that share paralogs with PLXNC1: view

Variants for PLXNC1 Gene

Sequence variations from dbSNP and Humsavar for PLXNC1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_050602 -
rs703682 -- 94,246,596(-) TACTC(A/G)TGACA intron-variant
rs832515 -- 94,257,633(-) accat(C/G)cctgg intron-variant
rs832516 -- 94,247,112(-) TAACA(C/T)AGTGA intron-variant
rs832517 -- 94,246,411(+) GTATC(A/G)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNC1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv9000 CNV Gain 18304495
nsv519828 CNV Loss 19592680
esv29104 CNV Loss 19812545
esv2663356 CNV Deletion 23128226
nsv437769 CNV Loss 16327808
esv2746225 CNV Deletion 23290073
nsv53225 CNV Loss 16902084
nsv832489 CNV Loss 17160897
nsv828 CNV Insertion 18451855
nsv520739 CNV Loss 19592680
esv4528 CNV Deletion 18987735
esv2746226 CNV Deletion 23290073

Variation tolerance for PLXNC1 Gene

Residual Variation Intolerance Score: 2.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.63; 86.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXNC1 Gene

HapMap Linkage Disequilibrium report
PLXNC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNC1 Gene

Disorders for PLXNC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLXNC1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
polycystic kidney and hepatic disease
  • polycystic kidney and hepatic disease 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLXNC1

Genetic Association Database (GAD)
PLXNC1
Human Genome Epidemiology (HuGE) Navigator
PLXNC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNC1
genes like me logo Genes that share disorders with PLXNC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXNC1 Gene

Publications for PLXNC1 Gene

  1. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. (PMID: 9586637) Comeau M.R. … Spriggs M.K. (Immunity 1998) 3 4 23 67
  2. Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression. (PMID: 18987670) Scott G.A. … Fender A. (J. Invest. Dermatol. 2009) 3 23
  3. The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis. (PMID: 19318806) Lazova R. … Scott G. (Am J Dermatopathol 2009) 3 23
  4. Molecular profiling of the "plexinome" in melanoma and pancreatic cancer. (PMID: 19462467) Balakrishnan A. … Tamagnone L. (Hum. Mutat. 2009) 3 23
  5. Mechanical tension alters semaphorin expression in the periodontium. (PMID: 19792857) Spencer A.Y. … Lallier T.E. (J. Periodontol. 2009) 3 23

Products for PLXNC1 Gene

Sources for PLXNC1 Gene

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