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Aliases for PLXNC1 Gene

Aliases for PLXNC1 Gene

  • Plexin C1 2 3
  • VESPR 3 4 6
  • Virus-Encoded Semaphorin Protein Receptor 3 4
  • Receptor For Virally-Encoded Semaphorin 3
  • Receptor For Viral Semaphorin Protein 3
  • Plexin (Semaphorin Receptor) 3
  • CD232 Antigen 4
  • Plexin-C1 3
  • PLXN-C1 3
  • CD232 3

External Ids for PLXNC1 Gene

Previous GeneCards Identifiers for PLXNC1 Gene

  • GC12P094074
  • GC12P095063
  • GC12P094475
  • GC12P093044
  • GC12P093066
  • GC12P094542
  • GC12P091610

Summaries for PLXNC1 Gene

Entrez Gene Summary for PLXNC1 Gene

  • This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLXNC1 Gene

PLXNC1 (Plexin C1) is a Protein Coding gene. Diseases associated with PLXNC1 include polycystic kidney and hepatic disease and melanoma. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include receptor binding and receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNC1 Gene

  • Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNC1 Gene

Genomics for PLXNC1 Gene

Regulatory Elements for PLXNC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLXNC1 Gene

Start:
94,148,723 bp from pter
End:
94,307,675 bp from pter
Size:
158,953 bases
Orientation:
Plus strand

Genomic View for PLXNC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLXNC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNC1 Gene

Proteins for PLXNC1 Gene

  • Protein details for PLXNC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60486-PLXC1_HUMAN
    Recommended name:
    Plexin-C1
    Protein Accession:
    O60486
    Secondary Accessions:
    • Q59H25

    Protein attributes for PLXNC1 Gene

    Size:
    1568 amino acids
    Molecular mass:
    175742 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with SEMA7A.

    Three dimensional structures from OCA and Proteopedia for PLXNC1 Gene

neXtProt entry for PLXNC1 Gene

Proteomics data for PLXNC1 Gene at MOPED

Post-translational modifications for PLXNC1 Gene

  • N-glycosylated.
  • Glycosylation at Asn86, Asn141, Asn149, Asn241, Asn252, Asn386, Asn407, Asn548, Asn582, Asn653, Asn686, Asn692, Asn771, Asn796, Asn821, and Asn890
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNC1 Gene

Antibody Products

No data available for DME Specific Peptides for PLXNC1 Gene

Domains for PLXNC1 Gene

Gene Families for PLXNC1 Gene

HGNC:
  • CD :CD molecules
  • PLXN :Plexins

Suggested Antigen Peptide Sequences for PLXNC1 Gene

Graphical View of Domain Structure for InterPro Entry

O60486

UniProtKB/Swiss-Prot:

PLXC1_HUMAN :
  • O60486
Domain:
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNC1: view

Function for PLXNC1 Gene

Molecular function for PLXNC1 Gene

GENATLAS Biochemistry:
plexin C1,calcium-dependent cell adhesion molecule at the neuronal cell surface,receptor for the semaphorin 7A (SEMA7A)
UniProtKB/Swiss-Prot Function:
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).

Gene Ontology (GO) - Molecular Function for PLXNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005102 receptor binding TAS 9586637
GO:0005515 protein binding IPI 20727575
genes like me logo Genes that share ontologies with PLXNC1: view

Phenotypes for PLXNC1 Gene

genes like me logo Genes that share phenotypes with PLXNC1: view

Animal Models for PLXNC1 Gene

MGI Knock Outs for PLXNC1:

Animal Model Products

miRNA for PLXNC1 Gene

miRTarBase miRNAs that target PLXNC1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLXNC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLXNC1 Gene

Localization for PLXNC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNC1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNC1 Gene COMPARTMENTS Subcellular localization image for PLXNC1 gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLXNC1: view

Pathways for PLXNC1 Gene

genes like me logo Genes that share pathways with PLXNC1: view

Pathways by source for PLXNC1 Gene

1 KEGG pathway for PLXNC1 Gene

Interacting Proteins for PLXNC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258526%0d%0a9606.ENSP00000261918%0d%0a
Selected Interacting proteins: ENSP00000258526 O60486-PLXC1_HUMAN for PLXNC1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for PLXNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9586637
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organismal development --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with PLXNC1: view

Compounds for PLXNC1 Gene

(6) Novoseek inferred chemical compound relationships for PLXNC1 Gene

Compound -log(P) Hits PubMed IDs
ctab 52 5
vegf 42.6 6
tyrosine 40.6 11
cysteine 7.52 4
calcium 0 2
genes like me logo Genes that share compounds with PLXNC1: view

Transcripts for PLXNC1 Gene

Unigene Clusters for PLXNC1 Gene

Plexin C1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLXNC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNC1 Gene

No ASD Table

Relevant External Links for PLXNC1 Gene

GeneLoc Exon Structure for
PLXNC1
ECgene alternative splicing isoforms for
PLXNC1

Expression for PLXNC1 Gene

mRNA expression in normal human tissues for PLXNC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLXNC1 Gene

This gene is overexpressed in Whole Blood (17.8).

Protein differential expression in normal tissues for PLXNC1 Gene

This gene is overexpressed in Fetal Brain (20.6) and Neutrophil (13.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PLXNC1 Gene

SOURCE GeneReport for Unigene cluster for PLXNC1 Gene Hs.584845

mRNA Expression by UniProt/SwissProt for PLXNC1 Gene

O60486-PLXC1_HUMAN
Tissue specificity: Detected in heart, brain, lung, spleen and placenta.
genes like me logo Genes that share expressions with PLXNC1: view

Expression partners for PLXNC1 Gene

In Situ Assay Products

Orthologs for PLXNC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLXNC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLXNC1 35
  • 90.11 (n)
  • 88.77 (a)
PLXNC1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNC1 35
  • 91.23 (n)
  • 91.21 (a)
PLXNC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxnc1 35
  • 87.73 (n)
  • 90.68 (a)
Plxnc1 16
Plxnc1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLXNC1 35
  • 99.66 (n)
  • 99.81 (a)
PLXNC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxnc1 35
  • 86.64 (n)
  • 89.22 (a)
oppossum
(Monodelphis domestica)
Mammalia PLXNC1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLXNC1 35
  • 66.81 (n)
  • 60.99 (a)
PLXNC1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNC1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxnc1 35
  • 53.75 (n)
  • 45.88 (a)
Str.17344 35
zebrafish
(Danio rerio)
Actinopterygii plxnc1 35
  • 52.29 (n)
  • 43.55 (a)
plxnc1 36
  • 40 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9975 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10318 35
Species with no ortholog for PLXNC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLXNC1 Gene

ENSEMBL:
Gene Tree for PLXNC1 (if available)
TreeFam:
Gene Tree for PLXNC1 (if available)

Paralogs for PLXNC1 Gene

Paralogs for PLXNC1 Gene

genes like me logo Genes that share paralogs with PLXNC1: view

Variants for PLXNC1 Gene

Sequence variations from dbSNP and Humsavar for PLXNC1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs703682 -- 94,246,596(-) TACTC(A/G)TGACA intron-variant
rs769283 -- 94,186,661(+) ATGCA(A/G)TCACT intron-variant
rs769284 -- 94,186,689(+) AGTCT(C/G)GGGGC intron-variant
rs832512 -- 94,277,193(-) GAGGA(C/T)CCAGC intron-variant
rs832513 -- 94,276,738(-) GAGTG(C/T)CTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNC1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv9000 CNV Gain 18304495
nsv519828 CNV Loss 19592680
esv29104 CNV Loss 19812545
esv2663356 CNV Deletion 23128226
nsv437769 CNV Loss 16327808
esv2746225 CNV Deletion 23290073
nsv53225 CNV Loss 16902084
nsv832489 CNV Loss 17160897
nsv828 CNV Insertion 18451855
nsv520739 CNV Loss 19592680
esv4528 CNV Deletion 18987735
esv2746226 CNV Deletion 23290073

Relevant External Links for PLXNC1 Gene

HapMap Linkage Disequilibrium report
PLXNC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNC1 Gene

Disorders for PLXNC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PLXNC1 Gene in MalaCards »

(2) Diseases for PLXNC1 Gene including...

(6) Novoseek inferred disease relationships for PLXNC1 Gene

Disease -log(P) Hits PubMed IDs
arpkd 48.4 1
cancer 28.1 4
metastasis 26.5 1
tumors 14.6 10
metastatic melanoma 13.4 2

Relevant External Links for PLXNC1

Genetic Association Database (GAD)
PLXNC1
Human Genome Epidemiology (HuGE) Navigator
PLXNC1
genes like me logo Genes that share disorders with PLXNC1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PLXNC1 Gene

Publications for PLXNC1 Gene

  1. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. (PMID: 9586637) Comeau M.R. … Spriggs M.K. (Immunity 1998) 3 4 23
  2. Mechanical tension alters semaphorin expression in the periodontium. (PMID: 19792857) Spencer A.Y. … Lallier T.E. (J. Periodontol. 2009) 3 23
  3. Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression. (PMID: 18987670) Scott G.A. … Fender A. (J. Invest. Dermatol. 2009) 3 23
  4. The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis. (PMID: 19318806) Lazova R. … Scott G. (Am J Dermatopathol 2009) 3 23
  5. Molecular profiling of the "plexinome" in melanoma and pancreatic cancer. (PMID: 19462467) Balakrishnan A. … Tamagnone L. (Hum. Mutat. 2009) 3 23

Products for PLXNC1 Gene

Sources for PLXNC1 Gene

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