PLXNC1 Gene

Aliases
for PLXNC1 gene

Previous GC identifers: GC12P094074 GC12P095063 GC12P094475 GC12P093044 GC12P093066 GC12P091610

Summaries
for PLXNC1 gene

Genomic Views
for PLXNC1 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_029419.12  

SwitchGear Promoter luciferase reporter plasmid: PLXNC1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLXNC1

PLXNC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P094542:  view genomic region     (about GC identifiers)

Proteins
for PLXNC1 gene

3 PDB 3D structures from and Proteopedia for PLXNC1:

3KUZ (3D)        3NVN (3D)        3NVQ (3D)    

Explore the universe of human proteins at neXtProt for PLXNC1: NX_O60486

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for PLXNC1 (Plexin C1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PLXNC1 OriGene Protein Over-expression Lysate: PLXNC1 OriGene Custom Protein Services for PLXNC1
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	Novus Biologicals PLXNC1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PLXNC1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PLXNC1 (Plexin C1)
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	Novus Biologicals PLXNC1 Antibodies
	Search for Antibodies for PLXNC1 at Abcam
	Uscn Antibodies for PLXNC1
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	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for PLXNC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PLXNC1

Protein Domains /
Families
for PLXNC1 gene

ProtoNet protein and cluster: O60486

Function
for PLXNC1 gene

miRNA Products:		OriGene 3'-UTR Clone: PLXNC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLXNC1
		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate PLXNC1 (see all 45):
		hsa-miR-193a-3p hsa-miR-3607-3p hsa-let-7d hsa-miR-219-5p hsa-miR-30d hsa-miR-507 hsa-miR-218 hsa-let-7g
		SwitchGear 3'UTR luciferase reporter plasmid: PLXNC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLXNC1 (see all 7) OriGene shRNA RFP: PLXNC1 OriGene siRNA: PLXNC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLXNC1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PLXNC1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNC1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNC1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLXNC1 (NM_005761)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLXNC1
		Search LifeMap BioReagents cell lines for PLXNC1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNC1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Plxnc1)

Pathways & Interactions
for PLXNC1 gene

	Super-pathway	contained gene-specific pathways
1	Axon guidance	Axon guidance 1.00 Developmental Biology 0.69
2	Other semaphorin interactions	Other semaphorin interactions 1.00
3	Axon guidance	Axon guidance 1.00
4	Sema4D in semaphorin signaling	Semaphorin interactions 0.44

4        Reactome Pathways for PLXNC1

	Developmental Biology
	Semaphorin interactions
	Other semaphorin interactions
	Axon guidance

1         Kegg Pathway  (Kegg details for PLXNC1)

Axon guidance

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for PLXNC1 gene

Transcripts
for PLXNC1 gene

Expression
for PLXNC1 gene

PLXNC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCCTGTGT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainHypothalamus			Brain
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Sclerotome cells (Primary Cell)			Bone, Cartilage, Somite

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLXNC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLXNC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLXNC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXNC1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNC1

Orthologs
for PLXNC1 gene

Paralogs
for PLXNC1 gene

Paralogs for PLXNC1 gene

PLXNB2²  PLXND1²  PLXNA3²  PLXNA1²  PLXNB1²  PLXNA2²  PLXNB3²  PLXNA4²  

17 SIMAP similar genes for PLXNC1 using alignment to 6 protein entries:     PLXC1_HUMAN (see all proteins):

DKFZp761P19121    PLXND1    PLXNB2    PLXNB1    PLXNA3    PLXNA4

Nbla00445    MET    PLXNA1    PLXNA2    MM1    PLXNB3

DKFZp686A04130    DKFZp686D04248    SEMA4A    SEMA4C    SEMA4B

PLXNC1 for paralogs           About GeneDecksing

Genomic Variants
for PLXNC1 gene

10/3038 NCBI SNPs in PLXNC1 are shown (see all 3038)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs558431361,2	C	--	91722107(+)	CACCA-/AAGAGAA	1	--	us2k1		0	--	--	--	--
rs768822621,2		--	91722107(+)	CACCAG/AAGAAC	1	--	us2k1		1		CSA	2
rs1136019161,2	C,	--	91722480(+)	AGCCCT/CAAGGA	1	--	us2k1		2		CSA WA	120
rs759434071,2	C,	--	91722506(+)	TGGCCG/ATTACG	1	--	us2k1		2		CSA WA	120
rs748705641,2	F,	--	91722629(+)	AGATTT/CCAGCA	1	--	us2k1		4		CSA WA NA	242
rs1127381661,2		--	91722806(+)	GATGCA/GCAACA	1	--	us2k1		2		CSA WA	120
rs1120439271,2		--	91722823(+)	TTTTTA/TATTTC	1	--	us2k1		2		CSA WA	120
rs733685541,2	C,	--	91722856(+)	AAGGCC/AATACC	1	--	us2k1		1		WA	2
rs1138558271,2	C,	--	91723459(+)	CAAGAC/TTTCAC	1	--	us2k1		2		CSA WA	120
rs1123644131,2		--	91723567(+)	CTTTCG/AGTGGA	1	--	nc-transcript-variant		1		CSA	2

HapMap Linkage Disequilibrium report for PLXNC1 (94542499 - 94701451 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PLXNC1
     3 CNVs: 49156 49155 66305
     3 Indels: 42517 11638 10698

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLXNC1

DNA2.0 Custom Variant and Variant Library Synthesis for PLXNC1

Disorders / Diseases
for PLXNC1 gene

20/23 diseases for PLXNC1

6 Novoseek disease relationships for PLXNC1 gene    About this table

Publications
for PLXNC1 gene

PubMed articles for PLXNC1 gene, integrated from 9 sources (see all 131): (articles sorted by number of sources associating them with PLXNC1)

Utopia: connect your pdf to the dynamic world of online information

1. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. (PubMed id 9586637)^{1, 2, 9} Comeau M.R.... Spriggs M.K. (1998)
2. Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. (PubMed id 20727575)^{1, 2} Liu H....He X. (2010)
3. Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression. (PubMed id 18987670)^{1, 9} Scott G.A....Fender A. (2009)
4. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PubMed id 10520995)^{1, 9} Tamagnone L.... Comoglio P.M. (1999)
5. The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis. (PubMed id 19318806)^{1, 9} Lazova R....Scott G. (2009)
6. Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively. (PubMed id 15746246)^{1, 9} Chabbert-de Ponnat I....Boumsell L. (2005)
7. Molecular profiling of the 'plexinome' in m elanoma and pancreatic cancer. (PubMed id 19462467)^{1, 9} Balakrishnan A....Tamagnone L. (2009)
8. Mechanical tension alters semaphorin expression in th e periodontium. (PubMed id 19792857)^{1, 9} Spencer A.Y. and Lallier T.E. (2009)
9. Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. (PubMed id 17671519)^{1, 9} Scott G.A....Fricke A.F. (2008)
10. Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs). (PubMed id 21610070)¹ Wang H....Park H.W. (2011)

External Searches for PLXNC1 gene

Genome Databases showing PLXNC1 gene

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Products
for PLXNC1 gene