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PLXNC1 Gene

protein-coding   GIFtS: 59
GCID: GC12P094542

Plexin C1

  See PLXNC1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plexin C11 2     Plexin (Semaphorin Receptor)2
VESPR2 3 5     plexin-C12
Virus-Encoded Semaphorin Protein Receptor2 3     Receptor For Viral Semaphorin Protein2
CD2322     Receptor For Virally-Encoded Semaphorin2
PLXN-C12     CD232 Antigen3

External Ids:    HGNC: 91061   Entrez Gene: 101542   Ensembl: ENSG000001360407   OMIM: 6042595   UniProtKB: O604863   

Export aliases for PLXNC1 gene to outside databases

Previous GC identifers: GC12P094074 GC12P095063 GC12P094475 GC12P093044 GC12P093066 GC12P091610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLXNC1 Gene:
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large
family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded
protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by
binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively
spliced transcript variants have been observed for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for PLXNC1 Gene:
PLXNC1 (plexin C1) is a protein-coding gene. Diseases associated with PLXNC1 include polycystic kidney and hepatic disease. GO annotations related to this gene include receptor activity and receptor binding. An important paralog of this gene is PLXNA1.

UniProtKB/Swiss-Prot: PLXC1_HUMAN, O60486
Function: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus
Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton
and to secretion of IL6 and IL8 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLXNC1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Spz1   Pax-5   E2F-2   GATA-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLXNC1 promoter sequence
   Search Chromatin IP Primers for PLXNC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLXNC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q23

PLXNC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXNC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P094542:  view genomic region     (about GC identifiers)

Start:
94,542,499 bp from pter      End:
94,701,451 bp from pter
Size:
158,953 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLXC1_HUMAN, O60486 (See protein sequence)
Recommended Name: Plexin-C1 precursor  
Size: 1568 amino acids; 175742 Da
Subunit: Monomer. Homodimer. Interacts with SEMA7A
3 PDB 3D structures from and Proteopedia for PLXNC1:
3KUZ (3D)        3NVN (3D)        3NVQ (3D)    
Secondary accessions: Q59H25

Explore the universe of human proteins at neXtProt for PLXNC1: NX_O60486

Explore proteomics data for PLXNC1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn86, Asn141, Asn149, Asn241, Asn252, Asn386, Asn407, Asn548, Asn582, Asn653,
                                 Asn686, Asn692, Asn771, Asn796, Asn821, Asn890
  • Modification sites at PhosphoSitePlus

  • See PLXNC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005752.1  
    ENSEMBL proteins: 
     ENSP00000258526   ENSP00000447843   ENSP00000446781   ENSP00000447625   ENSP00000446720  
     ENSP00000439225  
    Reactome Protein details: O60486

    PLXNC1 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for PLXNC1
    OriGene MassSpec for PLXNC1
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    Novus Biologicals PLXNC1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLXNC1

     
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    antibodies-online proteins for PLXNC1 (2 products) 

     
    antibodies-online peptides for PLXNC1

    PLXNC1 Antibody Products:

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    Abcam antibodies for PLXNC1
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    antibodies-online antibodies for PLXNC1 (12 products) 

    PLXNC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    antibodies-online kits for PLXNC1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLXN: Plexins
    CD: CD molecules

    Selected InterPro protein domains (see all 8):
     IPR002165 Plexin_repeat
     IPR002909 IPT
     IPR008936 Rho_GTPase_activation_prot
     IPR013783 Ig-like_fold
     IPR001627 Semap_dom

    Graphical View of Domain Structure for InterPro Entry O60486

    ProtoNet protein and cluster: O60486

    UniProtKB/Swiss-Prot: PLXC1_HUMAN, O60486
    Similarity: Belongs to the plexin family
    Similarity: Contains 1 Sema domain


    Find genes that share domains with PLXNC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLXC1_HUMAN, O60486
    Function: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus
    Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton
    and to secretion of IL6 and IL8 (By similarity)

         Genatlas biochemistry entry for PLXNC1:
    plexin C1,calcium-dependent cell adhesion molecule at the neuronal cell surface,receptor for the semaphorin 7A
    (SEMA7A)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005102receptor binding TAS9586637
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with PLXNC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PLXNC1:
     Increased Salmonella enterica  

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plxnc1):
     cellular  nervous system  normal  vision/eye 

    Find genes that share phenotypes with PLXNC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plxnc1tm1Alk for PLXNC1

       genOway: Develop your customized and physiologically relevant rodent model for PLXNC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLXNC1:
    hsa-mir-335-5p (MIRT017321), hsa-mir-193b-3p (MIRT016344), hsa-mir-26b-5p (MIRT029051)

    Block miRNA regulation of human, mouse, rat PLXNC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLXNC1 (see all 45):
    hsa-miR-193a-3p hsa-miR-3607-3p hsa-let-7d hsa-miR-219-5p hsa-miR-30d hsa-miR-507 hsa-miR-218 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidPLXNC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLXNC1
    Predesigned siRNA for gene silencing in human, mouse, rat PLXNC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLXNC1

    Clone
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    OriGene clones in human, mouse for PLXNC1 (see all 6)
    OriGene ORF clones in mouse, rat for PLXNC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLXNC1 (NM_005761)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNC1
    Addgene plasmids for PLXNC1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PLXNC1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLXC1_HUMAN, O60486: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PLXNC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLXNC1 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Semaphorin interactions
    Semaphorin interactions0.43
    Other semaphorin interactions0.00
    3Axon guidance
    Axon guidance


    Find genes that share SuperPaths with PLXNC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PLXNC1
        Other semaphorin interactions


    1 Kegg Pathway  (Kegg details for PLXNC1):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLXNC1
    Interactions:

        Search GeneGlobe Interaction Network for PLXNC1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for PLXNC1 (O604861, 3 ENSP000002585264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEMA7AO753261, 3, ENSP000002619184EBI-2927384,EBI-1753538 I2D: score=3 STRING: ENSP00000261918
    EVM139Q8JL801EBI-2927384,EBI-2927425
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9586637
    GO:0007165signal transduction IEA--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with PLXNC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLXNC1 (PLXC1)

    6 Novoseek inferred chemical compound relationships for PLXNC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ctab 52 9 18305261 (2), 16275926 (1), 20148037 (1), 12700098 (1)
    vegf 42.6 7 17222790 (1), 19887479 (1), 18363553 (1), 16424390 (1) (see all 6)
    tyrosine 40.6 11 12198496 (2), 18391791 (2), 10520995 (1), 16055703 (1) (see all 9)
    cysteine 7.52 7 15358240 (1), 14597639 (1), 7605632 (1), 12958590 (1)
    calcium 0 2 7605632 (2)
    arginine 0 1 15488183 (1)



    Find genes that share compounds with PLXNC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLXNC1 gene: 
    NM_005761.2  

    Unigene Cluster for PLXNC1:

    Plexin C1
    Hs.584845  [show with all ESTs]
    Unigene Representative Sequence: NM_005761
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258526(uc001tdc.3 uc010sut.2 uc009zsv.3) ENST00000546733
    ENST00000551850 ENST00000546659 ENST00000549810 ENST00000549217 ENST00000550080
    ENST00000547057 ENST00000551495 ENST00000545312 ENST00000549187
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLXNC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLXNC1 (see all 45):
    hsa-miR-193a-3p hsa-miR-3607-3p hsa-let-7d hsa-miR-219-5p hsa-miR-30d hsa-miR-507 hsa-miR-218 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidPLXNC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLXNC1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLXNC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNC1
    Addgene plasmids for PLXNC1 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLXNC1
      QuantiTect SYBR Green Assays in human, mouse, rat PLXNC1
      QuantiFast Probe-based Assays in human, mouse, rat PLXNC1

    Additional mRNA sequence: 

    AB208934.1 AF030339.1 AF035307.1 AK093735.1 AK124034.1 AK295226.1 AK307920.1 AK308985.1 
    BC029934.1 NR_037687.1 

    9 DOTS entries:

    DT.443808  DT.100019619  DT.405090  DT.95087108  DT.121195352  DT.75154351  DT.121195267  DT.91643805 
    DT.40309667 

    Selected AceView cDNA sequences (see all 131):

    BE220806 NM_005761 AI393889 BM146532 AI762246 AA663440 AA910509 AL708790 
    BC029934 AF030339 CA941979 AA258620 N45078 BF222461 N25656 AI963360 
    H98855 AA702661 AW674021 N26744 H79941 AK124034 AA321183 BX446559 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLXNC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCCTGTGT
    PLXNC1 Expression
    About this image


    PLXNC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
    PLXNC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLXNC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584845

    UniProtKB/Swiss-Prot: PLXC1_HUMAN, O60486
    Tissue specificity: Detected in heart, brain, lung, spleen and placenta

        Custom PCR Arrays for PLXNC1
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    QuantiFast Probe-based Assays in human, mouse, rat PLXNC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PLXNC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plxnc11 , 5 plexin C11, 5 87.73(n)1
    90.68(a)1
      10 (49.09 cM)5
    547121  NM_018797.21  NP_061267.11 
     947908665 
    chicken
    (Gallus gallus)
    Aves PLXNC11 plexin C1 66.81(n)
    60.99(a)
      417901  XM_416143.4  XP_416143.4 
    lizard
    (Anolis carolinensis)
    Reptilia PLXNC16
    plexin C1
    74(a)
    1 ↔ 1
    5(31206237-31255710)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.173442 Transcribed sequence with moderate similarity to protein more 76.12(n)    AL773892.2 
    zebrafish
    (Danio rerio)
    Actinopterygii plxnc11 plexin C1 52.29(n)
    43.55(a)
      562273  XM_005164780.1  XP_005164837.1 


    ENSEMBL Gene Tree for PLXNC1 (if available)
    TreeFam Gene Tree for PLXNC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLXNC1 gene
    PLXNA12  PLXNA22  PLXNB12  PLXNB22  PLXND12  PLXNA32  PLXNB32  PLXNA42  
    17 SIMAP similar genes for PLXNC1 using alignment to 6 protein entries:     PLXC1_HUMAN (see all proteins):
    DKFZp761P19121    PLXND1    PLXNB2    PLXNB1    PLXNA3    PLXNA4
    Nbla00445    MET    PLXNA1    PLXNA2    MM1    PLXNB3
    DKFZp686A04130    DKFZp686D04248    SEMA4A    SEMA4C    SEMA4B

    Find genes that share paralogs with PLXNC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLXNC1 (see all 3608)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383379031,2
    C--91721714(+) TGAGAC/TGCACG 1 -- us2k11Minor allele frequency- T:0.00NA 4550
    rs797942881,2
    C--91721726(+) AGTCCG/ATCGTC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1996596281,2
    --91721730(+) CGTCGC/TCGAAA 1 -- us2k10--------
    rs1492383301,2
    F--91721731(+) GTCGTC/TGAAAA 1 -- us2k11Minor allele frequency- T:0.00NA 4550
    rs1484124071,2
    C--91721759(+) TGTCCG/ATCTGC 1 -- us2k11Minor allele frequency- A:0.00NA 4546
    rs1436488381,2
    C--91721841(+) TTAGCA/GGACTC 1 -- us2k10--------
    rs1441199981,2
    --91721997(+) ATTTCG/TTCAGG 1 -- us2k10--------
    rs1486995961,2
    --91722048(+) CACCCA/TGAGCC 1 -- us2k10--------
    rs111074861,2
    C,F--91722075(+) GAAAAT/CGTACT 1 -- us2k16Minor allele frequency- C:0.24NA WA EA 364
    rs2009779811,2
    --91722104(+) AACAC-/CACAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLXNC1 (94542499 - 94701451 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PLXNC1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663356CNV Deletion23128226
    esv2746225CNV Deletion23290073
    esv2746226CNV Deletion23290073
    esv4528CNV Deletion18987735
    nsv828CNV Insertion18451855
    nsv520739CNV Loss19592680
    nsv832489CNV Loss17160897
    nsv437769CNV Loss16327808
    nsv53225CNV Loss16902084
    nsv519828CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604259    OMIM disorders: --

    1 disease for PLXNC1:    
    About MalaCards
    polycystic kidney and hepatic disease


    Find genes that share disorders with PLXNC1           About GenesLikeMe

    6 Novoseek inferred disease relationships for PLXNC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arpkd 48.4 1 11919560 (1)
    cancer 28.1 4 14500350 (1), 18275816 (1), 19461072 (1), 19462467 (1)
    metastasis 26.5 2 18987670 (1)
    tumors 14.6 12 19318806 (3), 19887479 (2), 18987670 (2), 15949770 (1) (see all 6)
    metastatic melanoma 13.4 5 19318806 (1), 18987670 (1)
    melanoma 0 11 18987670 (4), 19318806 (2)

    Genetic Association Database (GAD): PLXNC1
    Human Genome Epidemiology (HuGE) Navigator: PLXNC1 (2 documents)

    Export disorders for PLXNC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PLXNC1 gene, integrated from 10 sources (see all 135):
    (articles sorted by number of sources associating them with PLXNC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. (PubMed id 9586637)1, 2, 9 Comeau M.R.... Spriggs M.K. (Immunity 1998)
    2. Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. (PubMed id 20727575)1, 2 Liu H.... He X. (Cell 2010)
    3. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)
    4. Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression. (PubMed id 18987670)1, 9 Scott G.A....Fender A. (J. Invest. Dermatol. 2009)
    5. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PubMed id 10520995)1, 9 Tamagnone L.... Comoglio P.M. (Cell 1999)
    6. The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis. (PubMed id 19318806)1, 9 Lazova R....Scott G. (Am J Dermatopathol 2009)
    7. Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively. (PubMed id 15746246)1, 9 Chabbert-de Ponnat I....Boumsell L. (Int. Immunol. 2005)
    8. Molecular profiling of the &quot;plexinome&quot; in melanoma and pancreatic cancer. (PubMed id 19462467)1, 9 Balakrishnan A....Tamagnone L. (Hum. Mutat. 2009)
    9. Mechanical tension alters semaphorin expression in the periodontium. (PubMed id 19792857)1, 9 Spencer A.Y. and Lallier T.E. (J. Periodontol. 2009)
    10. Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. (PubMed id 17671519)1, 9 Scott G.A.... Fricke A.F. (J. Invest. Dermatol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10154 HGNC: 9106 AceView: PLXNC1 Ensembl:ENSG00000136040 euGenes: HUgn10154
    ECgene: PLXNC1 Kegg: 10154 H-InvDB: PLXNC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLXNC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PLXNC1 gene:
    Search GeneIP for patents involving PLXNC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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