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Aliases for PLXNB3 Gene

Aliases for PLXNB3 Gene

  • Plexin B3 2 3
  • PLXN6 3 4 6
  • Plexin-B3 3
  • Plexin 6 3
  • KIAA1206 4
  • PLEXB3 3
  • PLEXR 3

External Ids for PLXNB3 Gene

Previous HGNC Symbols for PLXNB3 Gene

  • PLXN6

Previous GeneCards Identifiers for PLXNB3 Gene

  • GC0XP147167
  • GC0XP149484
  • GC0XP150615
  • GC0XP151497
  • GC0XP152550
  • GC0XP152682
  • GC0XP153029
  • GC0XP141686

Summaries for PLXNB3 Gene

Entrez Gene Summary for PLXNB3 Gene

  • The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for PLXNB3 Gene

PLXNB3 (Plexin B3) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNB3 Gene

  • Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.

Gene Wiki entry for PLXNB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNB3 Gene

Genomics for PLXNB3 Gene

Regulatory Elements for PLXNB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLXNB3 Gene

Start:
153,764,196 bp from pter
End:
153,779,346 bp from pter
Size:
15,151 bases
Orientation:
Plus strand

Genomic View for PLXNB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLXNB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNB3 Gene

Proteins for PLXNB3 Gene

  • Protein details for PLXNB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULL4-PLXB3_HUMAN
    Recommended name:
    Plexin-B3
    Protein Accession:
    Q9ULL4
    Secondary Accessions:
    • B7Z3E6
    • F5H773
    • Q9HDA4

    Protein attributes for PLXNB3 Gene

    Size:
    1909 amino acids
    Molecular mass:
    206847 Da
    Quaternary structure:
    • Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain).
    SequenceCaution:
    • Sequence=BAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLXNB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLXNB3 Gene

Proteomics data for PLXNB3 Gene at MOPED

Post-translational modifications for PLXNB3 Gene

  • Glycosylation at Asn51, Asn231, Asn615, Asn802, Asn900, Asn957, Asn1101, and Asn1218
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNB3 Gene

No data available for DME Specific Peptides for PLXNB3 Gene

Domains for PLXNB3 Gene

Gene Families for PLXNB3 Gene

HGNC:

Suggested Antigen Peptide Sequences for PLXNB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULL4

UniProtKB/Swiss-Prot:

PLXB3_HUMAN :
  • Q9ULL4
Domain:
  • Contains 4 IPT/TIG domains.
  • Contains 3 PSI domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNB3: view

Function for PLXNB3 Gene

Molecular function for PLXNB3 Gene

GENATLAS Biochemistry: plexin B3,calcium-dependent cell adhesion molecule at the neuronal cell surface
UniProtKB/Swiss-Prot Function: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.

Gene Ontology (GO) - Molecular Function for PLXNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity --
GO:0005515 protein binding IPI 15184888
GO:0017154 semaphorin receptor activity IDA 15218527
GO:0019904 protein domain specific binding IPI 15218527
GO:0051022 Rho GDP-dissociation inhibitor binding IEA --
genes like me logo Genes that share ontologies with PLXNB3: view

Phenotypes for PLXNB3 Gene

MGI mutant phenotypes for PLXNB3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PLXNB3: view

Animal Models for PLXNB3 Gene

MGI Knock Outs for PLXNB3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLXNB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PLXNB3 Gene

Localization for PLXNB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNB3 Gene

Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNB3 Gene COMPARTMENTS Subcellular localization image for PLXNB3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PLXNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLXNB3: view

Pathways for PLXNB3 Gene

genes like me logo Genes that share pathways with PLXNB3: view

Pathways by source for PLXNB3 Gene

1 KEGG pathway for PLXNB3 Gene

Gene Ontology (GO) - Biological Process for PLXNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 19850054
GO:0007162 negative regulation of cell adhesion IDA 15218527
GO:0007165 signal transduction --
GO:0007275 multicellular organismal development --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with PLXNB3: view

Transcripts for PLXNB3 Gene

Unigene Clusters for PLXNB3 Gene

Plexin B3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLXNB3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PLXNB3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -

ExUns: 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c · 29d ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34 ^ 35a · 35b · 35c ·
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: - -
SP13:
SP14: -
SP15:

ExUns: 35d ^ 36 ^ 37 ^ 38a · 38b · 38c
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PLXNB3 Gene

GeneLoc Exon Structure for
PLXNB3
ECgene alternative splicing isoforms for
PLXNB3

Expression for PLXNB3 Gene

mRNA expression in normal human tissues for PLXNB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLXNB3 Gene

SOURCE GeneReport for Unigene cluster for PLXNB3 Gene Hs.632833

mRNA Expression by UniProt/SwissProt for PLXNB3 Gene

Q9ULL4-PLXB3_HUMAN
Tissue specificity: Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines.
genes like me logo Genes that share expressions with PLXNB3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PLXNB3 Gene

Orthologs for PLXNB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXNB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLXNB3 35
  • 84.39 (n)
  • 84.08 (a)
PLXNB3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNB3 35
  • 86.5 (n)
  • 86.91 (a)
PLXNB3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxnb3 35
  • 82.55 (n)
  • 84.55 (a)
Plxnb3 16
Plxnb3 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLXNB3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNB3 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxnb3 35
  • 82.39 (n)
  • 85.08 (a)
lizard
(Anolis carolinensis)
Reptilia PLXNB3 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5727 35
tropical clawed frog
(Silurana tropicalis)
Amphibia plxnb3 35
  • 58.41 (n)
  • 55.25 (a)
zebrafish
(Danio rerio)
Actinopterygii plxnb3 35
  • 58.81 (n)
  • 54.51 (a)
plxnb3 36
  • 48 (a)
OneToMany
PLXNB3 (2 of 3) 36
  • 26 (a)
OneToMany
PLXNB3 (3 of 3) 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta plexB 36
  • 31 (a)
OneToMany
plexB 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea plx-2 36
  • 26 (a)
OneToMany
plx-2 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for PLXNB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXNB3 Gene

ENSEMBL:
Gene Tree for PLXNB3 (if available)
TreeFam:
Gene Tree for PLXNB3 (if available)

Paralogs for PLXNB3 Gene

Paralogs for PLXNB3 Gene

genes like me logo Genes that share paralogs with PLXNB3: view

Variants for PLXNB3 Gene

Sequence variations from dbSNP and Humsavar for PLXNB3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs731416 -- 153,766,384(+) TCACC(C/T)GACTT intron-variant
rs731417 -- 153,766,385(+) CACCT(C/G)ACTTA intron-variant
rs1543781 -- 153,774,160(+) CCAGC(A/G)GCTTA intron-variant
rs1894294 -- 153,776,782(+) AGGCA(A/G)GGCAG intron-variant
rs2071121 -- 153,778,914(+) ACAGG(A/C)ACCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNB3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv2740633 CNV Deletion 23290073

Relevant External Links for PLXNB3 Gene

HapMap Linkage Disequilibrium report
PLXNB3
Human Gene Mutation Database (HGMD)
PLXNB3
Locus Specific Mutation Databases (LSDB)
PLXNB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNB3 Gene

Disorders for PLXNB3 Gene

No disorders were found for PLXNB3 Gene.

No data available for UniProtKB/Swiss-Prot for PLXNB3 Gene

Publications for PLXNB3 Gene

  1. Plexin-B3 is a functional receptor for semaphorin 5A. (PMID: 15218527) Artigiani S. … Tamagnone L. (EMBO Rep. 2004) 3 4 23
  2. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. (PMID: 16122393) Hartwig C. … Finckh U. (BMC Neurosci. 2005) 3 4 23
  3. Plexin B3 is genetically associated with verbal performance and white matter volume in human brain. (PMID: 17033634) Rujescu D. … Finckh U. (Mol. Psychiatry 2007) 3 23
  4. Identification of semaphorin 5A interacting protein by applying apriori knowledge and peptide complementarity related to protein evolution and structure. (PMID: 19329067) Sadanandam A. … Singh R.K. (Genomics Proteomics Bioinformatics 2008) 3 23
  5. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PMID: 10520995) Tamagnone L. … Comoglio P.M. (Cell 1999) 2 3

Products for PLXNB3 Gene

Sources for PLXNB3 Gene

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