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Aliases for PLXNB3 Gene

Aliases for PLXNB3 Gene

  • Plexin B3 2 3 5
  • PLXN6 3 4
  • Plexin 6 3
  • KIAA1206 4
  • PLEXB3 3
  • PLEXR 3

External Ids for PLXNB3 Gene

Previous HGNC Symbols for PLXNB3 Gene

  • PLXN6

Previous GeneCards Identifiers for PLXNB3 Gene

  • GC0XP147167
  • GC0XP149484
  • GC0XP150615
  • GC0XP151497
  • GC0XP152550
  • GC0XP152682
  • GC0XP153029
  • GC0XP141686

Summaries for PLXNB3 Gene

Entrez Gene Summary for PLXNB3 Gene

  • The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for PLXNB3 Gene

PLXNB3 (Plexin B3) is a Protein Coding gene. Diseases associated with PLXNB3 include glioma. Among its related pathways are Axon guidance and Developmental Biology. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNB3 Gene

  • Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.

Gene Wiki entry for PLXNB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNB3 Gene

Genomics for PLXNB3 Gene

Regulatory Elements for PLXNB3 Gene

Enhancers for PLXNB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLXNB3 on UCSC Golden Path with GeneCards custom track

Promoters for PLXNB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLXNB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLXNB3 Gene

Chromosome:
X
Start:
153,764,196 bp from pter
End:
153,779,346 bp from pter
Size:
15,151 bases
Orientation:
Plus strand

Genomic View for PLXNB3 Gene

Genes around PLXNB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNB3 Gene

Proteins for PLXNB3 Gene

  • Protein details for PLXNB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULL4-PLXB3_HUMAN
    Recommended name:
    Plexin-B3
    Protein Accession:
    Q9ULL4
    Secondary Accessions:
    • B7Z3E6
    • F5H773
    • Q9HDA4

    Protein attributes for PLXNB3 Gene

    Size:
    1909 amino acids
    Molecular mass:
    206847 Da
    Quaternary structure:
    • Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain).
    SequenceCaution:
    • Sequence=BAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLXNB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLXNB3 Gene

Proteomics data for PLXNB3 Gene at MOPED

Post-translational modifications for PLXNB3 Gene

  • Glycosylation at Asn 51, Asn 231, Asn 615, Asn 802, Asn 900, Asn 957, Asn 1101, and Asn 1218
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNB3 Gene

Antibody Products

No data available for DME Specific Peptides for PLXNB3 Gene

Domains & Families for PLXNB3 Gene

Gene Families for PLXNB3 Gene

Suggested Antigen Peptide Sequences for PLXNB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULL4

UniProtKB/Swiss-Prot:

PLXB3_HUMAN :
  • Contains 4 IPT/TIG domains.
  • Belongs to the plexin family.
Domain:
  • Contains 4 IPT/TIG domains.
  • Contains 3 PSI domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNB3: view

Function for PLXNB3 Gene

Molecular function for PLXNB3 Gene

GENATLAS Biochemistry:
plexin B3,calcium-dependent cell adhesion molecule at the neuronal cell surface
UniProtKB/Swiss-Prot Function:
Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.

Phenotypes for PLXNB3 Gene

genes like me logo Genes that share phenotypes with PLXNB3: view

Animal Models for PLXNB3 Gene

MGI Knock Outs for PLXNB3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLXNB3

miRNA for PLXNB3 Gene

miRTarBase miRNAs that target PLXNB3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNB3 Gene

Localization for PLXNB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNB3 Gene

Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNB3 Gene COMPARTMENTS Subcellular localization image for PLXNB3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PLXNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLXNB3: view

Pathways & Interactions for PLXNB3 Gene

genes like me logo Genes that share pathways with PLXNB3: view

Pathways by source for PLXNB3 Gene

1 KEGG pathway for PLXNB3 Gene

Gene Ontology (GO) - Biological Process for PLXNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007411 axon guidance TAS --
GO:0008360 regulation of cell shape IBA --
GO:0034260 negative regulation of GTPase activity IMP 20696765
GO:0050772 positive regulation of axonogenesis IBA --
genes like me logo Genes that share ontologies with PLXNB3: view

No data available for SIGNOR curated interactions for PLXNB3 Gene

Drugs & Compounds for PLXNB3 Gene

No Compound Related Data Available

Transcripts for PLXNB3 Gene

Unigene Clusters for PLXNB3 Gene

Plexin B3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -

ExUns: 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c · 29d ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34 ^ 35a · 35b · 35c ·
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: - -
SP13:
SP14: -
SP15:

ExUns: 35d ^ 36 ^ 37 ^ 38a · 38b · 38c
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PLXNB3 Gene

GeneLoc Exon Structure for
PLXNB3
ECgene alternative splicing isoforms for
PLXNB3

Expression for PLXNB3 Gene

mRNA expression in normal human tissues for PLXNB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLXNB3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.8), Monocytes (11.0), Frontal cortex (8.7), and Platelet (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLXNB3 Gene



SOURCE GeneReport for Unigene cluster for PLXNB3 Gene Hs.632833

mRNA Expression by UniProt/SwissProt for PLXNB3 Gene

Q9ULL4-PLXB3_HUMAN
Tissue specificity: Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines.
genes like me logo Genes that share expression patterns with PLXNB3: view

Protein tissue co-expression partners for PLXNB3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PLXNB3 Gene

Orthologs for PLXNB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXNB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLXNB3 35
  • 84.39 (n)
  • 84.08 (a)
PLXNB3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNB3 35
  • 86.5 (n)
  • 86.91 (a)
PLXNB3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxnb3 35
  • 82.55 (n)
  • 84.55 (a)
Plxnb3 16
Plxnb3 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxnb3 35
  • 82.39 (n)
  • 85.08 (a)
oppossum
(Monodelphis domestica)
Mammalia PLXNB3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNB3 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNB3 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxnb3 35
  • 58.41 (n)
  • 55.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5727 35
zebrafish
(Danio rerio)
Actinopterygii plxnb3 35
  • 58.81 (n)
  • 54.51 (a)
plxnb3 36
  • 48 (a)
OneToMany
PLXNB3 (2 of 3) 36
  • 26 (a)
OneToMany
PLXNB3 (3 of 3) 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta plexB 37
  • 40 (a)
plexB 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea plx-2 37
  • 25 (a)
plx-2 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for PLXNB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXNB3 Gene

ENSEMBL:
Gene Tree for PLXNB3 (if available)
TreeFam:
Gene Tree for PLXNB3 (if available)

Paralogs for PLXNB3 Gene

Paralogs for PLXNB3 Gene

genes like me logo Genes that share paralogs with PLXNB3: view

Variants for PLXNB3 Gene

Sequence variations from dbSNP and Humsavar for PLXNB3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2266879 - 153,770,343(+) ACCAC(A/G)TCACT reference, missense
rs5987155 - 153,776,089(+) CGAGA(C/T)GCAGC reference, missense
VAR_050601 -
rs6643791 - 153,774,047(+) CGCGA(C/G)GGGCC reference, missense
rs34762690 - 153,777,232(+) TGGCG(A/C/G)GGAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLXNB3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv2740633 CNV Deletion 23290073

Variation tolerance for PLXNB3 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXNB3 Gene

HapMap Linkage Disequilibrium report
PLXNB3
Human Gene Mutation Database (HGMD)
PLXNB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNB3 Gene

Disorders for PLXNB3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLXNB3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
glioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLXNB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNB3
genes like me logo Genes that share disorders with PLXNB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXNB3 Gene

Publications for PLXNB3 Gene

  1. Plexin-B3 is a functional receptor for semaphorin 5A. (PMID: 15218527) Artigiani S. … Tamagnone L. (EMBO Rep. 2004) 3 4 23 67
  2. Identification of semaphorin 5A interacting protein by applying apriori knowledge and peptide complementarity related to protein evolution and structure. (PMID: 19329067) Sadanandam A. … Singh R.K. (Genomics Proteomics Bioinformatics 2008) 3 23
  3. Plexin B3 is genetically associated with verbal performance and white matter volume in human brain. (PMID: 17033634) Rujescu D. … Finckh U. (Mol. Psychiatry 2007) 3 23
  4. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. (PMID: 16122393) Hartwig C. … Finckh U. (BMC Neurosci. 2005) 3 23
  5. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PMID: 10520995) Tamagnone L. … Comoglio P.M. (Cell 1999) 2 3

Products for PLXNB3 Gene

Sources for PLXNB3 Gene

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