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PLXNB3 Gene

protein-coding   GIFtS: 62
GCID: GC0XP153029

Plexin B3


(Previous symbol: PLXN6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plexin B31 2     Plexin 62
PLXN61 2 3 5     plexin-B32
PLEXB32     KIAA12063
PLEXR2     

External Ids:    HGNC: 91051   Entrez Gene: 53652   Ensembl: ENSG000001987537   OMIM: 3002145   UniProtKB: Q9ULL43   

Export aliases for PLXNB3 gene to outside databases

Previous GC identifers: GC0XP147167 GC0XP149484 GC0XP150615 GC0XP151497 GC0XP152550 GC0XP152682 GC0XP141686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLXNB3 Gene:
The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A,
and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for PLXNB3 Gene:
PLXNB3 (plexin B3) is a protein-coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4
Function: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates
neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of
PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse
as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1

Gene Wiki entry for PLXNB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLXNB3 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   Egr-3   oct-B3   oct-B2   Nkx2-5   POU2F2   POU2F1   COMP1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLXNB3 promoter sequence
   Search Chromatin IP Primers for PLXNB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLXNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

PLXNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLXNB3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153029:  view genomic region     (about GC identifiers)

Start:
153,029,651 bp from pter      End:
153,044,801 bp from pter
Size:
15,151 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4 (See protein sequence)
Recommended Name: Plexin-B3 precursor  
Size: 1909 amino acids; 206847 Da
Subunit: Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts
(via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain)
Sequence caution: Sequence=BAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z3E6 F5H773 Q9HDA4
Alternative splicing: 2 isoforms:  Q9ULL4-1   Q9ULL4-2   

Explore the universe of human proteins at neXtProt for PLXNB3: NX_Q9ULL4

Explore proteomics data for PLXNB3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn51, Asn231, Asn615, Asn802, Asn900, Asn957, Asn1101, Asn1218
  • Modification sites at PhosphoSitePlus

  • See PLXNB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001156729.1  NP_005384.2  

    ENSEMBL proteins: 
     ENSP00000355378   ENSP00000391650   ENSP00000396048   ENSP00000412454   ENSP00000445569  
     ENSP00000441919   ENSP00000444086   ENSP00000442736  
    Reactome Protein details: Q9ULL4

    PLXNB3 Human Recombinant Protein Products:

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    antibodies-online peptides for PLXNB3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLXN: Plexins

    Selected InterPro protein domains (see all 9):
     IPR014756 Ig_E-set
     IPR002165 Plexin_repeat
     IPR002909 IPT
     IPR008936 Rho_GTPase_activation_prot
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9ULL4

    ProtoNet protein and cluster: Q9ULL4

    1 Blocks protein domain: IPB013548 Plexin cytoplasmic region

    UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4
    Similarity: Belongs to the plexin family
    Similarity: Contains 4 IPT/TIG domains
    Similarity: Contains 3 PSI domains
    Similarity: Contains 1 Sema domain


    Find genes that share domains with PLXNB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLXB3_HUMAN, Q9ULL4
    Function: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates
    neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of
    PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse
    as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1

         Genatlas biochemistry entry for PLXNB3:
    plexin B3,calcium-dependent cell adhesion molecule at the neuronal cell surface

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding IPI15184888
         
    Find genes that share ontologies with PLXNB3           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Plxnb3):
     vision/eye 

    Find genes that share phenotypes with PLXNB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plxnb3tm1Mom for PLXNB3

       genOway: Develop your customized and physiologically relevant rodent model for PLXNB3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLXB3_HUMAN, Q9ULL4: Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the
    plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PLXNB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLXNB3 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Semaphorin interactions
    Semaphorin interactions0.43
    Other semaphorin interactions0.00
    3Axon guidance
    Axon guidance


    Find genes that share SuperPaths with PLXNB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PLXNB3
        Other semaphorin interactions


    1 Kegg Pathway  (Kegg details for PLXNB3):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLXNB3
    Interactions:

        GeneGlobe Interaction Network for PLXNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLXNB3 (Q9ULL41, 2, 3 ENSP000003553784) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METP085811, 3, ENSP000003172724EBI-311073,EBI-1039152 I2D: score=1 STRING: ENSP00000317272
    MST1RQ049121, 3, ENSP000002964744EBI-311073,EBI-2637518 I2D: score=1 STRING: ENSP00000296474
    SEMA4AQ9H3S12, 3, ENSP000003471174MINT-4507872 I2D: score=1 STRING: ENSP00000347117
    ARHGEF11O150853, ENSP000003571774I2D: score=3 STRING: ENSP00000357177
    MAGI2Q86UL83, ENSP000003461514I2D: score=2 STRING: ENSP00000346151
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IMP19850054
    GO:0007165signal transduction IEA--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance TAS--
    GO:0010593negative regulation of lamellipodium assembly ISS--

    Find genes that share ontologies with PLXNB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLXNB3 (PLXB3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLXNB3 gene (2 alternative transcripts): 
    NM_001163257.1  NM_005393.2  

    Unigene Cluster for PLXNB3:

    Plexin B3
    Hs.632833  [show with all ESTs]
    Unigene Representative Sequence: NM_001163257
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361971 ENST00000411613 ENST00000482654 ENST00000455214 ENST00000485980
    ENST00000448847 ENST00000469190 ENST00000472415 ENST00000538776(uc004fij.1)
    ENST00000538282 ENST00000538543 ENST00000538966(uc011mzb.1 uc011mzc.2 uc010nuk.2 uc004fii.2 uc011mzd.1)

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    Additional mRNA sequence: 

    AB033032.1 AF149019.1 AK292535.1 AK295762.1 AK295849.1 AK295894.1 AK296538.1 AK304705.1 
    AK307894.1 AY927551.1 BC131771.1 

    11 DOTS entries:

    DT.411749  DT.121309495  DT.102822682  DT.40109611  DT.100740225  DT.121309427  DT.121309449  DT.121309420 
    DT.121309478  DT.91992878  DT.92421832 

    Selected AceView cDNA sequences (see all 64):

    CD517568 AF149019 BF528615 BF345653 BQ722416 NM_005393 BP348957 CA397317 
    AB033032 Z40628 R46653 BX091694 CA425482 BM723513 BM721178 AI609808 
    AL039923 BG912057 BE890324 BP348513 CA454294 C01946 BM689380 CD300029 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB3 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:        -                                                                                                           -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c · 29d ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34 ^ 35a · 35b · 35c ·
    SP1:                                                                                                              -                             -     -         
    SP2:                                                                          -     -     -     -                                                               
    SP3:                                      -                                                                                                                     
    SP4:                                                                                      -     -                 -                                             
    SP5:                                                                                                                                                            

    ExUns: 35d ^ 36 ^ 37 ^ 38a · 38b · 38c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                    -               


    ECgene alternative splicing isoforms for PLXNB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLXNB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGCACGC
    PLXNB3 Expression
    About this image


    PLXNB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Spinal Cord (Nervous System)
    PLXNB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLXNB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632833

    UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4
    Tissue specificity: Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but
    not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in
    brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several
    glioma cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLXNB3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plxnb31 , 5 plexin B31, 5 82.55(n)1
    84.55(a)1
      X (37.40 cM)5
    1405711  NM_019587.21  NP_062533.21 
     737570905 
    lizard
    (Anolis carolinensis)
    Reptilia PLXNB36
    plexin B3
    61(a)
    1 ↔ 1
    2(86564919-86688943)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.57272 Xenopus laevis transcribed sequence with weak similarity more 74.86(n)    BX848740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plxnb31 plexin B3 58.81(n)
    54.51(a)
      566546  XM_689822.6  XP_694914.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta plexB3 axon guidance semaphorin receptor 40(a)   102A1   --
    worm
    (Caenorhabditis elegans)
    Secernentea plx-23   -- 25(a)   II(14413677-14421269)   --


    ENSEMBL Gene Tree for PLXNB3 (if available)
    TreeFam Gene Tree for PLXNB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLXNB3 gene
    PLXNB22  PLXND12  PLXNA32  PLXNA12  PLXNC12  PLXNA22  PLXNB12  PLXNA42  
    11 SIMAP similar genes for PLXNB3 using alignment to 7 protein entries:     PLXB3_HUMAN (see all proteins):
    DKFZp761P19121    PLXNB1    PLXNB2    PLXND1    Nbla00445    MM1
    PLXNA2    PLXNC1    PLXNA1    PLXNA3    PLXNA4

    Find genes that share paralogs with PLXNB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLXNB3 (see all 661)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833255311,2
    --141684732(+) GTTCCA/GGTTCC 2 -- us2k10--------
    rs1880632201,2
    --141685054(+) AGGCTC/TGCACC 2 -- us2k10--------
    rs59871501,2
    C,F,A--141685154(+) ATCCTG/CCTGCC 2 -- us2k15Minor allele frequency- C:0.50NA WA CSA 8
    rs59871511,2
    C--141685299(+) GGACAC/TGTGTG 2 -- us2k10--------
    rs48984401,2
    C,F,A--141685392(+) TTCTAG/AATCCC 2 -- us2k17Minor allele frequency- A:0.36NA WA CSA 11
    rs1396030291,2
    --141685449(+) CCCTCA/GCCGGC 2 -- us2k10--------
    rs1453538731,2
    C--141685491(+) GGGCCA/TGCCTG 2 -- us2k10--------
    rs1923046321,2
    C--141685613(+) AATGCA/GCTCTG 2 -- us2k10--------
    rs1842656971,2
    --141685688(+) GCAGGC/TTGGAA 2 -- us2k10--------
    rs22837501,2
    C,F,H--141685730(+) TACCCC/TGAGTC 2 -- us2k19Minor allele frequency- T:0.10EA NS NA 1302

    HapMap Linkage Disequilibrium report for PLXNB3 (153029651 - 153044801 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PLXNB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740633CNV Deletion23290073
    esv33199CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): PLXNB3

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLXNB3
    DNA2.0 Custom Variant and Variant Library Synthesis for PLXNB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300214    OMIM disorders: --


    Find genes that share disorders with PLXNB3           About GenesLikeMe


    Export disorders for PLXNB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLXNB3 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PLXNB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Plexin-B3 is a functional receptor for semaphorin 5A. (PubMed id 15218527)1, 2, 9 Artigiani S.... Tamagnone L. (EMBO Rep. 2004)
    2. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. (PubMed id 16122393)1, 2, 9 Hartwig C.... Finckh U. (BMC Neurosci. 2005)
    3. Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. (PubMed id 21706053)1, 2 Li X.... Lee A.Y. (Oncogene 2012)
    4. Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. (PubMed id 20696765)1, 2 Li X. and Lee A.Y. (J. Biol. Chem. 2010)
    5. Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)1, 2 Conrotto P.... Giordano S. (Oncogene 2004)
    6. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    7. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PubMed id 10520995)1, 3 Tamagnone L.... Comoglio P.M. (Cell 1999)
    8. Plexin B3 is genetically associated with verbal performance and white matter volume in human brain. (PubMed id 17033634)1, 9 Rujescu D....Finckh U. (Mol. Psychiatry 2007)
    9. Identification of semaphorin 5A interacting protein by applying apriori knowledge and peptide complementarity related to protein evolution and structure. (PubMed id 19329067)1, 9 Sadanandam A....Singh R.K. (amp 2008)
    10. Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. (PubMed id 19850054)1 Sadanandam A.... Singh R.K. (Microvasc. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5365 HGNC: 9105 AceView: PLXNB3 Ensembl:ENSG00000198753 euGenes: HUgn5365
    ECgene: PLXNB3 Kegg: 5365 H-InvDB: PLXNB3

    (According to HUGE)
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    HUGE: KIAA1206

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLXNB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLXNB3 gene:
    Search GeneIP for patents involving PLXNB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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