PLXNB3 Gene
protein-coding GIFtS: 61
GCID: GC0XP153029
|
|
plexin B3
(Previous symbol: PLXN6)
| |
Aliases
for PLXNB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Plexin B31 2 | | Plexin 62 | | PLXN61 2 3 5 | | Plexin-B31 | | PLEXB31 2 | | KIAA12063 | | PLEXR1 2 | | |
Export aliases for PLXNB3 gene to outside databasesPrevious GC identifers: GC0XP147167 GC0XP149484 GC0XP150615 GC0XP151497 GC0XP152550 GC0XP152682 GC0XP141686 |
Summaries
for PLXNB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PLXNB3:
The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, andplays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. (provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4Function: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulatesneurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well asinhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1
Gene Wiki entry for PLXNB3
|
Genomic Views
for PLXNB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLXNB3 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 Egr-3 oct-B3 oct-B2 Nkx2-5 POU2F2 POU2F1 COMP1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLXNB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLXNB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28PLXNB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP153029: view genomic region
(about GC identifiers)
Start:
|
153,029,651 bp from pter |
End:
|
153,044,801 bp from pter |
Size:
|
15,151 bases |
Orientation:
|
plus strand |
|
Proteins
for PLXNB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4 (See
protein sequence)Recommended Name: Plexin-B3 precursor Size: 1909 amino acids; 206847 Da
Subunit: Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (viacytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasmamembrane
Sequence caution: Sequence=BAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z3E6 F5H773 Q9HDA4Alternative splicing: 2 isoforms: Q9ULL4-1 Q9ULL4-2 Explore the universe of human proteins at neXtProt for PLXNB3: NX_Q9ULL4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULL4
PLXNB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001156729.1 NP_005384.2
ENSEMBL proteins: ENSP00000355378 ENSP00000391650 ENSP00000396048 ENSP00000412454 ENSP00000445569 ENSP00000441919 ENSP00000444086 ENSP00000442736 Reactome Protein details: Q9ULL4
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PLXNB3 for ontologies About GeneDecksing
PLXNB3 Antibody Products:
Assay Products for PLXNB3: |
Protein
Domains /
Families
for PLXNB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLXNB3 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q9ULL4ProtoNet protein and cluster: Q9ULL4 1 Blocks protein family: IPB013548 Plexin cytoplasmic region
UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4Similarity: Belongs to the plexin familySimilarity: Contains 4 IPT/TIG domainsSimilarity: Contains 3 PSI domainsSimilarity: Contains 1 Sema domain |
Function
for PLXNB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4Function: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulatesneurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well asinhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 Genatlas biochemistry entry for PLXNB3:plexin B3,calcium-dependent cell adhesion molecule at the neuronal cell surface
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNB3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PLXNB3 (NM_005393) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLXNB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNB3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
PLXNB3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Plxnb3tm1Mom for PLXNB3
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Plxnb3):
PLXNB3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PLXNB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Other semaphorin interactions | | | 3 | Axon guidance | | | 4 | Sema4D in semaphorin signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for PLXNB3
1 
Kegg Pathway (Kegg details for PLXNB3):
PLXNB3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLXNB3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/27 Interacting proteins for PLXNB3 (Q9ULL41, 2, 3 ENSP000003553784) via UniProtKB, MINT, STRING, and/or I2D (see all 27)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MET | P085811, 3, ENSP000003172724 | EBI-311073,EBI-1039152 I2D:
score=1 STRING: ENSP00000317272 | | MST1R | Q049121, 3, ENSP000002964744 | EBI-311073,EBI-2637518 I2D:
score=1 STRING: ENSP00000296474 | | SEMA4A | Q9H3S12, 3, ENSP000003471174 | MINT-4507872 I2D:
score=1 STRING: ENSP00000347117 | | ARHGEF11 | O150853, ENSP000003571774 | I2D:
score=3 STRING: ENSP00000357177 | | MAGI2 | Q86UL83, ENSP000003461514 | I2D:
score=2 STRING: ENSP00000346151 |
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0007275 | multicellular organismal development |
-- | -- | | GO:0007411 | axon guidance |
TAS | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
-- | -- |
PLXNB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for PLXNB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PLXNB3
Search CenterWatch for drugs/clinical trials and news about PLXNB3 / PLXB3
|
Transcripts
for PLXNB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PLXNB3 gene (2 alternative transcripts): NM_001163257.1 NM_005393.2 Unigene Cluster for PLXNB3: Plexin B3 Hs.632833 [show with all ESTs]Unigene Representative Sequence: NM_00116325712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361971 ENST00000411613 ENST00000482654 ENST00000455214 ENST00000485980
ENST00000448847 ENST00000469190 ENST00000472415 ENST00000538776(uc004fij.1)
ENST00000538282 ENST00000538543 ENST00000538966(uc011mzb.1 uc011mzc.2 uc010nuk.2 uc004fii.2 uc011mzd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNB3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PLXNB3 (NM_005393) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLXNB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNB3 |
Additional cDNA sequence: AB033032.1 AF149019.1 AK292535.1 AK295762.1 AK295849.1 AK295894.1 AK296538.1 AK304705.1 AK307894.1 AY927551.1 BC131771.1 11 DOTS entries: DT.411749 DT.121309495 DT.102822682 DT.40109611 DT.100740225 DT.121309427 DT.121309449 DT.121309420 DT.121309478 DT.91992878 DT.92421832 24/64 AceView cDNA sequences (see all 64): CD517568 Z40628 BQ722416 BF345653 NM_005393 BP348957 R46653 AF149019 CA397317 AB033032 BF528615 AL039923 BE890324 AI609808 BG912057 CA313922 BM721178 CA425482 CD300029 BG913187 BX091694 BM723513 BM688626 BM689380
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB3 (see all 15) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22 | ^ | 23 | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c | · | 29d | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b | · | 35c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 35d | ^ | 36 | ^ | 37 | ^ | 38a | · | 38b | · | 38c |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for PLXNB3
|
Expression
for PLXNB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PLXNB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGGCACGC
About this image
See PLXNB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLXNB3
SOURCE GeneReport for Unigene cluster: Hs.632833
UniProtKB/Swiss-Prot: PLXB3_HUMAN, Q9ULL4Tissue specificity: Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not incorpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver,pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines
SABiosciences Custom PCR Arrays for PLXNB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLXNB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLXNB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLXNB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXNB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNB3 |
Orthologs
for PLXNB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PLXNB3 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
PLXNB36 |
-- |
55(a) |
1 ↔ 1 |
2(86565621-86662335) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.57272 |
Xenopus laevis transcribed sequence with weak similarity more |
74.86(n) |
|
BX848740.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
plxnb31 |
plexin B3 |
59.12(n)
55.01(a) |
|
566546 XM_689822.5 XP_694914.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
plexB3 |
axon guidance semaphorin receptor |
40(a) |
|
102A1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
plx-23 |
-- |
25(a) |
|
II(14413677-14421269) -- |
ENSEMBL Gene Tree for PLXNB3 (if available)
TreeFam Gene Tree for PLXNB3 (if available) |
Paralogs
for PLXNB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PLXNB3 gene
- PLXNB22 PLXND12 PLXNA32 PLXNA12 PLXNA22 PLXNB12 PLXNC12 PLXNA42
11 SIMAP similar genes for PLXNB3 using alignment to 7 protein entries: PLXB3_HUMAN (see all proteins):DKFZp761P19121 PLXNB1 PLXNB2 PLXND1 Nbla00445 MM1
PLXNA2 PLXNC1 PLXNA1 PLXNA3 PLXNA4
PLXNB3 for paralogs About GeneDecksing
|
Genomic Variants
for PLXNB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PLXNB3 (153029651 - 153044801 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PLXNB3
1 CNV: 97103
Locus Specific Mutation Databases (LSDB): PLXNB3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLXNB3 |
|
Disorders
/ Diseases
for PLXNB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLXNB3 for disorders About GeneDecksing
OMIM gene information: 300214
OMIM disorders: --
5  diseases for PLXNB3: About MalaCardssporadic breast cancer breast cancer leukemia neuronitis
carcinoma
Export disorders for PLXNB3 gene to outside databases
|
Publications
for PLXNB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PLXNB3 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with PLXNB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Plexin-B3 is a functional receptor for semaphorin 5A. (PubMed id 15218527)1, 2, 9 Artigiani S.... Tamagnone L. (2004)
- Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. (PubMed id 16122393)1, 2, 9 Hartwig C....Finckh U. (2005)
- Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. (PubMed id 21706053)1, 2 Li X....Lee A.Y. (2012)
- Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. (PubMed id 20696765)1, 2 Li X. and Lee A.Y. (2010)
- Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)1, 2 Conrotto P.... Giordano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
- Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PubMed id 10520995)1, 3 Tamagnone L.... Comoglio P.M. (1999)
- Plexin B3 is genetically associated with verbal performance and white matter volume in human brain. (PubMed id 17033634)1, 9 Rujescu D....Finckh U. (2007)
- Identification of semaphorin 5A interacting protein by applying apriori knowledge and peptide complementarity related to protein evolution and structure. (PubMed id 19329067)1, 9 Sadanandam A....Singh R.K. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
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External Searches for PLXNB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PLXNB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PLXNB3 gene
(According to HUGE)
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Specialized Databases showing PLXNB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PLXNB3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PLXNB3 gene:
Search GeneIP for patents involving PLXNB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PLXNB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PLXNB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLXNB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLXNB3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PLXNB3 | | OriGene 3'-UTR Clone for PLXNB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLXNB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PLXNB3 | | OriGene Custom Protein Services for PLXNB3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLXNB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLXNB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLXNB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLXNB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLXNB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLXNB3 |
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| | | | Search Tocris compounds for PLXNB3 |
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 | | | PLXNB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLXNB3 |
|  |  |  | | | | Search ThermoFisher Antibodies for PLXNB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLXNB3 |
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